• Title/Summary/Keyword: 생체이용율

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The Effect of Corn Bran as a Fiber Source on the Utilization of Thiamin Niacin and Pantothenic Acid in Humans (옥수수겨가 티아민, 나이아신, 판토텐산의 생체이용율에 미치는 영향)

  • Yu, Bog-Hieu;Kies, Constance
    • Journal of Nutrition and Health
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    • v.25 no.6
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    • pp.450-460
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    • 1992
  • The study was performed to investigate the effect of corn bran as a fiber source on the utilization of thiamin niacin and pantothenic acid in human subjects for 8 weeks. Four different corn bran diets were fed : dry milled fine(DF) dry milled coarse(DC) wet milled fine(WF) and wet milled coarse(WC) Basal diet no corn bran bread added was employed as a control Apparent recovery of each B complex vitamin in urine was estimated to evaluate the vitamin and compared. The utilziation of three B vitamins was affected by the corn bran treatment. Dry milled corn bran had a higher recovery rate of thiamin(dry milled : 233% wet milled : 1.70%) than those receiving wet milled corn bran. Similar recovery pattern of niacin(dry milled : 1.94% wet milled : 1.50%) to that of thiamin was also observed. Particle size seemed to affect the vitamin utilization regardless of type of corn bran. Coarse bran gave a lower recovery value than fine corn bran in genreral. For pantothenic acid the recovery of the vitamin was affected to a greater extent by particle size of corn bran than by type of corn bran milling(fine: 60.22% coarse : 51.51%) Groups consuming wet milled corn bran\ulcorner(5`.57%) excreted more NDF than those fed dry milled corn bran(42.29%) Dry milled corn bran showed little or no water holding capacity poor fecal bulking properties and increased fecal transit time. The results suggest that corn bran supplementation exerts an negative effect on three B vitamin utilization.

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광독성, 광알러지성 물질의 안정성과 생체이용율증가 및 기전연구

  • 김봉희
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.328-328
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    • 1994
  • 광독성 및 광알러지를 일으키는 제반 약물이나 화학물질의 안정성과생체 이용율을 높이고 현재까지 확실하게 규명되어있지 않은 약물 및 화학물질에의한 광독성 광알러지성의 기전을 이해하고 설명할수있는 학문적 기초를 확립 하고저 phenothiazines 중 몇가지 약물를 택하여 적혈구를 이용한 광용혈 여부와 이에 미치는 ascorbic acid, butyl hydroxy anisole, dibutyl hydroxy toluene의 영향을 조사하였다. 각 약물 농도를 50$\mu\textrm{g}$/m1로 하고 UVA(350nm.2.5 ㎽/cm)조사시간은 30분으로 하여 적혈구의 광용혈현상을 Kahn등의 방법에의해 spectrophotometer로 측정한결과 chlorpromazine, perphenazine, thioridazine매 의한 광용혈정도는 ascorbic acid에의해 유의성 있게 감소되었다. 또한 적혈구를 가하기 전 각 약물을 미리조사시켜 생성된 물질에의한 광용혈현상의 광독성생성물질은 chlor- promazine과 thioridazine에서 보여졌으며, chlorpromazine의 광독성생성물질에 의한 적혈구 용혈현상만 ascorbic acid에의해 감소되었다.

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Bioavailability and Digestibility of Organic Calcium Sources by Bone Health Index (뼈건강 지표를 이용한 유기태 칼슘 급원의 생체이용성 및 소화율)

  • Han, Jeong-Ho;Kim, Eun-Mi;Cheong, Man-Ki;Chee, Sung-Kew;Chee, Kew-Mahn
    • Journal of Nutrition and Health
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    • v.43 no.1
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    • pp.12-25
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    • 2010
  • This study was carried out to evaluate the bioavailabilities and the digestibilities of oligopeptide chelated (peptide-Ca), anchovy bone (anchovy-Ca) and methionine hydroxyl analogue (MHA-Ca) calcium compared to those of calcium carbonate in rats. In exp1, $CaCO_3$, were added to the basal diet at level of 0, 30 and 60% calcium of the AIN-93G diet. In test groups, peptide-Ca, anchovy-Ca and MHA-Ca, were added to the basal diet to provide calcium at the level of 40% of AIN-93G. In exp1, the bioavailabilities were evaluated from the regression equation of the ratios of theological/ actual calcium intakes of each dietary treatment. In exp2, urine and feces was to evaluate the true- and apparent digestibility and apparent retention. In exp1, Ca-60% group had higher bone mineral density (BMD), bone mineral content (BMC) and bone breaking strength (BBS) than those of the other standard groups. The bone weight and ash content of the peptide-Ca and anchovy-Ca groups were significantly higher than those of the MHA-Ca. Bone calcium content were not significantly different from the test group. The bioavailability of the MHA-Ca group was shown higher BMD (71%), BS (38%) and BBS (27%) compared to another control group. But the regression coefficient for BMD, BS and BBS were lower compare with that of bone ash and BMC. In exp2, the true- and apparent digestibility of test groups were shown to over 90%. Peptide-Ca was not significantly different from other test group, but digestibility and retention were higher compare to other test groups. In conclusion, peptide-Ca, anchovy-Ca and MHA-Ca improved Ca bioavailability in the rats. The compounds were higher Ca digestibility compared with those of $CaCO_3$. It is assumed that difference of digestibility for test groups may be correlated to the bioavailability of test groups in BMD, BMC, BS, BBS and bone ash respectively.

Cephalexin 함유 생체점착성 마이크로캅셀의 제조 및 생물약제학적 평가

  • Kim, Jung-Hwan;Jung, Yeon-Bok;Han, Gun;Ji, Woong-Gil
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.346-346
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    • 1994
  • 1. 위장관통과 실험결과 polycarbphil 흑은 carbomer로 코팅한 생체막점착성 마이크로캅셀 모두가 Eudragit RS/RL 마이크로캅셀보다 위 및 소장상부에 다량 존재하는 것으로 보아 Polymer의 생체막점착성에 의해 제제의 위내용배출이 억제되었음을 알 수 있었다. 2. Polycarbophil 흑은 carbomer로 코팅한 생체점착성 마이크로캅셀의 AUC는 Eudragit RS/RL 마이크로캅셀의 결과에 비해 현저히 증가되었다. Polycarbophil로 코팅한 생체막점착성 마이크로캅셀은 carbomer로 코팅한 제제에 비해 Cm의 증가뿐아니라 전체적인 약물흡수의 증가와 높은 혈중농도의 지속을 보여주어 생체막점착성 제제의 이상적인 약물흡수패턴을 보여주었다. 3. 흡수속도효율 (ARE)면에서 생체막점착성 마이크로캅셀이 코팅전의 마이크로캅셀에 비해 약간 떨어졌으나, polycarbophil 코팅제제의 경우 전체적인 흡수양상이 마이크로캅셀에 비해 우수하고 또한 제어방출효율 (CRE)이 현저하게 증가되어 생체막점착성 제제로서의 유용성을 확인할 수 있었다. 4. 위내용배출의 지연효과, AUC, CRE 등을 종합해 볼때, Polycarbophil 로 코팅한 생체막점착성 마이크로캅셀은 투여횟수의 감소 및 생체이용율을 향상시키는 유용한 제제로 평가되었다.

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Development of Trans-Admittance Scanner (TAS) for Breast Cancer Detection (유방암 검출을 위한 생계 어드미턴스 스캐너의 개발)

  • 이정환;오동인;이재상;우응제;서진근;권오인
    • Journal of Biomedical Engineering Research
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    • v.25 no.5
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    • pp.335-342
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    • 2004
  • This paper describes a trans-admittance scanner for breast cancer detection. A FPGA-based sinusoidal waveform generator produces a constant voltage. The voltage is applied between a hand-held electrode and a scan probe placed on the breast. The scan probe contains an 8x8 array of electrodes that are kept at the ground potential. Multi-channel precision digital ammeters using the phase-sensitive demodulation technique were developed to measure the exit current from each electrode in the array. Different regions of the breast are scanned by moving the probe on the breast. We could get trans-admittance images of resistor and saline phantoms with an anomaly inside. The images provided the information on the depth and location of the anomaly. In future studies, we need to improve the accuracy through a better calibration method. We plan to test the scanner's ability to detect a cancer lesion inside the human breast.

Remote Face Recognition System through Internet (인터넷을 통한 원격 얼굴인식 시스템)

  • Song, Jee-Hwan;Park, Jong-Jin;Bae, Kyoung-Yul
    • Proceedings of the Korea Information Processing Society Conference
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    • 2003.11c
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    • pp.2005-2008
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    • 2003
  • 본 논문에서는 생체의 특징을 이용해 신분을 증명 또는 인증하는 생체인식 기술 중 지문이나 장문, 정맥, 홍채를 이용한 인식과 같이 장비에 접촉해야만 인증이 이루어지는 것과 달리 거부감이 없고, 별도의 전문 장비를 필요로 하지 않아 일반 대중들에 쉽게 접근할 수 있는 얼굴인식을 인터넷에 적용한 원격 신분증명 및 인증 시스템을 제안한다. 얼굴인식 알고리즘은 얼굴 특징을 분석하는 방식에 따라 PCA (Principal Component Analysis), ICA (Independent Component Analysis), FDA (Fisher Discriminant Analysis) 등이 발표되어 있다. 이들 알고리즘을 이용해 얼굴 특징을 분석한 결과를 원격지에 신속하고 정확하게 송수신할 수 있는 시스템이 요구됨에 따라 생체인식 시스템의 비교 평가와 함께 인터넷 상에서 얼굴인식을 이용한 원격 얼굴인식 시스템의 구성을 제안한다.

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Studies on Early Seedling Establishment and Early Growth Responses of Astragalus membranaceus Bunge with Different Seeding times, Application Conditions, and Green Manure Crops for Developing Organic Agriculture Relating to Cropping System (작부체계 활용 유기재배기술 개발을 위한 녹비작물, 토양투입 조건 및 파종시기에 따른 황기의 입모율과 초기생육 특성 연구)

  • Song, Beom-Heon;Lee, Kyung-A;Chang, Yoon-Kee;Kim, Young-Gook;Ahn, Tae-Jin;Ahn, Young-Sup;Park, Chung-Beom
    • Korean Journal of Soil Science and Fertilizer
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    • v.43 no.5
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    • pp.667-673
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    • 2010
  • Organic agriculture of especially medicinal crops has been interested and focused in taking the qualitative and safety agricultural products in order to maintain and improve the health and happiness of people. With respect to the organic agriculture relating to cropping system, objectives of this study were to examine the seedling establishment after seed germination and emergence and to investigate the early seedling growths of Astragalus membranaceus Bunge with treating two green manure crops, hairy vetch of legume and rye of gramineae, two different conditions of green manures, fresh and dry, and different seeding times. When the seeds were planted at once after treating the green manures with the fresh condition into the soil, the ratios of seedling establishment were very poor, less than 10% in hairy vetch and 20% in rye, respectively. They were increased gradually with delaying the seeding times after the treatments. With treating the green manures of dry conditions, the ratios of seedling establishment were up more than 50% in both hairy vetch and rye crops, showing that the damages of seedling establishment were more in hairy vetch than those in rye. The early seedling growths were slower in treating the green manures than those in the control, showing slow growth with fresh green manures compared to the dry. It would be very important and considered more to evaluate and utilize well the seed germination and the seedling establishment in cultivation of the organic agriculture using the green manure crops relating to the cropping system.

Body Composition Factor Comparisons of the Intracellular Fluid(ICW), Extracellular Fluid(ECW) and Cell Membrane at Acupuncture Points and Non-Acupuncture Points by Inducing Multiple Ionic Changes (생체이온 변화 유발 후 경혈과 비경혈에서의 생체 구조 성분 분석 및 비교를 통한 경혈 특이성 고찰)

  • Kim, Soo-Byeong;Chung, Kyung-Yul;Jeon, Mi-Seon;Shin, Tae-Min;Lee, Yong-Heum
    • Korean Journal of Acupuncture
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    • v.31 no.2
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    • pp.66-78
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    • 2014
  • Objectives : The specificity of acupuncture point has been a highly controversial subject. Existing researches said that ion-distribution differences are observed on the acupuncture point. This study was conducted under the assumption that multiple ionic changes induced by muscle fatigue would be different between the acupuncture point with non-acupuncture point. Methods : To induce the identical fatigue, twenty subjects performed the knee extension/flexion exercise using the Biodex System 3. ST32 and ST33 as well as adjacent non-acupuncture points were selected. We measured blood lactate and analyzed the median frequency(MF) and peak torque. To obtain the information on the extracellular fluid(ECW), intracellular fluid(ICW) and cell membrane indirectly, we used the multi-frequency bioelectrical impedance analysis(MF-BIA) method. Results : MF, peak torque and blood lactate level of all measurement sites were gradually returned to normal. Re resistance of ST32 had a stronger response, but a non-acupuncture point adjacent to ST33 had a larger response up to 20 minutes post exercise. Ri resistances were similar for both acupoints and non-acupoints. The $C_m$ capacitance of ST32 had a stronger response after inducing fatigue, but ST33 had a smaller response than a non-acupuncture point adjacent to it. Conclusions : In comparison with before and after inducing fatigue, the specificity of acupuncture points was not clearly observed. Hence, we concluded that the body composition factors extraction method had the limitation as a method of finding the specificity of acupuncture points by inducing fatigue.

A Study on Releasing Cryptographic Key by Using Face and Iris Information on mobile phones (휴대폰 환경에서 얼굴 및 홍채 정보를 이용한 암호화키 생성에 관한 연구)

  • Han, Song-Yi;Park, Kang-Ryoung;Park, So-Young
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.44 no.6
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    • pp.1-9
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    • 2007
  • Recently, as a number of media are fused into a phone, the requirement of security of service provided on a mobile phone is increasing. For this, conventional cryptographic key based on password and security card is used in the mobile phone, but it has the characteristics which is easy to be vulnerable and to be illegally stolen. To overcome such a problem, the researches to generate key based on biometrics have been done. However, it has also the problem that biometric information is susceptible to the variation of environment, whereas conventional cryptographic system should generate invariant cryptographic key at any time. So, we propose new method of producing cryptographic key based on "Biometric matching-based key release" instead of "Biometric-based key generation" by using both face and iris information in order to overcome the unstability of uni-modal biometries. Also, by using mega-pixel camera embedded on mobile phone, we can provide users with convenience that both face and iris recognition is possible at the same time. Experimental results showed that we could obtain the EER(Equal Error Rate) performance of 0.5% when producing cryptographic key. And FAR was shown as about 0.002% in case of FRR of 25%. In addition, our system can provide the functionality of controlling FAR and FRR based on threshold.

Effect of Sucrose and Supplementary Substances on the Germination Ecology and the Seedling Growth of Native Bletilla striata (자생 자란의 발아생태와 유식물 생육에 미치는 당과 첨가물의 영향)

  • 조근호;안영희
    • Korean Journal of Environment and Ecology
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    • v.14 no.3
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    • pp.205-211
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    • 2000
  • 본연구는 조경소재로 이용가능성이 크지만 현재 자생지가 파괴되어 복원이 요구되고 있는 야생자란의 대량번식을 위해 무균배양시 배지 내 담함량의 변화와 펩톤, 트립톤 등의 첨가가 종자발아와 계대배양 후 유식물의 생육에 미치는 영향을 알아보고자 실시하였다. 배지 내 펩톤과 트립톤의 첨가는 발아에 영향을 주지는 않았지만, 당의 함량은 그 농도가 10g/L까지 증가함에 따라 발아율을 높였다. 또한 발아 후 유식물의 생육시 당의 첨가는 뿌리의 생육을 두드러지게 향상시켰으며, 생체중도 거의 2~3배정도 많았다. 하이포넥스 배지(대조구)에서는 높은 발아율을 보였지만 유식물의 생육은 트립톤 첨가배지(2g/L)에서 많았는데 엽수, 뿌리수, 엽장 근장, 생체중 등이 모두 다른 처리구의 2~3배에 이르는 초기생육을 보였다. 계대배양 이후의 생육상은 펩톤 첨가배지에서 가장 많은 생육량을 보였는데 특히 엽장과 엽폭 그리고 근장이 다른 처리구보다 월등히 높은 경향을 나타냈다. 생체중도 한 개체당 0.18g으로 가장 높게 나타나 펩톤의 첨가가 계대배양 이후의 생육을 크게 촉지시키는 것으로 나타났다. 결론적으로 하이포넥스 배지에 트립톤 2g/L를 첨가하였을 때 발아율과 유식물의 생육이 다른 배지에 대해 매우 양호한 것으로 나타나 자생 자란의 종자발아용 배지로 가장 적당한 것으로 사료된다. 그리고 이후 계대배양시에는 펩톤의 첨가 (3g/L)가 유식물의 생육을 가장 촉진시키는 것으로 나타났다.

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