• Title/Summary/Keyword: 생존시간 추정

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Analysis of stage III stomach cancer using the restricted mean survival time (제한된 평균 생존시간을 이용한 위암 3기 자료 분석에 관한 연구)

  • Kim, Bitna;Lee, Minjung
    • The Korean Journal of Applied Statistics
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    • v.34 no.2
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    • pp.255-266
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    • 2021
  • The purpose of this study is to compare the effects of treatment on stage III stomach cancer data obtained from the SEER program of the National Cancer Institute and to identify the significant risk factors for the survival rates of stage III stomach cancer. Since the proportional hazards assumption was violated for treatment, we used the restricted mean survival time as an alternative to the proportional hazards model. The restricted mean survival time was estimated using pseudo-observations, and the effects of treatment were compared using a test statistic based on the estimated restricted mean survival times. We conducted the regression analysis using a generalized linear model to investigate the significant predictors for the restricted mean survival time of patients with stage III stomach cancer. We found that there was a significant difference between the restricted mean survival times of treatment groups. Age at diagnosis, race, substage, grade, tumor size, surgery, and treatment were significant predictors for the restricted mean survival time of patients with stage III stomach cancer. Surgery was the most significant predictor for increasing the restricted mean survival time of patients with stage III stomach cancer.

Modeling Clustered Interval-Censored Failure Time Data with Informative Cluster Size (군집의 크기가 생존시간에 영향을 미치는 군집 구간중도절단된 자료에 대한 준모수적 모형)

  • Kim, Jinheum;Kim, Youn Nam
    • The Korean Journal of Applied Statistics
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    • v.27 no.2
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    • pp.331-343
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    • 2014
  • We propose two estimating procedures to analyze clustered interval-censored data with an informative cluster size based on a marginal model and investigate their asymptotic properties. One is an extension of Cong et al. (2007) to interval-censored data and the other uses the within-cluster resampling method proposed by Hoffman et al. (2001). Simulation results imply that the proposed estimators have a better performance in terms of bias and coverage rate of true value than an estimator with no adjustment of informative cluster size when the cluster size is related with survival time. Finally, they are applied to lymphatic filariasis data adopted from Williamson et al. (2008).

Estimation of Survival Function and Median Survival Time in Interval-Censored Data (구간중도절단자료에서 생존함수와 중간생존시간에 대한 추정)

  • Yun, Eun-Young;Kim, Choong-Rak
    • The Korean Journal of Applied Statistics
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    • v.23 no.3
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    • pp.521-531
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    • 2010
  • Interval-censored observations are common in medical and epidemiologic studies; however, limited studies exist due to the complexity and special structure of interval-censoring. This paper introduces the imputation method and the self consistency method in the interval-censored data. We propose a new method of generating random numbers under an interval-censoring set-up. Through simulation studies we compare two methods under various simulation schemes in the sense of the mean squared error for estimating the median survival time and the mean integrated squared error for estimating the survival function. Under a moderate censoring percentage, the mean imputation method showed a better performance than the self-consistency method in estimating the median survival time and the survival function.

A Life Evaluation Method for Efficient Maintenance of Water Mains (상수관로의 효율적 유지관리를 위한 수명 평가 방법)

  • Choi, Chang-Log;Park, Su-Wan;Kim, Jeong-Hyun;Bae, Cheol-Ho
    • Proceedings of the Korea Water Resources Association Conference
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    • 2009.05a
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    • pp.271-275
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    • 2009
  • 본 연구에서는 상수관로의 잔존수명을 통계적 기법 중 하나인 비례위험모형(PHM)에 적용하여 평가하였다. 비례위험모형을 구축하기 위한 개별관로의 생존시간은 관로의 파손율이 한계파손율에 도달하는 시간으로 정의하였다. 즉, Park and Loganathan(2002)에서 제시한 GPBM을 적용하여 시간에 따른 개별관로의 파손율을 추정하고 추정된 파손율과 한계파손율의 상등관계를 통해 생존시간을 산정하였다. 또한, 본 연구대상관로에 대한 GPBM을 구축함에 있어, 매설시점에서 누적파손횟수를 0으로 한 파손기록을 입력자료에 추가하는 방법과 가중계수(WF)의 범위를 수정함으로써 기존의 GPBM을 보완하였다. 이로써 파손사건이 최소 1회 이상 기록된 강관 및 주철관에 대한 비례위험모형을 구축하였다. 이와 같이 수정된 방법론은 관로 파손사건 등의 자료의 축적이 미비한 국내 여건에서 비례위험모형 및 GPBM과 같은 통계적 모형을 구축할 때 유용할 것으로 사료된다. 본 연구대상관로의 비례위험모형에 포함된 유의한 공변수는 관종과 관경 그리고 길이이며 관종은 비례성 가정을 위배하여 시간종속형 변수로 모형화되었다. 최종 채택된 PHM모형을 통해 생존함수를 추정하였으며 추정된 생존함수를 이용하여 개별관로의 잔존수명 및 경제적 수명 그리고 각 수명에 대한 95% 신뢰구간을 산정하였다. 또한 개별관로의 경제적 수명에 영향을 미치는 공변수의 위험비율도 분석하였다. 분석결과 강관의 평균 경제적 수명은 약 25.1년이고 주철관은 약 21년으로 산정되었다. 또한 관종에 따른 경제적 수명에 도달할 상대적인 위험률은 전반적으로 주철관이 높으나 20년 이상 매설된 관로에서는 강관의 위험률이 높을 것으로 분석되었다. 관경과 길이는 크기에 비례하여 상대적 위험률도 증가하였다.

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Effect of Time-to-go Estimate to Impact Time Control Guidance Laws (충돌시간 제어 유도법칙에 대한 잔여비행시간 추정의 영향)

  • Kim, Mingu
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.47 no.8
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    • pp.558-565
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    • 2019
  • A lot of studies on the survivability of missiles have been widely studied, since the technology of modern warships equipped with state-of-the-art defense systems has been improved. The survivability of missiles can be improved by attacking a target simultaneously using multiple missiles. For this reason, impact time control guidance (ITCG) laws have been widely studied. This paper deals with the effect of time-to-go estimate to ITCG laws. In this paper, two kinds of time-to-go estimate are first introduced in two-dimensional and three-dimensional environment and then ITCG laws are derived using the time-to-go estimate. Numerical simulations are performed to analyze the performance of the designed ITCG laws and the effect of time-to-go estimate is discussed.

Analyzing Time in Port and Greenhouse Gas Emissions of Vessels using Duration Model (생존분석모형을 이용한 선박의 재항시간 및 온실가스 배출량 분석)

  • Shin, Kangwon;Cheong, Jang-Pyo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.30 no.4D
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    • pp.323-330
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    • 2010
  • The time in port for vessels is one of the important factors for analyzing the operation status and the capacity of ports. In addition, the time in port for vessels can be directly used for estimating the greenhouse gas emissions resulted from vessels in port. However, it is unclear which variables can affect the time in port for vessels and what the marginal effect of each variable is. With these challenges in mind, the study analyzes the time in port for vessels arriving and departing port of Busan by using a parametric survival model. The results show that the log-logistic accelerated failure time model is appropriate to explain the time in port for 19,167 vessels arriving and departing port of Busan in 2008, in which the time in port is significantly affected by gross tonnage of vessels, service capacity of terminal, and vessel type. This study also shows that the greenhouse gas emission resulted from full-container vessels, which accounted for about 61% of all vessels with loading/unloading purpose arriving and departing port of Busan in 2008, is about "17 ton/vessel" in the boundary of port of Busan. However, the hotelling greenhouse gas emissions resulted from non-container vessels (3,774 vessels; 20%) are greater than those from the full-container vessels. Hence, it is necessary to take into account more efficient port management polices and technologies to reduce the service time of non-container vessels in port of Busan.

Development of On-Board Survival Time Estimation System for Ships and Naval Vessels (탑재형 선박 및 함정의 생존시간 추정시스템 개발)

  • Hwang, Ho-Jin;Gong, In-Young;Lee, Gyeong-Jung
    • Journal of the Society of Naval Architects of Korea
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    • v.47 no.5
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    • pp.725-731
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    • 2010
  • Damages of ships and naval vessels due to accidents and attacks would arouse enormous loss of lives and properties. To prevent maritime accidents is the best, and many researches have been achieved. But maritime accidents occurs continuously and to minimize casualties is considered as the second best. This paper has focused on the method and implementation of survival time estimation system for ships(STES system). The developed STES system provides plain and easy operations to get the survival time of damaged ship and naval vessel. The officers feed damaged conditions simply and quickly, and grasp instantly the survival time for damages. It would be attained by query and retrieval of survival time DB collected in a design process. We also check an effectivity of the system by practical applications.

Generating censored data from Cox proportional hazards models (Cox 비례위험모형을 따르는 중도절단자료 생성)

  • Kim, Ji-Hyun;Kim, Bongseong
    • The Korean Journal of Applied Statistics
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    • v.31 no.6
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    • pp.761-769
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    • 2018
  • Simulations are important for survival analyses that deal with censored data. Cox models are widely used in survival analyses, therefore, we investigate how to generate censored data that can simulate the Cox model. Bender et al. (Statistics in Medicine, 24, 1713-1723, 2005) provided a parametric method for generating survival times, but we need to generate censoring times as well as survival times to simulate the censored data. In addition to the parametric method for generating censored data, a nonparametric method is also proposed and applied to a real data set.

Penalized variable selection in mean-variance accelerated failure time models (평균-분산 가속화 실패시간 모형에서 벌점화 변수선택)

  • Kwon, Ji Hoon;Ha, Il Do
    • The Korean Journal of Applied Statistics
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    • v.34 no.3
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    • pp.411-425
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    • 2021
  • Accelerated failure time (AFT) model represents a linear relationship between the log-survival time and covariates. We are interested in the inference of covariate's effect affecting the variation of survival times in the AFT model. Thus, we need to model the variance as well as the mean of survival times. We call the resulting model mean and variance AFT (MV-AFT) model. In this paper, we propose a variable selection procedure of regression parameters of mean and variance in MV-AFT model using penalized likelihood function. For the variable selection, we study four penalty functions, i.e. least absolute shrinkage and selection operator (LASSO), adaptive lasso (ALASSO), smoothly clipped absolute deviation (SCAD) and hierarchical likelihood (HL). With this procedure we can select important covariates and estimate the regression parameters at the same time. The performance of the proposed method is evaluated using simulation studies. The proposed method is illustrated with a clinical example dataset.

Nonparametric Estimation of the Survival Function under Progressively Random Censorship (점진적(漸進的) 임의중단법(任意中斷法)에서 생존함수(生存函數)의 비모수적(非母數的) 추정(推定)에 관한 연구(硏究))

  • Park, Byung-Gu;Lee, Kwang-Ho
    • Journal of the Korean Data and Information Science Society
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    • v.2
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    • pp.45-62
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    • 1991
  • In this paper we propose new nonparametric estimators of the survival function using spline function under the progressively random censoring scheme. This sampling scheme is applied in many practical situations such as clinical trials or the life testing problems. We also investigate the behaviors for some estimators in the proposed class and the performance of progressively random censoring scheme through the numerical examples and Monte Carlo simulation.

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