• The Microorganisms and Industry
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• v.19 no.4
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• pp.62-67
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• 1993

의약품을 중심으로 한 광학활성 생리활성물질의 제조 즉, 정밀유기합성은 정밀화학의 꽃이라 할 수 있다. 이러한 광학활성물질은 통상의 유기화학적 수법으로 합성하면 라세미체로 얻어지고 광학활성체로 얻을 수 없다. 그래서 최근 chiral 중심을 가지는 간단한 화합물(광학활성합성원료-chiral building block, chiral synthon)을 원료로 해서 입체 선택적으로 반응을 조절함으로써 다양한 광학활성표적 화합물을 합성하는 방법이 활발히 진행되고 있다. chiral building block의 제조 방법을 살펴보기로하자.

• The Korean Journal of Mycology
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• v.26 no.1 s.84
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• pp.78-85
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• 1998

During the screening of biological control agents for insect pests in the greenhouse, 70 dead insect-related fungi were isolated and tested insecticidal effect of their culture filtrates was tested. From this studies, CNAB-63 isolate showed strong control effects against the cotton aphids and the two-spotted spider mite as 65.19% and 77.55%, respectively. The insecticidal active compound of CNAB-63 isolate was purified from culture filtrate by silica gel chromotography, thin layer chromatography and HPLC. Purified active compound (CNAB) showed control effects against the two-spotted spider mite with 63.45% at $100\;{\mu}g/ml$ concentration. However, it did not exhibit antimicrobial activity against fungi and bacteria.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.04a
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• pp.104-104
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• 2018

흑구기자와 구기자에는 류신, 메티오닌, 페닐알라닌, 이소류신 등의 아미노산이 많이 함유되어 있고 무기염류, 베타카로틴, 비타민C 등이 다량으로 함유되어 있다. 이러한 생리활성 물질에 의하여 항산화 작용이 매우 큰 것으로 알려져있으며 간 기능보호, 콜레스테롤 제거, 자양강장 등의 효능이 있는 것으로 알려져있다. 특히 흑구기자에는 안토시아닌의 함유량이 매우 많아 수면장애 개선과 항노화, 피부주름억제, 피부재생효과 등이 있는 것으로 알려져있다. 또한 이러한 안토시아닌 색소는 암세포 발생과 전이를 억제하는것으로도 알려져있다. 즉, 구기자와 흑구기자는 혈액순환을 개선 시키고 혈관의 탄력을 증강시키어 심혈관질환을 개선하는 효과가 있다. 따라서 본 실험에서는 중국의 고원지대(해발 2500m 이상)에서 자생하고있는 구기자와 흑구기자의 생리활성 물질을 분석하여 항산화 효과를 검증하고자 하였다. 그 결과 총 폴리페놀 함량은 흑구기자와 구기자에서 비슷한 함유량을 나타내었다. 안토시아닌의 함량은 구기자보다 흑구기자에서 다량으로 함유되어 있다. 항산화 활성은 구기자보다 흑구기자에서 훨씬 더 양호한 결과를 나타내었다.

• Journal of the Korean Applied Science and Technology
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• v.39 no.1
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• pp.108-114
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• 2022

In this study, the antioxidant effect of black sea ginseng containing a large amount of eicosapentaenoic acid, a natural physiologically active substance, was investigated, and its superiority as a functional cosmetic raw material was presented. The ability of the sea cucumber extract to remove active oxygen was evaluated for the inhibitory effect on intracellular nitric oxide (NO) production. The physiologically active substances of sea cucumber have an antioxidant effect that removes free radicals, and as a result of evaluation, it was confirmed that excellent NO production was suppressed. Studies have shown that bioactive substances are involved in antioxidant effects, immune and inflammatory response regulation by showing high antioxidant efficacy even at low concentrations. It is thought that the antioxidant removal ability of sea cucumber greatly contributes to the antioxidant efficacy of phenolic components containing EPA (eicosapentaenoic acid) of the sea cucumber extract. It was found to be similar to the report that the antioxidant component of sea cucumber works. In addition, it is excellent for wound healing with the eicosapentaenoic acid (EPA) component contained in a large amount of sea cucumber extract, which has been proven to be involved in the inhibitory effect of inflammatory activity. As a result of this study, it was confirmed that the effect of the phenol component contained in the sea cucumber extract had a close causal relationship with the antioxidant activity.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.10a
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• pp.137.1-137
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• 2003

예로부터 류마티스 및 습진과 같은 피부병 등에 치료 효과가 있어 민간요법으로 널리 이용하여 왔던 천연수 중 하나인 온천수에 대하여 성분 분석 및 각종 생리활성에 대한 연구를 통하여 그 효과를 검증하고자 하였다. 943m에서 취수된 경산 사이판 온천수에 함유되어 있는 각종 성분을 분석한 결과 17종류의 성분이 검출되었으며 그중 무기물이 11종이 분석이 되었고 다른 온천수와 비교하여 K이나 Na가 비교적 많이 함유되어 있는 것이 특징이었다. 각종 발암성 물질에 대하여 경산 사이판 온천수의 돌연변이 억제활성을 검토하기 위해서 Samonella typhimurium TA98을 이용하여 Ames test를 행하였다. 그 결과 직접변이원인 4NQO에서는 40%의 억제 효과를 나타내었고 간접변이원인 Trp-P-1과 B(a)P은 각각 52.4%, 43.1%의 비교적 낮은 억제활성을 보였다. 또한 경산 사이판 온천수의 항암활성 규명을 위해 인간 암세포주를 이용한 SRB assay를 행하였는데 폐암세포인 A549에서는 66%, 위암세포인 AGS에서 45.6%, 유방암세포인 MCF-7에서 37%, 자궁암세포인 HeLa에서는 47.5%, 그리고 간암세포인 Hep3B에서는 52.7%의 억제율을 보였다.

• Bulletin of Food Technology
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• v.7 no.4
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• pp.13-39
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• 1994

• Journal of Life Science
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• v.17 no.7 s.87
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• pp.915-922
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• 2007

In order to discover physiologically active substance, we investigated a powder obtained by processing of Opuntia ficus-indica var. saboten Makino trunk. The powder was treated by sulfuric acid and then extracted by several solvents such as methanol, methylene chloride, ethanol etc. Among them, the best antimicrobial activity was showed by methylene chloride extract. To identify materials exhibiting physiological activation, the acid hydrolyzed extract was separated by 7 fractions through preparative silica gel TLC. The effective fraction exhibiting the best broad antimicrobial activity was identified, named as MBT-01108. From structural analysis of the products extracted to acid hydrolysis, a compound exhibiting the antimicrobial activities is identified to levulinic acid. Levulinic acid isolated from Opuntia ficus-indica var. saboten Makino may be applicable as a natural preservative of food or cosmetic and for prevention of bacterial diseases, an ingredient of acne, ageing and whitening cosmetics and an antimicrobial agent.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.8
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• pp.1136-1142
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• 2005

To develop new anti-aging foods or cosmetics by using antioxidants, SOD activator and elastase inhibitor, both potent anti-aging substances, were screened from various extracts of medicinal Plants and its optimal extraction conditions were investigated. Antioxidant activity has showed the highest in methanol extracts of Prunus persica (seed; 98.0$\%$). Methanol extracts of Morus alba (leave; 41.0$\%$) showed the highest elastase inhibitory activity while Lycium chinense (fruit; 197$\%$) showed the highest activation effect in SOD activity. The Prunus persica extract that exhibited the highest activity was extracted by treatment of Prunus persica powder with methanol at 40$^{\circ}C$ for 18 h and the SOD activity was maximum with extract from Lycium chinense extracted with deionized water at 30$^{\circ}C$ for 12 h. Elastase inhibitory activity of Morus alba was maximally extracted when it was treated with 70$\%$ methanol at 50$^{\circ}C$ for 12 h.

• Bulletin of Food Technology
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• v.14 no.3
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• pp.94-102
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• 2001

대두, 소위 황두는 중국, 아시아는 물론 세계에서 예로부터 광범위하게 식용으로 재배한 두류이다. 대두에는 식물성 유지와 단백질이 풍부하다. 역사 이래 인류는 콩으로부터 착유하거나 두부를 만들거나 동시에 가공하지 않고 직접 식용으로 이용하여 왔다. 근래에 두류에는 식물성 유지와 단백질 등의 영양소가 풍부하다는 것 이외에 새롭게 알려진 특수한 생물학적 작용을 하는 생리 활성 물질이 있다고 밝혀졌다. 그 예로는 대두 oligosaccharide, 대두 사포닌, 대두 이소플라본, 대두 인지질, 비타민 E 등이 있다.

• Journal of Animal Science and Technology
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• v.48 no.5
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• pp.709-718
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• 2006

In order to know the effects of Garlic, Scallion, Flavonoid, Urushiol, Anthocyanidin and Bio-MOS?? on pathogenic microbes and rumen anaerobic microbes, the growth rate of pathogens (including Escherichia coli O157, Salmonella paratyphi, Listeria monocytogenes and Staphylococcus aureus) and in vitro rumen microbial growth, gas production, ammonia concentration, carboxymethylcellulase(CMCase) activity, and microbial populations were investigated.The growth of pathogens was inhibited by supplementation of 0.1% Flavonoid, Scallion or Bio-MOS?? as biological active materials. And Scallion and Flavonoid had powerful antimicrobial properties on the pathogens applied in paper disc method.Although few effects by biological active materials disappeared in rumen fermentation in vitro, CMCase activity removed with supplementation of 1% of Flavonoid which had antimicrobial property in paper disc method. Scallion, having powerful antimicrobial property on pathogens and no inhibiting on rumen fermentation, might be a source in development of natural antimicrobial agent for ruminants.