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Hizikia Fusiformis Hexane Extract Decreases Angiogenesis in Vitro and in Vivo (Hizikia fusiformis 추출물의 in vitro 및 in vivo에서 혈관신생 감소 연구)

  • Myeong-Eun Jegal;Yu-Seon Han;Shi-Yung Park;Ji-hyeok Lee;Eui-Yun Yi;Yung-Jin Kim
    • Journal of Life Science
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    • v.33 no.9
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    • pp.703-712
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    • 2023
  • Angiogenesis, the formation of blood vessels from pre-existing vessels, is a multistep process regulated by modulators of angiogenesis. It is essential for various physiological processes, such as embryonic development, chronic inflammation, and wound repair. Dysregulation of angiogenesis causes many diseases, such as cancer, autoimmune diseases, rheumatoid arthritis, cardiovascular disease, and delayed wound healing. However, the number of effective anti-angiogenic drugs is limited. Recent research has focused on identifying potential drug candidates from natural sources. For example, marine natural products have been shown to have anti-cancer, anti-oxidant, anti-inflammatory, antiviral, and wound-healing effects. Thus, this study aimed to describe the angiogenesis inhibitory effect of Hizikia fusiforms (brown algae) extract. The hexane extract of H. fusiformis has shown inhibitory effects on in vitro angiogenesis assays, such as cell migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs). The hexane extract of H. fusiformis (HFH) inhibited in vivo angiogenesis in a mouse Matrigel gel plug assay. In addition, the protein expression of vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/extracellular signal kinase, and AKT serine/threonine kinase 1 decreased following treatment with H. fusiformis extracts. Our results demonstrated that the hexane extract of H. fusiformis (HFH) inhibits angiogenesis in vitro and in vivo.

A Comparative Study on Discrimination Issues in Large Language Models (거대언어모델의 차별문제 비교 연구)

  • Wei Li;Kyunghwa Hwang;Jiae Choi;Ohbyung Kwon
    • Journal of Intelligence and Information Systems
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    • v.29 no.3
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    • pp.125-144
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    • 2023
  • Recently, the use of Large Language Models (LLMs) such as ChatGPT has been increasing in various fields such as interactive commerce and mobile financial services. However, LMMs, which are mainly created by learning existing documents, can also learn various human biases inherent in documents. Nevertheless, there have been few comparative studies on the aspects of bias and discrimination in LLMs. The purpose of this study is to examine the existence and extent of nine types of discrimination (Age, Disability status, Gender identity, Nationality, Physical appearance, Race ethnicity, Religion, Socio-economic status, Sexual orientation) in LLMs and suggest ways to improve them. For this purpose, we utilized BBQ (Bias Benchmark for QA), a tool for identifying discrimination, to compare three large-scale language models including ChatGPT, GPT-3, and Bing Chat. As a result of the evaluation, a large number of discriminatory responses were observed in the mega-language models, and the patterns differed depending on the mega-language model. In particular, problems were exposed in elder discrimination and disability discrimination, which are not traditional AI ethics issues such as sexism, racism, and economic inequality, and a new perspective on AI ethics was found. Based on the results of the comparison, this paper describes how to improve and develop large-scale language models in the future.

Analysis of Eco-Citizenship Contents Elements in Home Economics Textbooks for the Introduction of Ecological Transformation Education (생태전환교육 도입을 위한 가정과 교과서의 생태시민성 내용 요소 분석)

  • Cho, Sung Mi;Park, Mi Jeong
    • Journal of Korean Home Economics Education Association
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    • v.35 no.2
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    • pp.1-20
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    • 2023
  • The purpose of this study is to extract and analyze ecological citizenship elements in the middle school home economics textbook used in the 2015 national curriculum for the introduction of ecological transformation education in the 2022 national curriculum. As a result of the analysis, the content analysis of the ecological citizenship factor was validated by six experts who are incumbent middle school home economics teachers, and the S-CVI value was 0.97, ensuring the validity of the ecological citizenship factor analysis. The results of analyzing 242 ecological citizenship factors extracted from home economics textbooks are as follows. According to the content area of the 2015 national home economics curriculum, the 'human development and family' area had the highest presence of ecological citizenship factors followed by the 'resource management and self-reliance' area and the 'home life and safety' area. Among the categories of ecological citizenship factors, 'value⋅attitude' was the most frequent, followed by 'process⋅function' and 'knowledge⋅understanding'. For each textbook composition system, ecological citizenship elements were extracted in the order of pictures, text, activities, and supplementary materials. There was a significant variation in the number of ecological citizenship factors among publishers, indicating the importance of the textbook writers' perception, interpretation, and direction of writing. Based on these analysis results, ecological citizenship teaching and learning activities applicable to home economics education were presented. This study highlights the potential for practicing ecological citizenship education in line with the new orientation of the curriculum on ecological transformation education through home economics education. Furthermore, it provides valuable baseline data for the development and implementation of textbooks for the 2022 national curriculum.

The Educational Acceptance of Religion in Multicultural Society: Focused on Cooperative Religious Education (다문화사회에서 종교의 교육적 수용 - 협력 종교 교육을 중심으로 -)

  • Kim Jin-young
    • Journal of the Daesoon Academy of Sciences
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    • v.45
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    • pp.153-186
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    • 2023
  • Since the 2000s, Korean society has been transitioning into a multicultural society with a sharp increase in the influx of various non-Koreans including immigrant workers, immigrant spouses, international students, and refugees. As a result, Korea, which had maintained religious peace and coexistence as a multi-religious society, is showing signs of increased risks of social problems such as the surfacing of conflicts between religions. Religion can contribute to the integration and safety of communities in the process of becoming a multicultural society, but at the same time, it requires discussion from an educational perspective because of its ambivalence in potentially causing conflict within communities. Considering that one of the main functions of religion is social integration, religious education is required for the stable settlement of multicultural societies. In recognition of this, discussion regarding a new perspective on religious education is needed to respond to religious diversity and to understand the current society and the means of becoming a global citizen. This new discussion would be a 'general religious education' model that provides an education covering various religious and non-religious worldviews in order to cultivate 'religious literacy.' However, in a multicultural society, while general religious education may be useful in reducing prejudice and discrimination among students in an integrated environment, it should also be recognized that a 'special religious education' would be needed to acknowledge the unique values of each human group. This would be the most effective approach to multiculturalism. Therefore, this study proposes a form of 'cooperative religious education,' which combines general religious education and special religious education as a direction for religious education. In providing readers with background context, this study will review Korean religious policies and religious education, and then present realistic methods that can be implemented in schools.

Actor Gang Ho Song's Realistic Character and Acting ; Based on the film (2017) (배우 송강호의 사실적인 캐릭터와 연기 ; 영화 <택시운전사>(2017)를 중심으로)

A Study on Bernard Lamy's La Rhétorique ou L'Art de Parler (베르나르 라미의 『수사학 또는 말하는 기법(1675)』에 관한 연구)

  • LEE, Jong Oh
    • Journal of International Area Studies (JIAS)
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    • v.13 no.1
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    • pp.345-368
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    • 2009
  • Our research task have goal to describe a treaty rhetoric known as 『La Rhétorique ou L'Art de Parler』(1688) which corresponds to a very wide field of which the step is not yet dubious in our country. Thus to study the rhetoric of Lamy borrowed from the thought of Descartes, we left the concept d' origin of language in traditional rhetoric in connection with logic and grammar (in first part). Also the second part is devoted to the tropes and the figures that are modified and deteriorated by the language of passion called 'rhetoric of passion or psychological of figure', etc. And the third part interests in the body of the speech being the character of l' heart. Under the influence of the rhetoric of Lamy, French rhetoric at the 17th century is held for an essential text when one interests in the history of the ideas and rhetoric, marked in its specificity (passion). The project of Lamy registered in the concept of passion like 'manners of speaking'. To close this study, which does one have to retain? The first remark to note is that Lamy founds his rhetoric in opposition to traditional designs dating from the beginning of Aristote. Second remark is the idea that one finds based in famous the books of Dumarsais at the 18th century and Fontanier at the 19th century. Admittedly, Lamy is a true rhetorician, grammairien which interests in the question of passions in the speech forces to reconsider the idea spread since Mr. Foucault, and makes it possible to understand the passage of the Great century at the Century of Lumuères. Even if this opinion is not shared, it will be agreed that the work of Lamy on passions or the phenomena sensory and psychological in the center of the language deserves reflexion.

Preventive Dimension of Confucian Morality regarding Adolescent Deviation (청소년 일탈에 대한 유교 도덕의 예방적 차원)

  • Shin, Chang Ho;Choi, Seung Hyun
    • The Journal of Korean Philosophical History
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    • no.27
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    • pp.417-446
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    • 2009
  • This study was to review the features of the preventive dimension in connection with adolescent deviation on the basis of the morality and ethics held by Confucian doctrine. To find solutions to the problems of adolescent deviation is never easy. As adolescent deviation always does occur, it is important to consider the methods that can minimize and prevent it. The traditional society of Korea laid weight on the education and training in the aspect of preventive measure against such adolescent deviation by emphasizing moral edification and realization of spiritual understanding for it. In this paper, the researcher tried to understand the problem situations by examining the image of such deviation and its type as well as the method on response thereto targeting the young generation of Korea. In addition, the researcher analyzed how the adolescent was recognized in the traditional society that was established on the Confucian values, and moral standards that applied to them, and the process of education as well. Through the moral concepts of Confucianism that were revealed in the Doctrine of the Mean (中庸, pronounced 'Jungyong' in Korean) in particular, the researcher sought the possibility of education on morality and ethics that will be able to prevent adolescent deviation. This study suggests that the morality and ethics held by Confucian doctrine can prevent adolescent deviation and open a new horizon of ethics education.

The Synesthetic Presence and Physical Movement of Nong-ak as Seen Through Affect Theory (정동 이론으로 본 농악의 공감각적 현존과 신체 운동)

  • Kwon, Eun-Young
    • (The) Research of the performance art and culture
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    • no.40
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    • pp.5-35
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    • 2020
  • Affect is intensity and quality that are generated as the physical body senses the outside world. Of experienced affect, notions that are granted meaning and interpretation are emotions. Affect theory distinguishes emotion and affect and by focusing on affect, it provides methods with which to analyze physical body responses and changes and it presents new possibilities to performing arts research that uses the physical body as a medium. Nong-ak is art that concentrates mainly on the occurrence of affect rather than 'representation'. Nong-ak is a performance type in which sound, color, texture, and physical movement overlap and exist in a synesthetic way. Here, physical things such as instruments, props, costumes, and stage devices are gathered together with non-physical things such as rhythm, mood, and atmosphere around human bodies. The physical body is stimulated by these things, displays tendencies that suit performances, and becomes 'the body without an image' as it immerses itself into the performance, acting while displaying 'quasi-corporeality'. The body, which moves automatically as if without consciousness, appears more easily within groups. To transition individuals of everyday life to 'the body without an image', Nong-ak executes the group physical exercise of 'Jinpuri'. Such physical exercise builds up affect by increasing nonverbal communion and communication and brings out the creativity of individuals within mutual trust and a sense of belonging. Affect and emotion stirred up by Nong-ak act as confirmation and affirmation of the existence, vitality, and ability of one's self and groups. Such affirmation recalls Nong-ak as a meaningful and important value from group dimensions and perceives it as a performance form that should be preserved and passed on.

A Comparative Study on theories of Korean Theatre and Japan Theatre : focused on 'Kwandaega(廣大歌)' and 'Poogjahwajun(風姿花傳)' (한·일 연극이론의 비교 연구 - 「광대가(廣大歌)」와 「풍자화전(風姿花傳)」을 중심으로)

  • Kim, Ikdoo
    • (The) Research of the performance art and culture
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    • no.23
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    • pp.5-36
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    • 2011
  • The purposes of this treatise are to compare theories of theatre in 'Kwandaega' with theories of theatre in 'Poongjahwajun', to recognize differences of theories between the former and the latter, and to find out the comparative characteristics of theories of Korean theatre. There are four differences between the former and the latter. These are as follows; Firstly, in the aspect of contents, the former is consisted of discussions about nature of theatre, discussions about acting, discussions about staging, and the latter is consisted of discussions about nature of theatre, discussions about acting, discussions about staging, discussions about origin, and discussions about dramaturgy. Secondly, in the aspect of nature, the nature of theatre in the former is recognition and practice as 'homo performans', the nature of theatre in the latter is realization of 'flower[花]'. Thirdly, in the aspect of acting, discussions about acting of the former are consisted of 'Sachae' theory'(Inmulchirae, Sasulchirae, Dekm, Nerumsae), discussions about acting of the latter are consisted of method of training per ages, method of training per role playings, trainings in everyday life. Fourthly, in the aspect of staging, the focus of staging in the former is realization of an endless series of changes[千變萬化], the focus of staging in the latter is realization of 'flower[花]'. There are four characteritics in the theories of Kwangdaega. These are as follows; Firstly, the contents of kwangdaega are consisted of discussions about nature of theatre, discussions about acting, discussions about staging. This theory is theory centered on actor/actress. Secondly, the nature of thestre in Kwangdaega is recognition and practice as 'homo performans', supporting of self-generational values, supporting of folk, new interpretation about secularism. Thirdly, the discussions about acting are consist of 'Sachae Theory'. Fourthly, the discussions about staging are consisted of realizations of an endless series of changes[千變萬化]

Beneficial Effects of Fermented Cricket Powder as a Hair Growth Promoting Agent in a Mice Model (생쥐 모델에서 쌍별 귀뚜라미 발효 분말의 발모 촉진제로서의 유익한 효과)

  • Hwang, Jihye;Hwang, Ui Wook
    • Journal of Life Science
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    • v.32 no.3
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    • pp.196-201
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    • 2022
  • Insects have been proposed as new protein sources for human nutrition, and protein availability is affected by insect characteristics. Fermentation can be used to obtain a variety of insect-based ingredients and products with unique properties, but its effect on protein availability is unknown. Fermented cricket (Gryllus bimaculatus) powder consists mainly of protein, and its oral administration has been reported to improve hair growth in androgenetic alopecia. The purpose of this study was to evaluate the hair-promoting activity of fermented cricket powder in an animal model using male C57BL/6 mice (25-30 g). The abdominal hair of the mouse (2x2.5 cm) was gently removed, and the groups fed as follows: Intact controls (no cricket powder); cricket powder only; and fermented cricket powder only. Food was applied daily for 11 weeks. Observational and physical examinations were performed and the results of the different groups compared. The application of fermented cricket powder significantly (p<0.01) promoted hair growth compared to the intact controls. The C57BL/6 results confirmed increased growth after seven weeks when the proportion of anagen follicles had increased by about 125% and 120% in the control and cricket powder groups, respectively. In conclusion, fermented cricket powder can be seen as a promising alternative alopecia treatment because it promotes hair growth, and, given the powder's composition, trace elements such as amino acids may have contributed to these effects.