• Korean Journal of Social Welfare
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• v.68 no.4
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• pp.119-141
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• 2016

This study analyzed on the basis of the norms and experience the Seongnam youth dividend ordinance. Youth dividend pros in the normative dimension to understand in order to achieve social justice. Further, youth dividend can replace the existing policy. On the other hand, the opposite of youth dividend is pointed out that the policy is ambiguous without morally justifiable. Also it has been pointed out inefficiencies means. Youth dividend Pros empirical dimension is a social considerations measures, there is a need for innovation by the failure of existing measures. On the other hand, youth dividend opposed to target efficiency is low, and that the problem is often to the contents of the salary. Because both sides are too contrast, consensus is difficult, can be political point of view is a significant impact. The basic income is a new thought experiment for human self-realization. Therefore, the production social welfare policy personality is a different policy science. That is, it is a long-term care social policy that requires a holistic life support. In addition, a non-empirical policy that requires a material support for the substantial freedom. Therefore, it is necessary to understand the philosophical meaning than scientific evaluation of traditional policy aiming to realize autonomous life. Therefore, radio waves of basic income through the welfare politics and exercise is still important strategy.

• KOMUNHWA
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• no.68
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• pp.59-75
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• 2006

At the beginning of the 21st century with taking a serious view of the harmony between human and nature, and of keeping an ecological balance, China has tried to reduce the gap in economy between rural districts and the urban city, and to carry out the policies for establishing a harmonious socialism through full-scale cooperation and continuous developments. And in order to preserve their traditional culture and to keep the historical legitimacy of People's Republic of China against urgent economical changes since the reform and openness, China has stressed the importance of training patriotic attitude on their cultural heritages. Thus the Chinese museums started to recognize more ad more the importance of social education as well as their functions of preserving the cultural property and of exhibiting it. And with them they have turned their attentions to an Ecomuseum, a new type of a museum. The ecomuseum in China was first established at a remote place between mountains where the ethnic minority inhabited. This was because of the feeling of some crises on culture native to the minority, followed by the process of China's Western Region Development. And it was recognized that they should participate actively in creating the cultural demand of the minority and in establishing a harmonious society with improving economic condition. Therefore in order to activate the ecomuseum it is localized and sinicized little by little through strengthening the management of cultural heritages of the minority.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.1
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• pp.143-151
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• 2015

Technology convergence, recently accelerated in various technical fields, can be achieved by discovering a new technology while exchanging the knowledge among the different technologies and utilizing such knowledge into the existing fields of technology. In particular, technology convergence actively occurs in knowledge-intensive ICT. However, limited research is available on the routes of ICT technical knowledge diffusion because of insufficient data. Therefore, this study built a database on the citations of patent data applied from 2006 to 2013 in Korea and their cited patents. We drew a patent citation network, a technology citation network and an applicant citation network, after which we analyzed the routes of technical knowledge diffusion. Results showed that ICT played a leading role in knowledge citation among technologies and that such diffusion took a shorter time in technology citation when it occurred more frequently and when the citation occurred between ICTs. In addition, most of the ICT showed a strong citation relationship with the other ICTs or such technologies in the field of physics or electricity, whereas electric elements (H01) showed various citation relationships with technologies other than ICT. Furthermore, we found a strong technology diffusion relationship between domestic corporations and domestic natural persons. National organizations often cited the patents of other applicants, whereas the patents of domestic corporations were actively cited between domestic corporations or by other applicants. Thus, this study is expected to be useful in measuring the performance of technologies, including the diffusion to other technologies. As well as in considering the routes of technical knowledge diffusion in Korea.

• The Journal of the Korea Contents Association
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• v.10 no.11
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• pp.169-179
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• 2010

In these days, space design is evolving to the mixed reality space where fused on-line and off-line. But, standard and measure of mixed reality space has not been suggested and there has been little research about media environment and expression method as a mixed system either. That's why here I suggest four media environments and their characteristics that act not only as a critical point in the mixed reality space based on ubiquitous technology but also as a standard for spatial discerning. 1) Real space that is a media environment only seen by human visual and tactical sense is evolving using expression methods like new materials based on digital technology and LED. 2) Augmented reality space is a media environment using information instruments is expressed with diverse 2D and 3D contents. 3) Cyber Space is a environment depends totally on media instruments is produced by perfect graphic information without any spatial and physical limitations. 4) Augmented cyber space is realized only through the displays in cyber studio and is a space where real objects and graphic information are mixed. Depending on the purpose of the experience, media environment and expressional characteristics of mixed reality space can be fused, blended, and mixed, and that can be realized to the intelligent information space where one can experience without spatial, visual, informational limitations. In the future, studies on physical characteristics of contents according to the media environment characteristics are necessary.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.445-449
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• 1996

한 국가의 과학기술 수준은 그 국가의 현재와 미래를 짐작케 하는 가장 중요한 척도라고 해도 과언은 아니다. 이에 따라 각국은 기술발전을 기하기 위하여 다양한 과학기술 정책을 펴고 있으며, 이러한 정책의 성패 여부는 국가의 과학기술 수준 뿐 아니라 국가의 미래에 지대한 영향을 미치게 된다. 그러나 세계무역기구(WTO)의 출범에 따라 기존의 과학기술 정책에 대폭적인 수정이 불가피하게 되었다. WTO는 공정한 무역질서의 회복을 위한 제반 규율을 대폭 강화하고 있으며, 여기에는 과학기술 정책과 관련한 부분들도 많이 포함되어 있다. 이로 인해 기존의 과학기술 정책에 대폭적인 방향수정이 요구되었고, 각 관련기관에서는 이에 대한 다양한 대응책들을 제시하고 있으나, 이러한 대응책들은 주로 민간 분야와 관련한 것이어서 미흡한 감이 있다. 이는 민간 분야에 파급효과가 지대한 것으로 알려지고 있는 국방과학기술에 대한 정책이 고려되지 않았기 때문이다. 사실 선진국에서는 국방과학기술분야에의 투자를 통해 많은 효과를 얻고 있다. 또한 국방 분야에 대한 문제는 WTO 체제에서 예외로 인정하고 있어, 새로운 환경에 대한 좋은 대응책이 될 수 있다. 그러므로 국방과학기술 정책에 대한 고려가 없는 과학기술 정책은 완전한 정책이라고 할 수 없다. 본 연구에서는 WTO의 출범에 대한 대응방안으로서 국방과학기술 정책의 효율적인 집행을 제안하였다. 이를 위해 우선 WTO의 성격과 WTO 출범으로 야기되는 과학기술 정책및 특히 국방과학기술 정책의 운용시의 변화요인들을 조사하였다. 또한, 국방과학기술 정책의 파급효과를 조사하였으며, 일곱 가지 사용가능한 국방과학기술 정책 대안들을 식별하였다. 또한 식별된 정책 대안들간의 비교를 통하여 효율적인 국방과학기술 정책 방안을 제시하였다.. 문제점들은 HED (Human Engineerign Discrepance) 목록으로 정리하여 설계에 반영하도록 하였다.로 마음의 안정감, 몸의 긴장 이완에 따른 건강 상태 유지, 수업 집중도 향상 등이 나타났다. 위와 같은 종합 적 분석 결과에 따라, 본 연구는 제조 현장의 생산성 향상 및 품질 향상과 연계하여 작업자의 작업 집중도 향상, 작업자의 육체적, 심리적 변화에 따른 생산성 및 품질 향상 변화 정도 등의 산업공학(인간공학) 제 분야의 여러 측면에서 연구 및 적용이 가능하리라 사료된다.l, 시험군:25.90$\pm$7.16mg/d1, 47% 감소)를 나타내었으며, 시험군의 AUC는 대조군에 비해 39% 감소하였고, 혈중 아세트알데히드의 농도는 투여 60분후 시험군(3.96$\pm$0.07nmo1/$m\ell$)이 대조군(6.45$\pm$0,64nmo1/$m\ell$)에 비해 유의성 있는 감소(39%)를 나타내었으며, 시험군의 AUC는 대조군에 비해 48% 감소하였다 한편, 시험관내 에탄올 대사 효소에 대한 바이오짐의 효과를 검색해본 결과 바이오짐(2.0 $\mu\textrm{g}$/assay)에 의해 Aldehyde dehydrogenase(1.5unit/assay)의 활성이 14% 증가되었다. 본 연구의 결과로 볼 때, 비지니스 및 바이오짐은 음주 후 상승된 혈중 에탄을 농도 및 아세트알데히드의 농도를 현저히 감소시키는 효과가 있었다.량 보호 관리, 도시 소공원 개발, 역사 문화 공원 조성, 하천 공간 복원, 공원 시설 기능 개선, 이용 프로그램 개발, 공원 관리 개선, 환경 피해 녹지의 회복, 도시 환경 림 조성, 녹지

• Journal of Life Science
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• v.20 no.2
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• pp.202-207
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• 2010

Ras genes are responsible for up to 30% of human tumor mutations and are composed of three isoforms: H-Ras, K-Ras and N-Ras. The post-translational modification of the CAAX motif of the Ras protein is essential in Ras actions. In the present study, we studied the effects of novel farnesyl transferase inhibitors (FTIs), YH3938 and YH3945, on the actions of oncogenic mutants of H-Ras, K-Ras and N-Ras. YH3938 and YH3945 completely reverted the proliferation and morphology of oncogenic H-Ras-transformed Rat2 cells, but not of oncogenic K-Ras-transformed Rat2 cells. Oncogenic N-Ras-transformed Rat2 cells were slightly affected. Activation of SRE promoters by oncogenic H-Ras and N-Ras, but not by K-Ras, were inhibited by treatment with YH3938 and YH3945. Using bandshift analysis, YH3938 suppressed the processing of oncogenic H-Ras and N-Ras, but not that of oncogenic K-Ras protein. YH3945 only inhibited the processing of H-Ras. From these results, we conclude that YH3938 and YH3945 specifically inhibit actions of oncogenic H-Ras through inhibition of its farnesylation, that YH3938 also inhibits N-Ras activity in a dose-dependent manner, and that these drugs have no effect on oncogenic K-Ras activity.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.

• Korean Journal of Ecology and Environment
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• v.49 no.2
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• pp.110-123
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• 2016

In order to obtain scientific information for the conservation of Utricularia japonica Makino, rare plant species, we investigated life history, phenology, growth and distribution in the east coastal region of Korea. Seven habitats of U. japonica were confirmed in this study. Turion of U. japonica rests overwinter at the bottom and ripens at the water surface and then usually germinate and sprout when the water warms in spring. A single shoot grown from turion divided into several shoots. Shoot decomposition started in October and formed a new turion at the end of the decomposed shoot. Flowering period was from early July to late October. Percentage of flowering ramets was significantly low as 6.3%. U. japonica showed the fastest growth rate from April to July, the maximum growth in August and the highest biomass in October. U. japonica tended to be concentrated in larger ramets in the water depth of 50 cm~150 cm in Cheonjin lake. The main factors affecting the growth of U. japonica were water temperature and turbidity. The establishment and growth of U. japonica in Cheonjin lake were determined by responses to water temperature with seasonal change and to light conditions caused by the different plants. These conditions affect the temporal and spatial distribution of U. japonica and population change. The findings of this study would be helpful to provide the basic information needed for the conservation and restoration of U. japonica.

• Journal of Life Science
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• v.15 no.1 s.68
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• pp.124-131
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• 2005

The regulation of gene expression plays an important rolet in cell cycle controls. In this study, a novel $mas3^+$ (mitosis associated protein) gene, a homolog of human SMARCADl, was isolated and characterized from a fission yeast Schizosaccharomyces pombe. The overall homology between the helicase proteins of the two species is $87\%$. This DEAD/H box-containing molecule has seven highly conserved sequence regions that allow us to place it in the SNF2 family of the helicase superfamily. Knock-out cell of $mas3^+$ gene was constructed using kanMX6 as a selection marker. Survival of mas3 null mutant exposed to UV or MMS was similar to those of wild type cells. $mas3^+$ expression was lowest at $G_2$ and gradually increased. Cytokinesis of mas3 null mutant was abnormal at $26^{\circ}C\;and\;35^{\circ}C$ and a large number of multi-septate cells were produced. These results indicate that the $mas3^+$ is involved in cytokinesis and cell shape control.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.207-216
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• 2013

The aim of this study is to design a classifier for sleep stage analysis and select important feature set which shows sleep stage well based on physiological signals during sleep. Sleep has a significant effect on the quality of human life. When people undergo lack of sleep or sleep-related disease, they are likely to reduced concentration and cognitive impairment affects, etc. Therefore, there are a lot of research to analyze sleep stage. In this study, after acquisition physiological signals during sleep, we do pre-processing such as filtering for extracting features. The features are used input for the new combination algorithm using genetic algorithm(GA) and neural networks(NN). The algorithm selects features which have high weights to classify sleep stage. As the result of this study, accuracy of the algorithm is up to 90.26% with electroencephalography(EEG) signal and electrocardiography(ECG) signal, and selecting features are alpha and delta frequency band power of EEG signal and standard deviation of all normal RR intervals(SDNN) of ECG signal. We checked the selected features are well shown that they have important information to classify sleep stage as doing repeating the algorithm. This research could use for not only diagnose disease related to sleep but also make a guideline of sleep stage analysis.