• Title/Summary/Keyword: 사용적합성평가

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Evaluation on the biocompatibility, bone cell activity and bone regenerative capacity of chitosan-PLLA bilayer porous membrane (Chitosan-PLLA 다층 다공성 차폐막의 생체적합성, 골세포활성도 및 골재생 능력에 관한 연구)

  • Park, Jun-Beom;Nam, Sung-Heon;Kim, Kyoung-Hwa;Lee, Sang-Chul;Lee, Seung-Jin;Kim, Tae-II;Seol, Yang-Jo;Lee, Yong-Moo;Ku, Young;Rhyu, In-Chul;Han, Soo-Boo;Chung, Chong-Pyoung
    • Journal of Periodontal and Implant Science
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    • v.35 no.3
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    • pp.549-561
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    • 2005
  • 이 연구의 목적은 새로이 제작된 chitosan-poly(L-lactic acid)(PLLA) 다층 다공성 차폐막의 생체적합성 및 골세포활성도 및 골재생능을 평가하는 것이다. 제작된 차폐막을 24 well에 넣고 clonal osteoblast-like cell line(MC3T3-E1)을 접종한 군을 실험군으로, 차폐막을 사용하지 않은 대조군으로 하였다. 배양 1일, 7일 및 14일째에 각 well에서 세포수를 측정하였다. 주사전자현미경을 이용하여 차폐막에 부착된 세포의 형태관찰을 시행하였다. RNA 추출 및 RT-PCR을 실시한 후, agarose gel상에서 전기영동하여 조골세포 표식자인 collagen type I(COL), osteopontin(OP) 및 osteocalcin(OC) mRNA의 발현을 관찰하였다. 제작된 매트릭스의 생체적합성 및 골재생능을 관찰하기 위하여 백서의 두개골에 직경 8mm의 원형 결손부를 형성한 후 차폐막을 이식한 군을 실험군으로, 아무 것도 넣지 않은 군을 대조군으로 하여 4주 경과 후 실험동물을 희생시킨 후 조직학적관찰을 시행하였다. 시간경과에 따른 부착세포수 관찰결과, 배양 14일까지 조골세포의 수가 지속적으로 증가하였고, 주사전자현미경으로 세포의 형태 관찰결과, 배양된 세포들은 중층의 형태로 성장하면서 시간경과에 따라 세포가 응집되는 양상을 나타내었다. 관찰 기간동안 COL, OP, 및 OC mRNA의 발현이 관찰되어 배양 전 기간동안 조골세포의 형질이 잘 유지되고 있음을 알 수 있었다. 백서 두개골 결손부에 이식된 차폐막은 염증반응 없이 주위 조직과 우수한 생체적합성을 나타내었으며, 차폐막을 이식하지 하지 않은 대조군에 비해 높은 신생골 형성을 나타내었다. 이상의 관찰결과로 새로이 제작된 chitosan-PLLA 차폐막은 우수한 생체적합성 및 골재생능을 나타냄을 알 수 있었으며, 향후 이를 골조직 재생 및 치주조직유도재생 분야에 응용될 수 있을 것으로 생각된다.

Physical Disturbance Improvement Evaluation and Habitat Suitability Analysis by Stable Channel Design (안정하도 설계에 따른 물리적 교란개선 평가와 서식적합도 분석)

  • Lee, Woong Hee;Choi, Heung Sik
    • Ecology and Resilient Infrastructure
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    • v.3 no.4
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    • pp.285-293
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    • 2016
  • This study conducted the evaluations of stable channel and physical disturbance improvement for optimal construction of river structures by focusing on Wonju River. A stable slope was analyzed sectionally for stable channel design, and in order to satisfy the stable slope, river structure improvement scenarios were deduced. Accordingly, through physical disturbance improvement evaluation for each scenario, the study extracted the optimal scenario for stable channel design and physical disturbance improvements. The changes in physical habitat were analyzed when river structure improvements were made for stable channel design and physical disturbance improvement. Zacco koreanus, an indicator fish of the soundness of the aquatic ecosystem, was selected as a restoration target species by investigating the community characteristics of fish fauna and river environments in the Wonju River. The habitat suitability was investigated by the PHABSIM model with the habitat suitability index of Zacco koreanus. The results of the prediction evaluation showed a slight decrease in habitat suitability and weighted usable area. However, it was not influenced by the improvements in the river structure. The study suggested river structure arrangement methods that can improve physical soundness and safety of Wonju River, and confirmed that there were no effects to the changes in the physical habitat.

Flame Resistance Performance of Architectural Membranes Using Basalt Woven Fabric (Basalt Woven Fabric을 적용한 건축용 막재의 난연특성)

  • Kim, JiHyeon;Song, Hun;Shin, HyeonUk
    • Fire Science and Engineering
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    • v.30 no.2
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    • pp.35-42
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    • 2016
  • The membrane structure provides high satisfaction with lightweight, improved workability, reduced cost, and a free shape. Thus, its applications expanding. On the other hand, in an architectural membrane that is vulnerable to fire, the development of various architectural membranes with flame resistance is in demand. Therefore, this study applied basalt woven fabric safety for flame resistance, excellent heat insulation and thermal properties on an architectural membrane. The PTFE- coated basalt woven fabric membrane was compared with a PTFE coated glass fiber membrane by DSC/TGA, strength properties, flammability, and incombustibility properties. In addition, this study confirmed the membrane applicability of basalt woven fabric and basalt-glass hybrid woven fabric through a comparison with existing architectural membranes.

A Study on the Durability of the Polyethylene Coatings for Underground Pipeline (매설강관용 폴리에틸렌 피복재의 내구성)

  • Ryu, Keun-chang;Lee, Seong-Min;Kho, Young-Tai;Argent, Colin
    • Journal of the Korean Institute of Gas
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    • v.6 no.4 s.18
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    • pp.40-46
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    • 2002
  • This study has been carried out to evaluate the reliability by examining the properties related to durability of commercially available coating systems in domestic. For this purpose slow crack growth resistance and oxidative induction time tests were introduced, which have been accepted as durability parameters in polyethylene pipes with low pressure. Based upon the experimental results on these parameters, desirable minimum values are proposed for the durability enhancement of the polyethylene coatings.

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Mobi-Kids Study: Exposure Assessment of Electromagnetic Radiation from Mobile Phones -II. Evaluation Method of Head SAR and Cumulative Dose (Mobi-Kids Study: 휴대전화의 전자파 노출량 평가 -II. 머리 SAR 및 누적노출 평가 방법)

  • Lee, Ae-Kyoung;Hong, Seon-Eui;Choi, Kyung-Hwa;Ha, Mina;Choi, Hyung-Do
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.24 no.12
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    • pp.1158-1166
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    • 2013
  • SAR calculation method following the Mobi-Kids study protocol is analyzed and evaluation method of cumulative RF dose from mobile phones which have been used by a subject of case and control groups is proposed. An SAR database is built by calculating SAR distributions in 4 head models at different ages for representative phone models with the same conducted power. To obtain SAR distribution in a subject's head for a specific commercial phone which had/have been used by him/her, an SAR correction factor using SAR compliance test results is determined. Cumulative dose is calculated by considering mobile phone characteristics and use pattern such as call time and laterality(right and left).

Evaluation of regulating gate impact in small agricultural watershed using coupled SWAT-CFD models (유역-전산유체역학 연계 모형을 이용한 농촌 소유역 하류의 제수문 영향 평가)

  • Kim, Dong Hyeon;;Kim, Da-Yun;Jang, Taeil
    • Proceedings of the Korea Water Resources Association Conference
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    • 2021.06a
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    • pp.473-473
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    • 2021
  • 새만금 유역의 하류 평야지대는 농업 관개 및 배수가 제수문의 영향을 받고 있으며, 상류 축산밀집시설에 따라 농업 비점오염원 유입이 수계 환경오염에 미치는 영향을 평가하는 것이 필요하다. 본 연구에서는 새만금 유역의 하류 제수문을 대상으로 유역 모형과 전산유체역학 모형을 이용하여 유입, 유출 그리고 오염원 등의 영향을 분석하고자 한다. SWAT (Soil and water assessment tool)은 유역 모형으로 수문순환 및 비점오염원을 모의하기 위해 개발한 모형이다. CFD(Computational fluid dynamics)는 구조물을 설계하고 유체, 기체 등의 역학을 모의할 수 있다. SWAT 모형을 이용하여 농촌 소유역을 대상으로 하류 제수문 위치를 출구로 지정하여 수문을 모의하고 그 결과자료는 CFD에 입력할 수 있다. CFD는 하류 제수문 구조물을 설계하고 SWAT 모형의 수문자료를 입력하여 제수문의 유입 및 유출 영향을 평가할 수 있다. SWAT 모형 구축을 위해 2015-2018년까지 기상, 수위, 유량 관측자료를 수집하였으며, 보정기간과 검증기간은 각 2년이며, 모형 성능 검증에 사용한 적합성 평가 지수는 R2 (Determine coefficient), RMSE (Root mean square error), 그리고 NSE (Nash-sutcliffe efficiency coefficient)를 사용하였다. 모형의 보정은 SWAT-CUP 자동보정프로그램을 사용하였으며, 모형의 보정지수는 NSE를 사용하였고, 1,000회 반복 수행을 통해 매개변수를 최적화하였다. CFD 모형은 제수문의 실제 규격을 바탕으로 동일한 구조를 고려하였으며, 수문조작을 고려하여 유입 및 유출을 모의하였다. 본 연구는 유역차원과 구조물 차원의 모델링을 연계하는 것으로 최근 기후변화에 따라 급격히 변화하는 유역환경에 대처할 수 있는 방안이 될 수 있을 것이며, 제수문 시설을 관리하는 기관에서도 합리적인 운영방안에 대한 기초자료로 기여할 수 있을 것으로 사료된다.

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Effect of $pi-Water$ on the Quality Characteristics of White Pan Bread ($\pi-Water$ 첨가가 식빵 품질 특성에 미치는 영향)

  • 김동호;오철환
    • Journal of the East Asian Society of Dietary Life
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    • v.14 no.1
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    • pp.47-53
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    • 2004
  • The characteristics of dough and the quality of white pan bread with 0∼1.5% $\pi$-water were investigated. The fermentation volume and weight of the white pan bread with $\pi$-water (0.1%, 0.5%, 1.0%, 1.5%) was higher than that of the control. The volume of white pan bread with $\pi$-water (0.1%, 1.0%, 1.5%) was higher than that of the control. Color L value of crust with $\pi$-water increased from 34.98 to 36.38∼41.36 and increased from 34.32 to 34.90∼43.33 after 3 days. Color a value increased from 14.78 to 14.99∼16.75. The hardness of the white pan bread increased from 29011.0 g/㎤ to 18681.7∼43551.2 g/㎤ as the added amount of $\pi$-water increased. The overall acceptability score of white pan bread was the highest with 0.1% $\pi$-water.

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Applicability Study of Geotextile Mesh Soil Nail on Slope Reinforcement Using Numerical Analysis (수치해석을 이용한 토목섬유망 네일의 사면보강에 대한 적용성 연구)

  • You, Kwang Ho;Jung, Yeun Hak;Ha, Ji Young
    • Tunnel and Underground Space
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    • v.25 no.3
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    • pp.264-274
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    • 2015
  • In this study, the applicability of geotextile mesh soil nails on slopes was evaluated by numerical analysis to reduce environmental problems which a general soil nailing might produce and to improve its economical efficiency and construction convenience. To this end, in situ pull-out tests were conducted for both general soil nail and geotextile mesh soil nail and their pull-out characteristics were analyzed. Also, finite difference method was used to verify the suitability of numerical simulation. Parameters for nail and ground conditions were selected and sensitivity analysis was performed for the evaluation of slope stability. In addition, analysis was performed by limit equilibrium method which is widely used for slope stability analysis in practice. As a result, if the nail diameter was same, there is no big difference between geotextile mesh soil nails and general soil nails in terms of slope stability. Therefore it can be expected that geotextile mesh soil nails could be effective for slope reinforcement since they could keep a slope as stable as general soil nails and give better economical efficiency and construction convenience than general soil nails.

Review for Items of Decommissioning Plan and Standard Review Plan (해체계획서 및 심사지침서 항목에 관한 고찰)

  • Kim H. S.;Son J. K.;Park K. R.;Kang K. D.;Kim K. D.;Ha J. H.;Jeong C. W.
    • Proceedings of the Korean Radioactive Waste Society Conference
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    • 2005.06a
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    • pp.40-48
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    • 2005
  • The licensees are to submit the decommissioning plan to regulatory body to decommission nuclear facilities. The standard review plan(SRP) of decommissioning is used to confirm and evaluate the decommissioning plan by the related regulations and standards. The licensees who want to decommission the nuclear facilities are required to submit the decommissioning plan according to Acts 31 of Atomic Energy Law. In this study, the items of reports and documents submitting to regulatory body were reviewed deliberately, and finally the major sub-items of decommissioning plan were established.

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Standard Procedures and Field Application Case of Constant Pressure Injection Test for Evaluating Hydrogeological Characteristics in Deep Fractured Rock Aquifer (고심도 균열암반대수층 수리지질특성 평가를 위한 정압주입시험 조사절차 및 현장적용사례 연구)

  • Hangbok Lee;Chan Park;Eui-Seob Park;Yong-Bok Jung;Dae-Sung Cheon;SeongHo Bae;Hyung-Mok Kim;Ki Seog Kim
    • Tunnel and Underground Space
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    • v.33 no.5
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    • pp.348-372
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    • 2023
  • In relation to the high-level radioactive waste disposal project in deep fractured rock aquifer environments, it is essential to evaluate hydrogeological characteristics for evaluating the suitability of the site and operational stability. Such subsurface hydrogeological data is obtained through in-situ tests using boreholes excavated at the target site. The accuracy and reliability of the investigation results are directly related to the selection of appropriate test methods, the performance of the investigation system, standardization of the investigation procedure. In this report, we introduce the detailed procedures for the representative test method, the constant pressure injection test (CPIT), which is used to determine the key hydrogeological parameters of the subsurface fractured rock aquifer, namely hydraulic conductivity and storativity. This report further refines the standard test method suggested by the KSRM in 2022 and includes practical field application case conducted in volcanic rock aquifers where this investigation procedure has been applied.