• Journal of Haehwa Medicine
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• v.23 no.2
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• pp.5-13
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• 2015

Objectives : The anti-inflammatory and antioxidant effects of water extracts of Sasangja-tang(SSJ) and Gami-sasangja-tang(GSJ) were investigated. The effects of SSJ and GSJ were compared. Methods : We performed cell viability assay in HaCaT cells and RAW 264.7 cells using 3-(4,5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide(MTT) assay. We measured chemokines(regulated on activation normal T-cell expression and secreted ; RANTES/CCL5, interferon-inducible protein; IP-10/CXCL10, macrophage-derived chemokine; MDC/CCL22) in HaCat cells, also we measured cytokines (tumor necrosis factor-${\alpha}$; TNF-${\alpha}$, interleukin-6; IL-6) and nitric oxide(NO) production in RAW 264.7 cells using enzyme-linked immunosorbent assay(ELISA) and NO assay. Western blot assay was used to evaluate the expression for inducible nitric oxide synthase(iNOS) in RAW 264.7 cells. Results : SSJ and GSJ did not affect the cell viability at the concentrations treated ($0-800{\mu}g/ml$). As a result of SSJ and GSJ treatment in HaCat cells stimulated by TNF-${\alpha}$(10 ng/ml) and interferon(IFN)-${\gamma}$(10 ng/ml), the production of RANTES and IP-10 was inhibited significantly. However there was no significant difference in the secretion of MDC. And in RAW 264. 7 cells stimulated by lipopolysaccharide(LPS, $1{\mu}g/ml$), SSJ and GSJ treatment significantly inhibited the secretion of TNF-${\alpha}$ and IL-6 and the production of NO. The expression of iNOS was also decresed by SSJ and GSJ treatment in RAW 264. 7 cells. Compared with SSJ, GSJ was superior to SSJ in inhibition of RANTES, IP-10, TNF-${\alpha}$, IL-6 and NO production at the concentration of $200{\mu}g/ml$. Conclusion : Both SSJ and GSJ have anti-inflammatory and antioxidant effects. And GSJ has better effects than SSJ.

• Korean Security Journal
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• no.36
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• pp.317-347
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• 2013

This study focuses on the characteristics of terrorist bombing incidents and causal factors on terrorist bombing incidents and number of casualty per incident in Afghanistan though statistical quantitative analysis. For doing so, the bombing data from GTD(Global Terrorism Database) of START program occurred from January 1st 2002 until December 31st 2011 was used. By using descriptive analysis, chi-square, and logistic regression analysis, characteristics of bombing incidents and causal factors on the frequency of incidents and the number of casualty were identified. According to the analysis results, a clear pattern was appeared in terrorist bombing incidents. This result suggests that terrorists rationally and strategically calculate bombing operations and therefore terrorist bombing incidents and number of casualty per incident are conditioned or affected by time, season, Pashtun tribal entity, production level of drugs, the characteristics of targets.

• Fire Science and Engineering
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• v.32 no.4
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• pp.86-94
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• 2018

A sports center fire in Jecheon caused 29 deaths and 40 injuries. This study focused only on the structural factors of the building and equipment to investigate the causes of casualties based on the fire investigation results at the sports center. The structural factors of the building and equipment were a piloti-type parking lot, lack of a fire compartment between the piloti-type parking lot and lobby, lack of an installed sprinkler system, lack of an installed fire door in the main stairs on the $1^{st}$ floor, lack of an installed fire water tank on the rooftop, an installed pocket fire door in the main entrance on the $2^{nd}$ floor, poor fire compartments in an EPS space and a pipe pit and on each floor, a leak in the joint of a drain pipe, plywood installed in the hoistway of the freight elevator and interior wall, illegal remodeling of a closed rooftop structure, which cannot discharge smoke and heat, installed styrofoam insulation in the inside of the parking lot ceiling, an installed tempered glass window, which cannot be opened in the ladies bathroom on the $2^{nd}$ floor, and a finished dryvit exterior wall.

• Fire Science and Engineering
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• v.32 no.5
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• pp.57-66
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• 2018

A sports center fire in Jecheon that caused 29 deaths and 40 injuries was analyzed based on initial response and management in order to investigate the causes of the casualties. The aspects of initial response included delay of reporting 119, not being guided to the exit for the body scrubber on the $2^{nd}$ floor for escape, opening the fire doors of the exits on the $1^{st}$ floor and $3^{rd}$ floor, not closing the fire door of the main stairs on the $3^{rd}$ floor, and not doing an emergency broadcast. The management aspects included closing the alarm valve of the sprinkler system on the $1^{st}$ floor, starting-stop of the fire pump controller, neglecting leakage of water and electricity between the false ceiling and ceiling in the parking lot, hiding the exit light in the ladies bathroom lounge on the $2^{nd}$ floor and piling up things in the exit, neglecting the button of an automatic door on the $2^{nd}$ floor, conventional fire safety management, insufficient inspection of fire equipment, and not working fire shutters and smoke exhaust windows.

• Fire Science and Engineering
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• v.34 no.3
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• pp.49-57
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• 2020

Apartment buildings are becoming taller and more densely populated with the advancements in science and the development of cities, Consequently, various amenities and safety facilities are being developed to improve the quality of life for residents. However, according to statistics, the number of casualties in apartments accounts for a high proportion of accidents, and the leading cause of the casualties is smoke emitted from fires while sleeping at night. Although it is best to install separate indoor facilities in apartments to minimize smoke damages to occupants, it is useful to minimize the smoke damages by utilizing the installed facilities while reducing the financial burden of occupants. Based on the review, the heat exchanger ventilation system and the kitchen collective exhaust system were selected, and the feasibility of these systems was verified through fire simulation. From the verification results, the available safe egress time improved by 27, 30, and 35 s on the 25th, 35th, 50th floors, respectively.

• Journal of the Korean Institute of Gas
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• v.22 no.6
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• pp.1-7
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• 2018

Currently chemical plant risk have been issued by occurring frequent accidents. Accidents can be generally composed of fire, explosion, release in chemical plant. In case of fire and explosion, accident victims are occurred immediately after accident but release accident, late emergency response cause damage to worker. Especially, there are many victims by late emergency response against chemical exposure to skin. In case of chemical exposure to skin, irreversible damage like death, blindness, burn can be prevented by washing immediately. Safety shower can provide the cleaning for chemical exposure to eye, skin. Most of chemical plants are built in 1980s so equipment become superannuated. In this reason, safety shower also cannot operate normally in emergency situation. Therefor safety shower should be managed by installation and management guideline. This study perform the establishment guideline for safety shower installation and inspection to increase the reliability.

• Journal of the Korea institute for structural maintenance and inspection
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• v.26 no.3
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• pp.64-71
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• 2022

In this study, fire and egress simulation was conducted for the egress safety evaluation of the nursing hospitals. A fire simulation was performed with or without the smoke exhaust system using the FDS, and the available safe egress time (ASET) of the nursing hospitals was calculated. In addition, an egress simulation considering the characteristics of occupants and egress delay time was performed using Pathfinder, and the required safe egress time (RSET) was calculated. By comparing the ASET and RSET, the egress safety of the nursing hospital with or without a smoke exhaust system was evaluated according to the number of egress guides and the egress delay time. The simulation results show that the number of casualties increased as the egress delay time increased, and the required safe egress time decreased as the number of egress guides increased. In addition, it was found that if a smoke exhaust system with the capacity specified in the KFPA is secured, the available safe egress time can be greatly increased and the number of casualties can be greatly reduced.

• Journal of Ginseng Research
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• v.31 no.4
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• pp.196-202
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• 2007

Skin wrinkles are associated with collagen synthesis and matrix metalloproteinase-I (MMP-1) activity. This study was carried out to select optimum ratio of 3 herbs in skin health food for anti-wrinkle. Human dermal fibroblast cell was incubated with experimental samples, which were Korean red ginseng ethanol extracts (ER), Torilis fructus water extracts (WT), Corni fructus water extracts (WC) and their mixtures (WM1, WM3). And then we determined effects on collagen biosynthesis, MMP-1 activity and SOD activity in human dermal fibroblast cell. In control group, collagen biosynthesis was amounted at 474.8 ng/ml and 533.9 ng/ml, 539.3 ng/ml, 514.1 ng/ml in ER, WT and WC respectively. Furthermore, WM3 (KTNG0345) was increased to 561.45 ng/ml. MMP-1 activity of ER, WT, WC, WM1 were determined to 31.9 ng/ml, 32.85 ng/ml, 32.0 ng/ml, 31.3 ng/ml and WM3 (KTNG0345) was decreased to 28.85 ng/ml. In addition, the experimental samples showed a antioxidative activities. From this results, we conclude that Korean red ginseng ethanol extracts, Torilis fructus water extracts, Corni fructus water extracts and their mixtures have a anti-wrinkle effect and WM3 (KTNG0345) may be regarded as an optimum composition for synergic effect producing. The standardized components of KTNG0345, ginsenoside-$Rb_1$, torilin and loganin were identified at 10.85 mg/g, 0.128 mg/g and 3.92 mg/g respectively.

• Journal of Korean Society of Transportation
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• v.30 no.2
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• pp.101-116
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• 2012

Accident prediction models have been utilized to predict accident possibilities in existing or projected freeways and to evaluate programs or policies for improving safety. In this study, a traffic accident prediction model for freeways was developed for the above purposes. When selecting variables for the model, the highest priority was on the ease of both collecting data and applying them into the model. The dependent variable was set as the number of total accidents and the number of accidents including casualties in the unit of IC(or JCT). As a result, two models were developed; the overall accident model and the casualty-related accident model. The error structure adjusted to each model was the negative binomial distribution and the Poisson distribution, respectively. Among the two models, a more appropriate model was selected by statistical estimation. Major nine national freeways were selected and five-year dada of 2003~2007 were utilized. Explanatory variables should take on either a predictable value such as traffic volumes or a fixed value with respect to geometric conditions. As a result of the Maximum Likelihood estimation, significant variables of the overall accident model were found to be the link length between ICs(or JCTs), the daily volumes(AADT), and the ratio of bus volume to the number of curved segments between ICs(or JCTs). For the casualty-related accident model, the link length between ICs(or JCTs), the daily volumes(AADT), and the ratio of bus volumes had a significant impact on the accident. The likelihood ratio test was conducted to verify the spatial and temporal transferability for estimated parameters of each model. It was found that the overall accident model could be transferred only to the road with four or more than six lanes. On the other hand, the casualty-related accident model was transferrable to every road and every time period. In conclusion, the model developed in this study was able to be extended to various applications to establish future plans and evaluate policies.

• Korean Journal of Pharmacognosy
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• v.29 no.4
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• pp.384-390
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• 1998

The methanol extract of Torilis Fructus showed potent anti-edematous effect in carrageenan-induced paw edema in rats. Systematic fractionation of the extract with hexane, chloroform, ethyl acetate and butanol resulted in potent anti-edematous action only in hexane fraction at an oral dose of 237 mg/kg which is corresponding to 4.8 g of raw Fructus. This hexane fraction showed inhibitory effects at 77 mg/kg p.o on vascular permeability in mice, at 8mg/pouch on leucocyte emigration in rats, and at 120 mg/kg p.o. on adjuvant arthritis model in rats. These results demonstrate that hexane fraction of the extract possesses potent anti-inflammatory effect which may support its traditional uses.