• Proceedings of the Korean Society of Disaster Information Conference
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• 2017.11a
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• pp.207-208
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• 2017

본 연구는 전국 고속도로별 첨두 비첨두 시간에 발생되는 교통사고 중 사망사고의 주요 요인들을 발견하고 분석하여 각 노선별 사고 특성을 제시하고자 한다. 이에 로지스틱 회귀분석을 통해 분석한 결과 남해선의 경우 첨두 시간에 발생되는 사망사고의 요인 중 주시태만이 첨두가 비첨두의 경우보다 높게 나타났고, 논산천안선, 호남선과 중부내륙선의 경우 모두 졸음의 사망사고 위험도가 첨두일 경우 비첨두의 경우보다 높게 나왔으며 논산천안선, 호남선의 경우 비첨두일 때 과속에도 영향을 받는 경향을 나타냈다. 특이하게 경부선의 경우 졸음의 사망사고 위험도가 오히려 비첨두일 경우가 첨두의 경우보다 높게 나타났다. 비첨두일 경우 경인선, 서해안선, 영동선 등의 노선에서도 졸음, 주시태만과 과속의 위험도가 나타났다.

• Microbiology and Biotechnology Letters
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• v.37 no.2
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• pp.140-146
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• 2009

Cyclosporin, an immunosuppressant, is a representative group of biologically active secondary metabolites produced by the fungus Tolypocladium inflatum. The amount and ratio of cyclosporin derivatives in the culture broth are an important factors for the production of cyclosporin A and the purification in the industrial process. Therefore, we studied the effect of amino acids and complex organic nitrogen sources using Tolypocladium inflatum mutants on the productivity of cyclosporin A and the ratio of cyclosporin derivatives. Overproducing mutant YHC-004 having seven times higher productivity than mother strain's could be obtained through the artificial mutation by UV irradiation. The concentration and kind of organic nitrogens and amino acids shows the profound effect on the productivity of cyclosporin A and ratio of cyclosporin derivatives. As a result, it was possible to raise the productivity and the ratio of cyclosporin A up to 3,430 mg/L and 93% respectively, but on the other hand the other cyclosporin derivatives decreased less than 2% in the culture broth.

• Food Industry And Nutrition
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• v.10 no.2
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• pp.26-31
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• 2005

천연물 유래 기능성 물질 탐색의 일환으로 녹차 추출물의 산업적 적용을 용이하게 하기 위하여 감마선 조사를 병용하여 추출물의 색도 및 라디칼 소거능을 확인하고, 이 추출 파우더를 돈육 패티에 적용하여 항산화, 색도 및 관능검사를 통해 기호도를 조사하였다. 생리활성을 가지는 녹차 잎 추출물의 라디칼 소거능은 $68.2\%$를 나타냈으며, 20 kGy로 조사했을 경우 비조사구와 큰 차이를 나타내지 않았다. 또한, 감마선조사에 의한 색도의 변화는 감마선 조사 후 $L^{\ast}-value$는 증가했고, $a^{\ast}$- 및 $b^{\ast}-value$는 감소하는 것으로 확인되었다. 또한, 녹차 잎 추출 파우더를 돈육 패티에 적용해본 결과 비첨가구에 비해 라디칼 소거능 및 지질 산화를 지연시키며, 조사된 녹차 잎 추출 파우더를 첨가한 돈육패티가 비첨가구 혹은 비조사된 녹차 잎 첨가구에 비해 저장 기간에 따라$L^{\ast}-value$가 높게 나타났다. 또한, 모든 처리구에서 관능적으로도 큰 차이를 보이지 않았다 그러므로 천연물 유래 녹차 추출물 파우더는 돈육 패티의 기능성 첨가제로서 우수하며, 감마선 조사는 녹차 잎 추출 파우더의 산업적 적용을 용이하게 하는 방법 중의 하나라고 사료된다.

• Journal of Life Science
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• v.12 no.6
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• pp.786-795
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• 2002

Three-day-old sunfower(Helianthus annuus L.) seedlings were do-rooted and incubated in the nutrient solutions that contained either deficient or sufficient boron supply, and exposure to various pH and temperatures. In the absence of boron, no adventitious roots were formed in the majority of the seedlings. Boron caused the development of numerous adventitious roots in the lower part of the hypocotyl. The low pH damage was ameliorated by the simultaneous application of calcium, implying the involvement of calcium-requiring process in overcoming proton toxicity. Borate showed a strong ameliorative effect with $Ca^{2+}$. These results suggest that the primary target of proton toxicity may be linked to a disturbance of the stability in the pectic polysaccharide network, where calcium plays a key role in plant roots. Maximum temperature for the growth of adventitious roots was $25^{\circ}C$. Although cessation of growth is the most apparent symptom of boron deficiency, exogenous ascorbate improved adventitious root growth in plants in the absence of boron. From the results it is suggested that the inhibition of adventitious root resulting from boron deficiency, low pH and temperature damage may be a consequence of disrupted ascorbate metabolism.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2005.05a
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• pp.343-347
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• 2005

이 실험의 목적은 GSE 첨가가 간장과 고추장 양념액의 저장 조건에 따라 식중독균의 생육억제효과와 pH 변화를 조사하는데 있다. 저장 초기 비첨가구 경우에 간장 양념액의 pH는5.50, 고추장 양념액은 4.92 이였으며, GSE 첨가에 따른 양념액의 PH는 거의 변화가 없었다. 저장기간에 따라 pH는 고추장 양념액 보다 간장 양념액에서 서서히 낮아졌다. 식중독균의 생육억제효과는 우선 $20^{\circ}C$의 간장 양념액을 $4^{\circ}C$와 비교해 볼 때 GSE 농도에 따라 균수가 변화하는 반면 $4^{\circ}C$의 간장 양념액은 큰 변화가 없음을 알 수 있었다. 그러나 고추장 양념액의 경우는 온도와 GSE 농도에 따라 식중독균수의 차이가 나지 않았다.

• The korean journal of orthodontics
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• v.30 no.5 s.82
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• pp.657-668
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• 2000

The purpose of this study was to evaluate the amount and interrelationship of the soft tissue of nose and maxillary changes and to identify the nasal morphologic features that indicate susceptibility to nasal deflection in such a manner that they would be useful in presurgical prediction of nasal changes after maxillary advancement surgery in skeletal Class III malocclusion. The sample consisted of 25 adult patients (13 males and 12 females) who had severe anteroposterior skeletal discrepancy. The patients had received presurgical orthodontic treatment. They underwent a Le Fort I advancement osteotomy, rigid internal fixation, alar cinch suture and V-Y advancement lip closure. The presurgical and postsurgical lateral cephalograms and lateral and frontal facial photographs were evaluated. The computerized statistical analysis was carried out. Soft tissue of nose change to h point change ratios were calculated by regression equations. The results were as follows 1. The correlation of maxillary hard tissue horizontal changes and nasal soft tissue vortical changes were high and the ${\beta}_0$ for soft tissue to ADV were 0.228 at ANt, 0.257 at SNt. 2. The correlation of maxillary hard tissue and nasal soft tissue horizontal changes were high and the ${\beta}_0$ for soft tissue to ADV were 0.484 at ANt, 0.431 at SNt, 0.806 at Sn. 3. The correlation of maxillary hard tissue horizontal changes and width changes of ala of nose were high and the ${\beta}_0$ lot alar base width ratio to ADV were 0.002. 4. The DRI, Prominence of nose, Pre-Op CA is not a quantitative measure that can be used clinically to improve the predictability of vertical and horizontal nasal tip deflection. In this study, increases in nasal tip projection and anterosuperior rotation occur when there is an anterior vector of maxillary movement. These nasal changes were Quantitatively correlated to magnitude of maxillary(A point) movement.

• Korean Journal of Cleft Lip And Palate
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• v.6 no.1
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• pp.17-25
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• 2003

Correction of the cleft-lip nasal deformity is a difficult task that requires clear understanding of the associated complex anatomy and function as well as the operation time, the selection of an operation method, On the expectation that it helps enhance understanding the current trend of cleft-rhinoplasty, authors analyzed secondary rhinoplasty between 1999 and 2002, In both the unilateral and bilateral cleft lip rhinoplasty, we reviewed the timing of repair, site of correction and it's major technique, incision or approach method, autogenous cartilage graft method, All patients with a septal deviation did not have a septal surgery, We were active in alar and nasal tip surgery and passive in septal and dorsal deformity correction, And for children, we used a conservative method but for adults, we used radical approach, Most surgeries are focused on esthetic goal and we thought that objective evaluation for nasal obstruction was needed for bener and predictable outcome.

• Journal of Korean Philosophical Society
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• v.145
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• pp.71-90
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• 2018

The purpose of this paper is to examine the concept of autonomy, which is the subject of respect, namely, narrow bioethical autonomy and relational autonomy, before discussing autonomy in the era of personalized healthcare based on self-tracking technology. There is a need to extend the scope of the autonomy concept through a review of the autonomy debates presented by Tom Beauchamp and James Childress. Then, I suggest that relational autonomy based on the capability approach as a broader autonomy than the autonomy of consultation is a suitable concept of autonomy as an object to form ethical guidelines in a new situation.

• Archives of Craniofacial Surgery
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• v.10 no.2
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• pp.120-126
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• 2009

Purpose: Autogenous cartilage is generally first choice in rhinoplasty because of its biocompatibility and resistance to infection. On the other hand, allogeneous cartilage graft might preferred over an autogenous graft to avoid additional donor site scars, morbidity and lengthened operating time. Allogenous costal cartilage ($Tutoplast^{(R)}$) not only have the advantage of averting donor site morbidity but also are resistant to infection, resembling autogenous cartilage graft. We report here a technique for rhinoplasty by using allogenous costal cartilage graft. Methods: Through open rhinoplastic approach, alar cartilage is released from upper lateral cartilage and relocated caudally. After relocation of alar cartilage, allogenous costal cartilage is immobilized by nonabsorbable suture material at caudal aspect of septal cartilage. Caudal end of allogenous costal cartilage is sutured between medial crura of alar cartilage. Tip projection is improved by using interdormal suture, transdormal suture and shield-shape cartilage graft which is harvested from concha Results: No significant resorption and infection was detected in any of patients. Aesthetic and functional results were satisfactory. Conclusion: The low incidence of major complication and versatility of allogeneous costal cartilage graft make safe and reliable source of cartilage graft in rhinoplasty.

• Archives of Plastic Surgery
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• v.37 no.5
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• pp.671-675
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• 2010

Purpose: In order to maintain corrected nasal tip projection, strong support is important. Authors used calvarial bone graft method for this purpose. Patients were followed up about permanency of the bone graft for a long time. Methods: From 1995 to 1998, author performed calvarial bone graft on 30 adult patients with secondary cleft lip and nose deformity. Patients were observed for 34 months. There were no specific complications, and results were satisfactory. We could confirm the permanence of the calvarial bone graft in 3 patients by photography and radiologic studies for 10 years follow-up. Results: None of the patients showed size change or displacement. But the portion of graft facing the tip was absorbed resulting in loss of tip projection and short nose in two patients. One patient had fracture on the middle of the graft. This caused depression from lower portion of the dorsum to the tip. Conclusion: Despite of autogenous grafts such as calvarial bone, absorption of the bone may occur when compressed with tension for a long period. And the graft in the nasal tip not having any contact with the nasal bone may cause absorption of the graft.