• 한국약용작물학회지
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• 제13권6호
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• pp.245-249
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• 2005

신이는 전통적으로 비염 등의 치료에 사용되어 왔는데, 신이 에탄올 추출물은 그람 양성균인 Staphylococcus aureus 그람 음성균인 Pseudomonas fluorescens균 및 곰팡이균인 Aspergillus niger에 대하여 모두 항균활성을 보였으며, proteinase로 활성화된 receptor-2에 의한 흰쥐 뒷발바닥 부종모델에서 신이 에탄올 추출물을 경구투여한 경우 typsin이나 $tc-NH_2$로 유발된 발바닥 부종, 혈관투과성, myoloperoxidase 활성도에서 유의성 있는 억제율을 보여 항염증 활성이 뚜렷함을 나타냈다.

• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.99-116
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• 2014

Objective : The purpose of this study is to analyze research trends on the effects of intranasal phototherapy on allergic rhinitis. Methods : We searched potentially relevant studies using electronic databases, such as PubMed, OASIS, KMbase, and RISS. Our review of clinical research in allergic rhinitis was restricted to an analysis of papers published within the last 5 years. Independent reviewers extracted data using a standardized form. Results : In total, twenty four studies were included. Eleven studies were analyzed, and five randomized trials were identified. They suggested to be effective and no serious side-effects. Conclusions : Intranasal phototherapy can be effectively used as an alternative to the treatment of allergic rhinitis. Further studies are needed on this topic in order to demonstrate the effectiveness clearly.

• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.91-98
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• 2014

Objective : This study aimed to assessment for concordance rate in pattern analysis between pattern diagnosis of KiFDA on allergic rhinitis in 2008 and doctor of Korean medicine. Methods : Data were obtained from 35 patients with allergic rhinitis(AR). They were asked to perform the questionnaires and had been interviewed by specialist of Korean Medicine. For correlation analysis, we used Cohen's Kappa. Results : The pattern diagnosis was done only 15 patients(42.9%). Correlation between pattern diagnosis of questionnaires and specialist showed 0.2105 in Kappa and 0.1993 in weighed Kappa. Conclusions : The result may provide the basis of modification in Pattern Diagnosis of KiFDA on allergic rhinitis in 2008.

• 대한기관식도과학회지
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• 제4권1호
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• pp.85-90
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• 1998

The role of the ECP(Eosinophilic cationic protein) is still unknown in the allergic rhinitis. In bronchial asthma, ECP can induce the exposure of the neuropeptidergic nerve to environments destroying the bronchial mucosa, aggravating the bronchial hypersensitivity and delay the mucociliary clearance. In the clinical aspect, we can (md that patients with perennial allergic rhinitis sometimes have sinusitis. The purpose of this article is to evaluate whether mucosal damage by ECP can play a role to develop the sinusitis by delaying the mucociliary clearance, and relationship between long symptom duration of allergic rhinitis and mucociliary clearance. In 32 perennial allergic rhinitis patients, we elucidated there is correlation among ECP presence, mucociliary clearance, sinusitis, and symptom durations. The obtained results were as follows : 1. ECP appeared in all mucosa of each specimen. 2. Mean mucociliary clearance time is 6 mins. 12 sec. in allergic patients with sinusitis, 6 mins. 36 sec in allergic patients without sinusitis. 3. n out of 32 cases have mucosal destruction. 4. Symptom duration is not correlated with the development of sinusitis. This study suggests that ECP may destroy the mucosa in allergic rhinitis and the mucociliary clearance of allergic rhinitis is not related to sinusitis and symptom dotation. Therefore development of sinusitis in allergic rhinitis seems not to be caused by delaying of mucociliary clearance due to mucosal destruction, but by some other factors.

• 한방안이비인후피부과학회지
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• 제28권3호
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• pp.76-87
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• 2015

Objectives : Allergic rhinitis is highly increased in these days. We aimed to investigate therapeutic effect ofShinchulsanby observing changes in blood cells and the protein expression level of IL-4 in spleen of Sprague-Dawley(SD) rats with allergic rhinitis.Methods : Fifteen SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitional and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. ThenShinchulsanwas orally administered only to the sample group for 28 days, while the rats in the control group was given normal saline.Results : 1.Shinchulsanshowed significantly decreased eosinophil level on the serum of the rat model.2.Shinchulsanshowed significantly decreased IgE level on the serum of the rat model.3.Shinchulsanshowed significantly decreased the protein expression levels of IL-4 in spleen of the rat model.4.Shinchulsanhad no hepatoxicity, according to AST and ALT on the serum.Conclusion : According to the above results, it is considered thatShinchulsanis helpful in treatment of allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제24권2호
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• pp.28-34
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• 2011

Background & Objectives : Allergic rhinitis is an inflammation or irritation of the mucous membranes that line the nose. Common symptoms include sneezing, a stuffy or runny nose, itchy eyes, nose and throat, and watery eyes. We aimed to determine therapeutic effects of Tribulus terrestris by observing changes of total IgE level and the scratching or rubbing around the nose behavior. Materials and Methods : Fifteen BALB/c mice were divided into three groups : AR group(allergic rhinitis elicitated), TT group(which ate herbal medicine) and AH group(which ate antihistamine). Allergic rhinitis was induced in the three groups by intraperitoneal and intranasal sensitization with 0.1% ovalbumin solution. Then Tribulus terrestris was orally administered only to the TT group of 28days, while the AH group was given antihistamine. We observed changes of total IgE level and the scratching or rubbing around the nose behavior. We used Kruskal-Wallis test statistically(p<0.05). Results : 1. Tribulus terrestris showed significantly decreased IgE level on the serum of the rat model. 2. Tribulus terrestris showed significantly decreased scratching or rubbing around the nose behaviors of the rat model. Conclusion : According to the above results, it is considered that Tribulus terrestris has an inhibitory effect on the process of allergic rhinitis and it can be used in relieving symptoms of allergic rhinitis.

• 대한의용생체공학회:의공학회지
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• 제40권4호
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• pp.125-131
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• 2019

As a non-invasive method for alleviating allergic rhinitis, there has been a recent ongoing research in the treatment of light from light emitting diodes (LEDs) and lasers. A total of 15 subjects diagnosed with allergic rhinitis were selected for this study. Red and near infrared light emitted from LEDs with wavelengths of 660nm and 940nm were illuminated three times daily (three minutes per cycle) for a total of two weeks. The degree of nasal congestion, runny nose, sneezing and nasal itching was evaluated by questionnaires before and after the test. Also, the serum IgE (Immunoglobulin E) was measured and compared before and after the test. As a result, the total score of symptoms of allergic rhinitis was decreased by 67% after the test (P<0.01). The level of IgE was decreased by 17% after the test (P<0.05). In conclusion, the non-invasive LED phototherapy method using red and near-infrared LED light was effective in alleviating symptoms of allergic rhinitis. There were no adverse effects or complications reported during and after the test.

• 한방안이비인후피부과학회지
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• 제32권1호
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• pp.74-82
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• 2019

Objective : The purpose of this study is to analyze the trends of allergic rhinitis related articles that have been published in the Journal of Korean Medicine Ophthalmology, Otolaryngology & Dermatology(JKOOD). Method : We studied 32 articles of allergic rhinitis published in JKOOD from 1988 to 2018. 24 articles are classified into two categories; treatment-related article and diagnosis-related article which include pattern identification. And we reviewed the other 8 articles briefly in discussion. Results : 16 treatment articles are classified into two categories; 13 case reports and 3 retrospective observation studies. In case reports, the studies are classified into three categories; 3 acupuncture group, 3 herbal medicine group or 7 herbal medicine with other parallel treatments group. Conclusions : Further studies are needed on allergic rhinitis including treatment, alternative medicine and methods of evaluation in order to develop a level of evidence.

• 항공우주의학회지
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• 제30권2호
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• pp.66-69
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• 2020

Since allergic rhinitis is a disease with a very high prevalence, it is common to find patients with allergic rhinitis among aviation workers. However, they are so afraid that the report of rhinitis will have a negative effect on the evaluation of one's work suitability. Therefore, aviation medical examiners (AMEs) must be able to accurately understand the nature of allergic rhinitis, and confidently explain that appropriate treatment of rhinitis has a positive effect on their performance. In the treatment of allergic rhinitis, there are some medications that may cause drowsiness, which may impair the accuracy and safety of the aviation service. Therefore, AMEs should accurately know safe drugs that do not cause drowsiness and prescribe them to patients. In addition, it is necessary to know exactly whether air workers may receive the latest treatments for allergic rhinitis, such as surgical treatment and immunotherapy, and be able to recommend these treatments appropriately. Therefore, in this paper, we first briefly describe the pathophysiology, genetics, causative antigen, symptoms, diagnosis, and treatment of allergic rhinitis. We also aimed to discuss safe medication and other treatment modalities for allergic rhinitis.

• 사상체질의학회지
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• 제18권1호
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• pp.138-146
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• 2006

1. Objectives The present study purposed to examine Taeumin after Sasang Constitutional medical treatment showed faster improvement in sneezing or rhinorrhea or nasal obstruction, the main symptoms of allergic rhinitis. 2. Methods One group treated by Sasang Constitutional medicine in allergic rhinitis patients of T aeumin is 20 cases. The other group treated by other herb medication in alletgic rhinitis patients of Taeumin is 15 cases. We analyzed the improvement of the main symptoms in 2 group who had allergic rhinitis for less than five years in the 2nd, 4th, 6th and 8th week of treatment. 3. Results & Conclusions (1) Sneezing showed a significant decrease from the 6th week of treatment in the group treated by Sasang Constitutional medicine and from the 6th week in the group treated by other herb medication. (2) Rhinorrhea showed a significant decrease from the 2nd week of treatment in the group treated by Sasang Constitutional medicine and from the 4th week in the group treated by other herb medication. (3) Nasal obstruction showed a significant decrease from the 4th week of treatment in the group treated by Sasang Constitutional medicine and from the 4th week in the group treated by other herb medication. (4) Satisfaction with subjective symptoms was higher in the group treated by Sasang Constitutional medicine than in the group treated by other herb medication but the difference was not significant (p>0.01). (5) Change in total symptom score showed a significant decrease from the 2nd week in the group treated by Sasang Constitutional medicine and from the 4th week in the group treated by other herb medication(p>0.01).