• The monthly packaging world
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• no.7 s.183
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• pp.124-143
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• 2008

식품의약품안전청은 식품의 기구나 용기로 사용되는 금속제에 대해 납, 크롬, 니켈 등 용출규격을 강화하고 내분비계장애물질(환경호르몬)으로 의심되는 비스페놀 A에 대해서도 강화된 기준을 마련하여 입안 예고 했다. 식약청은 현재 분리되어 있는 금속제 및 금속관의 규격을「금속제」로 통합하고 크롬 및 니켈에 대한 용출규격을 각각 0.1mg/L 이하로 신설하고자 하며, 납 0.1% 이상 함유한 금속으로 기구 및 용기포장의 식품과 직접 접촉하는 부분을 제조 금지토록 하는 등을 주요내용으로 정했다. 본 고에서는 주요 내용과 법안을 살펴보고 신.구조문을 비교해 살펴보도록 한다.

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.648-649
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• 2006

• The monthly packaging world
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• s.190
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• pp.124-144
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• 2009

식품의약품안전청이 가구 및 용기 포장의 기준 및 규격 일부를 개정고시했다. 식약청은 폴리카보네이트 등에 대해 비스페놀 A의 규정과 유리제, 도자기제 등에 대해 납, 카드뮴 규격을 강화하며, 금속관 및 금속제의 규격을 단일화하고 용출규격 강화 및 폴리아미드/나일론 재질에 대한 4,4‘-메틸렌디아닐린 용출규격을 신설하여 식품용 기구 및 용기 포장의 안전성을 확보하고자 한다. 본고에서는 주요 내용과 함께 신문구조문을 비교해 살펴보도록 한다.

• Applied Chemistry for Engineering
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• v.26 no.4
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• pp.463-469
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• 2015

Bisphenol A (BPA) in aqueous solution was measured using HPLC technique, which was established by acetonitrile analysis and KDP solution analysis methods. In these experiments the decomposition characteristics of BPA were compared using the ozone alone, ozone/pH 10, and ozone/hydrogen peroxide processes. About 70% of 10 mg/L of BPA was removed during 60 min by the ozone alone process, while 10 mg/L of BPA was completely removed by the ozone/pH 10 and ozone/hydrogen peroxide processes in 40 min and 60 min, respectively. The final decomposition efficiency drawn from results of TOC and HPLC analyses showed that the ozone/hydrogen peroxide process was the best among them, whereas the concentrations of TOC and reaction intermediates when using the ozone/pH 10 process were higher than those of the ozone alone process after 60 min of reaction. The ozone/hydrogen peroxide process was the most efficient among them when oxidizing organic carbons in water to $CO_2$ and $H_2O$.

• Composites Research
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• v.35 no.6
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• pp.412-418
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• 2022

Flame-retardant vinyl ester (VE) resin films were developed from the mixtures of brominated and non-brominated epoxy resins via esterification with methacrylic acid without reactive diluents. The films were used to fabricate carbon fiber (CF) prepregs via a hot melt impregnation process. The viscosity of VE resins suitable for film production was optimized by mixing low-viscosity bisphenol-A and high-viscosity brominated bisphenol-A epoxy precursors. Increasing the bromine content of the cured VE resin further increased the limited oxygen index (LOI) (39%), storage modulus (2.4 GPa) at 25℃ and residual carbonization (16.1%) values compared to non-brominated VE. Manual layup of as-prepared VE prepregs with subsequent curing led to the successful fabrication of CF-reinforced composites with high tensile and flexural strength. The results from the study hold high promise for a styrene-free, environmentally friendly VE composite process in the future.

• Korean Journal of Microbiology
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• v.52 no.3
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• pp.306-312
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• 2016

Microalgae are the potential bioindicators of environmental changes, for the environmental risk assessment as well as to set limits for toxic chemical release in the aquatic environment. Here, we evaluated the effects of two endocrine disrupting chemicals (EDCs), namely bisphenol A (BPA) and Aroclor 1016, on the green algae Tetraselmis suecica, diatom Ditylum brightwellii, and dinoflagellate Prorocentrum minimum. Each species showed wide different sensitivity ranges when exposed to these two EDCs; the 72 h effective concentration ($EC_{50}$) for these test species showed that Aroclor 1016 was more toxic than BPA. $EC_{50}$ values for the diatom D. birghtwellii were calculated at 0.037 mg/L for BPA and 0.002 mg/L for Aroclor 1016, representing it was the most sensitive when compared to the other species. In addition, these results suggest that these EDC discharge beyond these concentrations into the aquatic environments may cause harmful effect to these marine species.

• Analytical Science and Technology
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• v.13 no.4
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• pp.484-493
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• 2000

The simultaneous analysis of alkylphenols, chlorophenols and bisphenol A in biota samples was performed by gas chromatography-mass spectrometry-selected ion monitoring mode. The phenols were extracted from sample with organic solvent and Forisil and Silica columns for clean-up procedure were compared. Recovery studies were performed at 1-ppm level of phenols added to each biota sample. Their recoveries ranged between 83 and 116% with coefficient of variations of 2.4-11.9%. To improve the detection limits of phenols, trimethylsilyl (TMS) derivatization was applied. The gas chromatographic properties of free phenols and TMS derivatized phenols were also investigated.

• Journal of Marine Bioscience and Biotechnology
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• v.14 no.2
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• pp.61-68
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• 2022

This study aimed to investigate the hepatoprotective activities of the sea cucumber products, including extracts and hydrolysates, in vitro and in vivo. Dried sea cucumber, produced on the western coast of Korea, was boiled in water or 70% ethanol at 85℃ or 100℃ for 18 or 24 h, respectively, to extract bioactive compounds. The enzymatic hydrolysates were prepared by reacting the dried sea cucumber with pepsin or neutral protease (PNL) under optimal enzyme conditions. The anti-inflammatory effect of the samples was investigated using RAW 264.7 cells treated with lipopolysaccharide (LPS). The amount of nitric oxide (NO) was produced from the cells treated with LPS and each sample was compared. Therefore, the pepsin hydrolysate treatment decreased NO production compared to LPS sole treatment. Furthermore, the effects of the samples on cell injury in the hepatic cell line and bisphenolA-induced hepatic injury mouse model were investigated. The water extracts and the pepsin hydrolysates of sea cucumber significantly inhibited cell injury generated in the hepatocytes without cytotoxicity (p < 0.05), whereas the ethanol extracts were cytotoxic. However, these results indicate that the extracts and the enzymatic hydrolysates derived from sea cucumber can be used as beneficial materials for inhibiting liver damage.

• Journal of the Korean Chemical Society
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• v.68 no.4
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• pp.191-198
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• 2024

Endocrine disrupting chemicals (EDCs) are compounds that come from outside the body and disrupt hormone action within the body's endocrine system. Examples include parabens, benzophenones, bisphenols, and phthalates, which are currently used in a wide range of applications. However, continuous exposure to them can have negative effects on glycemic control, reproduction, metabolism, nervous system development, pregnancy, childbirth, and growth. In this study, human samples (urine) were pretreated using liquid-liquid-extraction to determine the exposure level of EDCs and then analyzed effectively and rapidly by UPLC-MS/MS. In this way, the analytical conditions were established and the reliability of the simultaneous analysis method was evaluated through method validation. The results showed that the accuracy ranged from 75.28 to 122.36% and the precision ranged from 2.16 to 22.74%. The analytical method established in this study can be used as a methodology for future studies to evaluate and monitor the exposure of EDCs in human samples.

• Environmental Mutagens and Carcinogens
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• v.21 no.2
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• pp.135-141
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• 2001

Endocrine disruptors have been implicated in carcinogenesis in animal studies, but carcinogenetic effects on human remain controversial. In order to examine the genotoxicity of two common endocrine disruptors, Bisphenol A and Diethylstilbestrol, cytogenetic endpoints including chromosome aberration (CA), sister chromatid exchange (SCE), micronuclei (MN) analyses and DNA damage by single cell gel electrophoresis (SCGE) were assessed. The effects of Bisphenol A and Diethylstilbestrol on the frequencies of CA and MN were increased in a dose-dependent manner and that of Bispheol A was more significant by Kendall'$\tau$test. Bisphenol A and Diethylstilbestrol also increased the frequency of SCE. Bisphenol A and Diethylstilbestrol induced DNA damage in a dose-dependent manner and the DNA damage induced by Diethylstilbestrol in human blood lymphocytes was more significant.