• Journal of the Korea Society of Computer and Information
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• v.27 no.8
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• pp.185-194
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• 2022

The purpose of this study was to verify the effects of long-distance horseback riding on blood lipid, adipokines and inflammatory markers in obese middle-aged women. The subjects of this study were 9 obese meddle aged women and the data analysed using the paired t-test. The result of this study were as follows: First, TC(p<.01), LDL-C(p<.01), and HDL-C(p<.001) were significantly increased after long-distance horseback riding(LDHR). Second, adiponectin was significantly increased(p<.01) and also PAI-1 was significantly decreased(p<.01) after LDHR. Third, IL-6 was significantly increased(p<.01) after LDHR. These results suggest that long-distance horseback riding has positive effect on changes blood lipid, adipokines, and inflammatory markers in obese middle-aged women. Therefore we consider that effects of long-distance horseback riding has partial examine on prevention and therapy of obesity in middle-aged obese women who undergo physical and emotional big changed.

• Monthly Duck's Village
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• s.67
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• pp.98-100
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• 2009

중국 최고의 미식가인 서태후가 미용식으로 즐겼다는 오리, 그만큼 비만예방과 고혈압 예방 및 치료에 탁월한 효과가 있는 다이어트 식품이라고 하는데...타 육류와 달리 불포화지방산의 함량이 높을 뿐 아니라 필수지방산인 리놀산과 아라키돈산이 함유되어 콜레스테롤 수치를 낮춰주는 역할을 해 스태미너 식품으로 꼽히는 오리. 또, 오리고기에는 독성물질을 분해하는 성분이 있어 유황을 먹인 오리는 해독복원의 으뜸으로 꼽힌다. 오리고기 속에 숨겨진 비밀을 알아본다.

• Journal of Korean Medicine for Obesity Research
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• v.17 no.1
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• pp.10-19
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• 2017

Objectives: The aim of study was to investigate the effect of herbal medicine on obesity and to define which seasonal factor could be utilized to make an obesity treatment program more effective. Methods: Three hundred and forty-four subjects were recruited and data were analyzed for weight, body fat, muscular volume, body fat ratio, body mass index (BMI) change and treatment duration. At first, age classification was performed for the comparisons. Moreover, starting season of treatment was categorized to determine it's influence over the treatment. Results: It was found the administration of herbal medicine could diminish every analyzed fields of entire patients. Compared among age groups, there were no significant differences of all fields. However, the categorization of start season showed significant differences of weight, BMI change and treatment duration. In addition, the analysis of assumed 10% weight loss elicited patients started treatment in spring and winter should spend 12 and 13 weeks and summer would be 9.5 weeks. Conclusions: It was found herbal medicine would be effective for female obesity and expected patients could achieve 5.91 kg weight loss for 65.88 days treatment. Summer group had significant shorter treatment duration and it was presumed summer group had more concentration for achievement. Days required for assumed 10% weight loss was calculated to be 84 days in spring, 67 days in summer, 96 days in winter. Hereafter, further controlled study with more numbers of patients should be needed to determine the goal of medical treatment for obesity.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.13-20
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• 2001

Obesity is an excess of body fat frequently resulting from an imbalance between energy intake and expenditure, raises the risk of morbidity from chronic diseases such as hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, fatty liver and osteoarthritis. Recently we experienced a 51 years old obese woman who was accompanied with hypertension, dyslipidemia and osteoarthritis. Through weight reduction program(very low calorie diet, Chegameuiintang, exercise) during 3 months, total weight loss was 17.0kg, her condition was improved.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.232-232
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• 1994

인삼이 면역계 질환의 일종인 과민성 반응에 대한 치료약으로서의 가능성을 연구하기 위해서 in viva와 in vitra실험을 수행하였다. in vitra실험으로서는 hyaluronidase의 활성을 지표로 삼았으며, in viva실험에서는 mouse이각, rat등피부, 복강 비만세포, 그리고 guinea pig의 ileum에서 면역반응에 대한 아답타겐의 작용을 관찰하였다. in uitra 실험에서는 hyaluronidase와 histamine 분비를 항알레르기 작용의 지표로 사용하였다. hyaluronidase의 경우 그 활성은 Cacl2로 활성화 시키기 전이나 후에 모두 아답타겐(100, 50, 및 10 mg/ml)에 의해서 현저하게 억제되었다. 한편 rat 복강 비만 세포에서의 histamine유리 시험에서는 아답타겐(0.5, 1, 5mg/ml)이 histamine유리가 증가되었다. Guinea pig의 ileum 평활근에서는 아답타겐이 평활근 자극 작용없이 항히스타민 효과률 나타내었다. in uiua 실험의 첫 단계로 우리는 혈관 투과성에 미치는 아답타겐의 효과를 mouse 이각과 rat 등피부에서 관찰하였다. Mouse이각에서의 실험에서는 hoistamine, serotonin, 그리고 LTC4로 challenge하여 관찰한 결과 histamine과 serotonin의 경우, 혈관투과성 항진은 아답타겐(50-400mg/m1)에 의해서 유의성있게 억제되었으나, rat 등 피부에서는 mouse에서와는 달리 48-hr PCA가 증가 되었고, histamine에 의한 혈관투과성 항진은 아답타겐에 의해 영향을 받지 않았다. 반면에 compound 48/80과 serotonin에 의한 혈관투과성 항진은 mouse 의 경우에서처럼 아답타겐에 의해 억제되었다.

• The Zoological Society Korea : Newsletter
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• v.18 no.2
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• pp.6-11
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• 2001

Peroxisome proliferator-activated receptor $\alpha$ (PPAR$\alpha$)에 대한 본격적인 연구는 고지혈증 치료제인 fibrate류의 약물들이 PPAR$\alpha$ activator로 작용한다는 사실이 밝혀짐으로써 크게 증대되었다. PPAR$\alpha$는 fibrate를 포함한 다양한 종류의 peroxisome proiferator (PP)에 의해 활성화되는데 이들을 쥐에 단기간 투여할 경우 간의 peroxisome수와 지 방산 산화효소의 유전자발현이 증가되고 장기간 투여 할 경우 간암을 발생시키지만, fibrate류의 약물들을 고지혈증 환자에게 투여 할 경우 간암을 발생시키지 않으므로써 PP에 대한 반응성에 있어서 species difference를 나타낸다 PPAR$\alpha$는 핵에 존재하는 orphan receptor로서 PP에 의해 활성화되어 9-cis-retinoic acid receptor(RXR)와 heterodimer를 이룬 후 target gene들의 upstream에 있는 peroxisome proliferator response element (PPRE)에 결합하여 target gene들의 발현을 조절한다. 지금까지 연구된 PPAR$\alpha$의 target gene들은 모두 lipid와 lipoprotein 대사를 조절하는 것으로 알려져 있으며, 이러 한 결과들을 기초로 lipid 대사 및 energy balance와 관련된 질병들 - 동맥경화증, 관상동맥질환, 비만, 제 2형 당뇨병 등에서 PPAR$\alpha$의 역할이 집중적으로 연구되고 있다. PPAR$\alpha$가 활성화되면 lipoprotein lipase와 HDL이 증가되고 apo C-III가 감소됨으로써 동맥경화증에 대한 예방적 기능을 나타내고, 몸무게를 감소시킴으로써 비만을 방지할 수 있으며, 인슐린 감수성을 증가시켜 제 2형 당뇨병의 치료효과를 가지는 것으로 보인다. 그러나 PPAR$\alpha$-null mouse에서는 이러한 효과들이 나타나지 않는 것으로 보아 이들 질병에서 PPAR$\alpha$가 중요한 역할을 하는 것으로 생각된다.

• Journal of Korean Medicine for Obesity Research
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• v.1 no.1
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• pp.57-62
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• 2001

Objectives : This study was designed to investigate the effects of Fangfengtongsheng-san on obese patients. Materials and Methods : 20 patients that take Fangfengtongsheng-san during 3weeks at obesitic clinic, Conmaul Oriental Hospital from June 2000 to October 2000 were selected for this study. Results : In the change of body composition, the reduction of weight was $2.46{\pm}1.31\;kg$, the reduction of percent body fat was $1.34{\pm}0.84%$, the reduction of 8MI was $0.96{\pm}0.17$. Conclusion: This study shows that Fangfengtongsheng-san is effective on weight reduction.

• Journal of Korean Medicine for Obesity Research
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• v.6 no.1
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• pp.1-10
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• 2006

Localized fat and cellulate have not only esthetic but health problem, they are treated by surgical or non-surgical method. There are elecro-acupuncture, ultrasound, radio frequency, endermologie, mesotherapy, and carbon dioxide therapy in prevalent non-surgical treatments. We reviewed the studies on them to analyze their seicntific evidence. The studies are not many. They reported good results of circumference loss or appearance improvement of histologic change but most of them have poor study design. Before marketing or using these modalities, it is ontcal to evaluate to their effectiveness through strict and scientific clinical trials.

• Journal of Digital Convergence
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• v.13 no.8
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• pp.503-514
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• 2015

The effects of Flavonol contents from Ginkgo biloba leaf on anti-atopy activity have not rarely been verified. This study is to investigate the effects of flavonol on Th2 cytokine production in MC/9 mast cells. For this, flavonol was analyzed by ELISA and Real-time PCR. Analysis results showed that flavonol significantly suppressed production of Th2 cytokines(IL-13, MIP-1a) in a dose dependent manner. The mRNA expression of IL-4, IL-5, IL-13, TNF-a were effectively restrained by Flavonol at the concentration 25,50,$100{\mu}g/m{\ell}$. And decrease of expression of NFAT-1, c-jun protein was confirmed by western blot analysis. These results indicate that flavonol has effects of decreasing the Th2 cytokine production in the MC/9 mast cell causing inhibition of transcription factors such as NFAT-1, c-jun. Thus, we would like to brief that flavonol may have the applicability as therapeutic agent for atopic dermatitis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.7
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• pp.950-956
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• 2012

Salicornia herbacea L. is an annual herb that grows in salt marshes and salt fields along the seashores. It is also commonly used as a folk remedy in Korea. The objective of this study was to investigate the beneficial effects of Salicorrnia herbacea L. (SH) hot water extract on obesity. Five-week old male Sprague-Dawley rats (n=36) were divided into two groups and provided either a normal fat diet (11.5% fat from kcal) or a high fat diet (40.5% fat from kcal) for 6 weeks to induce obesity. Then, rats were blocked into six groups of six mice each and provided either a diet containing SH (0.5% of diet; g/kg) or a normal diet for another 6 weeks. Final body weights were significantly reduced when rats were fed SH among the high fat diet groups (HNS and HHS). Serum triglyceride concentrations significantly decreased in every group provided SH. HDL-cholesterol concentrations significantly increased in SH-fed groups among the high fat diet groups. Further, atherogenic index significantly decreased when rats were fed SH diet (HHS). There were no differences in LDL-cholesterol between the high fat diet groups, and glucose concentrations decreased when rats were fed SH diet (HNS). These results indicate that dietary intake of Salicornia herbacea L. hot water extract might have beneficial effects on obesity by reducing body weight, fat weights, and improving blood lipid profile.