• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.365-374
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• 2019

Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2014.10a
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• pp.799-803
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• 2014

• Korean journal of applied entomology
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• v.56 no.3
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• pp.289-294
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• 2017

The Oriental fruit fly, Bactrocera dorsalis, has been designated as a main quarantine insect pest. Sensitive monitoring and diagnosis against B. dorsalis are required for early quarantine treatment. This study formulated a wax type dispenser containing methyl eugenol and biopesticide to attract and kill this insect. It also developed diagnostic PCR primers against five major quarantine fruit flies of B. dorsalis, B. cucurbitae, B. tryoni, B. latifrons, and Ceratitis capitata. The lure and diagnostic primers were evaluated in a field located in Kota Kinabalu, Malaysia.

• Electrical & Electronic Materials
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• v.37 no.1
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• pp.18-28
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• 2024

• The Science & Technology
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• v.33 no.3 s.370
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• pp.28-29
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• 2000

한국 의학계 실리콘밸리의 꿈을 키우고 있는 연세대 의과대학 생화학ㆍ분자생물학교실은 5명의 교수와 11명의 석ㆍ박사 연구진들이 당뇨병ㆍ혈우병 등의 질병에 관련된 연구와 여러 유전자의 조절기전 등의 연구에 땀을 흘리고 있다. 지난해 10월에는 교수 5명이 제네피아라는 벤처기업을 창업해 의약과 생명공학에 관련된 시약과 진단 및 치료제 개발을 진행하고 있다.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.235-235
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• 2012

반도체/디스플레이 공정의 설치 layout의 단순화와 전체 공정 cost의 저감을 위하여 대용량, 고진공 성능의 진공시스템 수요가 증대되고 있다. 이로써 고진공 펌프 국산화의 일환으로 터보분자 펌프와 크라이오 펌프 개발이 진행 중이다. 개발 시제품의 최종 상용화 단계에 진입하기 위한 목적으로 핵심부품의 진공, 기계적 특성평가, 운전상태 및 진공 특성평가, 신뢰성 확보/공정대응성 평가를 위한 관련 기술 및 장치가 개발되었다. 본 연구에서는 터보분자펌프의 공정별 gas load 다변화에 따른 기계적 안정성과 작동 신뢰성의 확인을 위해 내구성 평가 장치를 설계/제작하였다. 상용화 제품의 성능 테스트를 통한 RPM, 소비전력, 압력 그리고 온도 등의 패턴을 확인하여 내구성 평가시스템의 신뢰성을 확인하고 터보분자펌프의 성능 특성 변화를 고찰하고자 한다. 본 연구는 지경부 산업원천기술개발사업 중 "초고진공펌프 개발" 사업의 제 3 세부과제인 "고진공펌프 종합특성평가시스템 개발(과제번호: 11201044)" 및 "스마트형 진공 배기 진단 제어 시스템 개발(과제번호: 11201038)" 과제에서 수행된 연구결과의 일부임.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.08a
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• pp.92-92
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• 2011

지식경제부의 청정제조기반 산업원천개발사업의 일환으로 진행 중인 "초고진공펌프 개발" 과제 중 제 3 세부 과제인 "고진공펌프종합특성평가시스템 설계, 진단기술 개발" 과제에서 추진된 연구결과를 소개한다. 국내 초고진공펌프 개발 수준의 선진화를 위한 기본적인 초석 확립은 현존하는 모든 진공 발생 장치의 국제적 신뢰성이 있는 완벽한 성능평가의 구현에 있다고 할 수 있다. 크라이오펌프 및 복합분자펌프의 최종 상용화 단계에 진입하기 위한 목적으로 핵심부품의 진공, 기계적 특성평가, 운전상태 및 진공특성평가, 신뢰성 확보/공정대응성 평가를 위한 관련 기술 및 장치가 개발되었으며, 시작품 단계의 기 개발품을 평가 진단하는 사업 추진단계에 진입하고 있다. 현재 구축되고 있는 저진공/고진공펌프의 성능평가장치의 개요를 소개하면서 향후 크라이오 펌프 및 터보분자펌프의 개발 및 상용화 단계에서 필요한 국제적 규격 및 내부적 가이드라인을 기 수행되고 있는 측정 데이터베이스에 근거하여 제시하고자 한다. 또한 향후 2년간의 최종 상용화에 필요한 국제 신뢰성, 공정대응성 확보 등 핵심사업 추진내용 및 infra 구축의 상세설계 로드맵 초안을 고찰하고자 한다.

• The Journal of the Korea Contents Association
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• v.19 no.2
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• pp.259-268
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• 2019

Dengue virus is a typical mosquito-borne virus, and the half of the world's population is exposed to infection. Dengue virus causes relatively mild symptoms such as dengue fever. However, when not treated properly, it is known to cause severe symptoms such as dengue hemorrhagic fever and dengue shock syndrome with a mortality rate of over 20%. Development of dengue virus detection technology is very important because it is reported that early diagnosis of dengue fever can lower the mortality rate to less than 1%. In this study, patent search related to dengue virus detection technology was conducted in Korea, USA, Europe, Japan, and China. The quantitative analysis of 69 validated patents from the searched patents was conducted by country, year, and patent holder. In addition, in-depth analysis was carried out by classifying into three categories: molecular diagnostics, immuno-diagnostics, and cell culture-based diagnostics from all validated patents. From these results, we analyzed the patent trend related to dengue virus detection and dengue fever diagnosis technology and discussed the features and limitations of molecular diagnostics and immuno-diagnostics at present level. Furthermore, we discussed the direction of technology development and future prospects to overcome limitations.

• Journal of Genetic Medicine
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• v.7 no.1
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• pp.16-23
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• 2010

Many endocrine disorders have a genetic component. The genetic component is the major etiologic factor in monogenic disorders, while multiple genes in conjunction with environmental and lifestyle factors contribute to the pathogenesis in complex disorders. The development of the molecular basis of inherited endocrine diseases has undergone a dramatic evolution during the last two decades. The application of molecular technology allowed us to increase our understanding of endocrine diseases, and to impact on the practice of pediatric endocrinology related to diagnosis and genetic counseling. Identification of the mutation in the particular disease by genetic testing leads to precise diagnosis in the equivocal cases and prenatal diagnosis. However, clinicians should be cautious about determining therapeutic decisions solely on the basis of molecular studies, especially in the area of prenatal diagnosis and termination of pregnancy. This review describes an introduction to molecular basis of various inherited endocrine diseases and diagnosis by genetic testing.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.4
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• pp.375-381
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• 2018

Cytogenetic analysis plays an important role in examinations of a variety of human disorders. Over the years, cytogenetic analysis has evolved to a great extent and become a part of routine laboratory testing; the analysis provides significant diagnostic and prognostic results for human diseases. Microarray in conjunction with molecular cytogenetics and conventional chromosome analysis has transformed the outcomes of clinical cytogenetics. The advantages of microarray technologies have become obvious to the medical and laboratory community involved in genetic diagnosis, resulting in greatly improved visualization and validation capabilities. This article reviews how the field is moving away from conventional cytogenetics towards molecular approaches for the identification of pathogenic genomic imbalances and discusses practical considerations for the routine implementation of these technologies in genetic diagnosis.