• Proceedings of the Korean Aquaculture Society Conference
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• 2003.10a
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• pp.30-30
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• 2003

자성발생(gynogenesis)은 대상 어류의 성 결정기작이 암컷 동형접합성(female homogamety)인 경우 전 암컷 단성집단을 생산할 수 있으며, 단기간 내에 우수한 품종의 순계 획득과 유전적으로 동일한 clone 집단을 만들 수 있다(Thorgaard, 1986; 정 등 1996). 이에 제 1 난할 억제에 의한 메기 S. asotus에서의 체세포분열 억제성(mitotic) 자성발생 2배체가 유도된 바 있다(임 등, 2002), 염색체공학 기법 중 웅성발생 2배체(androgentic diploid)는 난자 핵을 불활성 시킨 후 정자 핵에 의해 제 1 난할억제에 의한 유전자 배가로 유도 될 수 있다. 본 연구는 염색체공학에 의한 메기 4배체 생산, 메기체세포분열 억제성 자성발생성 2배체의 효과적인 유도 조건 검정 및 메기 웅성발생성 2배체 생산을 위한 연구의 일환으로, 메기에서의 핵분열(korykinesis)에 관하여 조사하였다. 메기에서의 핵분열 수온 25$\pm$0.5$^{\circ}C$ 조건에서 수정 후 31분에 가장 현저하였다. 본 연구 결과를 Park and Im (2001)의 수온 24$^{\circ}C$에서의 제 1 난할 후기가 50분이며 mitotic interval이 18.5$\pm$1.2분인 결과와 비교시, 본 연구 결과의 수온 24$\pm$0.5$^{\circ}C$ 조건에서 핵분열이 수정 후 31분인 것은 핵분열과 세포질분열(cytokinesis)이라는 관점에서 정확히 일치한다. 염색체 수의 배가시, 핵분열 억제는 세포질 분열 억제에 비해 더욱 효과적으로서(Cherfas et al., 1993; Nam et al., 1999), 본 연구 결과의 핵분열 시간(수온 24$^{\circ}C$ 조건에서의 수정후 31분)을 기반으로 하여 차후, 4배체 메기와 체세포분열 억제성 자성발생 2배체 메기 및 웅성발생성 2배체 메기 유도 및 그의 생산성 향상에 관한 연구가 기대된다.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.1099-1106
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• 2006

정신질환자들은 자기감정을 표현하는 능력의 결손을 보인다. 이러한 자기 감정표현기술은 정신질환자들을 위한 사회기술훈련 (Social Skill Training) 과정 중 하나로서 정상적인 사회생활로의 복귀를 위해 반드시 필요하다. 지금까지의 자기감정표현 훈련 및 평가 방법은 치료자 능력의 차이에 따른 주관적 판단이 개입될 수 있다는 문제점을 가지고 있다. 가상현실 (Virtual Reality)은 컴퓨터를 이용한 최신의 방법으로, 최근 자폐증이나 공포증 등의 정신질환 분야에도 적용되고 있다. VR 을 사용하면 상호작용을 할 수 있고, 다양한 환경과 자극을 제시할 수 있으며, 3 차원 랜더링을 통해 몰입감을 제공할 수 있다. 또한 저장된 파라미터들을 바탕으로 객관적 판단을 할 수 있는 기준을 제시할 수 있으며, 안전하고 시간과 공간적 제약이 적은 환경 내에서 과제를 수행할 수 있다. 이에 본 연구에서는 자기감정표현기술의 객관적 평가를 위한 가상현실 시스템을 개발하고 정신분열증 환자와 정상인을 대상으로 실험을 진행하였다. 가상현실은 크게 긍정적 상황과 부정적 상황으로 이루어 지는데 집, 카페, 빵집, 길거리 등 다양한 환경에서 가족, 친구, 직장동료 등의 아바타가 실험 참가자에게 말을 건네고 참가자는 적절한 시기에 자신의 감정표현을 하도록 구성하였다. 실험을 하면서 정서 (긍정적 상황 Vs. 부정적 상황)에 따른 자기감정표현에 대한 파라미터로서 아바타가 말하는 동안 참가자가 아바타의 말에 주목을 하는 정도 (아바타가 말하는 동안 참가자가 아바타의 얼굴을 쳐다보는 시간)와 자기감정을 표현을 하는 시간 (아바타의 말이 끝난 후 감정표현을 시작하는 시간과 감정표현시간)과 상대방 아바타를 주목하는 정도 (참가자가 자기감정을 표현하는 중 아바타를 쳐다보는 시간) 등을 측정하였다. 측정결과 정상인이 정신분열병 환자에 비해 아바타를 주목하는 시간이나 자기감정표현을 하는 시간이 더 긴 경향이 있었다. 또한 부정적 상황에서 정신분열병 환자와 정상인 모두가 긍정적 상황에 비해 말하는 아바타에 더 잘 주목하였고, 자기감정을 표현하는 시간도 더 긴 것을 확인 하였다. 따라서 본 연구에서 도출된 파라미터는 실험 참가자의 자기감정표현의 정도를 객관적으로 나타낼 수 있을 것으로 생각된다. 또한 정신분열병 환자의 자기 감정표현능력을 측정하는 도구로 사용될 수 있을 것으로 생각된다.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.24 no.1
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• pp.30-36
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• 1979

The fertilizations of cv Palkweng, Noupoung, and TN 1 which were crossed artificially at 2$0^{\circ}C$ and 3$0^{\circ}C$ were examined. The meiosis and the rate of maturity of the above 3 cultivars, Iri #326, Milyang #29, Suwon #264, and 3 others which were transplated at different times in paddy field were examined, and the results of which were as follows. 1. Palkweng at 3$0^{\circ}C$ was fertilized within 1.5~4.0 hours ,after pollination and at 20\circ C was done within 2.8~4.5 hours after pollination. 2. Noupoung and TNI at 3$0^{\circ}C$ were fertilized within 2.0~5.5 hours after pollination and at 2$0^{\circ}C$ were done within 3.0~6.0 hours after pollination. 3. The rates of fertilization of the cultivated rice plants at 2$0^{\circ}C$ were dropped in general. TN 1 at 2$0^{\circ}C$ was often fertilized abnormally. 4. In the development of embryo, Palkweng was the earliest at 3$0^{\circ}C$ and TN 1 was the earliest at 2$0^{\circ}C$. 5. Although the time of transplant was late, the pollens of Palkweng was normal because the meiosis of that was normal. but the pollens of TNI was sterile in general because of the abnormal meiosis.

• Journal of Plant Biology
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• v.37 no.1
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• pp.69-76
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• 1994

The present work was conducted to examine the effect of tobacco smoke solution, and its components such as nicotine and catechol treated separately on the root tip cells of Allium cepa L The mitotic abnormalities in root tip cells treated with those three components were increased linearly, while the mitotic index was decreased following concentrations of the components. Chromosomal abnormalities showed 29.7%, 15.8% and 13.0% in the treatment of tobacco smoke solution, nicotine, and catechol, respectively. The abonormalities were included polyploid, c-mitosis, stickness at metaphase, laggard, bridge formation at anaphase or telophase, and micronucleus, abnormal nucleus at interphase, after the treatment of the components for 24 hours. hours.

• The Journal of the Korea Contents Association
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• v.13 no.12
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• pp.309-320
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• 2013

The purpose of this study was to examine the effectiveness of interventions for improving the social skills for people with schizophrenia by using method of meta-analysis. For the purpose of the study, master's theses, doctoral dissertations, and journal articles published in korea up to July, 2013 were systematically reviewed. As a result, a total of 22 studies were eligible for the inclusion criteria. The mean effect sizes and test for homogeneity of effect size(Q-statistic) were analyzed by using Comprehensive Meta-Analysis software 2.0. The main findings of the study were as follows. First, the average effect sizes for total social skill training programs were ES=0.838 of interpersonal capacity, ES=0.782 of social behavioral skills, ES=0.601 of self-assertiveness skills, and ES=0.293 of symptoms. Second, by analysing the moderate variables of the effect size for social skill training programs, 'a place of training', 'a major of trainer', 'running times' and 'sessions' were statistically significant. Based on the study results, the research and practice implications were discussed.

• Journal of Life Science
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• v.27 no.6
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• pp.623-631
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• 2017

In the subventricular zone (SVZ) and the subgranular zone of the brain, neurogenesis occurs throughout one's lifespan. Neural stem cells (NSCs) in these regions divide to maintain their stem cell pools as well as differentiate into neurons and glial cells. To monitor cell division, a thymidine analogue such as 5-ethynyl-2'-deoxyuridine (EdU) has been used. In some cases, EdU was applied to label newly born neurons. Here, we report about the effects of EdU on the proliferation and differentiation of NSCs cultured from mouse SVZ. First, when NSCs were cultured in a proliferation medium containing EdU for 24 hr, they did not generate any neurons under the following differentiation conditions. When EdU was applied to the proliferating NSCs for 1 hr prior to differentiation, neurogenesis was still substantially reduced. Second, EdU decreased cell proliferation of NSCs in dose- and time-dependent manners. Finally, EdU inhibited differentiation into oligodendrocyte lineage, while the number of glial fibrillary acidic protein (GFAP)-positive astrocytes increased. To our knowledge, these findings are the first to show the effects of EdU on the differentiation of SVZ NSCs and suggest that cell division is necessary for differentiation into neurons and oligodendrocytes.

• Journal of Embryo Transfer
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• v.16 no.2
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• pp.91-98
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• 2001

We evaluated the effects of the substrate and inhibitors related to phosphatidylinositol metabolism on in vitro maturation and fertilization of porcine oocytes. Cumulus-oocyte complexes were cultured in mTLP-PVA medium supplemented with or without inositol (250 mM) fur 46h. Subsequently, these oocytes were inseminated with fresh boar semen in mTALP-PVA medium for 6h. At 6h after insemination, oocytes were cultured for further 12 h in TCM-199 supplemented with 10% FBS (fetal bovine serum). The higher percentage of oocytes in inositol-supplemented medium reached metaphase of the second meiotic division compared to those in control (81.4% vs. 67.3%; P<0.()5). following 18 h of insemination, more number of male pronuclei were formed in the oocytes matured in inositol-supplemented medium than in those of control experiment (42.0% vs. 27.3%; P<0.05). When oocytes were cultured in medium with 10mM LiCl (chloride lithium) or 0.5mM dbcAMP (dibutyryl cyclic adenosine monophosphate) to determine the role of inositol on the maturation of oocytes, these two drugs inhibited the meiotic division of oocytes (P<0.05). However, addition of inositol to the culture medium did overcome the inhibitory effect of these drugs on the oocyte maturation. DbcAMP and verapamil supplemented synergistically arrested the meiotic division of oocytes. Addition of verapamil did not inhibit germinal vesicle breakdown, but it severly inhibited the second meiotic division of oocytes. These results suggest that inositol exert its improving effects on maturation, by activating the PI (phosphatidylinositol) cycle and causing beneficial changes in both cytoplasm and membrane of oocytes.

• Journal of Satellite, Information and Communications
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• v.12 no.4
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• pp.42-49
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• 2017

Delay- and Disruption-Tolerant Network (DTN) has been considered as a key technology to overcome main challenges in interplanetary communications such as an intermittent connectivity and high bit error rates. The lack of end-to-end connectivity between source and destination results in long and variable delays and data loss, hence the Internet Protocols cannot operate properly in such environments because it requires an end-to-end connectivity. The DTN, which utilizes 'store-and-forward' message passing scheme between nodes, can overcome the lack of end-to-end connectivity in Interplanetary Network (IPN). In this paper, DTN is applied to 3-hop relay IPN, where messages are transmitted from Earth ground station to Lunar lander through Earth satellite and Lunar orbiter. ONE simulator is used to reflect the real environment of IPN and an efficient resource management method are analyzed to guarantee the message delivery by optimizing a message TTL (Time to Live), buffer size and message fragmentation.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.47 no.1
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• pp.47-55
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• 2010

Although heart auscultation is an important tool for the diagnosis of heart disease, it is seen that the human ear is poorly suited for cardiac auscultation such as the paradoxical split of S2, the split of S2, and the summation of S2 and S3 gallop. In this paper, the analysis-synthesis method that is suitable for the characteristics of PCG is proposed to classify the heart sound. In analyzing the PCG according to matching pursuit method and synthesizing the PCG in each bandwidth based on the frequency characteristics, it sorts normal hearts with abnormal hearts that is difficult to classify as cardiac auscultation. The result shows that it qualifies the appearance of split in S2 and the paradoxical split of S2 and also can estimate the delay between the two components.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.2
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• pp.219-230
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• 2005

Objectives : This study was designed to compare the demographic data, clinical characteristics, developmental delay, and psychological tests between childhood-onset and adolescent-onset schizophrenic in-patients. Methods Medical records of the 17 childhood-onset (very early onset) Schizophrenia and 16 adolescent-onset (early onset) Schizophrenia in-patients were reviewed. Sex, age, psychiatric past history, prodromal symptoms and period, subtype, co-morbid disease, developmental delay, prescribed drug and dosage, treatment response, intelligence quotient (IQ), and Rorschach test were evaluated. Results : The mean admission age of childhood-onset (very early onset) group and adolescent-onset (early onset) group were 12.69$({\pm}2.34)$ and 15.13$({\pm}1.04)$ years. The mean onset age of childhood-onset(very early onset) group and adolescent-onset (early onset) group were 10.79$({\pm}1.95)$ and 14.46$({\pm}0.82)$ years. The mean prodromal period of childhood-onset (very early onset) group and adolescent-onset (early onset) group were 15.94$({\pm}12.33)$ and 8.06$({\pm}6.10)$ month. The time to remission period of childhood-onset (very early onset) group and adolescent-onset (early onset) group were 50.58$({\pm}24.67)$ and 30.06$({\pm}18.04)$ days. Longer time to remission period in childhood-osnet (very early onset) group was associated with earlier age of onset. The mean of total IQ, performance IQ, verbal IQ were at an average level. Discussion : Childhood-onset (very early onset) group and adolescent-onset (early onset) group Schizophrenia had different clinical and psychological features including prodromal period, and IQ subtests.