• Journal of Pharmaceutical Investigation
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• 제9권4호
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• pp.1-7
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• 1979

The analytical method of phenobarbital and mephobarbital in the pharmaceutical preparation were investigated by the partition chromatographic method. The influence of 13 kinds of excipients and various kinds of ingredients such as 8 kinds of antipyretics and 5 kinds of antacids on the partition chromatographic analysis of phenobarbital and mephobarbital in the preparation were investigated. The results were not affected by materials with the exception of caffeine, aspirin and sulpyrin.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2003년도 총회 및 춘계학술발표회
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• pp.229-232
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• 2003

본 연구는 울산지역 지하수오염 저감기술의 개발에 필요한 대수층의 공간적 분포특성을 파악하는 데 목적이 있다. 울산 공업도시의 대수층에서 공간적 분포특성을 파악하기 위하여 시추조사가 많이 필요 하지만 비용 및 시간 관계상 어려움이 있기 때문에, 지질조사 보고서나 논문 등에서 지하수자료와 시추 자료를 획득하여 지구통계기법을 이용한 울산지역 대수층의 공간적 분포를 모사하였다. 그리고 인구가 밀집되어 있는 남구와 중구를 중심으로 대수층 단면 분포를 모사하였다. 이와 같은 분석결과는 표토층 하부경계부와 풍화대 하부경계부에서 유사한 분포심도로 나타났으며, 지하수 수위는 표토층 하부경계와 암반층 상부경계부인 풍화대에 분포하는 것으로 나타났다.

• 가정과삶의질연구
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• 제14권3호
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• pp.47-62
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• 1996

The purpose of this study is to investigate how the husbands perceive home management behavior performed by wives and how much they are satisfied with it. This study also is to find out the variables affecting husbands' perception and satisfaction of it. The major findings were as follows: 1) The husbands perceived that wives are somewhat efficiently performing the home management(mean score:3.84 out of 5) and they are rather satisfied with wives' home management behavior(mean score; 3.69 out of 5). 2) The variables which affect husbands' perception of home management bahavior performed by wives and their satisfaction of it are husbands' age family life cycle and wives' health status. 3) The husbands' satisfaction of home management are influenced more by the husbands' perception about wives' home management behavior than by the demographic variables

• 대한한방부인과학회지
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• 제26권4호
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• pp.123-139
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• 2013

Purpose: Cold hypersensitivity is regarded to be associated with blood circulation. This study is aims to evaluate the effects and safety of oxygen chamber therapy on cold hypersensitivity by comparing the temperature and Visual Analogue Scale. Methods: 42 outpatients who visited ${\bigcirc}{\bigcirc}$ University Oriental Hospital from July 11th, 2013 to August 28th, 2013 were analyzed. Patients were subjected to thermometer, and those with thermal difference greater than $0.3^{\circ}C$ between upper arm and palm and also with more than VAS 4 of cold hypersensitivity were diagnosed with cold hypersensitivity. 42 outpatients diagnosed with cold hypersensitivity are divided into two groups, one is the experimental group consisted of 21 patients and other was control group consisted of 21 patients. The experimental group had oxygen chamber therapy 10 times for 4 weeks. Thereafter the effects of oxygen chamber therapy on cold hypersensitivity was analyzed with t-text using SPSS for Windows version 21. Results: After the oxygen chamber therapy, experimental group had considerable improvement on cold hypersensitivity, in consequence of decreasing rate of thermal difference and VAS of cold hypersensitivity. Ear deafness and hand numbness were reported as an adverse effects in experimental group, but there was no serious adverse effects. Conclusions: This clinical trial showed oxygen chamber therapy could be effective and safe to reduce cold hypersensitivity.

• 대한한방부인과학회지
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• 제19권4호
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• pp.225-244
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• 2006

Purpose : This study was performed to assess the clinical effect of Daejo-hwan(DJH) on climacteric syndrome, not only common symptoms such as hot flushes, anxiety, palpitation and so on, but also urogenital tract disturbances like vaginal dryness and sexual problems. Methods : We randomly divided 120 women with the climacteric syndrome into two groups. One group received only DJH 2 pills(4g) a time, three times a day for 8 weeks and the other group didn't get any treatment for the same period. We evaluated sonography, DXA, blood test, female hormone test and questionnaires in the beginning as well as after 8 weeks of the treatment. Symptoms were measured by Kupperman's index, Menopausal Rating Scale and the Greene Climacteric Scale. Results : In this study, DJH was innoxious on liver and kidney. And DJH in the treated group reduced climacteric symptoms significantly as compared to the control group without enlargement of uterus myoma and the change of estradiol. In Kupperman's index and MRS, DJH in the treated group especially had effects on fatigue, shoulder pain. anxiety, headache, hot flushes as well as sexual problems. Conclusion : These results suggest that DJH can be useful in treating various climacteric symptoms including sexual problems without influences on the size of uterus myoma and estradiol.

• 대한한방부인과학회지
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• 제23권4호
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• pp.164-175
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• 2010

Purpose: The purpose of this study is to report the effect of Traditional Korean Medicine therapy for patient in the state of post stillbirth by oligohydramnios Methods: The patient in this case was 33-year-old female who was pregnant by artificial insemination in 2010. Intrauterine growth restriction was discovered at 17 weeks after gestation. And oligohydramnios was found at 20 weeks after gestation. Amnioinfusion was done three times, amniotic fluid infection occurred in the process of amnioinfusion and she had a stillbirth. After stillbirth she came to our clinic with symptoms of abdominal tenderness, distention, mammalgia. The patient was treated by traditional herbal medicine therapy such as Saenghwa-tang(生化湯), Gungguijohyeol-eum(芎歸調血飮), Silso-san(失笑散) and Sasang constitution medicine(荊防地黃湯, 荊防敗毒散, 荊防瀉白散). The progresses of symptoms were evaluated by visual analogue scale. Results: After Traditional Korean Medicine therapy, the patient's symptoms caused by stillbirth was improved. Conclusion: This case study shows that the postpartum treatment in Traditional Korean Medicine therapy and Sasang constitution medicine is effective for the patient in the state of post stillbirth.

• 대한한방부인과학회지
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• 제19권1호
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• pp.125-138
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• 2006

Purpose : This study was to investigate the effects of Dohongsamul-tang extract on the rat with an surgically induced endometriosis. Methods : Four weeks after the operation for inducing the endometriosis to a matured female rat, the normal hyperplasia of the transplanted endometrium was identified in anatomico-histological aspects. By dividing each of the control group and Dohongsamul-tang administered experimental group into 8 rats, Dohongsamul-tang concentrates were administered orally to the experimental group with 1g/1ml/200g everyday for 40 days and then images were taken from the macroscopic tissues which were transplanted to the mesenterium, and the concentrations of progesterone, estradiol, tumor necrosis $factor-{\alpha}(TNF-{\alpha})$, and interleukin(IL)(-2, -4, -6, and -10) in the serum were measured. Results : Transplanted endometrium tissues showed the histological findings in accordance with the normal endometrium tissues and from the macroscopic findings the size of transplanted endometrium tissues showed a definite decrease. Compared to the control group, the experimental group showed significant decreases in the values of $TNF-{\alpha}$,IL-2, and IL-4 and significant increases in the values of IL-10. However, there were no significant differences in progesterone, estradiol and IL-6. Conclusion : From the above results, Dohongsamul-tang showed the strengthening of immunological function and anti-inflammatory effect. Therefore it is considered that Dohongsamul-tang will be very effective on the treatment of inflammation developed endometriosis, especially to treat the endometriosis without affecting the ovary functions.

• 대한한방부인과학회지
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• 제19권1호
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• pp.251-260
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• 2006

Purpose : To assess the duration of the therapeutic effect and recurrence symptoms after stopping Herb Medication therapy for climacteric womens. Methods : 28 climacteric womens received only Daejo-hwan(DJH): 2pills(4g) a time, three times a day for a total 8 weeks as maintenance therapy and were followed up for 3 months. Grading of climacteric symptoms were measured by Kupperman's index(K.I.), Greene scale(G.S.) and MRS. Results : The results were as follows. 1. After DJH-treatment, the climacteric symptoms were improved and each mean score of K.I., G.S., and MRS reduced significantly. 2. At 3 months after the end of treatment(EOT), each mean score of K.1., G.S., and MRS reduced significantly as compared with Baseline, and increased significantly as compared with EOT. 3. At 3 months after EOT, each climacteric symptoms kept up the favorable turn and the mean score of MRS reduced significantly as compared with Baseline, but made no significant difference as compared with EOT. Conclusion : In this study, we can consider the DJH-treatment therapeutic effect was kept up for 3 months after EOT and recurrence symptoms did not appeared after EOT to climacteric womens.

• 대한한방부인과학회지
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• 제20권1호
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• pp.84-98
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• 2007

Purpose : Polycystic ovarian syndrome(PCOS) is a endocrine disorder and still remains as one of the common causes of anovulation in women of reproductive age. There are some evidences that nerve growth factor(NGF) is involved in the pathogenesis of PCOS. In this research, the effects of ShingihwanhapChangbudodam- Tang(SCT) on the estradiol valerate(EV)-induced polycystic ovary(PCO) were investigated in rats. Methods : PCO was induced by single intramuscular injection with EV(4mg) in female rats. Rats in PCO control group(n = 8) were EV injected and orally administrated distilled water for sixty days. Rats in SCT-treated group(n = 8) were EV injected and orally administrated SCT for same duration. The weights of body, ovary and adrenal gland were measured. And also, ovarian histopathology and NGF immunohistochemistry were performed. Results : The weights of ovaries in SCT-treated group were significantly increased compared with control group. The numbers of secondly and mature follicles, and corpora lutea in SCT-treated group were significantly increased compared with control group. The numbers of atretic follicles were significantly decreased compared with control group. The expression of NGF positive reaction in the ovarian granulosa cells of SCT-treated group were lesser observed than control group. Conclusion : From the these results, we concluded that ShingihwanhapChangbudodam-Tang(SCT) has inhibitory effect on the development of EV-induced polycystic ovary. And it's effect may be related with decreased NGF activities in the ovary.

• 대한한방부인과학회지
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• 제18권3호
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• pp.203-214
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• 2005

Purpose : To assess the clinical efficacy of DJH on the dryness of vagina and difficulty in sexual intercourse in climacteric women. Methods : 7 climacteric women who are suffering from the dryness of vagina and sexual problems received DJH: 2 pills(4g) a time, three times a day for a total 8 weeks as maintenance therapy. We evaluated ultrasonography, BMD, blood test, urine analysis, female hormone test and questionnaire, Kupperman's index plus two questions about urogenital and sexual problems in before as well as after 8 weeks of treatment. Results : The results are as follows; 1. DJH reduced climacteric symptoms.(Kupperman's index from 61.4 to 30.2 points) 2. DJH was very effective to dryness of vagina and difficulty in sexual life caused by deficiency of estrogen. 3. The affirmative efficacy of DJH improved sexual satisfaction in consequence. Conclusion : The DJH showed positive effects on improving, not only the climacteric symptoms, but also the sexual satisfaction. It shows that DJH may represent a satisfactory therapeutic choice for those climacteric women with the urogenital tract disturbances and sexual problems.