• The Korea Swine Journal
• /
• v.13 no.5 s.141
• /
• pp.40-41
• /
• 1991

"쌀시장도 일부 개방이 불가피하다'는 상공장관이나 제네바 대사의 발언은 개발때 국민의 충격을 최소화 하기 위한 예방 접종이라는 평들이 많다. 이것이 사실이라면 당정협의회에서 즉시 제네바대사를 소환해서 면직시키라는 결정도 백신후유증이 너무 커 후유증을 치료하기 위한 치료제로 보면 될 것 이다

• Journal of Marine Life Science
• /
• v.4 no.1
• /
• pp.1-13
• /
• 2019

Fucoidan is a physiologically functional ingredient extracted from seaweed brown algae, which is a sulfated polysaccharide containing fucose as a main molecule backbone. Fucoidan has a variety of immune-modulating or -stimulating effects, including promoting antigen uptake and enhancing anti-bacterial, anti-viral and anti-tumor effects. In addition, recent studies have suggested the possibility of use of fucoidan as a vaccine adjuvant in the field of human vaccine. Use of fucoidan as supplementary feeds have already been studied, but the development of fucoidan as an adjuvant of fish vaccine is still premature. However, the intracellular uptake of fucoidan differs depending on the molecular weight of fucoidan, and there is a limit to the study on specific immune response including the production of antibodies to fish caused by an artificial infection of pathogen. Although the safety of fucoidan has been demonstrated in animal cells, there is a need to confirm the safety of fucoidan in fish. Therefore, active research in this field is needed to use fucoidan as a vaccine adjuvant. This study discussed the effects of fucoidan on immune stimulation, humoraland cellular- immunity including humans and animals. The prospect of fucoidan as a vaccine adjuvant in fisheries also reviewed.

• Journal of the Korea Convergence Society
• /
• v.13 no.2
• /
• pp.67-75
• /
• 2022

The purpose of this study is to present an appropriate management plan as a supplement to the scientific evidence of the currently operated distancing system for preventing COVID-19. The currently being used mathematical models are expressed as simultaneous ordinary differential equations, there is a problem in that it is difficult to use them for the management of entry and exit of small business owners. In order to supplement this point, in this paper, a method for quantitatively expressing the risk of infection by people who gather is presented in consideration of the allowable risk given to the gathering space, the basic infection reproduction index, and the risk reduction rate due to vaccination. A simple quantitative model was developed that manages the probability of infection in a probabilistic level according to a set of visitors by considering both the degree of infection risk according to the vaccination status (non-vaccinated, primary inoculation, and complete vaccination) and the epidemic status of the virus. In a given example using the model, the risk was reduced to 55% when 20% of non-vaccinated people were converted to full vaccination. It was suggested that management in terms of quarantine can obtain a greater effect than medical treatment. Based on this, a generalized model that can be applied to various situations in consideration of the type of vaccination and the degree of occurrence of confirmed cases was also presented. This model can be used to manage the total risk of people gathered at a certain space in a real time, by calculating individual risk according to the type of vaccine, the degree of inoculation, and the lapse of time after inoculation.

• Korean Journal of Microbiology
• /
• v.35 no.1
• /
• pp.82-88
• /
• 1999

In this study, to evaluate newly developed Japanese encephalitis (JE) vaccine candidate CJ50003, we assessed its immunogenicity along with a previously commercialized inactivated JE Biken vaccine. The CR0003 viral antigens produced in Vero cells were administered suhcutaneouly to mice either with alum-adjuvanled or free form. The ELISA titers and neutralizing (NEUV antibody titers accounting for major protective immunity in JE were determined. Mice given alum-adjuvanted vaccine had a 10 times higher antigen-specific NEUT antibody response than did those which {lad received free antigens. This NEUT antibody response was maintained until day 168 with NEUT titer more than 1:160. Even with the 0.5 ng of alum-adjuvanted antigen dose, NEUT titer was induced more than 1:10 which is considered as an evidence for seroconversion and protection. Thc mice immune sera had a similar rate of cross-reactivity against three different viral antigens, Nakayama-NlH, P3 and SA14; as determined by ELISA assay. In a mice challenge model, vaccination with the GI50003 conferred more protection than with commercialized Biken vaccine against Nakayama virus. These data demonstrated that CJ50003 vaccine candidate has an excellent prophylactic efficacy and implicated it has a strong potential for further development and commercialization.

• Environmental and Resource Economics Review
• /
• v.30 no.1
• /
• pp.27-48
• /
• 2021

We extend and modify the canonical epidemiology model of Eichenbaum, Rebelo and Trabandt (2020) to investigate the general equilibrium effects of COVID-19 spread in the Korean economy when vaccine, treatment and social distancing are available. Particularly, we develop a SIR-macro model which considers possibility of moral inattention of the overconfident agents through which people is more likely to be infected. Our model implies that people's decision to cut back on consumption and work reduces the severity of the epidemic and thus exacerbate the size of the economic recession caused by the epidemic. Another finding is that the average 13 weeks to develop the vaccine and treatment will lead to 2% drop of consumption.

• Journal of Practical Agriculture & Fisheries Research
• /
• v.20 no.1
• /
• pp.89-96
• /
• 2018

The object of this study was to evaluate the change of antibody titers on virus strains after inoculation with commercial killed equine influenza (EI) vaccines in horses. Serum antibodies of 20 Thoroughbred yearlings were detected using hemagglutination inhibition test for 41 weeks. Second vaccination is inoculated 4 weeks after the initial vaccination. Most of antibody titers were not increased until 4 weeks after first vaccination. The highest titers were detected 6-10 weeks after vaccination. The titers were decreased slowly and maintained for 16 weeks after inoculation. We could barely detect the antibody 41 weeks after vaccination in most cases. Vaccine anergia were appeared in 3 horses (15%) but it depended on virus strains. A/Equine/La Plata/93(H3N8) strain that induce high and durable antibody responses was the most effective among three strains. This study presents the first comprehensive data on the endurance of antibody titers against EI. Our data also suggests that yearlings should be inoculated three times in order to maintaining optimal antibody titers against EI. We speculate the causes of anergia were vaccine break down or individual specificity. Further research is needed to investigate immunological unresponsiveness. This was the first study on strain of equine vaccine in Korea.

• Pediatric Infection and Vaccine
• /
• v.30 no.1
• /
• pp.1-11
• /
• 2023

Respiratory syncytial virus (RSV) is a pathogen with a high burden of disease and social cost among infants worldwide, but the development of a vaccine has been delayed. The recent understanding of the pathogenesis of RSV, progress in reverse genetics, and successful implementation of other maternal immunizations have prompted the recent rapid development of monoclonal antibodies (mAbs) and vaccines for RSV prevention. Phase 3 clinical trials for two next-generation mAbs (nirsevimab and clesrovimab) and two maternal RSV pre-F vaccines are currently underway or have been recently completed. Soon, we might be able to protect young infants through long-acting mAbs and/or maternal immunization. Additionally, the development of live-attenuated vaccine candidates that are capable of avoiding enhanced RSV disease is ongoing. We need to gain familiarity with these newly developed strategies and collect epidemiological data on domestic RSV to adequately prepare for a new era of RSV prevention.

• The Science & Technology
• /
• no.10 s.413
• /
• pp.8-10
• /
• 2003

부정적 생각은 면역기능 떨어뜨린다/ 간접흡연, 심장질환 위험 높여/ 먼지만한 오염탐지 결정체 개발/ 적포도주 · 땅콩 속에 수명연장 물질/ 잘못된 생활 - 식습관이 심장병의 원인/ 웨스트나일 바이러스 백신 개발/ 치매환자 기억상실 유발 단백질 발견/ 첨단 나노기술 방탄군복 개발 추진/ 사람-토끼 DNA가진 잡종배아 생산/ 구리가 알츠하이머병 유발 가능성/ 항우울제로 새 신경세포 성장 촉진

• Proceedings of the Korean Aquaculture Society Conference
• /
• 2006.05a
• /
• pp.459-460
• /
• 2006

• Proceedings of the Korean Institute of Industrial Safety Conference
• /
• 2003.10a
• /
• pp.378-383
• /
• 2003

콘크리트 구조물은 여러 가지 원인에 의해 손상을 입거나 시간이 지남에 따라 노후화가 진행된다. 이와 같이 손상을 입거나 노후화가 진행된 구조물은 그 내구성능이 저하되어 계속 사용하기 위해서는 보수를 하거나 보강해야만 한다. 구조물을 보수하거나 보강하는 것은 구조물의 수명을 크게 연장하는 일로 여러 가지의 경제적인 효과가 있기 때문에 이에 대한 연구와 공법 개발 등이 활발히 이루어지고 있다.(중략)