• Radiation Oncology Journal
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• v.22 no.4
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• pp.298-306
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• 2004

Purpose: The purpose of this study was to identify Radiosensitivity of proteins in tissues with different radiosensitivity. Materials and Methods: C3H/HeJ mice were exposed to 10 Gy. The mice were sacrifiud 8 hrs after radiation. Their spleen and liver tissues were collected and analyzed histologicaly for apoptosis. The expressions of radiosusceptibillty protein were analyzed by 2-dimensional electrophoresis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Resilts: The Peak of apoptosis levels were $35.3{\pm}1.7{\%}$ in spleen and $0.6{\pm}0.2{\%}$ in liver at 8 hrs after radiation. Liver, radioresistant tissues, showed that the levels of ROS metabolism related to proteins such as cytochromm c, glutathione S transferase, NADH dehydrogenase, riken cDNA and peroxiredoxin Vl increased after radiation. The expression of cytochrome c increased significantly in spleen and liver tissues after radiation. In spleen, radiosensitivity tissue, the identified proteins showed a significantly quantitative alteration following radiation. It was categorized as signal transduction, apoptosis, cytokine, Ca signal related protein, stress-related protein, cytoskeletal regulation, ROS metabolism, and others. Conclusion: Differences of radiation-induced apoptosis by tissues specifted were coupled with the induction of related radiosensitivity and radioresistant proteins. The result suggests that apoptosis relate protein and redox proteins play important roles in this radiosusceptibility.

• Korean Journal of Remote Sensing
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• v.33 no.2
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• pp.159-169
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• 2017

The Satellite Electro-Optic Payload System needsspecial requirements with the conditions of limited power consumption and the space environment of solar radiation. The acquired image quality should be mainly depend on the GSD (Ground Sampled Distance), SNR (Signal to Noise Ratio), and MTF (Modulation Transfer Function). On the well-manufactured sensor level, the thermal noise is removed on ASP (Analog Signal Processing) using the CDS (Corrective Double Sampling); the noise signal from the image sensor can be reduced from the offset signals based on the pre-pixels and the dark-pixels. The non-uniformity shall be corrected with gain, offset, and correction parameter of the image sensor pixel characteristic on the sensor control system. This paper describes the SNR enhancement method of the satellite EOS payload using the mentioned noise remove processes on the system design and operation, which is verified by tests and simulations.

• Journal of Radiation Protection and Research
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• v.37 no.1
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• pp.16-24
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• 2012

In the present study, a gamma-ray detector and associated signal processing circuit was developed for a side-absorber of a dual-mode Compton camera. The gamma-ray detector was made by optically coupling a CsI(Tl) scintillation crystal to a silicon photodiode. The developed signal processing circuit consists of two parts, i.e., the slow part for energy measurement and the fast part for timing measurement. In the fast part, there are three components: (1) fast shaper, (2) leading-edge discriminator, and (3) TTL-to-NIM logic converter. AC coupling configuration between the detector and front-end electronics (FEE) was used. Because the noise properties of FEE can significantly affect the overall performance of the detection system, some design criteria were presented. The performance of the developed system was evaluated in terms of energy and timing resolutions. The evaluated energy resolution was 12.0% and 15.6% FWHM for 662 and 511 keV peaks, respectively. The evaluated timing resolution was 59.0 ns. In the conclusion, the methods to improve the performance were discussed because the developed gamma-ray detection system showed the performance that could be applicable but not satisfactory in Compton camera application.

• Radiation Oncology Journal
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• v.28 no.3
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• pp.147-154
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• 2010

Purpose: To investigate the radiosensitizing effect of the selective epidermal growth factor receptor (EGFR) inhibitor nimotuzumab in human colorectal cancer cell lines. Materials and Methods: Four human colorectal cancer cell lines, HCT-8, LoVo, WiDr, and HCT-116 were treated with nimotuzumab and/or radiation. The effects on cell proliferation, viability, and cell cycle progression were measured by MTT, clonogenic survival assay, flow cytometry, and Western blot. Results: An immunoblot analysis revealed that EGFR phosphorylation was inhibited by nimotuzumab in colorectal cancer cell lines. Under these experimental conditions, pre-treatment with nimotuzumab increased radiosensitivity of colorectal cancer cell lines, except for cell line HCT-116. However, cell proliferation or cell cycle progression was not affected by the addition of nimotuzumab, irrespective of irradiation. Conclusion: Nimotuzumab enhanced the radiosensitivity of colorectal cancer cells in vitro by inhibiting EGFR-mediated cell survival signaling. This study provided a rationale for the clinical application of the selective EGFR inhibitor, nimotuzumab in combination with radiation in colorectal cancer cells.

• Journal of Radiation Protection and Research
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• v.39 no.2
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• pp.81-88
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• 2014

Recently, a new imaging method, gamma vertex imaging (GVI), was proposed for the verification of in-vivo proton dose distribution. In GVI, the vertices of prompt gammas generated by proton induced nuclear interaction were determined by tracking the Compton-recoiled electrons. The GVI system is composed of a beryllium electron converter for converting gamma to electron, two double-sided silicon strip detectors (DSSDs) for the electron tracking, and a scintillation detector for the energy determination of the electron. In the present study, the modules of a charge sensitive preamplifier (CSP) and a shaping amplifier for the analog signal processing of DSSD were developed and the performances were evaluated by comparing the energy resolutions with those of the commercial products. Based on the results, it was confirmed that the energy resolution of the developed CSP module was a little lower than that of the CR-113 (Cremat, Inc., MA), and the resolution of the shaping amplifier was similar to that of the CR-200 (Cremat, Inc., MA). The value of $V_{rms}$ representing the magnitude of noise of the developed system was estimated as 6.48 keV and it was confirmed that the trajectory of the electron can be measured by the developed system considering the minimum energy deposition ( > ~51 keV) of Compton-recoiled electron in 145-${\mu}m$-thick DSSD.

• Radiation Oncology Journal
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• v.23 no.1
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• pp.51-60
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• 2005

Purpose : Selective inhibition of multiple molecular targets may improve the antitumor activity of radiation. Two specific inhibitors of selective cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) were combined with radiation on the HeLa cell line. To investigate cooperative mechanism with selective COX-2 inhibitor and EGFR blocker, in vitro experiments were done. Materials and Methods : Antitumor effect was obtained by growth inhibition and apoptosis analysis by annexin V-Flous method. Radiation modulation effects were determined by the clonogenic cell survival assay. Surviving fractions at 2 Gy ($SF_2$) and dose enhancement ratio at a surviving fraction of 0.25 were evaluated. To investigate the mechanism of the modulation of radiosensitivity, the cell cycle analyses were done by flow cytometry. The bcl-2 and bax expressions were analyzed by western blot. Results : A cooperative effect were observed on the apoptosis of the HeLa ceil line when combination of the two drugs, AG 1478 and NS 398 with radiation at the lowest doses, apoptosis of $22.70\%$ compare with combination of the one drug with radiation, apoptosis of $8.49\%$. In cell cycle analysis, accumulation of cell on $G_0/G_l$ phase and decrement of S phase fraction was observed from 24 hours to 72 hours after treatment with radiation, AG 1478 and NS 398. The combination of NS 398 and AG 1478 enhanced radiosensitivity on a concentration-dependent manner in HeLa cells with dose enhancement ratios of 3.00 and $SF_2$ of 0.12 but the combination of one drug with radiation was not enhanced radlosensitivity with dose enhancement ratios of 1.12 and SF2 of 0.68 (p=0.005). The expression levels of bcl-2 and bax were reduced when combined with AG 1478 and NS 398. Conclusion : Our results indicate that the selective COX-2 inhibitor and EGFR blocker combined with radiation have potential additive or cooperative effects on radiation treatment and may act through various mechanisms including direct inhibition of tumor cell proliferation, suppression of tumor cell cycle progression and inhibition of anti-apoptotic proteins.

• Journal of the Korean Society of Radiology
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• v.1 no.1
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• pp.39-44
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• 2007

In this study, wireless measurement technique for human motion was developed to monitor movement disorder patients during their daily life. MICA, TinyOS, and nesC, developed by UC Berkeley, were used as wireless sensor, its software platform, and programming language. The human motion data, generated by two axial accelerometer(ADXL202) was transmitted to PDA(iPaq3630) by 916Mhz short range communication chip(TR1000). It could be stored at PDA by simple Windows CE programming. To test the developed device, it was attached at human chest and the acquired data was shown as a graph during his motion of sitting, standing, and lying. The result showed that human motion could be logged without any hooking and constraints. Therefore, this device can be used to monitor patient's movement disorder and activity of daily life(ADL).

• The Journal of the Korea Contents Association
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• v.14 no.11
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• pp.355-361
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• 2014

The aim of the present study was to evaluate a relative emission of image plate (IP) in computed radiography (CR) system by using relative sensitivity in film/screen methods. The characteristic curve was obtained by using the uniform aluminum 11-step wedge penetrometer. X-ray exposure factors on radiographic digital image were 50 kVp, 10 mAs. We adjusted zero of all parameter of algorithms (MUSICA) so proximate to raw data and applied to 200 of exposure class. Modeling on relative emission of IP are used IP without fading time and IP after 4 hours, 8 hours, 12 hours, 24 hours in the respective storage after X-ray exposure. The results of this study showed that the sensitivity point density at the measuring of relative sensitivity in CR was suited pixel values of the 2000 easy to relatively measure the characteristic curve and when relative sensitivity is decreased, the amount of light emitted from the image signal for generating was also decreased. In conclusion, the proposed method of measurement of relative sensitivity can be utilized to evaluate the quantity of relative emission of IP in CR system.

• Journal of the Korean Society of Radiology
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• v.9 no.4
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• pp.213-217
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• 2015

To report problems found in a patient who has implemented stent implantation and then conducted a perfusion MRI using ASL(Arterial Spin Labeling), in order to suggest a solution to them. The perfusion MRI was conducted, using pCASL among ASL methods. Data from pCASL(Pseudo Continuous Arterial Spin Labeling) was acquired together with the structural image simply by changing position(labeling gap 15 mm, 170 mm) of the labeling pulse to avoid stent. Data was processed through the ASLtbx. When perfusion MRI was acquired using pCASL, it showed that the position of the conventional labeling pulse (labeling gap 24 mm) was overlapped with that of stent, which made signal intensity in right brain tissue appear as if it were void. When the labeling pulse was positioned (labeling gap 15 mm) to avoid stent, high signal intensity images were acquired. In labeling pulse (labeling gap 170 mm), the signal intensity was more reduced due to relaxation before labeled blood arrived at the imaging slice. pCASL can be stably repeated measurements because it does not use a contrast agent. And it should be selected with the appropriate image acquisition parameters for the high quality image.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.571-573
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• 2004

본 논문에서는 휴대용 선량계 시스템에 거리 무선 통신 방식중 Bluetooth를 이용하여 선량계를 구현한 것에 대해 논하였다. 휴대용 선량계란 감마선과 속중성자 및 열중성자를 현장에서 실시간으로 측정 할 수 있는 기기이다. 휴대용 선량계는 선랑계의 소형화를 위해 모듈별로 구성하여 공간의 최적화를 취하였다. 모듈의 구성은 시스템의 전반적인 제어를 하는 CPU부 센서로부터 측정한 데이터를 처리하는 신호처리부 방사선량을 측정하는 센서부로 구성되어졌다. 센서 모들의 PIN 다이오드와 MODFET 센서를 이용하여 감마선, 속중성자, 열중성자를 측정한다. 휴대용 선량계를 관리하고 측정한 데이터의 백업 및 분석을 위하여 PC용 관리프로그램과 근거리 무선 통신(Bluetooth)을 사용하여 통신하도록 만들어 사용하였다. 측정 지역의 방사선량을 휴대용 선량계로 측정하여 PC용 관리프로그램에서 실시간으로 방사선량을 확인 할 수 있다.