• Clinical and Experimental Pediatrics
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• v.46 no.11
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• pp.1112-1117
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• 2003

Purpose : Recent advances in the methods of treating cancer in young patients have led to both an increased frequency of CNS complications as well as prolonged life expectancy. We intend to analyze the clinical aspects and laboratory findings of patients with CNS complications during and after treatment. Methods : We reviewed the medical records of 174 childhood cancer patients treated with chemotherapy admitted to the Dept. of Pediatrics, Keimyung University Dongsan Hospital, from January 1995 to November 2002. Among them, 15 cases with CNS complications were investigated in this study. Results : CNS abnormalities were found in 13 patients by CT or MRI during treatment such as leukoencephalopathy(n=7), mineralizing microangiopathy(n=4), brain infarction(n=3), intracranial hemorrhage(n=1), and hypoxic ischemic encephalopathy(n=1). It was found that two patients had two or more CNS abnormalities. Two patients who had no imaging abnormalities had convulsions, possibly after the addition of intrathecal methotrexate. The patients with intracranial hemorrhage and brain infarction had rapid and fatal clinical courses. The hypoxic ischemic encephalopathy following electrolyte imbalance completely recovered after correction of electrolyte. Conclusion : The CNS complications that occur during and after chemotherapy influence prognoses significantly, and remain neurologic sequelae. Therefore early diagnosis and prophylaxis for CNS complications and regular physical examination of patients who have recieved cancer therapy are strongly recommended.

• Korean journal of food and cookery science
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• v.6 no.2
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• pp.97-104
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• 1990

건조 수산가공품 및 혼합조미료 각 5종의 위생적 살균 및 저장방법의 개발을 목적으로 현행살균 방법으로 살균효과의 불충분, 제품의 품질저하, 약제성분의 잔유 등 많은 문제점을 내포한 ethylene oxide에 의한훈증처리와 방사선 조사와의 미생물 살균효과, 이화학적 특성 및 관능적 품질에 미치는 영향을 검토한 결과는 다음과 같다. 시료의 미생물 오염은 전 세균이 $10^3~10^7$ CFU/g으로 그중 90%이상이 내열성 세균이었으며, 곰팡이류는 $10^2~10^3$ CFU/g, 대장균도 시료 5종에서 $10^2~10^6$ CFU/g이나 오염되었다. 살균효과 실험에서 대장균군, 곰팡이류는 5~10 kGy 방사선 조사로서 완전 사멸되었으며, 전세균도 오염도가 매우 높았던 혼합조미료 몇종을 제외하고는 제거되었다. 반면, ethylene oxide훈증처리는 전 미생물의 살균이 불충분하였다. 이 화학적 특성 즉, TBA가 TMA-N 함량, 아미노산, 무기질, 색도 등은 적정 선량의 방사선 조사로서는 무처리구 시료와 거의 차이가 없었으나, ethylene oxide 훈증처리구는 심한 품질의 변화를 나타내었다. 또한 관능검사에 의한 전반적 기호성에 있어서도 방사선조사구가 무처리구 및 ethylene oxide 처리구보다 유의적으로 우수함을 나타냈다.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.25 no.1
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• pp.141-150
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• 1995

종양유발성 골연화증은 종양에 의하여 생성된 활동성 펩티드호르몬과 유사한 물질이 골이나 위장관에 작용하여 칼슘대사와 인대사의 변화를 일으키거나, 정상적인 비타민 D대사에 장애를 일으킴으로써 2차적으로 발생되는 대사성 질환으로 알려져 있다. 이의 발생빈도는 매우 낮으며, 임상적으로는 체중과 신장의 감소, 전신적인 골격의 동통 및 근무력증과 병적 골절이 동반되어 나타난다. 방사선사진에서는 골소주의 전반적인 소실, 피질골의 비박, 위골절, 치조백선의 소실 등을 보이고, 실험실 소견에서는 혈청인의 농도와 신세뇨관에서 인의 재흡수율의 감소 및 혈청 알칼리성 인산화효소 농도의 상승이 관찰된다. 본질환은 종양이 제거되면 별도의 부가적인 치료 없이도 임상적, 방사선학적 소견 및 실험실 소견의 뚜렷한 개선을 보이므로 이의 치료에 있어서 정확한 진단이 매우 중요하다. 저자들은 전신적인 동통과 근무력증을 주소로 내원한 환자들에게서 발생된 종양유발성 골연화증 3예를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다.

• Journal of Radiation Industry
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• v.18 no.2
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• pp.147-153
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• 2024

Radioactive liquid waste generated during operation and overhaul is collected and reused through the radioactive liquid waste treatment system and continuous monitoring system in the nuclear power plant or discharged to the outside if it satisfies the limit within the control and monitoring. However, there are concerns about boric acid management, which controls the power output of nuclear power plants in radioactive liquid waste. Due to the behavior of boric acid, it is difficult to remove it in the existing liquid radwaste system, and the concentration of boric acid water discharged tends to be higher than the natural state of 5 ppm, so additional facilities should be considered. Therefore, this study aims to evaluate the radiological effects of radioactive waste treatment facilities that are under development and use them as a basis for managing worker exposure and evaluating the safety of facilities in the future.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.95-102
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• 1986

Among the skeletal tuberculosis, tuberculous spondylitis is high incidence and curable disease, if early diagnosis and treatment are possible. We reviewed clinical manifestations and radiologic analysis of 30 cases tuberculous spondylitis from May 1983 to Sept. 1986, at Yeungnam medical center, Yeungnam University. The results were follows : 1. The frequent involve sites were thoracolumbar vertebra. 2. The continuous lesion is 86.7% of the all cases. 3. The most common type was intervertebral type, and lytic and sclerotic lesion were same incidence. 4. Paravertebral abscess, kyphosis and disc space narrowing were demonstrated more than 80.0% of the cases. 5. Computed tomography was more accurate diagnostic method rather than conventional plain study to evaluation of extent of lesion, involvement of spinal canal and cord, and size and location of paravertebral abscess. And CT guided abscess drainage procedure was helpful to diagnosis and treatment. 6. Ultrasonography was helpful to differential diagnosis between paravertebral abscess and other solid mass, and useful to follow up study of paravertebral abscess after treatment.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.1
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• pp.69-76
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• 1991

A 9-year old boy suffering from cleidocranial dysplasia associated with impacted 4 supernumerary teeth and unerupted all permanent teeth is presented with his mother. The pedigree showed autosomal dominant pattern of inheritance, and the raiographic features of them were very similar in clavicle, skull, vertebrae, peivis and extremities. Although almost of the skeleton was involved with this syndrome, they did not recognize any other problem but except dental problem. In mother, who was wearing removable partial dentures leaving 24 impacted teeth in her jaws, the radiographic abnormalities like cystic lesion were not detected. And in the son, who showed impacted 4 supernumerary and all permanent teeth, we have attempted surgical extraction of the supernumerary teeth and periodic surgical opening of the alveolar bone covering the permanent dentition to induce the eruption of permanent teeth at the proper position, Orthodontic treatment has also been combined to correct class III malocclusion state.

• Journal of the Korean Arthroscopy Society
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• v.9 no.2
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• pp.180-185
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• 2005

Purpose: To purpose of this study is to evaluate the clinical and radiological results of arthroscopic meniscus repair using Rapid Loc device. Materials and Methods: A retrospective study was performed on 44 cases which had been turned out longitudinal tear without degeneration. We repaired all cases with Rapid Loc device. Patients were evaluated using clinical examination, Orthopaedische Arbeitsgemeinschaft Knie (OAK) scheme, and MRI. We regarded patients with joint line tenderness, swelling or McMurray positive test as clinical failure. Results: A mean age was 33.3 years and follow-up period was average 15 months. Clinical results were excellent 15 cases(34.1%), good 20 cases(45.5%), fair 7 cases(15.9%), poor 2 cases(4.5%). MRI showed grade 115 cases(33.3%), grade II 22 cases(50%), grade III 7 cases(16.7%). Clinical failures were 8 cases and only one complication was developed. Conclusion: Rapid Loc device showed the excellent results in meniscus repair. We regard it has a lot of advantages in safety, softness, ease, ability to control tension at repair site.

• The Journal of Korean Society for Radiation Therapy
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• v.33
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• pp.117-125
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• 2021

Purpose: To purpose of this study is to find the correlation of the Set-up error according to the couch rotation and suggest additional margin setting for the GTV. Target and Method: Each scenario treatment plan was created by making the frequency of non-coplanar beams different among all beams. The set-up error value was measured by using the Exact System and the dose accuracy was evaluated by creating a re-treatment plan. Results: When the couch was rotated by 30°, 45°, 60°, and 90°, the mean of the X-axis values was measured to be 0.29 mm, 0.26 mm, 0.51 mm, and 0.08 mm, respectively. The mean of the Y-axis values was measured to be 0.75 mm, 0.5mm, 0.35 mm, and 0.29 mm, respectively. The mean of the Z-axis values was measured to be 0.5 mm, 0.28 mm, 0.22 mm, and 0.1 mm, respectively. There were dose reductions of 0.1%, 3.1%, 1.9% in D99 for 1-NC VMAT, 2-NC VMAT, and 3-NC VMAT, respectively. Conclusion: When treating with 50% or more of non-coplanar beams among total beams, image verification is required. And it is considered to make the treatment plan by adding a 1.5 mm margin to the GTV.

• Journal of Radiation Protection and Research
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• v.19 no.1
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• pp.51-68
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• 1994

It is good method to use frequency of chromosome aberration in Lymphocytes for a biological dosimetry in cases of accidental exposure to radiation. But in cases of past exposure, biological dosimetry is limited because the frequency of aberration decreases by time after exposure. To provide a basic data for estimation of past radiation exposure, the changing pattern of frequency of unstable chromosome aberration by time interval after exposure was studied. Observation was made on peripheral lymphocytes of 41 blood samples from 20 patients treated for uterine cervical carcinoma and endometrial carcinoma. The patients received 50.4Gy radiation to whole pelvis. Elapsed times after the completion of radiation therapy were 1 day, 3, 6, 9, 12, 24, 52, 104, 156, 208, 260 and 520 weeks. All the blood sample were microcultured. The Ydr, Qdr and Qdra were calculated from frequency of unstable aberration. Ydr did not decrease for 3 weeks after radiation therapy, and thereafter, decreased very rapidly and reached 0.05 at two years after radiation therapy and decreased very slowly until 5 years after radiation therapy. Relationship between unstable chromosome aberration and time interval after radiation therapy was described as $Ydr=0.259{\times}exp(-0.0429T)+0.0560{\times}exp(-0.00106T)$ (time in weeks) Qdr remained constant at 1.51 until 24 weeks after radiation therapy and then decreased to 1.17 at 52 weeks. Therafter, it did not change. Qdra remained constant at 1.10 for 12 weeks after radiation therapy and decreased to 0.81 at 52 weeks. Thereafter, it remained constant. Two superimposed exponential Ydr disappearance rate suggests that it is possible to calculate the past exposure dose. When the elapsed time after exposure is short, Qdr and Qdra are useful papameters for biological dosimetry for past radiation exposure.

• Radiation Oncology Journal
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• v.29 no.2
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• pp.71-82
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• 2011

Purpose: To evaluate the biochemical control rate and the rate of side effects after performing permanent brachytherapy of localized prostate cancer. Materials and Methods: 67 patients with localized prostate cancer were treated with brachytherapy between April 2007 and December 2008. Of these, 43 patients who were followed up and did not receive external radiotherapy were evaluated for the change in prostate specific antigen (PSA) level and the occurrence of side effects. In total, 18 patients were classified as low risk, 19 patients as intermediate risk, and 6 patients as high risk. The prescription dose was 145 Gy. Results: A PSA increase greater than 2 ng/mL occurred in 2 patients (4.7%). Radiation Therapy Oncology Group (RTOG) grade 1 and 2 acute urologic complications (UC) occurred in 40 and 3 patients, respectively. Further, 5 patients had RTOG grade 1 acute rectal complication (RC). The numbers of RTOG grade 1, 2, and 3 chronic UC were 1, 4, and 1, respectively. The numbers of RTOG grade 1, 2, and 4 chronic RC were 5, 10, and 3, respectively. The statistically significant risk factors (RF) of acute RC were the minimal dose in the most irradiated 0.1 cc volume ($D_{0.1cc}$, p=0.041) and absolute volume receiving 150% of the prescribed dose ($V_{150cc}$, p=0.038) in the entire rectum (ER). The percentage ($V_{100%}$, p=0.019) and absolute volume ($V_{100cc}$, p=0.047) in the involved rectum (IR) were also statistically significant. The RF of chronic RC were $V_{100%}$ (p=0.011) in the ER and the $D_{0.1cc}$ (p=0.049), $V_{100cc}$ (p=0.023) in the IR. The number of used seeds were related with acute UC (p=0.028). Conclusion: Permanent brachytherpy of localized prostate cancer showed a favorable short term biochemical control rate. As such, selective intermediate and high risk patients can be managed with permanent brachytherapy. The effort to reduce rectal complication is also necessary.