• Radiation Oncology Journal
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• v.18 no.1
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• pp.51-58
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• 2000

Purpose :The effect of PTK inhibitors (herbimycin A and genistein) on the induction of radiation-induced apoptosis in Ph-positive KS62 leukemia cell line was investigated. Materials and Methods :K562 cells in exponential growth phase were irradiated with a linear accelerator at room temperature. For 6 MV X-ray irradiation and drug treatment, cultures were initiated at 2×106 cells/mL. The cells were irradiated with 10 Gy. Stock solutions of herbimycin A and genistein were prepared in dimethyl sulphoxide (DMSO). After incubation at 37$^{\circ}C$ for 0$\~$48 h, the extent of apoptosis was determined using agarose gel electrophoresis and TUNEL assay. The progression of cells through the cell cycle after irradiation and drug treatment was also determined with flow cytometry. Western blot analysis was used to monitor bel-2, bel-X$_{L}$ and bax protein levels. Results :Treatment with 10 Gy X-irradiation did not result in the induction of apoptosis. The HMA alone (500 nM) also failed to induce apoptosis. By contrast, incubation of K562 cells with HMA after irradiation resulted in a substantial induction of nuclear condensation and fragmentation by agarose gel electro-phoresis and TUNEL assay. Genistein failed to enhance the ability of X-irradiation to induce DNA fragmentation. Enhancement of apoptosis by HMA was not attributable to downregulation of the bel-2 or bel-X$_{L}$ anti-apoptotic proteins. When the cells were irradiated and maintained with HMA, the percentage of cells in G2/M phase decreased to 30$\~$40$\%$ at 48 h. On the other hand, cells exposed to 10 Gy X-irradiation alone or maintained with genistein did not show marked cell cycle redistribution. Conclusion : We have shown that nanomolar concentrations of the PTK inhibitor HMA synergize with X-irradiation in inducing the apoptosis in Ph (+) K562 leukemia cell line. While, genistein, a PTK inhibitor which is not selective for p210$^{bcr/abl}$ failed to enhance the radiation induced apoptosis in KS62 cells. It is unlikely that the ability of HMA to enhance apoptosis in K562 cells is attributable to bel-2 family. It is plausible that the relationship between cell cycle delays and cell death is essential for drug development based on molecular targeting designed to modify radiation-induced apoptosis.

• Radioisotope journal
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• v.12 no.2
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• pp.83-87
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• 1997

이 글은 1996년 일본아이소토프협회와 관련기관이 공동 개최한 '제22회 일본아이소토프ㆍ방사선 종합회의'에서 발표된 논문 중 일부를 요약하여 연재중이며, 총4회중 두 번째 내용임.

• Proceedings of the Korean Society of Radiological Science
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• 1997.05a
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• pp.96.2-97
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• 1997

• Proceedings of the Korean Society of Radiological Science
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• 1996.10a
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• pp.112-112
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• 1996

• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.54-54
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• 2003

목적 : 방사선치료는 복잡하고 다양한 장비를 이용하여 고에너지 고선량의 방사선을 다루기 때문에 세심한 정도관리를 바탕으로 기술적 관점에서의 적절한 방사선치료장비 사용과 실제 환자치료시의 절차들에 대한 완벽한 지침서가 마련되어야 할 필요가 있다. 본 연구의 목적은 의료용 선형가속기에 연관된 방사선사고와 잠재적 사고유형들을 분석하여 환자와 종사자의 안전을 보장하고 사고를 예방키 위한 안전관리 기준을 개발하고자 하였다. 대상 및 방법 : 본 연구에서는 국내 13 개 방사선치료기관에 대한 안전관리 실태를 자체 개발한 100 여 문항의 설문으로 조사, 분석하였다. 또한, 국제적으로 사용하고 있는 안전관리기준들과 보고된 방사선 사고사례 들을 조사하였고, 방사선치료 전 과정을 통해 잠재적 사고유형을 추정함으로서 방사선치료의 안전관리를 위 해 필요한 요구사항들을 도출하고 이를 바탕으로 의료용 선형가속기에 관련된 안전관리 기준을 마련하였다. 결과 : 본 연구에서는 방사선치료 시 환자와 종사자의 안전을 보장하고 사고방지를 위하여 단계별 안전관리 기준을 개발하였으며, 방사선 치료과정에서 일어날 수 있는 다양한 실수나 사고들을 일목요연하게 관리 할 수 있는 흐름도를 구축하였다. 결론 : 본 연구 결과는 방사선치료에 사용되는 선형가속기에 대한 방사선의 안전과 품질보증을 개선하게 될 것으로 생각된다. 또한, 잠재적 방사선 사고의 예방뿐 아니라 국내의 방사선치료 안전관리 기준 마련에 기초자료로 활용될 수 있을 것이다.

• Radiation Oncology Journal
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• v.28 no.1
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• pp.16-22
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• 2010

Purpose: We analyzed the incidence and related factors of radiation dermatitis; at first, to recognize whether a decrease in radiation dermatitis is possible or not in breast cancer patients who received radiation therapy. Materials and Methods: Of 338 patients, 284 with invasive breast cancer who received breast conservation surgery with radiotherapy at Chonbuk National University Hospital from January 2007 to June 2009 were evaluated. Patients who also underwent bolus, previous contralateral breast irradiation and irradiation on both breasts were excluded. For patients who appeared to have greater than moderate radiation dermatitis, the incidence and relating factors for radiation dermatitis were analyzed retrospectively. Results: A total of 207 and 77 patients appeared to have RTOG grade 0/1 or above RTOG grade 2 radiation dermatitis, respectively. The factors found to be statistically significant for the 77 patients who appeared to have greater than moderate radiation dermatitis include the presence of lymphocele due to the stasis of lymph and lymph edema which affect the healing disturbance of radiation dermatitis (p=0.003, p=0.001). Moreover, an allergic reaction to plaster due to the immune cells of skin and the activation of cytokine and concomitant hormonal therapy were also statistically significant factors (p=0.001, p=0.025). Conclusion: Most of the breast cancer patients who received radiation therapy appeared to have a greater than mild case of radiation dermatitis. Lymphocele, lymphedema, an allergy to plaster and concomitant hormonal therapy which affect radiation dermatitis were found to be significant factors. Consequently, we should eliminate lymphocele prior to radiation treatment for patients who appear to have an allergic reaction to plaster. We should also instruct patients of methods to maintain skin moisture if they appear to have a greater than moderate case of radiation dermatitis.

• Journal of the Korean Society of Radiology
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• v.17 no.4
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• pp.565-572
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• 2023

This study was conducted to analyze the status radiological imaging examinations assessment in Korea medical institutions conducted in the public sector and suggest a direction for improvement. Among the assessment of medical institutions, the main assessment related to radiographic imaging examinations are the certification evaluation of medical institutions and the adequacy assessment of radiographic imaging examinations. The certification evaluation of medical institutions evaluates the image inspection operation process, provision of accurate results, and compliance with safety management procedures. In the assessment of adequacy of radiographic imaging examinations, structural indicators related to manpower and equipment, patient evaluation implementation rate, and exposure reduction programs were included. However, for safer and higher-quality radiological imaging examinations, it is necessary to increase the participation rate of medical institutions in certification evaluations. In addition, it is necessary to improve the manpower indicator, and incentive payments can be considered to induce quality improvement of medical institutions in the future. Integrated management of radiation exposure at the national level should also be carried out simultaneously.

• 대한방사선방어학회:학술대회논문집
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• 2011.11a
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• pp.90-91
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• 2011

• Journal of the Korean Society of Radiology
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• v.17 no.6
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• pp.977-983
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• 2023

Due to the development of the domestic economy and science, the people's standard of living has increased. Accordingly, we want to improve the quality of life. In other words, we guarantee human rights and pursue dignity and value as human beings. Therefore, the medical field extends human life and helps maintain a healthy life. The social medicine that protects human rights is forensic medicine. Forensic medicine identifies deaths and analyzes the cause using forensic radiology images. Forensic radiology is the acquisition and provision of medical images by the radiographer. Therefore, the radiographer must have expertise by completing forensic science-related courses. Recently, medical and nursing schools have opened and operated various subjects such as forensic medicine and forensic nursing. However, the Department of Radiology science is the only school that offers courses related to forensic science. For the future development and exploration of the radiographer and department of radiology science, forensic education should be considered. For this purpose, we investigated the necessity and demand for forensic education in the department of radiology science undergraduate and graduate schools. The department of radiology science students' awareness of forensic science was found to be 2.977 points, but the need for forensic science education for the radiographer was high at 3.759 points. In addition, current students' demand for forensic science courses was high at 84.1%, with the majority responding that it was necessary to open and operate the course. This study was able to determine the demand for forensic science-related subjects among the department of radiology science undergraduate and graduate students, and there is a need to explore diversity and expertise in education. We hope that it will be used as basic data for the development of forensic medicine and radiology science.

• Journal of Radiation Industry
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• v.2 no.1
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• pp.43-51
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• 2008

Radiation technology is currently used in a number of industrial processes such as sterilization, cross linking of polymer, food irradiation, rubber vulcanization in the tire manufacturing, contaminated medical waste, etc. Gamma ray and electron beam are the key examples of well-established economical applications of radiation processes. The purpose of this paper is to review the recent technological trends and activities for radiation processes in order for the industrial end users to better understand, and obtain useful information about the technology. It is clear that the radiation processing technology has potential for a variety of the industrial applications.