• Tuberculosis and Respiratory Diseases
• /
• v.53 no.3
• /
• pp.253-264
• /
• 2002

Background : It has been reported that the expression of protein which influences on the cell cycle is significantly involved in the development, progress, treatment response, and survival of cancer, and also that the degree of expression of p27 and CDK4 is related to the prognosis. Recent research has revealed that uteroglobin, tumor suppressor gene, is related to cell cycle. This study is focused on the relations between expression of proteins related to cell cycle and clinical index of and survival of NSCLC. Methods : We examined immunohistochemically specimens of 110 surgically resected NSCLCs for expression of p27, CDK, Uteroglobin. Tissue array slide were obtained from 110 surgically resected NSCLCs. Immunohistochemical staining was performed by immuno-peroxidase technique using avidin-biotinylated horseradish peroxidase complex. Results : In 110 patients with resected NSCLCs, the ratio of male to female was 87:13, the median age was $56.43{\pm}9.41$ yrs. The positive staining of p27 was detected in 75% of the cases. A non-statistically significant trend toward increased p27 expression was observed in smoker and squamous cell cancer. The positive staining of CDK4 was detected in 89%, which was the highest expression of protein among 3 types. The survival ratio of CDK4 negative staining group was higher than that of positive staining group, which was significant diffrernce(P<0.05). There was no association between p27 or uteroglobin expression and survival. Conclusion : The expression degree of CDK4 is related to the prognosis. This findings suggests that the measurement of CDK4 may be useful in identifying patient at high risk for disease recurrence and survival.

• Journal of the Korean Ceramic Society
• /
• v.38 no.10
• /
• pp.908-913
• /
• 2001

Paper sludge Ash (PA) and Fly Ash (FA) wastes are usually land-filled for reclamation or substituted for cements as a resource. It could also offer some advantages when they are substituted for clay to preserve the environment. To recycle those wastes, the sintered specimen made of PA-FA-Clay system were examined to find the microstructure and physical properties. The ratio of clay to wastes was fixed as 30:70 by wt%, while PA to FA within waste portion were varied in the range of $1:6{\sim}7:0$. Those specimens were fired in $1150{\sim}1350^{\circ}C$. It was found that the relative density of sintered specimen was increased with amount of PA added at low sintering temperature (i.e, $1150{\sim}1200^{\circ}C$). This is due to increased amount of liquid during sintering. It is shown, however that at high sintering temperature ($1250{\sim}1350^{\circ}C$), the relative density of specimens was decreased with amount of PA added. This is because of overfiring phenomenon which may be able to induce an inhomogeneous microstructure and increased porosity. The mechanical properties of sintered specimen were depended upon the homogeneity of microstructure in accordance with SEM (Scanning Electron Microscopy) and pore size distribution analysis. For example, the compressive strength of 10PA-60FA-30Clay specimen sintered at $1225^{\circ}C$ was twice higher than that of 70PA-30Clay specimen even thought the relative density of those specimen was similar. This decreased strength of 70PA-30Clay specimen appears to be an inhomogeneity of microstructure due to overfiring.

• The Korean Journal of Pharmacology
• /
• v.11 no.1 s.17
• /
• pp.33-38
• /
• 1975

The clinical efficacy of Ethaverine, a peripheral vasodilator, was studied according to a double-blind, non-cross over method in 29 diabetic patients with peripheral arterial diseases. The clinical improvement was assessed from the history of patients including the incidence and frequency of intermitten claudication. Ethaverine, after 4 weeks of therapy, was not effective in improving clinical symptoms compared to placebo. Ethaverine, however, was an efective vasodilator than placebo. The quality of vasodilation induced by Ethaverine, was similar to that of alcohol. A new clinical method of studying peripheral vasodilator was presented. The clinical symptoms of peripheral vascular arterial disease in the lower extrimities include reduced intensity of palpable pulses, coldness, and discoloration of the skin. Intermittent claudication may be present. Pathologic changes in vessel architecture precede the symptoms, and recognition of impending vascular insufficiency is a determining factor in selecting vasodilating therapy or surgical management. Also, post-operative patients who have chronic peripheral vascular arterial disease may be candidates for subsequent vasodilating therapy. Peripheral vasodilators, according to the series of reports, may be indicated in vasospastic peripheral vascular condition rather than an occlusive vascular disease and the vessel responds best when a relatively large vascular beds are involved rather than a small, capillary beds. Recently, the clinical efficacy of peripheral vasodilators have been challanged by many clinical investigators and clinicians. In this study, we have re-evaluated the efficacy of Ethaverine HCl as peripheral vasodilator in patients with vasospastic peripheral arterial disease. Ethaverine is claimed to be two to four times as potent a spasmolytic agent as papaverine in a variety of laboratory and clinical work.

• Journal of the Korean GEO-environmental Society
• /
• v.18 no.7
• /
• pp.37-47
• /
• 2017

In this study, a series of full-scale field tests on prebored and precast steel pipe piles and the corresponding numerical analysis have been conducted in order to study the characteristics of pile load-settlement relations and shear stress transfer at the pile-soil interface. Dynamic pile load tests (EOID and restrike) have been performed on the piles and the estimated design pile loads from EOID and restrike tests were analysed. Class-A type numerical analyses conducted prior to the pile loading tests were 56~105%, 65~121% and 38~142% respectively of those obtained from static load tests. In addition, design loads estimated from the restrike tests indicate increases of 12~60% compared to those estimated in the EOID tests. The EOID tests show large end bearing capacity while the restrike tests demonstrate increased skin friction. When impact energy is insufficient during the restrike tests, the end bearing capacity may be underestimated. It has been found that total pile capacity would be reasonably estimated if skin friction from the restrike tests and end bearing capacity from the EOID are combined. The load-settlement relation measured from the static pile load tests and estimated from the numerical modelling is in general agreement until yielding occurs, after which results from the numerical analyses substantially deviated away from those obtained from the static load tests. The measured pile behaviour from the static load tests shows somewhat similar behaviour of perfectly-elastic plastic materials after yielding with a small increase in the pile load, while the numerical analyses demonstrates a gradual increase in the pile load associated with strain hardening approaching ultimate pile load. It has been discussed that the load-settlement relation mainly depends upon the stiffness of the ground, whilst the shear transfer mechanism depends on shear strength parameters.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.38 no.3
• /
• pp.33-40
• /
• 2010

Many trails have been built and utilized in each sub-basin of Apsan Park. This study focused on the conditions and the present flora of several overused trails within three basins called Kun-Gol, Anjiroung-Gol, and Meaja-Gol in Apsan Park. There are two purposes for this study. The first is to make a plan for restoration by classifying the type of damage to these overused trails. The second is to provide preliminary data for reestablishing a more pleasant urban nature park. As a result of the survey, the average length of these trails is 9.0km and mean width is 2.0 to 2.6m. 2,108m of the sections studied(23.4% of the total) had exposed root, 3,199m of the sections studied (35.5% of the total) had exposed rock, 3,270m of the sections studied(36.6% of the total) displayed damaged pathways, and 4,841m of the sections studied (53.8% of the total) had higher soil hardness. Eighty-three areas of deterioration were found and there has been extensive property destruction. As an indication of human disturbances, the Naturalization Index and Urbanization Index appeared as: Kun-Gol, 7.0%, 5.5%; Anjiroung-Gol, 8.3%, 4.5%; Meaja-Gol 8.6%, 6.2%; in total, 7.8%, 8.3%. As a method of checking the level and extent of the damage process, an impact rating classification was used at each point on the trails. Kun-Gol had the highest rating and Anjiroung-Gol had the lowest rating in impact rating classification. With the impact rating classification, it was found that each trail would continue to worsen, meaning that roots and rocks are more likely to be further exposed and the trail width will continue to widen through overuse. An actual plan for reparations and restoration of the trails is needed through further study.

• Journal of Life Science
• /
• v.27 no.9
• /
• pp.1020-1030
• /
• 2017

Epidemiology studies have reported a reduced incidence of colon cancer among populations that consume a large quantity of ${\omega}3-polyunsaturated$ fatty acids (${\omega}3-PUFAs$) of marine origin. Herein, we demonstrated a mechanism of anticancer action of ${\omega}3-PUFAs$, showing that they suppressed invasion and tumorigenicity in colon cancer cells. Docosahexaenoic acids (DHA) inhibited the cell growth of HT29 cells. This action likely involved apoptosis, given that the DHA treatment increased the cleaved form of PARP and sub G1 cells. Moreover, the invasiveness of HT29 cells was inhibited following DHA treatment, whereas arachidonic acid (AA) had no effect. The levels of Matrix-metalloproteinase-9 (MMP-9) and MMP-2 mRNA decreased after DHA pretreatment. DHA treatment inhibited MMP-9 and MMP-2 promoter activities and reduced VEGF promoter activity. DHA pretreatment also inhibited the activities of prostaglandin-2 (PGE2)-induced MMPs and the VEGF promoter. Cyclooxygenase-2 (COX-2) overexpression increased the activity of MMPs and that of the Vascular endotherial growth factor (VEGF) promoter in HT29 cells, and DHA inhibited NF-kB and COX-2 promoter reporter activities. As shown by in vivo experiments, when mouse colon cancer cells (MCA38) were implanted into Fat-1 and wild-type mice, both the tumoral size and volume were dramatically inhibited in Fat-1 transgenic mice. Furthermore, TUNEL-positive cells increased in tumors from Fat-1 mice compared with wild mice. In immunohistochemistry, the intensity of CD31 in Fat-1 tumors was weaker. These findings suggest that ${\omega}3-PUFAs$ may inhibit tumorigenicity and angiogenesis as well as cancer cell invasion by suppression of COX-2, MMPs and VEGF via the reduction of NF-kB in colon cancer.

• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.36 no.2
• /
• pp.30-37
• /
• 2018

The uniformed regulations for control of the height of buildings owned by individuals to protect landscape of cultural properties are causing serious social conflicts by limiting the development of landowners. It is urgent need of introducing indicators that can resolve such conflicts and evaluate the regulations of buildings, which can satisfy urban development as well as landscape management of cultural properties. Therefore, the purpose of this study is to simulate landscape changes according to the Cultural Heritage Protection Act and National Land Planning and Utilization Act by using Unity3D in the Pungnammun Gate(Treasure No. 308) of Jeonju and its surroundings, where architectural cultural property forms the symbolic landscape of the city. Then some items such as view points, target points were introduced and the quantitative evaluation of landscapes was attempted by applying the indicator of 3D Visual Exposure. As a result, the viewing opportunity and viewing area of Pungnammun Gate were not significantly influenced by changes in landscape according to the two laws. However, the change of the height of buildings by the National Land Planning and Utilization Act, which has the greatest development capacity, confirmed the possibility of weakening the identification of the Pungnammun Gate by increasing 3D Visual Exposure of the background buildings more than two times. Finally, it was confirmed that the skyline of Pungnammun Gate was clearly infringed upon development under the National Land Planning and Utilization Act, but the skyline was maintained similar to the current situation in the regulation by the Cultural Heritage Protection Act. Thus, this study is meaningful in that the application of 3D Visual Exposure showed the possibility of utilization as an indicator for quantitatively evaluating the protection of view on cultural property and skyline according to the changes of building heights.

• Journal of the Korean Institute of Traditional Landscape Architecture
• /
• v.38 no.2
• /
• pp.95-107
• /
• 2020

The purpose of this study is to provide the basic data by analyzing and analysing the Growth Conditions of old Trees in Yangdong village. This study investigated about the conducted on tree information, soil information, and tree health. The result are as follows. The trees information in Yangdong Village consists of Juniperus chinensis, Salix chaenomeloides, Salix pseudolasiogyne, Celtis sinensis, Zelkova serrata, Gleditsia japonica, and Gleditsia sinensis trees, The range of height was 4.0~17.0m, and the diameter was 0.51~1.34m, Juniperus chinensis trees of No.17 was most large. In the results of soil analysis, there showed that acidity was pH4.1~6.3, hardness of 5~48mm, organic matter content of 21.2~29.1g/kg, electrical conductivity(EC) of 0.34~1.76dS/m, available P₂O₅ of 79.8~451.6mg/kg, exchangeable K of 0.22~1.71cmol+/kg, exchangeable Ca of 4.98~7.44cmol+/kg, exchangeable Mg of 0.67~2.19cmol+/kg, exchangeable Na of 0.19~1.04cmol+/kg and cation exchange capacity(C.E.C) of 7.23~13.02cmol+/kg. As a result, the highest number of tree health levels is 8 of 11trees of Celtis sinensis, 2 of 7trees of Zelkova serrata, and 3 of Gleditsia sinensis, and 13 of 30 trees of health levels, The Older trees with high infection, spoil and hollowed part were the remaining trees except for the healthy part. Relatively, more than half of the number of targets is infected, decay, and the hollowed site, and it is necessary to perform surgery on the damaged area. In addition, preservation and protection measures should be implemented by supplying root nutrients for trees, controlling nutrients in the body to prevent secondary and tertiary damages that cause the infection site to metastasize to the health site, In order to continually monitor the trees, measures to improve the location environment and management of the trees should be sought.

• Clinics in Shoulder and Elbow
• /
• v.12 no.2
• /
• pp.207-214
• /
• 2009

Purpose: In arthroscopic rotator cuff repairs there are generally weak link in tendon suture interface, arthroscopic rotator cuff repairs can have higher retear rates than open repairs. The purpose of this study was to compare the strength of UU (Ulsan University) suture than open modified MA (Mason-Allen) suture when suture anchored into bone. Materials and Methods: The human supraspinatus tendons were harvested from the shoulder of the cadaver and split in 2 times, producing four tendons per one shoulder, for a total of 24 specimens. Two suture configurations (UU, MA) were randomized and checked on each set of tendons. Specimens were cyclically loaded under force control between 5 and 30 N at 0.25 Hz for fifty cycles. Each specimen was loaded to failure under displacement control at 1 mm/sec. Cyclic elongation, peak to peak displacement, stiffness, ultimate tensile load, mode of failure were checked. Results: No significant difference was found between two suture configuration with respect to peak to peak displacement, cyclic elongation, and stiffness. With regard to ultimate failure load, there were no significant difference statistically between the UU suture and modified MA suture (109.4 N, 110.6 N). The most common mode of failure between both sutures was suture pull-out through the tendon. Conclusion: The UU suture and modified MA suture produced similar biomechanical properties.

• Korean Journal of Agricultural and Forest Meteorology
• /
• v.19 no.4
• /
• pp.280-292
• /
• 2017

Hail is not a frequently occurring weather event, and there are even fewer reports of hail damages to forest stands. Since the 2000s, an increase in hail incidence has been documented in Europe and the United States. In Korea, severe hails occurred in Jeollanam-do province on May 31 and in Gyeongsangbuk-do province on June 1, 2017. Hail size was ranged from 0.5 to 5.0 cm in diameter in Jeollanam-do, and from 1.5 to 3.0 cm in Gyeongsangbuk-do. This study was aimed to analyze the hail damages to forests by species and topography based on damage-categorized maps created by using drones and aerial photographs, and to analyze relationships of the damages with meteorological factors. The total damaged forest area was 1,163.1ha in Jeollanam-do, and 2,942.3ha in Gyeongsangbuk-do. Among the 'severe' damaged area 326.7ha, 91% was distributed in Jeollanam-do, and concentrated in the city of Hwasun which covers 57.2% of the total 'severe' damaged area. The most heavily damaged species was Korean red pine(Pinus densiflora S. & Z.) followed by P. rigida. Most broad-leaved trees species including oaks were recovered without any dead trees found. Liliodendron tulipifera was the most severely damaged in terms of the rate of 'severe' degree individuals which are needed to be checked whether they will die or be recovered. Cause of the death of pines was considered as the combination of physical damage caused by the hail and long-lasting drought with high air temperature that occurred before and after the hail event. No pathogens and insects were found which might have affected to tree deaths. We suggested a dieback mechanism of the pine trees damaged by hail and drought.