• Food Science and Industry
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• v.52 no.3
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• pp.261-271
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• 2019

Gut microbiome have recently provided evidence that the gut microbiota are capable of greatly influencing all aspects of physiology and immunology. Although a number of recent studies have shown that probiotics can modulate gut microbiota structure, the mechanism underlying this effect remains to be elucidated. In a disease state, the relative abundances of beneficial gut bacteria are generally reduced, which is restored by constant probiotic supplementation. Oral administration of probiotics improved the disease state by (1) inducing differentiation and function of regulatory T cells, (2) reducing inflammatory response, (3) modulating the gut environment, and (4) increasing the proportions of short-chain fatty acid- or beneficial metabolite-producing gut microbiota including the genera Bifidobacterium, Faecalibacterium, Akkermansia, etc. In this review, current knowledge on how probiotics can influence host's health by altering gut microbiota structure and on how probiotics and beneficial gut bacteria can be applied as next-generation probiotics will be discussed.

• Bio news
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• no.5
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• pp.16-17
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• 2004

• Proceedings of the Korean Society of Crop Science Conference
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• 2019.09a
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• pp.213-213
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• 2019

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2011.03a
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• pp.81-81
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• 2011

식물성 원료인 콩, 쌀이나 밀기울의 풀, 송진 등과 알긴산이 포함되어 있는 해조류는 예로부터 접착제로 사용되어 왔으며, 최근 친환경 소재 개발의 영향으로 천연바인더에 대한 기술개발이 큰 관심이 되고있다. 국내에서는 재지분야에서 천연바인더 기술개발이 이루어진 바 있으며, 잉크 고착제로써 개발이 시도된 적이 있으나 천연 바인더가 섬유의 염색가공에서 사용된 예는 거의 찾아보기 어렵다. 최근, 염색공정 중 날염시 염료와 섬유를 고착시키기 위해 로진을 천연바인더로 사용된 예가 있으나, 원료 추출의 어려움과 날염 후 접착력 및 끈적임 등의 문제로 인해 상용화에 필요한 기술개발이 문제로 남아 있다. 독일의 한 연구에 의하면 천연바인더로 녹말, 설탕, 셀룰루오스, 식물성 기름, 식물성 단백질 등이 합성 바인더와 비교 실험된 예가 있으며, 이런 천연바인더가 파이버보드(섬유판)에 사용되기도 하였다. 또한 미국의 바이오물질, 바이오시스템 공학과에서 옥수수대와 switchgrass를 이용하여 천연바인더를 개발하였으며, bridge 타입의 메카니즘을 연구한 바 있다. 천연바인더는 여전히 값비싸고, 바인더로서 섬유에 적용하기에는 딱딱한 단점이 있으며, 수분에 대한 저항력이 떨어져 추출에서부터 적용까지 전반에 걸쳐 기술개발이 필요한 분야이다. 본 연구에서는 셀룰로오스 섬유의 염색가공 공정에서 기능성 마이크로 캡슐을 부착할 수 있는 천연바인더를 개발하기 위하여 갈조류에서 알긴산을 추출하였으며, 알긴산이 셀룰로오스 섬유에 바인더로서 어떤 특징을 나타내는지에 대하여 연구하였다.

• 축산식품과학과 산업
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• v.9 no.2
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• pp.58-65
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• 2020

우울증은 동기, 의욕, 관심, 주의력, 정신기능 및 식욕의 감소를 특징으로 하는 일종의 기분 장애이다. 우울증은 유전적, 내분비 및 환경적 스트레스를 포함한 다양한 원인에 의해 발생하지만 가벼운 우울증은 식이요법으로 개선되는 것으로 보고되었다. 따라서 우울증 환자를 치료하기 위해서는 기능성 및 영양 보충제를 포함한 다양한 식품 공급원이 필요하다. 치즈에는 숙주 건강에 유익한 영향을 미치는 생리 활성 펩타이드가 포함되어 있다. 특히 저지(Jersey) 우유는 홀스타인(Holstein) 우유보다 고형분 함량이 높은 것으로 보고되었다. 이 연구는 저지(Jersey) 와 홀스타인(Holstein) 우유의 가우다 치즈(Gouda cheese)가 만성 스트레스(CUMS, chronic unpredictable mild stress)에 미치는 영향을 조사했다. 치즈를 먹인 만성 스트레스 마우스 모델의 개선적 변화는 젖소 종에 관계없이 통계적으로 유의미하게 효과적으로 나타났다. 흥미롭게도 PCR을 통한 분변 미생물 균총 분석에서 저지 치즈를 섭취함으로써 Bacteroidetes가 증가하고 Firmicutes가 유의적으로 감소하는 것으로 나타났다. 종합하면, 본 연구는 치즈 섭취가 스트레스 개선 작용이 있음을 제시하며, 특히 장내 미생물 균총의 유익한 방향으로의 변화가 관찰되는데, 치즈의 생리활성물질 혹은 장내미생물 균총의 대사물질들이 이러한 행동·정신학적 개선 작용과의 연관성이 있음을 시사한다.

• Journal of the East Asian Society of Dietary Life
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• v.12 no.5
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• pp.431-453
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• 2002

최근, 소비자들은 건강에 유익하고, 신선하며, 향기가 좋고 맛있는 음식을 찾고 있다. 즉, 식도락을 즐기면서 동시에 건강을 추구하고 있는데, 전 세계에서 사용되고 있는 다양한 향신료가 바로 이 같은 요구를 충족시켜줄 수 있을 것으로 생각된다.

• Journal of Practical Agriculture & Fisheries Research
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• v.19 no.1
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• pp.99-108
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• 2017

It is Lespedeza cuneata. G. don used as a remedy for cough, asthma, premature ejaculation and so on, though it has been used for a long time. In order to investigate the possibility of using Lespedeza cuneata. G. don as a raw material for functional food, we examined useful substances through analysis. In the study, 124 useful substances were analyzed and 84 of them were found to be functional. In 6 species, 6 of them were found to be functional and 5 of them were functional. In the present study, the other useful substance, D-pinitol, also confirmed its functionality. Potassium isolespedezate and Potassium lespedezate act as antibiotics, Trifolin acts as an antibiotic and hepatoprotectant, and Vitexin acts as a hepatoprotectant. D-pinitol has shown excellent efficacy in patients with prediabetic and insulin-resistant diabetes. As it contains a large amount of useful substances, it can be utilized as a highly functional food.

• Journal of Korea Game Society
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• v.9 no.1
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• pp.93-103
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• 2009

A Serious Game helps the learners to recognize the problems effectively, grasp and classify important information needed to solve the problems and convey the contents of what they have learned. Owing not only to this game-like fun but also to the educational effect, The Serious Game can be usefully applied to education and training in the areas of scientific technology and industrial technology. This study proposes the Serious Game that users can apply to biotechnology by using intuitive multi-modal interfaces. In this study, a stereoscopic monitor is used to make three dimensional molecular structures, and multi-modal interface is used to efficiently control. Based on a such system, this study easily solved the docking simulation function, which is one of the important experiments, by applying these game factors. For this, we suggested the level-up concept as a game factor that depends on numbers of objects and users. The proposed system was evaluated in performance comparison in result time of a new drug design process on AIDS virus with previous approach.

• Food Science and Industry
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• v.52 no.3
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• pp.229-240
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• 2019

Ever since the definition "live microorganisms which when administered in adequate amounts confer a health benefit on the host"and guidelines of probiotics by the Food and Agriculture Organization of the United Nations and the WHO were announced, the research and product development using probiotics has been hugely successful. As a result, probiotics products become an important part of the functional food market. Recently, thanks to rapidly growing microbiome research, more diverse roles and health benefits of probiotics are being elucidated. Based on those results, pharmabiotics using probiotics are anticipated. In addition, in order to be internationally competitive and distributed, efforts should be made for certification such as GRAS/NDI notification through quality control that meets global standards. In this paper, we reviewed several aspects of probiotics concerning recently amended definition of probiotics, the regulation of probiotics, the strain specificity of efficacy, the association with microbiome research, and the market trends.

• Korean Chemical Engineering Research
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• v.46 no.6
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• pp.1100-1106
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• 2008

In this study, we presented rapid and simple fabrication method of functionalized surface on various substrates as a universal platform for the selective immobilization of cells. The functionalized surface was achieved by using deposition of polyelectrolyte such as poly(allyamine hydrochloride) (PAH), poly(diallyldimethyl ammonium chloride) (PDAC), poly(4-ammonium styrene sulfonic acid) (PSS), poly(acrylic acid) (PAA) and fabrication of poly(ethylene glycol) (PEG) microstructure through micro-molding in capillaries (MIMIC) technique on each glass, poly(methyl methacrylate) (PMMA), polystyrene (PS) and poly(dimethyl siloxane) (PDMS) substrate. The polyelectrolyte multilayer provides adhesion force via strong electrostatic attraction between cell and surface. On the other hand, PEG microstructures also lead to prevent non-specific binding of cells because of physical and biological barrier. The characteristic of each modified surface was examined by using static contact angle measurement. The modified surface onto several substrates provides appropriate environment for cellular adhesion, which is essential technology for cell patterning with high yield and viability in the micropatterning technology. The proposed method is reproducible, convenient and rapid. In addition, the fabrication process is environmentally friendly process due to the no use of harsh solvent. It can be applied to the fabrication of biological sensor, biomolecules patterning, microelectronics devices, screening system, and study of cell-surface interaction.