축산식품과학과 산업

Korean Society for Food Science of Animal Resources (한국축산식품학회)
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Ingestion of Gouda Cheese Ameliorates the Chronic Unpredictable Mild Stress in Mice

마우스 모델에서 Gouda Cheese 섭취에 따른 만성 스트레스 개선 효과

  • Kang, Min Kyoung (Department of Functional Food and Biotechnology, Jeonju University) ;
  • Yun, Bohyun (Department of Animal Science and Institute of Milk Genomics, Jeonbuk National University) ;
  • Oh, Sangnam (Department of Functional Food and Biotechnology, Jeonju University)
  • 강민경 (전주대학교 의과학대학 바이오기능성식품학과) ;
  • 윤보현 (전북대학교 농업생명과학대학 우유유전체연구소) ;
  • 오상남 (전주대학교 의과학대학 바이오기능성식품학과)
  • Published : 2020.10.31
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Abstract

우울증은 동기, 의욕, 관심, 주의력, 정신기능 및 식욕의 감소를 특징으로 하는 일종의 기분 장애이다. 우울증은 유전적, 내분비 및 환경적 스트레스를 포함한 다양한 원인에 의해 발생하지만 가벼운 우울증은 식이요법으로 개선되는 것으로 보고되었다. 따라서 우울증 환자를 치료하기 위해서는 기능성 및 영양 보충제를 포함한 다양한 식품 공급원이 필요하다. 치즈에는 숙주 건강에 유익한 영향을 미치는 생리 활성 펩타이드가 포함되어 있다. 특히 저지(Jersey) 우유는 홀스타인(Holstein) 우유보다 고형분 함량이 높은 것으로 보고되었다. 이 연구는 저지(Jersey) 와 홀스타인(Holstein) 우유의 가우다 치즈(Gouda cheese)가 만성 스트레스(CUMS, chronic unpredictable mild stress)에 미치는 영향을 조사했다. 치즈를 먹인 만성 스트레스 마우스 모델의 개선적 변화는 젖소 종에 관계없이 통계적으로 유의미하게 효과적으로 나타났다. 흥미롭게도 PCR을 통한 분변 미생물 균총 분석에서 저지 치즈를 섭취함으로써 Bacteroidetes가 증가하고 Firmicutes가 유의적으로 감소하는 것으로 나타났다. 종합하면, 본 연구는 치즈 섭취가 스트레스 개선 작용이 있음을 제시하며, 특히 장내 미생물 균총의 유익한 방향으로의 변화가 관찰되는데, 치즈의 생리활성물질 혹은 장내미생물 균총의 대사물질들이 이러한 행동·정신학적 개선 작용과의 연관성이 있음을 시사한다.

Keywords

References

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