• Prospectives of Industrial Chemistry
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• v.22 no.6
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• pp.26-40
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• 2019

고령화 사회에 접어들면서 신경, 정신질환으로 인한 사회경제적 부담이 늘어나고 있다. 이를 해결하기 위해서는 관련된 신경 회로를 직접적으로 자극하거나 그곳에서 일어나는 일을 실시간으로 감지할 수 있는 장비의 개발이 필수적이다. 하지만 이를 위한 수많은 공학적 도구의 개발에도 불구하고, 뛰어난 공간적/시간적 분해능, 세포형의 선택성, 장시간 안정성을 보유한 신경 인터페이스의 개발은 아직까지도 연구가 필요한 분야이다. 특히 신경전달 원리를 모두 이용하고자 하는 다기능 인터페이스의 개발은 최근 많은 연구자들의 관심 주제이고, 유연성을 가지는 인터페이스 개발 또한 안정성뿐만 아니라 신경 신호의 수명을 좌우하는 중요한 요소이기에 그 중요성을 인정받고 있다. 이를 해결하기 위한 여러 가지 과학적 시도 중에서도, 열 인장 공정으로 제작되는 섬유 형태의 장비는 그 통합적 기능을 수행하는 한 가지 방법으로써 많은 관심을 받고 있다. 이 기술은 다양한 기하학적 구조, 기능적 요소 등을 통합하는데 매우 유리하며, 또한 기존 반도체 공정으로 다루기 어려운 유연성 물질로 마이크로 스케일의 인터페이스를 제작하는 데에 매우 효과적이다. 본 기고문에서는 먼저 현재까지 개발되고 있는 다기능 유연 신경 인터페이스의 연구동향을 소개하고, 특히 그 중에서도 최근에 주목받고 있는 광섬유 기반의 인터페이스 개발에 대해 이야기하고자 한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.352-358
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• 2017

Frontotemporal dementia, the second most common cause of early onset dementia, is a neurodegenerative clinical syndrome characterized by progressive deficits in behavior, executive function and language. Although motor symptoms in frontotemporal dementia are represented by motor neuron disease, parkinsonism and progressive supranuclear palsy syndrome, there have been no reports of motor weakness caused by the direct involvement of central motor nervous systems in frontotemporal dementia. Moreover, no association between clinical dementia groups and complex regional pain syndrome has been reported. We diagnosed a rare case with motor weakness and complex regional pain syndrome of lower limbs due to central nervous system lesion in a patient with frontotemporal dementia by magnetic resonance imaging, electrodiagnostic study and three phase bone scan. Following steroid therapy for complex regional pain syndrome, pain was improved. Functional improvement was noted after rehabilitation therapy, including functional electrical stimulation, muscle strengthening exercise and gait training during hospitalization. This case report suggests that rehabilitation therapy for motor weakness in frontotemporal dementia could be effective for improving overall function.

• The Journal of the Korea Contents Association
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• v.10 no.8
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• pp.104-110
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• 2010

In the field of biotechnology, computer can play varied roles such as the ordinal analysis, ordianl comparison, nutation tracing, analogy comparison for drug design, estimation of protein function, cell mechanism, and verifying the role of a gene for preventing diseases. Additionally, by constructing database, it can provide an application for the cloning process in other data researches, and be used as a basis for the comparative genetics. For the most of researcher about biotechnology, they need to use the tool that can do all of job above. This study is focused on looking into problems of existing systems to analysis bio data, and designing an improved analyzing system that can propose a solution. In additional, it has been considered to improve the performance of each constituent, and all the constituents, which have been separately processed, are combind in a single system to get over old problems of the existing system.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.7
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• pp.903-909
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• 2021

Caenorhabditis elegans whose DNA sequence was completely identified is a representative species used in various research fields such as gene functional analysis and animal behavioral research. In the mean time, many researches on the bio-monitoring system to determine whether water is contaminated or not by using the swimming activities of nematodes. In this paper, we show the possibility of using the swimming activities of C. elegans in the development of a machine learning based bio-monitoring system which identifies chemicals that cause water pollution. To characterize swimming activities of nematode, BLS entropy is computed for the nematode in a frame. And, BLS entropy profile, an assembly of entropies, are classified into several patterns using clustering algorithms. Finally these patterns are used to construct data sets. We recorded images of swimming behavior of nematodes in the arenas in which formaldehyde, benzene and toluene were added at a concentration of 0.1 ppm, respectively, and evaluate the performance of the developed HMM.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.1
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• pp.57-63
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• 2009

UV irradiated skin cells produce reactive oxygen species (ROS). ROS is known to be the primary cause of skin inflammation that is eventually leading to skin aging through decrease of collagen in the dermis. In this study, we evaluated basic efficacy of anti-aging, anti-inflammation and anti-melanogenesis using two antioxidative mineral-bio waters (Mineral-bio water 1 (MIBA-W1) and Mineral-bio water 2 (MIBA-W2)). Both antioxidative mineral-bio waters reduced TNF-${\alpha}$ expression which was induced upon UV irradiation. MIBA-W 1 increased collagen synthesis from UVB irradiated fibroblast at 0.01 % concentration but MIBA-W2 shows slight, but linear increase. Stimulation of melanogenesis by ${\alpha}$-MSH treatment in the cultured B16-F1 melanoma was significantly reduced by the treatment of MIBA-W2 in a dose dependent manner. Taken together, antioxidative MIBA-W1 and 2 seem to have potential applications as functional cosmetic materials.

• Ecology and Resilient Infrastructure
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• v.6 no.3
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• pp.163-170
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• 2019

The civil engineering materials used to stabilize the slopes of new riverbanks have a great impact on the types and growth of vegetation introduced after the completion of construction procedure. Recently, microbial-derived, ${\beta}$-glucan- and xanthan gum-based biopolymers are attracting attention as an ecofriendly strengthening material of riverbanks that can possibly stimulate plant growth. This study aimed to assess ecological effects of biopolymer application on native plants in Korean riverbanks. In particular, since dominant plant species could shape characteristics of an ecosystem, we examined the effects of biopolymer on the dominant plant species in riverbanks. Overall, biopolymer did not affect seed germination rates of testing plant species. In contrast, plants grew more vigorously in the soil mixed with biopolymer compared to those in the control soil. The biomass of Echinochloa crus-galli especially increased around two times more in the biopolymer treatment. Plants produced heavier root biomass and leaves with larger specific leaf area, which possibly contributes to the tolerance of environmental stress like drought. These results suggest that biopolymers treated on river banks are expected to stimulate plant growth and increase stress tolerance of domestic dominant plant species.

• Proceedings of the Safety Management and Science Conference
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• 2013.11a
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• pp.615-623
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• 2013

오늘날 기술의 발전으로 시스템들은 점차 대형화 복잡화 되어가고 있다. 이처럼 점차 대형화 복잡화 되어가고 있는 시스템들은 더욱 커진 사고 및 고장에 대한 위험을 내재하게 된다. 또한 대형 복합 시스템에서 발생하는 사고 및 고장은 바로 큰 재산피해나 인명피해와 직결 될 수 있다. 따라서 체계적인 안전관리의 필요성이 점차 커지고 있다. 이에 대응하여 철도, 항공, 해양 등의 산업에서는 각 산업에 적합한 안전관리체계를 수립하려 노력하고 있으며, 표준 및 매뉴얼을 제정하여 보급에 앞장서고 있다. 또한 시스템에서 전장품 및 소프트웨어가 차지하는 비중이 커지면서 기능안전이 안전분야의 이슈가 되고 있다. 이에 따라 IEC 61508, ISO 26262, IEC 61511 등 기능안전관련 표준들이 제정되어 기능안전을 달성하기 위한 기반을 제공하고 있다. 한편 국내 철도산업에서도 철도안전법의 재정을 기점을 철도 산업전반에 걸쳐 많은 환경변화가 이뤄지고 있고 이에 대응하기 위해 철도 안전시스템을 바탕으로 한 안전관리체계를 구축하였다. 한편 다양한 운영체계를 갖고 있는 철도시설 및 운영기관이 존재하는 국가 철도 안전관리체계의 안전규제를 체계화하기 위해서는 체계적인 요구사항의 분석에 따른 시스템 아키텍처의 설정이 요구되고 있다. 이러한 아키텍처의 설정은 현재에 대한 분석과 미래의 철도안전시스템의 특성을 구조화하여 향후 비전을 프레임워크로 표현함으로서 구현이 가능해진다. 본 논문에서는 현재의 안전관리체계의 도입 배경 및 도입 현황에 대해서 분석하고, 최근 기존의 안전관리체계와 더불어 최근에 안전분야에서 이슈가 되고 있는 기능안전 표준을 반영한 안전관리체계의 구축을 위해 안전관리체계에 대한 아키텍처를 구현하고자 하며 이때, 모델링을 바탕으로 한 접근을 제시한다.

• Journal of Dental Rehabilitation and Applied Science
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• v.33 no.2
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• pp.154-162
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• 2017

Tooth wear, one of the physiological changes in the elderly patient's mouth, generally does not require treatment, but requires prosthodontic restoration when occlusal disharmony, poor masticatory function, pulp exposure occurs. One of the primary considerations in prosthodontic restoration for tooth wear is vertical dimension. It is necessary to make an accurate diagnosis and analysis, correct judgement of the interdental relationship for predictive treatment plan. A step-by-step approach considering dental care for aged is also required. In this case, a 93-year-old male patient presented with worn dentition and mobility of existing fixed dental prosthesis. After diagnosis and evaluation, maxillary rehabilitation without any change in the occlusal vertical dimension was performed and this shows satisfactory results both functionally and morphologically.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.2
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• pp.503-514
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• 2013

Mobile Healthcare is a new type of health care services for managing health and life irrespective of time and space by uniting IT and BT. For this service bio-signal measurement using WBAN, and data analysis and monitoring technologies based on mobile devices are essential. Generally, however, mobile application has low compatibility because of the features of mobile platform, we have to redevelop it to support the corresponding platform. In this paper we introduce a Mobile Healthcare System which can function as gateway and monitoring based on hybrid app to create ubiquitous healthcare monitoring system compatible with various mobile devices by overcoming the difference of platforms. The proposed system consists of sensor composition part, monitoring composition part, and server composition part.

• Journal of Food Hygiene and Safety
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• v.35 no.4
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• pp.304-311
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• 2020

Galacto-oligosaccharides (GOS) are prebiotics that have a beneficial effect on human health by promoting the growth of probiotic bacteria in the gut, in addition to having various applications in the food industry. GOS are generally produced from lactose in a reaction catalyzed by β-galactosidase. Synthesis of GOS from whey permeate (WP) (ultrafiltration of whey, concentrated then spray dried) using surface engineered β-galactosidase in Pichia pastoris (P. pastoris) is a novel method to convert waste into a valuable product. Cell-surface display is the expression of peptides and proteins on the surface of living cells by fusing them to functional components of cells. Surface engineered cells have many potential uses. The Flo1p flocculation functional domain, thought to be located near the N terminus, recognizes and adheres non-covalently to cell-wall components such as α-mannan carbohydrates, causing reversible aggregation of cells into flocs.