• 유체기계공업학회:학술대회논문집
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• 2003.12a
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• pp.231-237
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• 2003

A numerical study has been conducted to investigate the effect of an inlet flow pulsation on mixing of two solutions with different concentrations in a micro conduit. We treat an unsteady, incompressible and two-dimensional flow through a micro conduit by adopting the momentum equations with the electrostatic force due to streaming current and the concentration equation. The feasibility of the inlet flow pulsation to enhance the mixing process inside the micro conduit is carefully examined by varying the inlet pulsation frequency. When a low-frequency pulsation is induced at the inlet, the interface between two solutions with different concentrations becomes wavy, which results in mixing enhancement. As the pulsation frequency increases, the waviness of the interface becomes meager, and the concentration gradients at the interface approach the value for the non-pulsating steady flow.

• The Journal of the Acoustical Society of Korea
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• v.41 no.5
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• pp.501-506
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• 2022

Echogenic liposome contains both liquid and gas inside the shell. In ultrasound mediated drug delivery, sonoporation, these new microbubbles can be an attractive drug carrier since they can be loaded water soluble drugs and drug molecules can be unloaded at the specific location with ultrasound sonication. In this paper, the structure of the echogenic liposome was confirmed with EF-TEM and the positive effect of sonoporation with echogenic liposome was comparatively evaluated on MDA-MB-231 cells which is a type of breast cancer cell with Doxorubicin. Control group (Group 1), Doxorubicin only (Group 2), sonoporation with Doxorubicin and hollow microbubbles (Group 3), sonoporation with Doxorubicin loaded echogenic liposome (Group 4) were classified and experiments were conducted. According to the results, Group 4 is at least 1.4 times better in inducing necrosis of cancer cells. Therefore, we conclude echogenic liposome could be one of the most useful form of microbubbles in sonoporation.

• Journal of Sensor Science and Technology
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• v.18 no.1
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• pp.42-47
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• 2009

In this paper we propose a microfluidic chip that measures the mechanical stiffness of cell membrane using impedance measurement. The microfluidic chip is composed of PDMS channel and a glass substrate with electrode. The proposed device uses patch-clamp technique to capture and deform a target cell and measures impedance of deformed cells. We demonstrated that the impedance increased after the membrane stretched and blocked the channel.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1087-1090
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• 2005

In precision machinery systems for medical and chemical applications, micropumps with a low pulsation have been demanded and investigated for accurate delivery of a small amount of liquid. This study proposes sheet type check valves instead of ball type check valves for PZT pumps and performs some tests on dynamics characteristics of check valves having different design parameter with variable frequency. The selected materials of check valves is NBR, PP film, Polyimide and Stainless steel(SUS304). In the experiment, dynamic characteristics of stainless steel thin plate have better performance than others.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1275_1276
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• 2009

Micropump is very useful component in micro/nano fluidics and bioMEMS applications. Using the flexural vibration mode of PZT bar, a piezopump is successfully made. The PZT bar is polarized with thickness direction. The proposed structure for the piezo-pump consists of an input and an output port, piezoelectric ceramic actuator, actuator support, diaphragm. The traveling flexural wave along the bar is obtained by dividing two standing waves which are temporally and spatially phase shifted by 90 degrees from each other. Fluid is drawn into a forming chamber, eventually the forming chamber closes trapping the fluid therein.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.11
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• pp.856-862
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• 2008

This paper presents the characterization of a continuous magnetophoretic microseparator for separating white and red blood cells from peripheral whole blood cells based on their native magnetic properties. The magnetophoretic microseparator separated the blood cells using a high gradient magnetic separation (HGMS) method without the use of additives such as magnetic beads or probing materials. Experimental results show that the paramagnetic capture mode microseparator can continuously separate out 93.5% of red blood cells and 97.4% of white blood cells from diluted whole blood, and the diamagnetic capture mode microseparator can continuously separate out 89.7% of red blood cells and 72.7 % of white blood cells by using applying an external magnetic flux of 0.2 T using a permanent magnet.

• Journal of Sensor Science and Technology
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• v.14 no.5
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• pp.308-312
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• 2005

We present a microfluidic chip designed for the detection of antibody by using quantum dots fluorescence and a microbead-based assay. A custom designed PDMS microfluidic chip with multi-layer channel is utilized for capturing microbeads; antibody injection into each micro-well; QD injection; and fluorescence detection. The experiment using the fabricated microfluidic chip has been performed on solutions with various concentrations of antibody and has shown correlated fluorescent intensities.

• Journal of the Korean Magnetics Society
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• v.16 no.4
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• pp.221-227
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• 2006

We have synthesized uniform nanometer sized magnetite particles using chemical coprecipitation technique through a sonochemical method with surfactant such as oleic acid. Magnetite phase nanoparticles could be observed from X-ray diffraction. Magnetite nanoparticles is surface phase morphology and biopolymer-microspheres for Application Medical. Magnetite nanoparticles coated biopolymer. Atomic Force Microscope (AFM) was used to image the coated nanoparticles. Magnetic colloid suspensions containing particles with sodium oleate, chitosan and $\beta$-glucan have been prepared. The morphology of the magnetic biopolymer microsphere particles were characterized using optical microscope. Magnetic hysteresis measurement were performed using a superconducting quantum interference device (SQUID) magnetometer at room temperature to investigate the magnetic properties of the biopolymer microspheres and magnetite coated biopolymer including magnetite nanoparticles. Magnetic Resonance (MR) imaging was used to investigate biopolymer coated nanoparticles and biopolymer microspheres.

• Proceeding of EDISON Challenge
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• 2013.04a
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• pp.360-364
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• 2013

본 연구에서는 아음속 저 레이놀즈 수에서 NACA0012에 나타난 층류 박리 거품과 천이유동에 대해 연구하였다. 천이유동조건과 완전난류유동 조건에 따른 EDISON 계산 결과 값과 실험값의 공력계수를 비교하였다. 또한, EDISON 계산 결과 값과 Xfoil을 이용하여 나온 결과 값의 천이점 비교를 통해 Xfoil의 천이 모델과 EDISON 천이 모델간의 차이를 비교하였다.

• 유체기계공업학회:학술대회논문집
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• 2002.12a
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• pp.482-485
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• 2002

Development projects in KAIST rotted to the micro thermal device is introduced. Multi disciplinary research team is composed by combustion group and semiconductor group in KAIST and catalyst research center in KRICT to develop micro thermal/fluidic device and various items are on development. Among the projects, various kind of componenst that is required by the micro thermal devicesystem is introduced. Technology related to development of micro combustor, Micro igniter, micro fabrication of 3D structure, micro reactor and micro catalyst preparation is introduced.