• Title/Summary/Keyword: 무작위 대조군 연구

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Increased cervical lordosis after deep acupuncture in patients with neck pain: nonrandomized clinical control trial (경추통 환자에게 있어서 내경(內徑)의 심자(深刺)방법이 경추 전만의 각도 변화에 미치는 영향)

  • Lee, Seung-deok
    • Journal of Acupuncture Research
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    • v.21 no.6
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    • pp.195-207
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    • 2004
  • 목적 : 경추통에 대한 침구치료의 효과여부가 현재까지 시행된 무작위 대조군 시험의 검토에서 논란이 되고 있는데, 경추통에 대한 치료 효과의 검증에 최근 들어 경추 전만각도의 변화를 측정하는 것이 점차 많이 사용되고 있는 실정이다. 하지만 아직까지 변형된 형태의 경추 견인 등 몇몇 요소들이 경추전만을 변화시켰다는 보고는 있었으나, 침치료 중 深刺의 방법이 경추의 만곡을 변화시켰다는 보고는 없었다. 방법 : 자침의 방법 중 深刻(五刺法 중 合谷刺 또는 關刺)방법이 경추 전만의 변화를 주는가에 대하여 검증하기 위하여 심자 치료를 시행한 19명의 실험군과 치료를 시행하지 않고 단순히 방사선 촬영만 시행한 21명의 대조군의 단순 방사선 사진을 후향적 연구의 방법으로 비교하였으며, 아울러 심자 자침군에서는 VAS를 측정하여 통증의 정도의 변화를 함께 연구하였다. 결과 : 연구결과 자침을 시행하지 않은 대조군에서는 VAS와 경추 전만의 Cobb각도에서 유의성 있는 변화가 나타나지 않았으나, 심자의 방법으로 자침한 군에서는 치료 전후의 VAS가 유의한 차이를 나타내었고, 경추의 전만 각도에서도 경추 2번과 7번 사이의 Cobb의 각도에서 유의성 있는 변화를 나타내었다(p < 0.05). 결론 : 이러한 연구 결과들은 심자의 자침방법이 경주의 통증을 줄여줄 뿐만 아니라 경추의 구조적 변화를 일으킬 수 있음을 나타내 주는 것이다.

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Comparison of Video Lecture and Instructor-Led Lecture for the Recognition of Cardiac Arrest : Korean Youths (심정지 인지를 위한 동영상 교육과 강의식 교육의 비교 연구 : 청소년을 대상으로)

  • Jung, Eun-Kyung;Lee, Hyo-Cheol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.9
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    • pp.139-145
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    • 2018
  • It is the first step to survive cardiac arrest for the general public to recognize cardiac arrest rapidly. The purpose of this study is to investigate the effective method of education by analyzing the degree of cardiac arrest recognition after performing the agonal breathing education in a video lecture or instructor-led lecture. The study subjects were assigned to either a video lecture or instructor-led lecture in a randomized way and were compared after the education according to the degree of recognition of cardiac arrest in the randomized controlled study. The study was conducted from October 30, 2015 to October 31, 2015. And the study subjects were 104 youths aged 15 years or older, of which 52 were selected as the experimental group and the remaining 52 as the control group. The results did not show a significant difference between these two groups when the subjects are given the video lecture where patients showed no reaction or sign of breathing(p=0.741). However, in the video lecture where there was no reaction of patients but still sign of agonal breathing, 43 people(82.7%) in the experimental group and 33 people(63.5%) in control group have successfully performed CPR and there has been a significant difference (p=0.006). Therefore, we could conclude that video lecture was more efficient than instructor-led lecture when teaching CPR.

Effects of Virtual Reality Based Video game and Rehabilitation Exercise on the Balance and Activities of Daily Living of Chronic Stroke Patients (가상현실기반 비디오게임과 재활운동이 만성기 뇌졸중 환자의 균형 및 일상생활동작에 미치는 영향)

  • Lee, Hyun-Min
    • Journal of the Korean Society of Physical Medicine
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    • v.8 no.2
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    • pp.201-207
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    • 2013
  • 연구목적: 닌텐도 위를 이용한 가상현실기반 비디오게임 프로그램을 만성기 뇌졸중 환자에게 적용하여 균형능력 및 일상생활동작에 어떠한 영향을 미치는지 알아보고, 뇌졸중 환자의 재활프로그램으로서 적용 가능성이 있는지 알아보고자 한다. 연구방법: 만성기 뇌졸중 환자를 무작위로 가상현실기반 비디오게임 프로그램을 적용한 실험군(n=7)과 적용하지 않은 대조군(n=10)으로 구분하여 연구를 진행하였다. 연구에 참여한 모든 대상자에게 30분의 Bobath therapy와 15분간의 FES 치료를 기본적으로 실시하였다. 이에 더하여 실험군은 가상현실기반 비디오게임 프로그램을 1일 30분이내, 주 5회, 3주간 실시하였다. 대조군은 자전거 운동과 보행훈련으로 30분간 시행하였다. 실험 전 후 눈뜨고 외발서기(OLST; open leg standing test), Timed Up and Go(TUG) 검사, 10m 걷기 검사, Functional Independence Measure(FIM)를 측정하였다. 실험 전과 실험 후 측정값의 차이를 비교하기 위해 Wilcoxon Signed Ranks Test를 실시하였다. 그리고 각 측정값의 변화량에 대한 실험군과 대조군 사이의 차이를 알아보기 위해 Mann-Whitney U Test를 실시하였다. 연구결과: 실험결과는 다음과 같다. 1) 실험군에서는 FIM의 유의한 증가와 TUG, 10m 걷기 검사의 유의한 감소를(p<.05) 보였다. 대조군에서는 OLST의 증가와 TUG, 10m walking test의 감소가 나타났지만 통계적으로 유의하지 않았다. 오직 FIM에서만 유의한 증가가 나타났다(p<.05). 2) 실험 전 후의 실험군과 대조군의 각 측정값들의 평균차를 비교한 결과 실험군은 대조군보다 실험 전 후 OLST, TUG, 10m walking test 차이의 평균은 컸지만 통계적으로 유의하지 않았다. 결론: 이상의 결과로부터 가상현실기반 비디오게임이 만성기 뇌졸중 환자의 동적균형능력 및 일상생활동작 향상에 효과가 있음을 알 수 있었다.

Effects of Auricular Acupressure on Constipation and Depression in Shift- Work Nurses (귀지압이 교대근무 간호사의 변비와 우울에 미치는 영향)

  • Kim, Jan Dee;Park, Ji Suk;Choi, Da Hee;Choi, Gyu Won;Lee, Eun Jin
    • The Journal of the Korea Contents Association
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    • v.22 no.4
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    • pp.689-699
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    • 2022
  • The purpose of this study was to examine the effects of auricular acupressure on constipation and depression in shift-work nurses. The data was collected from May to June 2021 at A hospital in area I, and 40 nurses working in shifts participated in this study. This study was an open-label randomized controlled trial. 40 nurses who had constipation were randomized to the experimental group (n=20) or control group (n=20). Auricular acupressure was performed for 2 weeks at the corresponding points of constipation and depression for the experimental group. Auricular acupressure for 2 weeks significantly decreased constipation scores compared to the control group (F=7.74, p<.001). The mean difference in depression scores before and after acupressure in the experimental group (2.90±2.86) was larger than the difference in the control group (1.35±3.12), but it was not statistically significant (t=-1.64, p=.055). Auricular acupressure was effective in relieving constipation in shift-work nurses. Auricular acupressure could be considered as a treatment option for constipation.

Effect of intravenous ascorbic acid administration on fatigue after laparoscopic myomectomy: A randomized, double-blind, placebo-controlled trial (복강경 자궁근종절제술을 받은 여성에서 정맥 내 아스코르브산 투여가 피로에 미치는 영향: 무작위 배정 양측맹검 위약대조 임상시험)

  • Hwang, Woo Yeon;Kim, Kidong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.2
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    • pp.434-439
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    • 2021
  • We assessed the effects of intravenous (IV) ascorbic acid administration on fatigue in women undergoing laparoscopic myomectomy. We analyzed the secondary endpoint results of a randomized, double-blind, placebo-controlled trial. Fifty patients undergoing laparoscopic myomectomy received IV ascorbic acid (2g) or placebo (randomly 1:1 ratio) intravenously during surgery. On day 2 post-surgery, we measured the level of fatigue using the Brief Fatigue Inventory-Korean version. Forty-five women (experimental arm 23, control arm 22) were eligible for analysis after 5 women (experimental arm 2, control arm 3) were excluded due to withdrawal of consent, cancellation of surgery or non-measurement of the endpoints. The baseline and operative characteristics were similar between arms and the global fatigue score of the experimental arm (4.56 ± 2.63) was not significantly different from that of the control arm (5.21 ± 2.02, P = 0.351). However, the fatigue score of the experimental arm tended to be lower than that of the control arm in most domains. IV ascorbic acid administration did not significantly reduce the level of fatigue in women undergoing laparoscopic myomectomy as compared to placebo. More research is needed to better understand the effects of ascorbic acid on fatigue in surgical patients.

Activation of IL-1β, IGF-1 and IGF-2 in Injured Rat Skeletal Muscle by Low Power He-Ne IR Laser and Electrical Stimulation (저출력레이저와 전기자극에 의한 골격근 손상 흰쥐의 IL-1β, IGF-1, IGF-2 활성)

  • Kim, Jong-Soon;Rho, Min-Hee
    • The Journal of the Korea Contents Association
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    • v.8 no.11
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    • pp.251-262
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    • 2008
  • In this study we investigated the effects of physical therapeutic intervention through electromyography, ultrasonographic imaging and changes of the IL-$1{\beta}$, IGF-1 and IGF-2 in skeletal muscle of rats injured experimentally. The twenty Sprague-Dawley male rats were randomly divided into the 4 groups: a normal, a control, a low power laser and a neuromuscular electrical stimulation group. Abnormal spontaneous activities had not been shown, both in normal and skeletal muscle injured rats. The maximum diameter of the calf muscle was significantly increased in the low power laser and neuromuscular electrical stimulation groups compared with control group. The level of the serum IL-$1{\beta}$ was more decreased in the low power laser and neuromuscular electrical stimulation groups than that of control group. The activation level of the IGF-1 and the IGF-2 were significantly higher in the control, low power laser and neuromuscular electrical stimulation groups than that of normal group. However, there was no statistically significant difference among the control, low power laser and neuromuscular electrical stimulation groups.

Effects of Light Therapy on Stress, Depression, Quality of Sleep and Quality of Life in Middle-Aged Women: A Randomized Controlled Trial (빛 요법이 중년여성의 스트레스, 우울, 수면의 질 및 삶의 질에 미치는 효과: 무작위 대조군 연구)

  • Jang, Mi-Kyeong;Hur, Myung-Haeng
    • Journal of the Korea Convergence Society
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    • v.12 no.7
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    • pp.317-327
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    • 2021
  • This study is a randomized controlled trial to compare the effects of light therapy on stress, depression, sleep quality and quality of life in middle-aged women. The participants of this study were 56 middle-aged women who worked at the same office. Data collection period was from August 26 to September 13 for the control group and from September 16 to October 4 for the experimental group. Subjective stress, depression, quality of sleep and quality of life in middle-aged women were measured by Numeric Rating Scale (NRS), Center for Epidemiology studies of scale (CES-D), Verran & Synder-Halpern Sleep scale (VHS) and WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF). Stress index was measured using a Canopy9 RSA (IEMBIO, Gangwondo, Korea) equipment. The data were analyzed by mean, standard deviation, real number and percentage, χ2-test, t-test, repeated measures ANOVA and ANCOVA using IBM SPSS Statistics version 25.0. The results showed that the experimental group applying light therapy had significantly lower subjective stress (F=6.30, p<.001) and higher quality of life (F=2.80, p=.049) than the control group, There was no difference in objective stress index, depression, and sleep quality. As a result, light therapy is partially effective in subjective stress and quality of life for middle-aged women, and further research is needed on middle-aged women working in work environments with limited light exposure.

Microleakage Assessment of Resin Infiltration Combined Restoration in Artificial Decalcified-Cavitated Lesion (인공 우식 수복시 레진 침투법 전처리의 미세누출에 대한 효과)

  • Jang, Eunjeong;Park, Soyoung;Shin, Jonghyun;Kim, Shin;Jeong, Taesung
    • Journal of the korean academy of Pediatric Dentistry
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    • v.47 no.3
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    • pp.257-265
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    • 2020
  • This study was performed to evaluate the restoration combined with resin infiltration (RI) of early cavitated smooth surface caries lesion in terms of microleakage. Flowable resin and resin-modified glass ionomer cement (RMGIC) were compared. Sound 20 extracted 3rd molars were divided into 2 groups randomly. Artificial decalcified lesion was induced. Cavities were prepared on the mesial and distal surfaces, and randomly set as experimental and control group. RI was applied to the experimental group before cavity restoration. The control group was restored without RI. In group I and II, flowable resin and RMGIC was used for restoration respectively. After thermocycling and silver nitrate immersion, microleakage was assessed by μ-CT. Depth of microleakage was lower in experimental group than control group only in group II (p = 0.05). Microleakage depth was lower in group II than group I in both experimental and control groups (p = 0.05). RI pretreatment before restoration of early cavitated caries lesions might reduce the microleakage and help long-term maintenance of restoration. In this study, RMGIC was less polymerization shrinkage. Restoration with RMGIC after RI pretreatment reduced the microleakage of the restoration compared to the flowable resin.

Factors Associated with Renal Dysfunction, Including Highly Active Antiretroviral Therapy in Korean HIV-Infected Patients (HIV 감염 환자에서 고활성 항레트로바이러스 요법을 포함한 신기능 장애 위험인자 연구)

  • Yeo, Jee-Young;Shin, Hyoung-Shik;Chin, Bum-Sik;Lee, Yu-Jeung
    • Korean Journal of Clinical Pharmacy
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    • v.22 no.2
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    • pp.95-102
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    • 2012
  • HIV 치료를 위한 강력한 항바이러스 약물요법이 널리 사용됨에 따라 HIV에 감염된 상태에서 신장질환 발생 위험성을 지닌 채 오랜 기간 생존하는 환자들이 증가하고 있다. 본 연구는 국립중앙의료원 감염병 센터를 내원한 만18세 이상의 HIV 감염 환자를 대상으로 HIV 감염 환자에게 신기능 장애를 유발하는 위험인자를 평가하고자 환자군 대조군 연구를 후향적으로 실시하였다. 2006년 1월부터 2011년 3월까지 5년 3개월 동안 신기능이 저하된 모든 HIV 감염 환자를 환자군으로 하며, 정상 신기능을 가진 HIV 감염 환자들 중 대조군을 무작위로 선정하여 환자군과 대조군을 1:2의 비율로 하였다. 환자군과 대조군을 비교해 만성신질환을 유발하는 위험인자를 평가하기 위한 분석변수로 성별, 연령, CD4+ 세포수, 혈중 바이러스 수, HAART 56일 이상 여부, 당뇨병과 C형 간염을 선정하였다. 또한 추가적으로 개별 antiretroviral 약물들 사용과 신기능이 얼마나 관련되어 있는지 알아보기 위해 각각의 약물과 eGFR의 상관관계를 분석하였다. 환자군은 CD4+ 세포수가 < $200{\times}10^6$ cells/l 인 군이 7.7배(OR: 7.7; 95% CI, 1.8-32.9) 단백뇨가 있는 환자의 경우 7.8배(OR: 7.8; 95% CI, 1.6-37.8) 더 유의하게 만성신질환 발생위험이 높았다. 개별 antiretroviral 약물들과 eGFR의 상관관계를 분석한 결과, lamivudine 이 eGFR 과 약한 음적 상관관계를 보이는 것으로 나타났으며(r = -.211, p < .05), 다른 약물들의 경우 통계적으로 유의한 값을 보이지 않았다. 이번 환자군-대조군 연구는 HIV 감염 환자들이 만성 신질환으로 발전하는데 여러 인자들의 역할에 대해 평가하고자 하였다. 여러 변수들을 평가해 본 결과, 만성 신질환 환자들의 경우 CD4+ 세포수가 < $200{\times}10^6$ cells/l 이거나 단백뇨를 동반한 경우가 통계적으로 유의하게 많았다.