• Applied Chemistry for Engineering
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• v.21 no.6
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• pp.593-602
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• 2010

Chitosan as a natural polymer has superior physicochemical properties such as biocompatibility, biodegradability and nontoxicity, but application of chitosan for therapy of cancer and gene related-disease has been limited by poor solubility in aqueous solution. Therefore, low molecular weight water-soluble chitosan (LMWSC) with high reactivity and strong positive charge can be applied as a delivery system having function to carry in the specific tissue the bioactive material like poor solubility drug, or therapeutic gene and developed as a therapeutic system having good therapeutic efficiency. The most important factor for therapy of various diseases is to reveal the antigen or receptor expressed in specific lesion tissue and the antibody and ligand which can bind with antigen is to introduce at the biomaterials for enhancement the therapeutic efficiency. The studies for cationic synthetic polymer as drug or gene delivery have been actively performed, but it has many problems such as toxicity in the body, therapeutic efficiency. From this point of view, this article demonstrated the introduction of functional groups to target the specific tissue and therapeutic strategy using the modification of LMWSC with free-amine group. The development of these delivery system will provide a positive vision for cancer therapy.

• The Journal of the Acoustical Society of Korea
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• v.30 no.1
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• pp.9-16
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• 2011

When a hydrofoil ship plies at high speed, there exist possibilities of collision with ocean mammals dwelling near the surface. An active sonar located within the immersed hydrofoil structure that provides the lift for the vessel, can be used for early warning of their presence. The proper functioning of the active sonar system depends on its ability to reject noise and pick up the target signal. In this article, we measured the noise on a hydrofoil of an operating ship with two flush-mounted hydrophones. The measurements were conducted for the purpose of (1) identifying the effect of operating state of machinery likes engine, cooler and generator (2) observing the change of noise depending on the measuring position (3) observing the change of noise with increasing ship speed. To verify our experiment, experiments were performed three times and the measured results are compared with other investigations and they show similarity to each other. The results are analyzed with frequency domain in order to apply to operating active sonar detecting system and focus on high frequency band within sonar's operating frequency region. Through these experiments and analysis, it is expected that we can identify the generated noise around hydrofoil where active sonar is installed and these results lead us to design active sonar that could distinguish target signal from noise more effectively.

• Journal of Global Scholars of Marketing Science
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• v.16 no.1
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• pp.73-91
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• 2006

This study was conducted for market segmentation of cruise tourist according to launching the "T" in Busan. Benefit segmentation was used to identify attributes of cruise services; importance of ship's physical appearance and importance of service and activities. 24 attributes were distilled to 5 factors: 'Facility & Service', 'Atmospherics of cruise ship', 'Escape', 'Choice', 'Safety'. A K-means cluster analysis identified three clustered segments for five importance factors in which high loyalty customers were found to be the most important segment. Based on the findings, three distinct groups were formed: 'Moderators', 'High Loyalty', 'Spurious'. The most important factors by high loyalty groups were identified 'Safety', 'Facility & Service', 'Atmospherics of cruise ship', 'Choice', 'Escape' in order. The results of the study showed statistically significant differences among the three groups in terms of demographic and behavioral variables. Especially, the target market should be considered by 'High Loyalty' group and 'Moderators' group in order. Positioning strategies and marketing mix strategies for effectively targeting the segments were discussed.

• Asia Marketing Journal
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• v.13 no.3
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• pp.233-248
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• 2011

This case illustrates a story of passionate and innovative new market development by Pulmuone, a fresh food provider in Korea. The company has been successfully developing a new market by introducing a (non-frying) fresh ramen, 'Jayeonun Masitda - The Nature Is Tasty' in the packaged ramen market dominated by fried ones. In this case, a detailed new market development process by Pulmuone will be investigated including; company overview, a new product development process, marketing strategy formulation, marketing mix implementation, market performance, and future directions. Pulmuone has been making efforts to create a new product category by marketing non-frying ramens since 1995, but with a modest success. In 2011, Pulmuone finally succeeded to develop an innovative product, 'Jayeonun Masitda' that brought more health and nutrition conscious consumers' attention in the ramen market. The company intended to change the current competitive structure in the ramen market, i.e., from the strength of taste and the amount of ingredient to fried/non-fried and the freshness of ingredient. By this new positioning, Pulmuone aimed to reshaping the ramen market into competition between healthy and unhealthy ramens. Pulmuone has been successful in developing a new market. Sales revenue of 'Jayeonun Masitda' has been continuously increasing, and customers are found to be highly satisfied with the product resulting in a high repeat purchase rate. The company's successful new market development can be attributed to a faithful new product development process, innovative technology, an appropriate positioning strategy, and consistent marketing communication. In addition, Pulmuone's eco-friendly corporate image and the organization's passion to grow are also important factors for success of this new market development.

• Progress in Medical Physics
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• v.25 no.1
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• pp.15-22
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• 2014

The IMRT is proper implement to get high dose deliver to tumor as its shape and selective approach in radiation therapy. Since the IMRT is performed as modulated the radiation fluence by the MLC created the open shapes and its irradiation time, the dose of segment of radiation field effects on the cumulated portal dose. The accurate output factor of small and step shape of segment is important to improve the determination of deliver tumor dose as it is directly proportional to dose. This experiment performed with the 6 MV photon beam of Clinac Ex(Varian) from $3{\times}3cm^2$ to $0.5{\times}0.5cm^2$ small field size for collimator jaw in MLC free and/or for MLC open field in fixed collimator jaw $10{\times}10cm^2$ using the CC01 ion chamber, SFD diode, diamond detector and X-Omat film dosimetry. As results of normalized to the reference field of $10{\times}10cm^2$ of MLC, the output factor of $3{\times}3cm^2$ showed $0.899{\pm}0.0106$, $0.855{\pm}0.0106$ for $2{\times}2cm^2$, $0.764{\pm}0.0082$ for $1{\times}1cm^2$ and $0.602{\pm}0.0399$ for $0.5{\times}0.5cm^2$. The output factor of MLC open field has shown a maximum 3.8% higher than that of the collimator jaw open field.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.10
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• pp.1175-1184
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• 2008

Delay-sum back projection(DSBP) algorithm and the time reversal algorithm based on the finite-difference time-domain method are compared. The two algorithms, which operate in the time domain, can process the ultra-wideband (UWB) radar data to generate images that are close to the original location and shape of the target. For the experiment, the UWB radar consists of a network analyzer, a resistive V dipole antenna, a scanner, and a control computer. The radar aperture is synthesized by linearly scanning the antenna. A calibration procedure is applied to the measured data to remove signal distortion and clutter. The two algorithms are applied to the same data on the same platform. It is shown that the DSBP algorithm produces better images but takes longer time to produce the images than the FDTD-TR algorithm.

• The Journal of the Acoustical Society of Korea
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• v.41 no.2
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• pp.210-217
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• 2022

Passive source depth estimation has been studied for decades since the source depth can be used for target classification, target tracking, etc. The purpose of this paper is to solve the problem of ambiguity in the previous paper [S.-il. Cho et al. (in Korean), J. Acoust. Soc. Kr. 38, 120-127 (2019)] that source depth is estimated in two points. The patterns of phase shift of Channel Impulse Response(CIR) reflected in ocean surface and bottom is used for removing ambiguity of the source depth estimation, and after removing ambiguity, source depth is estimated at one point through the intersection of CIR. In order to extract CIR in case of unknown source signal and continuous signal or noise, Ray-based blind deconvolution is used. The proposed algorithm is demonstrated through numerical simulation in ocean waveguide.

• The Journal of Korean Society for Radiation Therapy
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• v.23 no.1
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• pp.59-66
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• 2011

Purpose: Investigation of the clinical use of tangential fields technique using TOMO direct in comparison to conventional LINAC based radiation therapy after breast partial mastectomy. Materials and Methods: Treatment plans were created for 3 left-sided breast cancer patients who had radiation therapy after breast partial mastectomy by using wedged tangential fields technique, field in field technique (FIF), TOMO Direct, TOMO Direct intensity modulated radiation therapy (IMRT) under the normalized prescription condition ($D_{90%}$: 50.4 Gy/28 fx within CTV). Dose volume histogram (DVH) and isodose curve were used to evaluate the dose to the clinical target volume (CTV), organ at risk (OAR). We compared and analyzed dosimetric parameters of CTV and OAR. Dosimetric parameters of CTV are $D_{99}$, $D_{95}$, Dose homogeneity index (DHI: $D_{10}/D_{90}$) and $V_{105}$, $V_{110}$. And dosimetric parameters of OAR are $V_{10}$, $V_{20}$, $V_{30}$, $V_{40}$ of the heart and $V_{10}$, $V_{20}$, $V_{30}$ of left lung. Results: Dosimetric results of CTV, the average value of $D_{99}$, $D_{95}$ were $47.7{\pm}1.1Gy$, $49.4{\pm}0.1Gy$ from wedged tangential fields technique (W) and FIF (F) were $47.1{\pm}0.6Gy$, $49.2{\pm}0.4Gy$. And it was $49.2{\pm}0.4$ vs. $48.6{\pm}0.8Gy$, $49.9{\pm}0.4$ vs. $49.5{\pm}0.3Gy$ Gy for the TOMO Direct (D) and TOMO Direct IMRT (I). The average value of dose homogeneity index was W: $1.1{\pm}0.02$, F: $1.07{\pm}0.02$, D: $1.03{\pm}0.001$, I: $1.05{\pm}0.02$. When we compared the average value of $V_{105}$, $V_{110}$ using each technique, it was the highest as $34.6{\pm}9.3%$, $7.5{\pm}7.9%$ for wedged tangential fields technique and the value dropped for FIF as $16.5{\pm}14.8%$, $2.1{\pm}3.5%$, TOMO direct IMRT as $7.5{\pm}8.3%$, $0.1{\pm}0.1%$ and the TOMO direct showed the lowest values for both as 0%. Dosimetric results of OAR was no significant difference among each technique. Conclusion: TOMO direct provides improved target dose homogeneity over wedged tangential field technique. It is no increase the amount of normal tissue volumes receiving low doses, as oppose to IMRT or Helical TOMO IMRT. Also, it simply performs treatment plan procedure than FIF. TOMO Direct is a clinical useful technique for breast cancer patients after partial mastectomy.

• Proceedings of the KSRS Conference
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• 2009.03a
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• pp.46-52
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• 2009

TerraSAR-X 자료를 이용하여 고해상 X-밴드 SAR 시스템을 이용한 조간대 적용 가능성을 시험하였다 연구대상지역은 강화도 남단과 영종도를 잇는 조간대이며, 단일편파자료와 이중편파자료를 이용하였다. 연구내용은 다음과 같은 세 가지로 분류된다. 첫째, X-밴드 영상에서의 연안의 레이더 반사도 특성 연구 및 waterline 추출 정밀도를 평가하였다. 연안지역의 wateline은 HH 편광자료의 레이더 반사도 특성을 통하여 추출하였을 때 가장 신뢰도가 높았으며, TerraSAR-X 시스템의 짧은 파장과 높은 제도정밀도로 인하여 정밀한 지리좌표로의 변환이 가능하였다 연구지역의 조간대 지형 경사도는 평균적으로 수평방향으로 60m당 20cm의 고도변화를 가지므로, TerraSAR-X HH 편광자료를 이용한 waterline 추출은 정밀한 조간대 DEM 추출로 응용될 수 있다. 둘째, 이중편파자료의 편파특성을 이용한 조간대 염생식물의 산란특성 관측하였다. 조간대에서 수륙의 경계부에서 잘 관측되는 칠면초와 같은 염생식물은 해수면변화에 따른 조간대의 육지화를 모니터링 하는데 좋은 표적이 된다. TerraSAR-X 이중편파자료의 산란특성을 이용한 염생식물 관측결과는 2007년에 현장에서 취득된 실측자료와 비교하여 3dB 이내의 정밀도로 일치하였다 셋째, 단일편파 자료의 레이더 간섭기법을 이용한 조간대 DEM 작성 시도하였다. 조간대 내에서 육지화가 진행된 지역은 표면에 염생식물이 발달하였음에도 불구하고 높은 간섭긴밀도를 나타내었다. 레이더 간섭기법을 통한 DEM의 제작은 일반적인 조간대에서는 적용이 제한적이며, TanDEN-X의 적용이 필요하다.

• Proceedings of the KAIS Fall Conference
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• 2010.05b
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• pp.855-858
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• 2010

이 연구의 목적은 흰쥐의 궁둥신경의 손상을 준 뒤 달리기운동을 시켜 운동이 근육재생에 효과가 있는지를 밝힐 목적으로 시행하였다. 수컷 Sprague-Dawley계 흰쥐의 궁둥신경을 압궤손상을 준후, 하루 60분 씩 주 5회 운동을 시켰다. 궁둥신경 압궤손상 후 12일(5일간 운동), 19일(10일간 운동), 26일(15일간 운동), 33일(20일간 운동 및 61일(40일간 운동)에 흰쥐를 희생시켜 장딴지근육을 절취하여 냉동절편을 만들었으며 중간세사인 desmin과 vimentin에 대한 면역조직화학적 염색방법을 시행하였고 NADH-TR을 이용한 효소조직화학적 방법으로 뼈대근육의 변성 등을 관찰하였다. 중간세사단백 중 desmin은 근육섬유의 변성 및 재생과정 모두에서 발현되며 vimentin은 재생과정에서만 발현되었다. 대조군보다 실험군에서 desmin과 vimentin의 면역 반응성이 높았고, 실험군의 근육섬유들은 손상 후 61일째에 횡단면에서 각을 갖고 있어 정상 근육섬유임을 입증해 주었으나 대조군의 근육섬유는 정상으로 회복되지 않은 둥근 근육섬유가 관찰되었다. 19일째의 NADH-TR반응에서 대조군에서는 근육 섬유형 군집(fiber type grouping)으로 인해 diformazan 과립이 뭉쳐져 있음을 볼 수 있으나 실험군에서는 점점 diformazan 과립이 고르게 분포됨을 볼 수 있었다. 재신경지배가 일어 날 때 나타나는 표적근육섬유(target fiber)는 NADH-TR반응에서 26일 실험군의 일부 근육섬유에서 처음으로 관찰되었다. 61일째 NADH-TR반응에서 대조군은 아직도 diformazan 과립이 근육섬유성 군집을 보였으나 실험군에서는 정상군과 다름없는 염색성이 관찰되었다. 이상의 결과로 흰쥐 궁둥신경 압궤손상 후 트레드밀 달리기 운동이 흰쥐 다리 뼈대근육의 중간세사발현에 효과가 있다고 생각된다.