• 시큐리티연구
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• 제21호
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• pp.121-134
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• 2009

한국사회는 지금 경제 규모의 팽창, 인구의 도시집중, 전통적 가치관의 혼란 등 사회의 다변화로 인한 범죄의 흉폭화, 기능화, 전문화 현상으로 나타나고 있으며 이로 인한 시큐리티 업체에 대한 일반인들의 관심이 날로 증가하고 있다. 이로 인해 민간경비원들의 수요도 계속 증가되고 있으며, 또한 그에 따른 근무시간의 증가로 이어지고 있다. 이 연구는 민간 경비원들의 근무시간에 따른 피로수준과 면역기능을 비교 분석함으로써 민간 경비원들의 건강증진을 통해 민간경비 산업 발전에 기초자료를 제공하는데 있다. 서울, 경기지역 민간 경비원을 대상으로, 근무시간 40시간 미만, 40~50시간 그리고 50시간 이상의 세 집단으로 분류하여 일반피로와 면역기능을 비교 분석한 결과 다음과 같은 결론을 얻었다. 첫째, 근무시간에 따른 일반피로는 근무시간이 많아질수록 높게 나타났다. 둘째, 근무시간에 따른 NK 세포의 함량은 근무시간이 많을수록 낮은 농도를 나타내었다. 셋째, 근무시간에 따른 면역글로블린(Ig-G, Ig-A, Ig-M)의 농도는 근무시간이 많을수록 낮은 농도를 나타내었다. 이 연구 결과를 볼 때, 민간 경비원들의 일반피로 및 면역기능은 근무시간에 많은 영향을 받는다고 볼 수 있다. 결론적으로 민간 경비원의 피로를 감소와 건강증진을 위해서는 주당 근무시간을 줄여야 할 것이다.

• 한국응용과학기술학회지
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• 제37권3호
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• pp.551-563
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• 2020

본 연구는 성인 지적장애인의 수영프로그램 참여에 따른 건강관련 지표들의 특징을 규명하고자 수행되었다. 이를 위해, 부산지역에 거주하고 있는 20-39세 사이의 성인 지적장애인 20명을 선정하였으며, 수영프로그램에 참여한 운동군 10명과 동일한 기간 특별한 신체활동에 참여하지 않고 일상적인 생활을 해 온 통제군 10명의 두 집단으로 분류하였다. 대상자들의 건강체력, 스트레스 호르몬 및 면역기능을 측정하여 자료를 수집하였으며, 자료분석은 SPSS 18.0을 이용하여 대응 t-test, 독립 t-test 및 two-way ANOVA를 실시하였다. 그 결과 운동군에서 근력(p<.001), 근지구력(p<.001), 유연성(p<.001), 심폐지구력(p<.01) 향상에 유의한 차이가 있었고, 통제군은 유의한 차이가 나타나지 않았다. 스트레스 호르몬인 코티졸(p<.01)은 운동군에서 유의하게 감소하였고, 통제군에서는 유의한 차이가 없었다. 면역글로블린인 IgA(p<.05), IgG(p<.001), IgM(p<.05)은 운동군에서 유의한 증가가 있었고, 통제군에서는 유의한 차이가 나타나지 않았다. 따라서 규칙적인 수영프로그램은 성인 지적장애인의 건강체력 향상에 매우 효과적인 운동프로그램이라 할 수 있으며, 스트레스를 감소시키고 면역기능 개선에 도움을 줄 수 있음을 보여주는 결과로, 향후 성인 지적장애인들의 건강유지와 만성질환 예방을 위해 적극적인 신체활동 프로그램 개발과 중재의 필요성을 시사한다.

• 동의생리병리학회지
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• 제17권6호
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• pp.1479-1486
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• 2003

In order to evaluate the antiallergic effects of Kamiohihyosan(KCHS), studies were done. We measured the cytotoxic activity for lung fibroblast cell, cytokines transcript expression, production of IL-4, IL-10, IFN-γ, proliferation of B cell in anti-CD40mAb plus rIL-4 stimulated murine splenic B cells. The results were obtained as follows: KCHS was not showed cytotoxicity in the fibroblast lung cell, KCHS increased the gene synthesis of INF-γ, TNF-α, IL1-β, IL-6, IL-10(m-RNA), KCHS decreased the gene synthesis of IL-4, IL-5, TGF-β(m-RNA), KCHS decreased the appearance of IL-4, IgE significantly, KCHS increased the appearance of IL-10, IFN-γ significantly, KCHS decreased the proliferation of B cell significantly, The facts above prove that KCHS is effective against the allergy. Thus, I think that we should study on this continuously.

• Journal of Oral Medicine and Pain
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• 제23권2호
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• pp.109-117
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• 1998

Fixed orthodontic appliances for the treatment of malocclusion has iatrogenic side effect such as demineralization of enamel, gingivitix and gingival hyperplasia. The purpose of this study is to longitudinally investigate the salivary microorganisms and immunoglobulin A after delivery of fixed orthodontic appliances for 10 months. Eight orthodontic patients were included in this study and the author has investigated the numbers of general bacteria, Streptococcus mutans Staphylococcus aureus and concentration of immunoglobulin A from unstimulated whole saliva. The author examined these parameters at prebracketing, 1 month after, 4 months after, 7 months after and 10 months after delivery of fixed orthodontic appliances. The obtained results were as follows : There were significant increases in the number of salivary general bacteria, Streptococcus mutans and Staphylococcus aureus after delivery of fixed orthodontic appliances The numbers of general bacteria were significantly increased at 1 month after (p<005), 4 months after (p<0.05), 7 months after (p<0.01), compared with prebracketing. However it showed no difference at 10 month after compared with 7 months after bracketing. The Numbers of Staphylococcus aureus were significantly increased at 1 month after (p<0.05), 4 months after(p<0.01), 7 month(p<0.01), compared with prebracketing. However it showed decreasing pattern at 10 months after compared with 7 months after bracketing. There was no significant difference in the concentration of immunoglobulin A after delivery of fixed orthodontic appliances.

• 한국간호교육학회지
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• 제13권2호
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• pp.169-176
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• 2007

Purpose: The purpose of this study was to verify the effect of aromatherapy hand massage on stress responses and serum Immunity of RN's before the night duty. Method: The data were collected during the period from Oct. 10 to Nov. 15, 2005 at S-Hospital in Seoul. There were forty-eight subjects, 24 for the experimental and 24 for the control group. A Pre & post test were conducted to measure pulse rate, perceived stress(level and score) and a blood sample for cortisol and IgA. In the experimental group, lavender and geranium were used. Data were analyzed by descriptive statistics, $x^2$-test and t-test with SPSS program. Result: The pulse rate was reduced but there were no significant differences between the two groups. Scores of subjective stress(VAS) decreased significantly after aromatherapy hand massage and the level of serum Cortisol was reduced significantly. The level of serum IgA was elevated significantly. Conclusion: Aromatherapy hand massage could be a useful intervention to reduce stress and elevate the immunity of nurses during the night duty.

• Journal of Oral Medicine and Pain
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• 제17권2호
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• pp.87-97
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• 1992

The purpose of this study is to investigate the age-and sex-related changes in the pH of resting saliva, viscosity, microorganisms and immunoglobulin A of stimulated whole saliva, and to investigate their correlations. The 120 healthy subjects were included in this study and the author used cone-and plate digital viscometer for viscosity, MSB agar for Streptococcus mutans, SL Rogosa agar for lactobacilli, and single radial immunodiffusion technique for immunoglobulinA. The obtained results were as follows : 1. There was no significant difference in pH, viscosity, Streptococcus mutans lactobacilli and immunoglobulin A of the saliva between males and females. 2. The viscosity values of stimulated whole saliva showed the increasing pattern with aging. 3. DMFS (or dmfs) rate was not correlated with pH, viscosity, Streptococcus mutans, lactobacilli and immunoglobulin A of the saliva. 4. There was a significant difference in the concentration of immunoglobulin A between the group under 10 and groups above 10. 5. The viscosity values of stimulated whole saliva showed the increasing pattern with decreasing of the number of Streptococcus mutans.

• 한국약용작물학회지
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• 제16권2호
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• pp.100-105
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• 2008

We previously examined extracts, isolated from Scutellaria baicalensis (SB), chemical mediators, and IgE by mesenteric lymph node (MLN) lymphocytes in rats. The present study was to evaluate the effects of extracts of SB on the MLN lymphocytes function of mice given orally by 20 mg/kg for 2 weeks with dextran sulfate sodium (DS)-induced colitis. Results show that IgE levels in MLN lymphocytes was low, while IgA was high, in mice given SB compared to that fed water. Concentrations of $Inteferon-{\gamma}$ and interleukin (IL)-2 of T cells by concanavalin A treatment was significantly higher in the SB fed group than the normal group. Activation-induced IL-4 and IL-10 secretion was lower in SB fed mice compared control mice after DS-induced colitis. These results suggested that SB suppresses the inflammation in DS-induced colitis through the modulation of Th1/Th2 balance to down-regulate $Th_2$ response in MLN lymphocytes.

• 동의생리병리학회지
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• 제17권4호
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• pp.1065-1074
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• 2003

In order to evaluate the antiallergic effects of Kamiyukgunja-tang (KYGJT), studies were done. We measured the cytotoxic activity for lung fibroblast cell, cytokines transcript expression, production of INF-γ, IL-10, IL-4, GM-CSF, IL-1 β, TNF-α. IL-5 proliferation of B cell in anti-CD40mAb plus r1L-4 stimulated murine splenic B cells. The results were obtained as follows : 1. KYGJT was not showed cytotoxicity in the fibroblast lung cell. 2. KYGJT increased the gene synthesis of INF-γ, IL-10, GM-CSF(m-RNA). 3. KYGJT decreased the gene synthesis of IL-1β, IL-4, TNF-α, IL-5(m-RNA). 4. KYGJT decreased the appearance of TNF-α significantly. 5. KYGJT decreased the appearance of IgE significantly. 6. KYGJT decreased the proliferation of B cell significantly. 7. KYGJT decreased the appearance of Histamin Release Production significantly. The facts above prove that KYGJT is effective against the allergy. Thus. I think that we should study on this continuously

• 대한간호학회지
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• 제45권3호
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• pp.367-377
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• 2015

Purpose: The purpose of this study was to evaluate the effects of essential oil on oxidative stress, immunity, and skin condition in atopic dermatitis (AD) induced mice. Methods: This study was a $3{\times}3$ factorial design. Factors were oil type (Lavender, Thyme, and 2:1 mixture of lavender and thyme oil [blending oil]) and treatment period (0 day, 7 days, and 21 days). The samples were 45 mice with AD and randomly assigned to nine groups of five mice per group. The dependent variables such as superoxide radical, IgE, degranulated mast cells, and epidermal thickness were measured. Data were collected from February to April in 2014. Descriptive statistics, One-way ANOVA, Two-way ANOVA, and Tukey's HSD test were performed using the SPSS WIN 20.0 program. Results: Dependent variables were not statistically significantly different by the three oil types (p >.05). Essential oils such as lavender, thyme, and blending oil were all effective in reducing AD symptoms and especially 2:1 blending oil were most effective. There were statistically significant differences by the three treatment periods in all dependent variables (p <.001). There were statistically significant interactions between oil types and treatment periods in all dependent variables (p <.01). For decreasing superoxide radical, degranulated mast cells, and epidermal thickness, 2:1 mixed oil should be applied for at least 21 days. Otherwise to reduce IgE, 2:1 mixed oil should be used for at least 7 days. Conclusion: These findings provide bases for developing effective interventions for AD patients to manage their AD symptoms.

• 한국식품위생안전성학회지
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• 제18권2호
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• pp.61-66
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• 2003

본 연구는, Vibrio parahaemolyticus에 대한 면역 글로블린 Y(IgY)를 생산하기 위하여 시행되었다. Vibrio parahaemolyticus는 중요한 병원성 균이며, 위장염을 유발시키는 원인 균이다. 따라서, 난황에서 Vibrio parahaemolyticus에 대한 항체를 생산하기 위하여 항원 LPS(lipopolysaccharide)를 암탉에 주사하였다. 면역은 2주 간격으로 4차까지 실시하였으며, 추가면역으로 2주 간격으로 3차까지 실시한 후 ELISA로 그 항체 역가를 측정하였다. 난황에서의 항체생성은 1차 면역 후 1주일부터 나타나기 시작하였으며, 7주에 최고 역가에 도달하였고, 이러한 역가는 13주 이후까지 지속되는 것으로 나타났다. 한편 혈청에서의 항체 역가도 난황에서의 경향과 유사하였다. 정제시킨 IgY를 본 연구의 water-dilution방법과 상업용 IgY분리 kit로 그 정제 정도를 비교해본 격과 큰 차이를 나타내지 않았으며, Vibrio parahaemolyticus외의 다른 Vibrio 속 및 세균들과의 교차반응성 조사에서 특별한 교차반응이 없었다. 본 연구에 나타난 결과로, 아주 적은 양의 LPS 항원으로 역가가 높은 항체의 생산이 가능하였으며, 이러한 결과들로 보아 난황은 유행성 위장염을 유발하는 병원성 균의 특이 항체 개발을 위한 좋은 공급원이 될 것으로 생각된다.