• Journal of Korean Academy of Fundamentals of Nursing
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• v.18 no.4
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• pp.520-528
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• 2011

Purpose: Patients with chronic hepatitis B need lifelong health care because of progressive liver damage. The purpose of this study was to identify factors associated with self-management compliance among patients with chronic hepatitis B. Methods: The research was a cross-sectional, descriptive design using questionnaires. The participants were 118 patients with chronic hepatitis B from outpatient department in a tertiary hospital. Their ages ranged from 20 to 64. Data were analyzed using descriptive statistics, t-test, ANOVA and multiple regression with PASW statistics 19.0 program. Results: There were statistically significant differences in self management compliance by gender, age, job, alcohol consumption, and smoking. A positive correlation existed between self-management compliance, awareness of the importance of management, and self efficacy. Stepwise multiple regression analysis for self-management compliance revealed that the most powerful predictor was self efficacy. Self efficacy, age, and alcohol consumption explained 37.5% of the variance. Conclusion: The results indicate a need to promote self-management compliance with these participants. The findings also suggest that consideration be given to characteristics of age and alcohol consumption in developing strategies for enhancing self efficacy and developing programs to promote self-management for patients with chronic hepatitis B.

• Korean Journal of Adult Nursing
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• v.26 no.3
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• pp.287-299
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• 2014

Purpose: The aim of this study was to investigate the factors contributing to health-related quality of life (HRQOL) among patients with chronic hepatitis B (CHB). Methods: A cross-sectional, descriptive design was used. The sample included 114 patients in a gastroenterology outpatient department at one hospital located in G city. Data were collected using a structured questionnaire from June to December 2009. The collected data were analyzed using SPSS/WIN 15.0. Results: Health-related quality of life was most strongly related to age, sex, income, occupation, and the care provider. Old age, female gender, lower income, not having an occupation and having a non-medical person were associated with lower HRQOL ($R^2$=.03~.22, p=.041~<.001). Conclusion: CHB infection had a negative impact on HRQOL among the older, female gender, low socioeconomic status and not having medically knowledgeable care givers. Interventions beyond nursing care may be needed to improve the quality of health for patients with Chronic Hepatitis B.

• Journal of Life Science
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• v.18 no.9
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• pp.1207-1211
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• 2008

The pro-inflammatory cytokine tumor necrosis factor-$\alpha$ (TNF-$\alpha$) is an important mediator of the immune response in hepatitis B virus (HBV) infection. Since the production of TNF-$\alpha$ is mostly regulated at the transcriptional level and polymorphisms in the TNF-$\alpha$ promoter alter its expression, TNF-$\alpha$ promoter polymorphisms could affect the pathogenesis of chronic HBV infection. In this study, we investigated the potential association of TNF-$\alpha$ promoter polymorphisms with chronic HBV infection. The study included 181 patients with chronic HBV infection, 201 persons who had been spontaneously recovered from hepatitis B, and 170 unrelated healthy controls. The -308G/A and -238G/A polymorphisms in the TNF-$\alpha$ promoter were analyzed by PCR-restriction fragment length polymorphism. The distribution of both the -308 and -238 genotypes in the patient group was not statistically different from that in the spontaneous recovery and control groups (p>0.05). There was also no significant difference in the allele frequency between the groups (p>0.05). The results suggest that the TNF-$\alpha$ -308 and -238 promoter polymorphisms are not associated with the development of chronic HBV infection in the Korean population.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.325-332
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• 1986

Since Combes' first description of hepatitis B virus associated membranous glomerulonephritis, many reports have shown a strong association of hepatitis B virus infection with various types of nephropathies, especially membranous glomerulonephritis and membranoproliferative glomerulonephritis. Recently, the authors experienced a case of membraoproliferative glomerulonephritis, type I in a 16-year-old male patient with persistent HBs and HBe antigenemia. One year prior to admission the patient was told of hepatitis at routine check, but he remained asymptomatic throughout. He was admitted to our hospital with chief complaints of proteinuria and microscopic hematuria found on routine urinalysis. Liver and kidney biopsy revealed chronic persistent hepatitis and membranoproliferative glomerulonephritis type I, respectively. We report a case of hepatitis B virus associated nephropathy with review of the literatures. Considering the endemic nature of hepatitis B virus infection in Korea, the incidence of hepatitis B viurs associated nephropathy would be proportionally high in comparison with those of other countries. So, the importance of this entity merits special consideration in our country. Further study concerning pathogenesis, epidemiology, and treatment may be needed.

• Journal of Korean Academy of Nursing
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• v.39 no.6
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• pp.805-817
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• 2009

Purpose: This ethnograpy was done to explore patterns of health care behavior in patients with chronic health problems. Methods: The participants were 15 patients with chronic hepatitis B and 2 family members. Among the patients 4 had progressed to liver cirrhosis and liver cancer. Data were collected from iterative fieldwork in a department of internal medicine of I hospital. Data were analyzed using text analysis and taxonomic methods. Results: Illness and disease, relationship between health care givers and clients, and communication patterns between health professions and clients were discussed as the context of health care behavior. Health care behavior of the participants was categorized by its focus: every day work centered, body centered, organ centered, and pathology centered. Conclusion: Participants' health care behavior was guided by folk health concept and constructed in the sociocultural context. Folk etiology, pathology, and interpretation of one's symptoms were influencing factors in illness behavior. These findings must be a cornerstone of culture specific care for the chronic diseases.

• Korean Journal of Occupational Health Nursing
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• v.21 no.3
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• pp.201-208
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• 2012

Purpose: This study aims at comparing nurses' knowledge, attitudes and nursing intention toward AIDS and Chronic Hepatitis B(CHB). Methods: The data were collected through self-reported questionnaires from 245 nurses between July and August, 2011. The nurses were recruited from 3 hospitals located in Seoul and Gyeonggi province. Pearson correlation coefficient and stepwise multiple regression were adopted to analyze the data. Results: Regarding AIDS, higher knowledge level was correlated with positive attitudes only(r=-.22, p<.001), which were correlated with favorable nursing intention(r=-.41, p<.001). Higher CHB knowledge level was correlated with both positive attitudes toward CHB(r=-.14, p= .030) and favorable nursing intention(r=.18, p= .004). Nursing intention toward AIDS was affected by attitudes(${\beta}$=.58, p<.001) and explained 16.6% of the variance. Both knowledge(${\beta}$=.35, p=.028) and attitudes(${\beta}$=-.49, p<.001) influenced nursing intention toward CHB and explained 19.1% of the variance. Conclusion: We need to promote nurses' positive attitudes toward AIDS to increase their nursing intention for people living with AIDS.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.5 no.1
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• pp.65-79
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• 1998

The purpose of this study was to identify the effect of structured patient education on knowledge of Hepatitis B type and behavior about self care in chronic hepatitis B patients, and to fine the strategy to promote their self care behavior. The research design was quasi-experiment research. The study method had been done by investigating the experimental group and control group through the questionnaire on 50 patients who had been out patient medicine department in U university hospital in Ulsan from september 1st 1997 to the end of October, 1997. The analysis of the collected material had been done for the homogeneity test in which general characterics of experimental group and control group had been tested by $x^2-test$ and the homogeneity test of the knowledge of hepatitis B type and self care behavior before by t-test. To test the hypothesis the t-test had been given for the difference of the knowledge of hepatitis B type and self care behavior between the two groups and the correlation between knowledge of hepatitis B type and self care behavior performance had been tested by Pearson's correlation coefficient. The results as follows : 1. The 1st hypothesis 'The experimental group which received the structured education should be higher in the knowledge of hepatitis B type than the control group' was supported(t=-6.25, P=.000). 2. The 2nd hypothesis 'The experimental group which received the structured education whould be higher in the self care behavior performance than the control group' was supported(t=-5.15, P=.000). 3. The 3rd hypothesis 'The higher the knowledge of hepatitis B type in the patient the higher the self care behavior performance degree' was supported(r=.492, P=.001). In conclusion, the patients who received the structured education showed the increase in the degree of knowledge of hepatitis B type and self care behavior performance. so the structured education had been judged the nursing intervention had been prerequisite in increasing knowledge of hepatitis B type and self care behavior performance of the chronic hepatitis B patients.

• Journal of Preventive Medicine and Public Health
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• v.35 no.2
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• pp.129-135
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• 2002

Objective : The primary objective of this study was to estimate the prevalence of HBsAg-positives in the late 1990's among Korean adults. In addition, we evaluated the association of age, a residential area, a vaccination rate, a family history of chronic liver diseases and a past history of acute liver disease with the seropositivity of HBsAg, and estimated the prevalence of chronic HBV infection by follow-up for 6 month or more. Methods : A total of 10 areas, six metropolitan and four small cities, were selected. In each cities, one health screening center was selected for recruitment of study subjects. The study subjects were enrolled from a general health examination program that is provided by medical insurance companies. Questionnaires on various risk factors were administered to the study subjects. Sera was drawn and tested for HBsAg by radioimmunoassay. HBeAg and ALT were also tested for those of HBsAg positive. The HBsAg positives was retest for HBsAg 6 months later Results : Among the study subjects (n= 1816), the seroprevalence of HBsAg was 5.5% (95% CI=4.5%-6.6%), 7.4% in men (95% CI=5.8-9.4) and 3.6% in women (95% CI=2.5-5.0). A past history of acute liver disease and a family history of chronic liver diseases was shown to be risk factors for HBsAg positivity. Among the 31 HBsAg-positives, negative seroconversion rate was estimated to be 3.2%, Thus, prevalence of chronic HBV infection was estimated to be 5.3% (95% CI=3.7-6.6). Conclusion : In this study, the HBsAg seroprevalence rate was lower than that of the other studies in 1980's, particularly in young adult and women. Considering the public health importance of liver cancer and chronic liver diseases, the further effort is needed to prevent and reduce the HBV infection.

• The Journal of Korean Academic Society of Nursing Education
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• v.20 no.1
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• pp.108-117
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• 2014

Purpose: The purpose of this study was to develop and validate health care providers' counseling manual in mobile application for lifelong health care among patients with chronic hepatitis B. Methods: The mobile application was developed using a prototyping approach and system developing life cycle method, evaluated by users for their satisfaction with the counseling manual and experts for the quality of the manual. To evaluate application of the counseling manual, knowledge and counselor self-efficacy of the subjects were measured and compared before and after application of the counseling manual. Results: There were statistically significant increases in knowledge and counselor self-efficacy in the user group. A mobile application with high accessibility and applicability including information and counseling factors can promote counseling competence of the nurse as health care provider caring chronic hepatitis B patients. Conclusion: The results of this study indicate that the counseling manual in mobile application is effective in increasing knowledge and counselor self-efficacy among nurses to promote lifelong health care among patients with chronic hepatitis B. Therefore, it can be usefully utilized in the field of nursing for patients with chronic hepatitis B as a nursing intervention.

• Pediatric Infection and Vaccine
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• v.25 no.2
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• pp.72-81
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• 2018

Purpose: This prospective study aimed to investigate the therapeutic efficacy of lamivudine in children with chronic hepatitis B virus (HBV) infection. Methods: During July 2003 through October 2015, children with chronic hepatitis B who visited our institution were included in this study. Fifty-five patients, who received first-line treatment of lamivudine (3 mg/kg, 100 mg maximum) for over three months, were enrolled. After initiating lamivudine, alanine aminotransferase (ALT), HBV-DNA, and HBV markers were followed up at 1 month, 3 months, and every 3 months, thereafter. The treatment endpoint was determined as 1) normalization of ALT, 2) HBeAg seroconversion, and 3) anti-HBe positivity for twelve consecutive months. Results: Thirty-one male (56.4%) and 24 female (43.6%) patients were included. The mean age at treatment initiation was 8.1 years. The mean duration of treatment was 23.4 months. ALT normalization was found in 98.2% (54 of 55). Anti-HBe seroconversion was found in 70.6% (36/51). Loss of HBsAg was found in 10.9% (6/55). All biochemical responses occurred under age seven. The rate of virologic response (defined as HBV-DNA <2,000 IU/mL) at six months after treatment initiation was 78.7% (37/47). At twelve months after reaching treatment endpoint, 87.2% (34/39) maintained their virologic response. Resistance to lamivudine was found in 16.4% (9/55). Conclusions: Lamivudine treatment in Korean pediatric patients with chronic hepatitis B showed better outcomes compared with other studies that implemented similar protocols in foreign populations. Further studies are needed to investigate the efficacy of newly recommended antiviral drugs on the Korean pediatric population.