• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.121-121
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• 2022

마자인(麻子仁)은 뽕나무과에 속하는 대마(Cannabis sativa L.)의 종자로써, 治血虛津虧, 腸燥便秘하며, 中風汗出, 逐水, 利小便, 破積血, 復血脈, 乳婦産後餘疾, 長髮 등에 사용한다고 기록되어 있다. 마자인 종자의 외피에는 환각성분인 Tetrahydrocannabinol (THC) 및 뇌전증과 다발성경화증 등 희귀, 난치성 질환의 치료제로 사용되는 Cannabidiol (CBD) 성분이 함유되어 있다. 따라서 외피를 제거한 마자인은 햄프씨드(Hemp Seed)로써 식품으로 이용되지만, 외피를 제거하지 않은 마자인은 의약품으로써 사용이 되고 있다. 마자인은 윤조탕, 자윤환, 마자인환 등 다양한 한의학 처방에 사용되지만, 외피에 함유되어있는 THC 및 CBD의 함유량 및 안전성에 대한 연구는 밝혀지지 않았다. 이에 마자인 함유처방의 안전성을 입증하는 실험방법을 설계하였다. 우선 의약품으로 유통되는 마자인의 외피에 THC 및 CBD 성분이 있는지를 확인하기 위해 마자인을 다양한 용매별 (물, 헥산 등)로 추출한 후 LC/MS를 이용해 성분 유무를 확인한다. 또한, 마자인 함유 처방 (마자인환, 자윤환, 윤조탕 등)을 복용하였을 경우 혈중에 THC 및 CBD 성분이 있는지를 확인하는 방법으로 실험동물에 마자인 함유 /처방을 투여한 후 혈액을 채취한다. 마찬가지로 성분 유무를 측정하는 방법은 LC/MS를 이용해 확인한다.

• Journal of Animal Science and Technology
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• v.53 no.2
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• pp.107-111
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• 2011

This study was undertaken to reveal the relationship between genetic variations and the basic coat color classification system in Jeju horses. Genetic variations of the melanocortinreceptor 1 (MC1R) and agouti signaling protein (ASIP) genes were investigated using pyrosequencing technique. A nucleotide substitution mutation for MC1R g.901C>T and an ASIP 11-bp deletion mutation were screened. Black horses had MC1R $E^+$/- ($E^+/E^+$ or $E^+/E^e$) and ASIP $A^a/A^a$ genotypes. In contrast, chestnut horse genotypes were MC1R $E^e/E^e$ and ASIP -/-. Thus, black and bay horses have at least one dominant MC1R allele, $E^+$, whereas chestnut horses have homozygous recessive alleles $E^e/E^e$. This suggests that the MC1R genotypes determine chestnut or black/bay coat color, regardless of the genotype distribution of ASIP. In addition, the horses with MC1R $E^+$/- and a dominant ASIP $A^A$/- allele showed bay coat color, but not black, suggesting that the ASIP $A^A$ allele represses black coat color development in the hairs of the body, but not in the mane and all four legs. Pedigree analysis showed a consistent relationship between the genotype distribution of the MC1R and ASIP genes and basic coat color patterns, even in the $F_1$ progeny. The results of this study revealed the relationship between the coat color phenotype and genetic background and suggested that useful information may be provided for molecular breeding of Jeju horses.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2016.05a
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• pp.55-57
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• 2016

콜럼버스는 1492년 1차 대서양 항해시 '자신이 추정한 1일 항해거리를 줄여서 항해일지에 기록하였다. 그 동안 콜럼버스가 1차 항해 때 '항행거리(航程)를 조작했다'는 주장은 자연스러운 일로 받아들여져 왔다. 그러나 최근 이에 대한 새로운 해석이 제기되었다. 1983년 제임스 켈리가 '콜럼버스가 항해거리를 조작했다는 항정 조작설은 콜럼버스가 마일(mile)을 포르투갈 레구아(portugal $l\grave{e}gua$)로 전환하느라고 추산치를 5/6로 줄인 것을 콜럼버스의 항해일지 요약자인 라스 카사스($Bartolom\grave{e}$ de las Casas, 1484-1566)가 오해했다'고 주장하였고, 이를 1992년 필립스 부부가 지지하고, 2013년 주경철 교수가 국내에 소개하였다. 그러나 이는 선박과 항해에 대한 전문 지식의 결여에서 비롯된 오해다. 이 논문에서는 콜럼버스가 1차 항해시 항정을 조작한 것이 아니라 항해일지 요약자인 라스 카사스의 오해에서 비롯되었다는 제임스 켈리, 필립스 부부, 주경철 교수의 주장을 비판적으로 재검토해보고자 한다. 2에서는 항정 조작이 없었다는 켈리, 필립스, 주경철 교수의 주장을 요약하였고, 3에서는 항정 조작 여부를 검증하기 위해 콜럼버스의 1차 항해의 속력을 계산해 본 결과 3.81노트 내외로 추산되었다. 그리고 4에서는 콜럼버스가 항정을 조작할 수밖에 없었던 이유가 그의 대양 항해 경력이 일천했던 탓에 시간당 평균속력을 과대하게 빠르게 추산했기 때문이라는 견해를 제시하였다. 콜럼버스의 '항정 조작설'을 검토하는 것은 항해와 선박에 대한 올바른 이해 없이 전문분야사인 해양사를 연구했을 때 발생할 수 있는 오류를 보여주는 사례의 하나로서 우리들에게 시사해 주는 바가 적지 않을 것이다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.991-993
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• 2005

데스크탑 그리드(Desktop Grid) 환경에서는 자원 제공자인 데스크탑의 자율적 연산 참여와 탈퇴를 허용하기 때문에 기존 데스크탑 그리드 시스템들은 연산 도중 잦은 중단으로 인해 연산의 완료 시간이 지연되고, 연산 수행의 신뢰성이 저하되며 연산의 완료를 보장하지 못하고 있다. 기존의 데스크탑 그리드 시스템들은 이러한 데스크탑의 동적 특성을 반영하지 못하고 있을 뿐만 아니라 데스크탑의 연산 수행 양식을 고려하지 않아 시스템의 안정성과 성능이 저하되었다. 신뢰성 높은 연산 수행을 지원하고, 데스크탑의 비예측적 연산 수행 속성을 극복하기 위해서는 데스크탑의 동적인 특성인 휘발성(volatility)을 고려한 스케줄링이 필요하다. 본 논문에서는 휴리스틱 접근을 통해 동적으로 가변하는 데스크탑의 상태를 보다 정확하게 모델링 하는 가용성 기반 마코브 작업 스케줄링 기법을 제안한다. 제안 기법은 데스크탑의 가용성을 기반으로 과거 연산 수행에 대한 패턴을 확률 모델링하여 미래 연산 수행 유형을 예측함으로써 연산 수행 도중의 불안정한 자원 제공 현상을 완화시키며 안정적인 스케줄링을 지원하여 시스템의 신뢰성과 성능을 향상시킨다.

• Journal of Korean Medicine Rehabilitation
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• v.25 no.1
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• pp.1-15
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• 2015

Objectives The aim of this study was to investigate the effects of Cannabis Fructus on exercise capacity and cognitive function in chronic hypoperfusion induced vascular dementia rat model. Methods Vascular dementia rat models were induced by chronic cerebral hypoperfusion through bilateral common carotid arteries occlusion (BCCAO). All rats were randomly divided into 4 groups: normal group; control group; CF I group (feeding Cannabis Fructus 100 mg/kg); CF II group (feeding Cannabis Fructus 300 mg/kg). In order to study the effects of oral administration of Cannabis Fructus on vascular dementia rat models, corner turn test, hole board test, radial arm maze test, passive avoidance test were taken and Acetylcholine (ACh) activity, Acetylcholinesterase (AChE) activity, serum of Vascular endothelial growth factor (VEGF) protein level were measured. Also histological findings of the liver, kidney, brain and the change of Tau immunoreactive neurons in hippocampus were observed. Results CF I and CF II showed significant improvement in corner turn test, hole board test, radial arm maze test, passive avoidance test, Acetylcholine (ACh) activity, Acetylcholinesterase (AChE) activity, the serum of Vascular endothelial growth factor (VEGF) protein level and the change of Tau immunoreactive neurons in hippocampus. CF I showed more significant effect than CF II in these tests. However in histological observations of the liver and kidney both CF I and CF II showed glomerular injury and hepatotoxicity. Conclusions These results suggest that Cannabis Fructus was helpful in improving exercise capacity and cognitive function on Chronic hypoperfusion induced Vascular Dementia rats. However Cannabis Fructus affects the liver and kidney, therefore suggest that this is an area for further study.

• Korean journal of food and cookery science
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• v.5 no.1
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• pp.53-62
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• 1989

Granular shapes and size, physicochemical properties and gelatinization properties of potato starches from Irish cobber (the dry type), Dejima (the moist type), Shepody and Superior were investigated. The starch granule was round or oval and the size of Irish cobbler and Shepody starch were $11~30\mu\textrm{m}$ and those of Superior and Dejima were$ 21~40\mu\textrm{m}$. Blue value, amylose content, relative crystallinity and density of Irish cobbler were the highest, but that of Dejima were the lowest. Water binding capacity, swelling power, transmittance. peak viscosity and breakdown of amylogram of Superior starch were the highest, but that of Irish cobbler starch were the lowest. Gelatinization temperature of DSC of Irish cobbler starch was the highest, but that of Superior starch was the lowest.

• Geophysics and Geophysical Exploration
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• v.17 no.2
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• pp.49-57
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• 2014

3D magnetic inversion, based on the assemblage of 2D forward modeling and inversion as a practical technique to reflect the a priori information, was conducted to investigate the spatial distribution features of black-shale related and pyrometamorphic uranium deposit and several lithological units of Ogcheon Super Group in an area of Geumsan. By using the 3D visualization technique with suitable susceptibility interval and horizontal slice map, the spatial distribution of magnetic susceptibility corresponded to the black shale related uranium bearing lithological units, Black Slate member was well coincided with a information of uranium deposit. Also, even though it is indirect indicator for the detetction of uranium deposits interbedded in Gray Hornfels member, spatial susceptibility distribution which shows the south-east magnetic linearment corresponding to the Majeon-ri formation and Dark Gray Slate were matched well. From this investigation, we inferred that maximum depth extension which Black Slate member can be separately recognized with respect to adjacent Dark Gray Slate with strong magnetic susceptibility anomaly is about 150m with reference elevation level of 306m. In addition, Majeon-ri formation located south of Black Slate member revels relatively high magnetic susceptibility range but shows high spatial susceptibility fluctation. And, as an intrusive rocks, Jurassic Biotite Granite shows relatively low magnetic susceptibility characteristics. On the contrary, Cretaceous granite distributed in soutthern part of the study area shows the relatively high susceptibility distribution.

• Journal of Society of Preventive Korean Medicine
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• v.2 no.1
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• pp.13-30
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• 1998

Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorou.a.il (5). were tested for their growth inhibitory effects against SK-MEL-3 cell lines using two different 3-(4,5-dimethylthiazol- 2yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. These compounds showed inhibitory activity in vitro in the micromolar range against SK-MEL-3 cell lines. In general, the antitumor activity of these compounds (1, 2, 3, 4 and 5) was in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $IC_{50}$ values of these compounds in tumor cell lines shows that their susceptibility to these compounds decrease in the following order : OLVTL > CBG > CBD > 5-FU > CRNL in MTT assay, CBG > OLVTL > CBD > GRNL > 5-FU in SRB assay. Cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their cytotoxic effects on NIH 373 fibroblasts using two different MTT assay and SRB assay. These compounds exhibited potent cytotoxic activities in vitro in the micromolar range against NIH 373 fibroblasts. In general, the cytotoxic activities of these compounds (3, 4 and 5) were in a dose-dependent over the micromolar concentration range $1\;to\;100{\mu}M$. The comparison of $CD_{50}$ values of these compounds on NIH 373 fibroblasts shows that their susceptibility to these compounds decrease on the following order ; CBD > 5-FU > CBG in MTT assay and SRB assay. Cannabigerol (3) was shown the least cytotoxic activity on NIH 373 fibroblasts. Cannabigerol (3) exhibited the most growth-inhibitory activity against SK-MEL-3 cell lines.

• Journal of dental hygiene science
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• v.16 no.1
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• pp.77-83
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• 2016

The purpose of this study was to evaluate effects of oral health education for occupational health nurses. The subjects were 300 occupational health nurses which participated in continuing education of Korean Association of Occupational Health Nurses. Oral health education contents consisted of basic knowledge about oral health, prevention of periodontal disease, oral health care for workers, and oral health program for workers. In order to evaluate the effects of oral health education, we performed questionnaire surveys before and after the education regarding their perceived oral health status and concern for oral health, knowledge about prevention of periodontal disease, attitude about oral health promotion, and needs for implementation of oral health promotion program. The data were analyzed by paired t-test to compare the change of knowledge and attitude according to the education. Linear regression analysis was carried out to assess the factors related to the improvement of their knowledge and attitude. The findings indicated that oral health knowledge and attitude of occupational health nurses were significantly improved by oral health education. A factor of the improvement of knowledge and attitude was concern for oral health. And they would like to be provided primarily oral health education for occupational health nurses. Finally, this study suggested that oral health education for occupational health nurses had significantly effects on improving oral health knowledge and attitude.

• Journal of the Korea Convergence Society
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• v.8 no.4
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• pp.231-237
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• 2017

This study investigated differences in perception by 240 males in their teens, 20s, 30s, and 40s residing in Seoul, Incheon, and Gwangju about seven items for male makeup, and analyzed makeup items preferred by men, perception about male makeup users, and relationship between success and appearance, thereby providing basic materials to activate the beauty market for males and developing goods for male users. The result was that most males thought the influence of their appearance on their social success was great and in particular, 23.3% of respondents thought that their appearance affected their success by 50% or higher percentage. The items most preferred by the respondents were concealers, color lotions, and BB creams; 60.8% considered them positive. This showed that basic color cosmetics had already been established as one of the essential goods for men. In contrast, the respondents had slightly negative perception about items like mascaras, eyeliners, and eyeshadows. Overall, those who were young, unmarried, and city dwellers had positive perception about such cosmetics by and large. The above data will be able to be used to develop various makeup goods for male consumers oriented toward success and implement diverse marketing strategies, thereby activating the beauty market for males.