• Journal of Korean Physical Therapy Science
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• v.10 no.1
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• pp.190-197
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• 2003

This study was designed to investigate the function of estrogen in related with the effects of the antiestrogen on morphologic changes of efferent ductules of the adult male mouse. Estrogen is synthesized in the male reproductive system and is found in high concentrations in rete and seminal fluids. Adult male mice, 30 days old, were injected subcutaneously with ICI(5mg/mouse) once per week for 8 weeks. Tissues were fixed by vascular perfusion on days 8, 10, 12, 14, 16, 25 and 59 post-treatment. The lumen of efferent ductules began to dilate from the day 8 and continued to the day 59 post-treatment. Epithelial cell height in the efferent ductules of the treated mice decreased all the time periods, compared to the control. Cell height in proximal region of the efferent ductules in the treated groups decreased most by 38%. Supranuclear cytoplasmic height in epithelial cell of the ducts also showed the decrease of 46%, 39% and 33% in proximal, conus and common regions in the treated groups, respectively. ICI 182,780 treatment in the male mouse reproduced a similar morphological abnormalities that were observed in the efferent ductules of the ${\alpha}ERKO$ mouse.

• Journal of Food Hygiene and Safety
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• v.36 no.1
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• pp.77-85
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• 2021

Glucosylceramides (GluCer) are known to play an important role in both water retention and epidermal permeability barrier function in the mammalian stratum corneum. In this study, we investigated the effects of pineapple fruit extract containing glucosylceramides (PFEG) on the maintenance and recovery of skin barrier function using atopic dermatitis-induced animal models. Five-week-old male Hos:HR-1 mice were divided into four groups fed on standard diet, unsaturated fatty acids-deficient (HR-AD) diet, and HR-AD diet supplemented with 0.01% or 0.1% pineapple-GluCer. Skin barrier function was evaluated by transepidermal water loss (TEWL), dermal moisture content, moisture content of the stratum corneum and wrinkle formation. The control group (HR-AD administration group) showed increased transepidermal water loss (TEWL), while the epidermal moisture content and the moisture content of the stratum corneum slowly decreased. However, in the PFEG groups (with 0.1% or 0.01% glucosylceramide), the TEWL levels were significantly reduced at 2 weeks. The PFEG also helped maintain skin moisturizing function by significantly suppressing the decrease of the epidermal moisture content and the moisture content of the stratum corneum. These results show that the PFEG is effective for maintaining and improving the function of the skin barrier. Therefore, this study suggests that PFEG is a potential candidate material for skin functional foods.

• Radiation Oncology Journal
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• v.25 no.4
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• pp.242-248
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• 2007

Purpose: To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model. Materials and Methods: Twenty-four ICR mice were divided into three groups-the normal control group, the no rhEGF group (treatment with cisplatin and radiation) and the rhEGF group (treatment with cisplatin, radiation and rhEGF). A model of mucositis induced by cisplatin and radiotherapy was established by injecting mice with cisplatin (10 mg/kg) on day 1 and with radiation exposure (5 Gy/day) to the head and neck on days $1{\sim}5$. rhEGF was administered subcutaneously on days -1 to 0 (1 mg/kg/day) and on days 3 to 5 (1 mg/kg/day). Evaluation included body weight, oral intake, and histology. Results: For the comparison of the change of body weight between the rhEGF group and the no rhEGF group, a statistically significant difference was observed in the rhEGF group for the 5 days after day 3 of. the experiment. The rhEGF group and no rhEGF group had reduced food intake until day 5 of the experiment, and then the mice demonstrated increased food intake after day 13 of the of experiment. When the histological examination was conducted on day 7 after treatment with cisplatin and radiation, the rhEGF group showed a focal cellular reaction in the epidermal layer of the mucosa, while the no rhEGF group did not show inflammation of the oral mucosa. Conclusion: These findings suggest that rhEGF has a potential to reduce the oral mucositis burden in mice after treatment with cisplatin and radiation. The optimal dose, number and timing of the administration of rhEGF require further investigation.

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.1050-1055
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• 2006

최근 3D 모바일 게임이 이슈가 되고 있다. 휴대폰이 필수품인 시대가 왔고 휴대폰만 있으면 어디서든 게임을 즐길 수 있다는 점 때문에 모바일 게임 산업은 급속도로 발전하고 있다. 그리고 점차 모바일 환경이 하드웨어가 발전하고 3D 가 지원되는 게임 전용폰이 나오면서 모바일 3D 게임이 많이 개발되고 있다. 그러나 휴대폰의 기본 기능은 통화하는 것이니 만큼 PC 에서의 게임이나 플레이스테이션 같은 게임기와는 구조에 차이가 있다. 모바일 환경에서는 휴대폰 버튼만을 사용하여야 한다는 제약이 있다. 그래서 현재 출시된 여거 모바일 게임의 UI 와 기존 PC 게임의 UI 를 비교하고 휴대폰이라는 제한된 환경에서의 도시경영 3D 시뮬레이션 게임을 위한 효율적인 UI 를 만들고자 하였다. 휴대폰에서는 마우스를 사용할 수 없기 때문에 기본적인 게임 조작은 전부 버튼으로 조작할 수 있게 하였다. 그리고 도시경영시뮬레이션 게임이기 때문에 일반 아케이드 게임이나 캐주얼게임에 비해 상대적으로 메뉴가 많고 복잡하다. 그래서 사용자가 설명을 바로 보면서 메뉴를 선택할 수 있도록 메뉴선택은 전부 숫자버튼을 사용하였다. 그리고 사용자가 메뉴를 외우고 있지 않아도 사용가능 하도록 화면 위에 메뉴설명이 같이 나오게 하였다. 사용자는 메뉴별 설명을 보면서 원하는 쪽으로 선택을 하게 된다. 지역설정에서는 마우스의 드래그기능이 안되기 때문에 처음시작점과 끝부분을 선택하여 마우스를 대신하였다.

• Journal of Korea Multimedia Society
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• v.11 no.3
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• pp.373-385
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• 2008

The evolution of input device for computer has pretty much slowed down after the introduction of mouse as feinting input device. Even though stylus and touch screen were invented later on which provide some alternatives, all these methods were designed to have close range interaction with computer. There are not many options available for user to interact with computer from afar, which is especially needed during presentation. Therefore, in this paper, we try to fill the gap by proposing a laser pointer interaction system to allow user to give pointing input command to the computer from some distance away using only laser pointer, which is cheap and readily available. With the combination of image processing based software, we could provide mouse-like pointing interaction with computer. The proposed system works well not only in currently plane screen, but also in flexible screen by incorporating the feature of non-linear coordinate mapping algorithm in our system so that our system can support non-linear environment, such as curved and flexible wall.

• Progress in Medical Physics
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• v.6 no.2
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• pp.93-101
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• 1995

In this paper, we implemented a digital medical image management and a remote monitor display system for a personal computer. The designed system can display up to a 1280${\times}$1024 image which can accomodate eight images with a 256${\times}$256${\times}$8bits. When one of these images is clicked by the mouse, the selected image can be displayed with 256${\times}$256${\times}$8bits or 1024${\times}$1024${\times}$8bits. For the selected image, we can use one of the image processing functions in this system and send it to a remote monitor for the close examinations. To search and store digital images effectively, we constructed and image database management system with the B＋TREE structure. This system can be operated in an IBM-PC 386 or higher and all the function are performed easily with a mouse to provide a user firendly environment.

• KSCI Review
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• v.14 no.2
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• pp.165-174
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• 2006

This paper is a matter of remote control apparatus and display remote control system comprising the same. The remote controller is a wireless remote pointing device that is included a function of mouse and a function of remote controller for VOD etc. It is assembled a sending signal part to communicate with display device, a image sensor part to capture a seen of front view and a main body. Also, it includes a control part that analyzes the captured image, calculates a relative moving factor that main body is moved by user, and then controls the mouse cursor on the display device. The remote control apparatus is able to capture a seen of front view, to analyze the captured image, and to move a mouse cursor point on the display device as much as it calculated relative moving factor. Therefor it brings down the cost of production by a product design that is increased user satisfaction. And it, using the patent and the new product design, will make an epoch in development of the remote control system for Ubiquitous broadcasting industry.

• The Korean Journal of Food And Nutrition
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• v.27 no.4
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• pp.603-608
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• 2014

Pleurotus ostreatus have been used as a traditional remedy and food source. Its anti-inflammatory, anti-oxidation effects have been previously reported. The production of cytokines (IL-$2{\beta}$, IFN-${\gamma}$, and TNF-${\alpha}$) secreted by LPS- and non LPS-stimulated macrophages, were detected by ELISA assay using a cytokine kit. Mouse splenocytes proliferation increased with Pleurotus ostreatus water extracts supplement at 5, 10, 50, 100, 250, 500, $1,000{\mu}g/mL$ after a 48hr pre-treatment with the mitogen (ConA or LPS). The cytokine production (IL-$2{\beta}$, IFN-${\gamma}$, and TNF-${\alpha}$), measured by a cytokine ELISA kit, increased on water extracts supplementation. This in vitro study suggested that supplementation with Pleurotus ostreatus water extracts may enhance the immune function by regulating the splenocyte proliferation and enhancing cytokine production.

• Journal of the Korea Society of Computer and Information
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• v.12 no.2 s.46
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• pp.161-170
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• 2007

This paper is a matter of remote control apparatus and display remote control system comprising the same. The remote controller is a wireless remote pointing device that is included a function of mouse and a function of remote controller for VOD etc. It is assembled a sending signal part to communicate with display device, a image sensor part to capture a scene of front view and a main body. Also, it includes a control part that analyzes the captured image, calculates a relative moving factor that main body is moved by user, and then controls the mouse cursor on the display device. The remote control apparatus is able to capture a seen of front view, to analyze the captured image, and to move a mouse cursor point on the display device as much as it calculated relative moving factor. Therefor it brings don the cost of production by a product desist that is increased user satisfaction. And it, using the patent and the new product desist, will make an epoch in development of the remote control system for Ubiquitous broadcasting industry.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.9
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• pp.1279-1292
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• 2022

This study proposes a non-contact input method based on face recognition and Pyautogui mouse control as a system that can help users who have difficulty using input devices such as conventional mouse due to physical discomfort. This study includes features that help web surfing more conveniently, especially screen zoom, scroll function, and also solves the problem of eye fatigue, which has been suggested as a limitation in existing non-contact input systems. In addition, various set values can be adjusted in consideration of individual physical differences and Internet usage habits. Furthermore, no high-performance CPU or GPU environment is required, and no separate tracker devices or high-performance cameras are required. Through these studies, we intended to contribute to the realization of barrier-free access by increasing the web accessibility of the disabled and the elderly who find it difficult to use web content.