• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.9
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• pp.1249-1255
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• 2015

We examined the effects of selenium-binding peptide from sericin hydrolysates on the bioavailability of selenium-deficient rats. Three-week-old male rats were fed a selenium-deficient diet for 4 weeks while the normal control group was fed a normal diet. The selenium-deficient rats were divided into three groups: no treatment, organic selenium (OS), and inorganic selenium (IS). After selenium supplementation for 4 weeks, the level of serum glutathione reduced form in rats treated with organic selenium was significantly higher than that of inorganic selenium. Selenium retention rate also increased significantly in the organic selenium group compared to the inorganic selenium group [selenium deficient diet (DD)+OS 50.25% vs. DD+IS 17.04%, P<0.05]. In conclusion, binding of selenium to peptides from sericin hydrolysates seems to improve its bioavailability, and can hasten a cure for selenium deficiency in experimental rats.

• Journal of Practical Agriculture & Fisheries Research
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• v.4 no.1
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• pp.89-109
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• 2002

필수 미량원소인 셀레늄은 인간의 건강에 기본적으로 중요한 역할을 하는 물질이다. 항산화 관여 효소의 작용과 구조역할을 담당하는 셀레늄이 함유된 단백질(selenoproteins)은 항산화 기능이 있을 뿐만 아니라, 갑상선호르몬의 활성화에 관여하는 것으로 밝혀졌다. 또한, 셀레늄은 정상적인 면역체계의 유지에 필요하며, HIV(human immunodeficiency virus)가 진행되어 AIDS로 발전되는 것을 억제하는 작용이 있다는 사실도 밝혀지고 있으며, 정자의 생성과 운동성에 관계하기도 한다. 우울증 환자가 셀레늄을 섭취하게 되면 효과가 있으며, 셀레늄이 순환계질환의 발생을 억제하는 것으로 알려지고 있다. 특히 최근에는 셀레늄의 섭취가 암발생을 예방할 수 있다는 역학조사결과를 토대로, 대규모 셀레늄 임상실험이 다국적 연구의 형태로 2개의 프로젝트(PRECISE, SELECT)가 수행 중이다. 한편, 셀레늄의 항암효과에 대한 세포수준에서의 연구가 활발하게 이루어지고 있으며, 어느 정도 가시적인 결과를 보이고 있다. 따라서, 셀레늄에 대한 재평가가 우리 나라에서도 이루어져야 한다. 그러기 위해서는 지역별로 셀레늄의 정확한 섭취량조차도 파악되어 있지 않을 뿐만 아니라 일일권장량 값조차 정확하지 않은 현실을 볼 때, 셀레늄의 기본적 연구에 대한 관심을 가져야 할 때라고 판단된다.

• Journal of Nutrition and Health
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• v.26 no.7
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• pp.899-906
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• 1993

Human blood selenicum(Se) level depends on the Se content and bioavailablilty of foods. In countries where the soil has low Se content, the differences of Se intake and blood Se concentration are shown according to the type of diet. In this study, Se status of women eating an average German diet(175 German healthy women) and wholesome nutrition group(243 women) were studied. There were significant differences in wholeblood and plasma Se levels between the two groups. In average German diet group, mean wholeblood Se concentration was 84.97ug/l and plasma Se concentration was 75.02ug/l. In wholesome nutrition group mean wholeblood Se concentration and plasma Se concentration with Se levels, correlation analysis was conducted between Se concentration and BMI, age and daily food intake. BMI and age did not correlate significantly with wholeblood and plasma Se levels. In wholesome nutrition group, serum and wholeblood Se levels had significant correlation with fish intake.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2006.04a
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• pp.255-258
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• 2006

인위적인 오염원이 존재하지 않는 농촌지역 지하수공에서 검출빈도가 매우 낮은 세레늄 성분에 대하여 양수조건에 따른 세레늄의 농도변화를 연구하였다. 양수에 따른 세레늄 농도변화의 연구는 현장지하수 수질이 지하수 먹는물 수질기준보다. 높은 2개의 지하수공에서 수행되었다. 본 연구를 통해, 세레늄 성분이 먹는물 수질기준을 초과한 지하수공의 지속적인 이용여부를 판단하였다. 또한, 양수시험공 주변의 세레늄 농도를 측정하여 배경농도를 파악하였으며, 시험공 내에서 구간별 채수를 수행하여 세레늄 성분이 산출되는 주대수층 구간을 파악하였다. 양수조건에 따른 세레늄의 농도변화를 연구하기 위한 방법은 하루 8시간을 기준으로 양수하는 단기적인 방법과, $4,950m^3$을 594시간 동안 장기양수하면서 농도변화를 측정하였다. 본 연구를 통해, 지하수 내 세레늄 성분의 농도변화는 장기양수에 의해 변화함을 알 수 있었다.

• Journal of Practical Agriculture & Fisheries Research
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• v.7 no.1
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• pp.118-130
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• 2005

This study was conducted to evaluate the spent composts of selenium-enriched mushrooms as a feed selenium Source. Total selenium (Se) contents and Se profiles in the spent mushroom composts (SMC) were determined. In addtion, we also investigated the metabolism in relation to Se accumulation in the mushroom. Mushrooms used in this study were Flammulina velutipes and Se enriched mushrooms were grown for 60 days by adding 2 mg of inorganic Se (Na₂SeO₃) per kg of mushroom composts (MC) on as-fed basis and it was compared with mushrooms not to add Se to the MC. Total Se contents for Se-treated mushrooms were significantly increased (P<0.0001) by 20-fold (4.51 ㎍/g of dry) compared to Se-untreated (0.23 ㎍/g of dry). On the contrary, organic Se proportion was significantly lower (P<0.0001) in the Se-treated mushroom (72.3%) than Se-untreated (100%, not analytically detected of inorganic Se). Se distribution upon a length in the Se-treated mushrooms was the highest in the bottom part (6.86 ㎍/g of dry) near to MC, and top and middle parts were significantly lower (3.71 and 3.01 ㎍/g of dry, respectively) than the bottom (P<0.001). In the SMC from Se-treated mushrooms, a high concentration of Se (5.04 ㎍/g of dry) was still remained, but that from Se-untreated mushrooms was significantly low (P<0.0001) as 0.08 ㎍/g of dry. Se-treated SMC showed a high rate of organic Se (65.67%), suggesting that most of inorganic Se in the SMC was converted to organic Se by mushroom mycelia, and Se-untreated SMC showed 100% of organic Se, not being detected of inorganic Se. Prior to mycelia inoculation in the mushroom culture, the sterilization of MC brought approximately 18% of Se loss in the MC. This result is in accordance with facts generally known that Se is weak in the high temperature and it is consequently volatilized under that condition. Apparent and net accumulation rates (%) for Se into mushrooms were 14.81 and 10.14%, respectively and their difference (4.67%) is considered that it is due to the volatilization into the air via metabolic process of mushroom itself. From the result of this study, inorganic Se addition to MC for mushroom improved the Se content in the mushroom and SMC from Se-enriched mushrooms contained a high concentration of Se. Mycelium and fruiting body from mushrooms converted inorganic Se in MC to organic Se, indicating a high proportion of organic Se in the mushroom and SMC. Therefore, Se in Se-enriched mushroom and SMC was recognized as Se sources of food for human as well as feed for livestock.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2014.11a
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• pp.84-85
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• 2014

레늄미량함유 염산용액중에서 추출제로 Alamine304-1(Henkel), Cyanex272(Daihachi)와 $D_2EHPA(Henkel)$를 사용하여 용매추출공정으로 레늄의 추출거동을 조사하였다. 수상에 존재하는 레늄은 60 ppm이며, Kerosine과 추출제를 혼합한 합성용액을 사용하였다. 레늄 회수의 최적조건을 조사하기 위해 추출제의 종류 및 농도, 수상과 유기상의 상비, HCl의 농도, 불순물 분리 실험 등을 진행하였다. 수상의 pH가 2 이하이고, 상비는 1:1로 하여 1 % Alamine304-1으로 10분간 반응시킨 후 상온에서 1시간 이상 정치시켰을 때 레늄의 추출율이 99 % 이상으로 가장 우수하였으며, Cyanex272와 D2EHPA를 사용한 경우에는 레늄의 거의 추출되지 않았다.

• Journal of Nutrition and Health
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• v.55 no.4
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• pp.430-440
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• 2022

Selenium is an important trace mineral that plays an essential role in maintaining the body's immunity with oxidative stress defense and antioxidant activity, immunity, thyroid hormone control, defense against drug or heavy metal harm, and reducing the risk of chronic diseases. A selenium deficiency increases the risk of various chronic diseases, such as cancer, cardiovascular disease, diabetes, neurological disease, osteoarthritis, muscle necrosis and weakness, thyroid disease, and inflammatory diseases. This paper explains the criteria for establishing and revising selenium in the 2020 Dietary Reference Intake for Koreans (KDRIs) and reviews the current status of the selenium database and suggestions for setting the 2025 KDRIs in the future. In the 2020 KDRIs, the selenium intake with the maximum plasma selenoprotein P level was used as the criteria. The weight and coefficient of the variation were applied to the Chinese' reported values. Compared to 2015 KDRIs, there were some revisions in the selenium dietary reference intakes by gender and age according to the change in reference weight. To improve and revise selenium dietary reference intakes in the future, a selenium intervention study is needed to determine the maximum level of plasma selenoprotein P in Koreans. In addition, a revision of the selenium database of the nutritional assessment program (CAN-Pro 5.0) is needed. An analysis of the selenium content of foods should be expanded to assess the selenium intake accurately. In addition, research on the relationship between selenium intake and the biological indicators in the body is required for healthy people and subjects of special environments, such as patients and athletes with various oxidative stress.

• Journal of The Korean Society of Grassland and Forage Science
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• v.33 no.4
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• pp.281-289
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• 2013

This study was conducted to investigate the effects of feeding seleniferous whole crop barley silage (WCBS) on the growth performance, blood and carcass characteristics, and tissue selenium deposition infinishing Hanwoo steers. A total of 20 growing Hanwoo steers were selected and assigned to one of the following feed groups: control (0.1 ppm Se), T1 (0.3 ppm Se), T2 (0.9 ppm Se), and T3 (0.9 ppm of inorganic Se). Five steers were allocated to each treatment group, and the trial lasted for 90 days. All experimental diets combined seleniferous and/or non-seleniferous WCBS up to a ratio of 30%. For the T3 diet, 0.9 ppm Se in the form of sodium selenite was added to the control diet. Dietary level and type of selenium did not affect feed intake and body weight gain. Blood total lipid and triglyceride concentrations were significantly (p<0.05) lower in the T2 group than in control. Blood immunoglobulin G concentration increased significantly (p<0.05) with increasing levels of dietary selenium; concentrations were significantly (p<0.05) higher in T2 and T3 than in control. Blood selenium concentration was the highest (p<0.05) in T2. No significant difference was observed in dressing rate, ribeye area, marbling score, meat color and fat color. Further, no association was found between levels and chemical form of dietary selenium and quality and quantity of meat. To the contrary, tissue selenium content in kidney, liver, and hind leg increased significantly (p<0.05) with increasing levels of selenium; however, feeding inorganic selenium did not introduce a significant increase in tissue selenium content of finishing Hanwoo steers. The results indicated that the selenium present in seleniferous WCBS was an effectively absorbable selenium source, suitable for increasing tissue selenium content in beef. Approximately 100 g of hind leg muscle from steers fed on the T2 diet met approximately 69% of the recommended daily selenium requirements.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.73-77
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• 2004

Selenium containing peptide was produced by culturing yeast with selenium, Selenium was broadly incorporated in the various size of proteins based on the GPC analysis of the total yeast protein. The ratio of selenium to protein increased with the concentration of added selenium in the culture medium. Antioxidant activity (glutathione peroxidase-like activity) was proportional to the concentration of selenium concentration in the peptide. Different size of proteins were obtained by hydrolyzing the total yeast protein by protease XIV. Average molecular weight of selenium peptide was analyzed by GPC. Glutathione peroxidase (GPx) activity of the selenium peptide increased as the size of peptide decreased. Sodium selenite had strong inhibition on the yeast growth than sodium selenate. The ratio of selenium to protein was higher with sodium selenate than with sodium selenite. These results showed the potentials of selenium peptide production by yeast cultivation.

• Korean Journal of Organic Agriculture
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• v.18 no.4
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• pp.541-548
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• 2010

This study was established on which the selenium (Se), known as one of the functional elements in the human body, treatment was the most effective for the Se uptake in the soil and tree. Se treatments included foliar application, soil fertigation, and trunk injection. Se fertigation and control had similar soil $P_2O_5$, K, and Mg concentrations, and calcium and Se concentrations in the soil were greater on the control and Se fertigation, respectively. Leaf characteristics were not different among the treated trees. No differences were observed for the leaf K and Ca concentrations among the treated trees, and foliar Mg was greater on the Se treated trees than the control. Se foliar application and trunk injection had greater Se concentrations in the leaves and fruits than the Se fertigation and control.