• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.17-26
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• 2019

In order to study the role of legato to singers in vocal music performance, this paper adopts the methods of demonstration and induction and comparison to analyze the three factors affecting the creation of legato in performance and propose solutions. When thinking about the influence of singing skills on legato, singers will be able to solve such issues as breathing, articulation and vocal register, thus improving their singing skills. When thinking about the influence of singing language on legato, singers will make an in-depth study on the phonetic and structural features of the language to reach legato in language, thus promoting the in-depth study of singers on the singing language. When thinking about the influence of singing emotion on legato, singers will solve the problem of emotional coherence from two aspects of thought and emotion to create legato of emotion, thus promoting the expression of singers' emotion in the work. Obviously, legato plays an important role in improving singers' singing skills, singing language and singing emotion. The aim of the paper is to encourage singers to further deepen their attention to legato in vocal music performance and make better use of legato in singing.

• The Korean Journal of Pharmacology
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• v.19 no.2
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• pp.25-34
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• 1983

In this isolated study, it was aimed to elucidate the pharmacological properties of non-cholinergic, non-adrenergic inhibitory responses in the longitudinal strips of rabbit portal vein. 1) The portal vein responded inhibitory to electrical field stimulation in a frequency - and calcium-dependent manner after pretreatment with atropine, guanethidine and ergotamine, simultaneously. 2) When exogenous ATP, ADP, adenosine and cyclic AMP were added, respectively, they only showed the relaxations in the higher concentration without mimicing or affecting the inhibitory response induced by the electrical stimulation. The antagonist of purine substances, neither quinine nor isobutyl-methyl xanthine did influence on the relaxation. 3) The inhibitory response was significantly increased in the presence of $1{\mu}g/ml 4-amino-pyrineine (4-AP) which is $K^+-conduction$ blockade, but higher concentration of 4-AP directly decreased the vascular tone. 4) Though repeated application of ATP revealed the inhibitory effect on the relaxation, however, that of adenosine resulted rather increase of the amplitude. 5) After pretreatment with $^3H-adenosine$, $^3H-efflux$ induced by ATP or adenosine was markedly enhanced, but the electrical stimulation caused less $^3H-efflux$. 6) ^3H-efflux by electrical stimulation was not affected by the administration 4-AP, tetrodotoxin and adenosine.

• Journal of Pharmaceutical Investigation
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• v.26 no.4
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• pp.315-321
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• 1996

It has been indicated that problems associated with insulin iontophoresis are low bioavailability, slow absorption rate and the use of high dosage. Pretreatment of skin as a method of solving these problems was used in alloxan-induced diabetic white rabbits. Skins were treated with skin needle, electric razor, knife razor and scotch tape. Transport data shows that insulin delivery was enhanced significantly by the treatment which disrupt the barrier properties of stratum corneum. The data also shows that insulin absorption lasted for several hours after the cessation of iontophoresis. The degree of skin treatment was estimated by measuring the electrical resistance of skin. When the skins were treated with skin needle and electric razor, the standard deviations of resistance were small, which suggests the possibility of uniform delivery of insulin. The dermal responses after the invasive delivery were evaluated in accordance with OECD Guideline. It seems that electrical resistance of the skin correlate well with the dermal irritation.