The Korean Journal of Pharmacology (대한약리학회지)
- Volume 19 Issue 2
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- Pages.25-34
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- 1983
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- 0377-9459(pISSN)
Pharmacological Characteristics of Non-cholinergic, Non-adrenergic Inhibitory Responses in Rabbit Portal Vein
가토 문맥에 있어서 비 코린성, 비 아드레나린성 억제성 반응에 관한 약리학적 특징
- Jung, Hyun-Ok (Department of Pharmacology, College of Medicine, Busan National University) ;
- Hong, Ki-Whan (Department of Pharmacology, College of Medicine, Busan National University)
- Published : 1983.12.30
Abstract
In this isolated study, it was aimed to elucidate the pharmacological properties of non-cholinergic, non-adrenergic inhibitory responses in the longitudinal strips of rabbit portal vein. 1) The portal vein responded inhibitory to electrical field stimulation in a frequency - and calcium-dependent manner after pretreatment with atropine, guanethidine and ergotamine, simultaneously. 2) When exogenous ATP, ADP, adenosine and cyclic AMP were added, respectively, they only showed the relaxations in the higher concentration without mimicing or affecting the inhibitory response induced by the electrical stimulation. The antagonist of purine substances, neither quinine nor isobutyl-methyl xanthine did influence on the relaxation. 3) The inhibitory response was significantly increased in the presence of
가토의 문맥 절편에서 비 코린성-비 아드레나린성 이완반응에 대한 약리학적 성질을 규명하여 다음과 같은 결과를 얻었다. 1) 가토 문맥 절편에 있어서 비 코린성-비 아드레나린성 전기자극반응은 자극빈도의 증가에 따라 예민하게 증가하였으며,
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