• Journal of Life Science
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• v.28 no.8
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• pp.931-937
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• 2018

Triptolide is a compound found in Tripterygium wilfordii and reported to have an anti-inflammatory and anti-oxidant activities. A previous study shows that the dietary supplementation with triptolide increases resistance to environmental stressors, including oxidative stress, heat shock, and ultraviolet irradiation, and extends lifespan in C. elegans. Here, we investigated the underlying mechanisms involved in the lifespan-extending effect of triptolide. The effect of triptolide on age-related diseases, such as diabetes mellitus and Alzheimer's disease, was also examined using animal disease models. The longevity phenotype conferred by triptolide was not observed in the eat-2 mutant, a well-known genetic model of dietary restriction, while there was an additional lifespan extension with triptolide in age-1 and clk-1 mutants. The long lifespan of age-1 mutant is resulted from a reduced insulin/IGF-1-like signaling and the clk-1 mutant lives longer than wild-type due to dysfunction of mitochondrial electron transport chain reaction. The effect of dietary restriction using bacterial dilution on lifespan also overlapped with that of triptolide. The toxicity of high glucose diet or transgenic human amyloid beta gene was significantly suppressed by the supplementation with triptolide. These findings suggest that triptolide can mimic the effect of dietary restriction on lifespan and onset of age-related diseases. We conclude that triptolide can be a strong candidate for the development of dietary restriction mimetics.

• The KIPS Transactions:PartA
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• v.13A no.1 s.98
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• pp.27-34
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• 2006

Designers should know CAD tool/license information such as available number of licenses or tools, types, and configuration methods to use CAD tools properly in their group. Usually, this information is provided by managers who administrate CAD tool and license servers in the specific design group. In the previous CAD tool/licenses sharing methods, designers have to get CAD tool/license information manually and setup the environments with their own hands. n a new designer comes into the design working group, the designer wastes unnecessary design time, because of these processes. As a result, designer's poductivity and utilization of CAD tools will decrease Besides, managers also waste their time and effort, since they should provide CAD tool/license information manually to each designer. In this paper, we present an automated scheme to share CAD tool/license information based on directory service. The proposed methods automate the communication processes between managers and designers that minimze unnecessary time to share CAD information. In addition, as this system maintains the consistency of CAD information automatically that remove the repeated work of managers and designers, it improves the enciency of sharing. Besides, it automates the license configuration steps using prof(y Last, we offer Executable Proxy which is proper for thin CAD application. We believe this scheme will reduce designers and managers' time and effort as well as maximize the utilization of CAD tools.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.43 no.3 s.309
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• pp.76-83
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• 2006

A main objective of audio equalizer is for user to tailor acoustic frequency response to increase sound comfort and example applications of audio equalizer includes large-scale audio system to portable audio such as mobile MP3 player. Up to now, all the audio equalizer requires manual setting to equalize frequency bands to create suitable sound quality for each genre of music. In this paper, we propose an intelligent audio graphic equalizer system that automatically classifies the music genre using music content analysis and then the music sound is boosted with the given frequency gains according to the classified musical genre when playback. In order to reproduce comfort sound, the musical genre is determined based on two-step hierarchical algorithm - coarse-level and fine-level classification. It can prevent annoying sound reproduction due to the sudden change of the equalizer gains at the beginning of the music playback. Each stage of the music classification experiments shows at least 80% of success with complete genre classification and equalizer operation within 2 sec. Simple S/W graphical user interface of 3-band automatic equalizer is implemented using visual C on personal computer.

• Korean Journal of Microbiology
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• v.44 no.4
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• pp.271-276
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• 2008

Ribosome stalling by nascent sticky peptide has been reported in several organisms across the kingdom. To test whether small subunit (SSU) rRNA is involved in this phenomenon, we developed a genetic system that utilized the specialized ribosome system to isolate SSU rRNA mutants that enable ribosomes to bypass the SecM-derived sticky peptide in protein synthesis. In this system, CAT-SecM mRNA, which encodes CAT protein containing the sticky peptide derived from SecM, is only translated by specialized ribosomes. These ribosomes were shown to transiently stall on CAT-SecM mRNA followed by the synthesis of the sticky peptide. Expression of specialized ribosomes resulted in the decreased steady-state level of CAT-SecM mRNA, which is consistent with a notion that ribosome stalling induces mRNA degradation. Isolation and characterization of SSU rRNA mutations using this genetic system that are sufficient to circumvent ribosome stalling induced by the SecM-derived sticky peptide will provide evidence of SSU rRNA function in mRNA cleavage.

• Journal of Life Science
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• v.31 no.5
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• pp.527-535
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• 2021

Lysosomes are organelles surrounded by membranes that contain acid hydrolases; they degrade proteins, macromolecules, and lipids. According to nutrient conditions, lysosomes act as signaling hubs that regulate intracellular signaling pathways and are involved in the homeostasis of cells. Therefore, the lysosomal dysfunction occurs in various diseases, such as lysosomal storage disease, neurodegenerative diseases, and cancers. Multiple forms of stress can increase lysosomal membrane permeabilization (LMP), resulting in the induction of lysosome-mediated cell death through the release of lysosomal enzymes, including cathepsin, into the cytosol. Here we review the molecular mechanisms of LMP-mediated cell death and the enhancement of sensitivity to anticancer drugs. Induction of partial LMP increases apoptosis by releasing some cathepsins, whereas massive LMP and rupture induce non-apoptotic cell death through release of many cathepsins and generation of ROS and iron. Cancer cells have many drug-accumulating lysosomes that are more resistant to lysosome-sequestered drugs, suggesting a model of drug-induced lysosome-mediated chemoresistance. Lysosomal sequestration of hydrophobic weak base anticancer drugs can have a significant impact on their subcellular distribution. Lysosome membrane damage by LMP can overcome resistance to anticancer drugs by freeing captured hydrophobic weak base drugs from lysosomes. Therefore, LMP inducers or lysosomotropic agents can regulate lysosomal integrity and are novel strategies for cancer therapy.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.24 no.1
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• pp.139-145
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• 2006

The advantage of the lidar data is in fast acquisition and process time as well as in high accuracy and high point density. However lidar data itself is difficult to classify the earth surface because lidar data is in the form of irregularly distributed point clouds. In this study, we investigated land cover classification using both lidar data and optical image through a supervised classification method. Firstly, we generated 1m grid DSM and DEM image and then nDSM was produced by using DSM and DEM. In addition, we had made intensity image using the intensity value of lidar data. As for optical images, the red, blue, green band of CCD image are used. Moreover, a NDVI image using a red band of the CCD image and infrared band of IKONOS image is generated. The experimental results showed that land cover classification with lidar data and optical image together could reach to the accuracy of 74.0%. To improve classification accuracy, we further performed re-classification of shadow area and water body as well as forest and building area. The final classification accuracy was 81.8%.

• Journal of Adhesion and Interface
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• v.10 no.2
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• pp.106-112
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• 2009

In the present work, novel biocomposites made with biodegradable Lyocell woven fabrics and poly (butylene succinate) were successfully fabricated for the first time. Lyocell/poly(butylene succinate) biocomposites with different fiber loadings of 0, 30, 40, 50 and 60 wt% were prepared by compression molding with a sheet interleaving manner. The effect of Lyocell fabric loading on the interlaminar shear strength, tensile and flexural properties, heat deflection temperature, thermal expansion behavior, and thermal stability of the biocomposites was investigated. The properties strongly depended on the fabric loading and the results were consistent with each other. It was demonstrated that the Lyocell fabrics played a remarkable role in improving the properties of poly(butylene succinate) resin by incorporating the fabrics into the resin. The greatest inter-laminar, tensile, flexural and thermal properties of the biocomposites were obtained with Lyocell fabrics of 50% by weight.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.3
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• pp.189-197
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• 2016

This study is aimed at providing basic data necessary for promoting consumption of professional sports licensing in the industry through service quality. Specifically, the current study examines the effects of service quality and licensing product intentions on professional sports and evaluates the moderating identity. For this study, we distributed a total of 480 questionnaires to those sampled through non-probability sampling from people living in small and medium cities including Seoul. Collected data were coded and entered into the computer, and statistically processed using SPSS Statistics 18 The results were as follow: First, service quality of professional sports significantly effect on licensing product intentions, but identity could not effect on licensing product intentions. Second, Identity as a moderating variable has significantly positive effect on the relationship between star player of service quality and Licensing Product Intentions. In conclusion, the companies that participate as title sponsors in professional sports were proven to promotion their licensing product intentions, as identified with sports fans through service quality of professional sports such as record, attractiveness, star player and locally affiliated.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.1
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• pp.751-760
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• 2009

This research aims to develop the strategy and method to enhance the reliability of image matching results and improve the efficiency of the matching process by utilizing LIDAR data in the main image matching processes. In this work, we present the methods to utilize LIDAR data in the selection of matching entities, the search for the matched entities and the evaluation of the matching results. The proposed method has been applied to medium-resolution digital aerial images and LIDAR data acquired at the same time. The results have been analyzed in comparison with an existing method using a virtual horizontal surface rather than LIDAR DEM. This analysis indicates that the proposed method can show significantly more improved performance than the existing method. The results of this study can contribute to the improvement of the currently available commercial image matching software and the enhancement of the DEM derived from LIDAR data and matching results.

• The Journal of the Korea Contents Association
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• v.17 no.2
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• pp.219-229
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• 2017

The purpose of this study is to clarify the changes of life skills of elementary school students who practice kumdo. For this, 579 elementary school students were studied, and exploratory factor analysis, reliability test, and confirmatory factor analysis were conducted. After that, we conceptualized the life skills of elementary school students who practice kumdo. Based on these results, one-way MANOVA was conducted to analyze the difference in life skills perceived by elementary school students according to sex and career. The results are as follows. First, the elementary school students' life skill developed through the kumdo training showed four factors: personality, social skills, problem solving skills, and health care. Second, there was no gender difference of life skill according to the kumdo training, and there were differences in social skill and health care depending on the experience of kumdo training. In addition, life skill factors influencing daily life satisfaction of elementary school students practicing kumdo were social skills, problem solving skills, and character.