• Journal of the Korean Society of Radiology
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• v.10 no.2
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• pp.139-144
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• 2016

The study of radiation-hazard in the human skin tissue is carried out by direct irradiating to experimental animals. The influences of a radiation to the animal's skin tissue are analyzed from this experiment. However, this also accompanies losses in terms of both time and economy. In this study, we simulated human tissue by using a swine skin tissue. The depth of the swine skin tissue for the experiment is determined, and the amount of the direct radiation below this skin depth is analyzed numerically. The amount of the radiation occurred by exposure below the skin tissue can be inferred. Moreover, it is possible to use only cells effectively and animal experiments to analyze the body-hazard by radiation.

• The Korea Swine Journal
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• v.12 no.2 s.126
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• pp.130-134
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• 1990

돼지의 피부질환은 발생후의 치료보다는 예방에 힘써야 한다. 피부병 예방을 위해서는 규칙적인 돈사소독과 청소, 적절한 보온과 환기, 여름철의 습기제거와 적당한 일광욕을 실시해 주는 것이 좋다.

• Journal of Radiation Protection and Research
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• v.40 no.1
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• pp.65-72
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• 2015

The basic concepts of radiation-induced skin damage have been established, the biological mechanism has not been studied. In this study, we have examined the effects of gamma rays on skin injury and cyclooxygenase(COX)-2 expression. Gamma irradiation induced clinicopathological changes in a dose- and time-dependent manner in mini-pig skin. The histological changes were consistent with the changes in gross appearance at 12 weeks after irradiation. After three days' irradiation, apoptotic cells in the basal layer were found more frequently in irradiated skin than in normal skin, with the magnitude of the effect being dose-dependent. The thickness of the epidermis transiently increased 3 days after irradiation, and then gradually decreased, although changes in the epithelial thickness of the irradiated field were not observed with irradiation doses over 50 Gy. In the epithelium, there was an initial degenerative phase, during which the rate of basal cell depletion was dependent on the radiation dose (20-70 Gy). One week after irradiation, COX-2 expression was mostly limited to the basal cell layer and was scattered across these cells. High COX-2 expression was detected throughout the full depth of the skin after irradiation. The COX-2 protein is upregulated after irradiation in mini-pig skin. These histological changes associated with radiation exposure dose cause the increased COX-2 expression in a dose-dependent fashion.

• Korean Journal of Clinical Pharmacy
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• v.13 no.2
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• pp.97-105
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• 2003

아스코마이신(ascomycin)의 macrolactam 유도체인 피메크로리무스(pimecrolimus; 엘리델 [Elidel], SDZ ASM 981; Novartis Pharma AG, 바젤, 스위스)는 세포선택성을 지닌 염증성 사이토카인(cytokines) 억제제로서 아토피피부염, 알레르기성 접촉피부염, 자극성 접촉피부염 및 판형 건선 등 염증성 피부질환의 치료제로 개발되었다. T세포와 비만세포의 염증성 사이토카인 생산 분비를 억제하고 사전 형성된 염증성 매개물질의 비만 세포 분비를 저해한다. 국소 투여된 피메크로리무스는 알레르기성 접촉피부염(allergic contact dermatitis [ACD]) 돼지 모델에서 고역가 코르티코스테로이드 클로베타졸-17-propionate(corticosteroid clobetasol-17-propionate)와 동등한 효과를 나타낸다. 하지만 피메크로리무스는 클로베타졸과는 달리 피부 위축을 일으키지 않는다. 경구 투여시 피메크로리무스는 마우스와 랫트 ACD 치료에 있어서 타크로림무스(tacrolimus [FK 506])와 동등한 혹은 더 우수한 효과를 나타낸다. 또한 피메크로리무스는 아토피피부염 급성 징후 유사 모델인 저마그네슘 혈증 탈모 랫트(hypomagnesemic hairless rat)의 피부 염증과 소양증을 효과적으로 감소시킨다. 피메크로리무스는 랫트에서 다음과 같은 측면의 전신 면역반응 손상 효과가 타크로리무스 와 비교하여 낮게 평가된다: (1)국소 이식편대 숙주 반응, (2)양(sheep) 적혈구에 대한 항체 형성, (3)신장이식. 시험관내 평가시 돼지 피부를 통한 피메크로리무스 투과 속도가 타크로리무스보다 10배 낮게 측정되므로 생체에서 경피 흡수가 더 적게 될 것으로 판단된다. 상기 자료로 판단컨대 피메크로 리무스는 피부에 대한 항염증 활성이 높을 뿐 아니라 전신 면역반응 손상 부작용이 낮은것으로 사료된다.

• The Korea Swine Journal
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• v.14 no.10 s.158
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• pp.152-155
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• 1992

• The Korea Swine Journal
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• v.15 no.10 s.170
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• pp.132-135
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• 1993

• 대한방사선방어학회:학술대회논문집
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• 2011.04a
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• pp.74-75
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• 2011

• Journal of the korean veterinary medical association
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• v.14 no.2
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• pp.113-116
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• 1978

• Tribology and Lubricants
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• v.30 no.1
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• pp.36-45
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• 2014

Understanding steel/skin contact phenomena is important for the study of object manipulation in robotics and has been a topic of great interest. In this study, pig skin was taken as a surrogate model for human skin, and its adhesive, friction, and deformation behaviors were measured under various exposure times to air. Indentation, friction, and scratch tests were performed at $25^{\circ}C$ and 45% relative humidity. The influences of adhesion and deformation on the coefficient of friction were characterized; the pig skin was found to be sensitive to the sliding velocity and normal load under the controlled experimental conditions.

• Analytical Science and Technology
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• v.21 no.3
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• pp.222-228
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• 2008

On living skin the chances of a successfully developing latent fingerprint are very limited. This is due to the fact that continual perspiration and rapid absorption diffuse into the lipophillic layer on skin. A study was conducted to investigate effectively developing method of latent fingerprints on human skin surfaces and pig skin likely corpse's skin. We used commercial fingerprint powder, black powders, black magnetic powder, fluorescence magnetic powder, Cyanoacrylate fuming (CA) and direct lifting methods (lifting paper, glasses and photo glossy paper). Developing of fresh fingerprints on living skin was achieved with S-powderblack, CA fuming and CA fuming following S-powder, fluorescence powder. The other powder tends to overwhelm the latent print and the background. But, latent fingerprint residue was disappeared with time after deposit on a living surface. In case of pig skin likely corpse's skin, latent fingerprint detection was achieved with CA fuming following S-powder and deposited print during 6 hr at $25^{\circ}C$, 40% relative moisture yielded excellent fingerprints with clear ridge details using 1 min CA fuming. And enhancement of fingerprint detection image using forensic light source was achieved.