• Journal of Nutrition and Health
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• v.52 no.2
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• pp.129-138
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• 2019

Purpose: Medicinal herbs have recently attracted attention as health beneficial foods and source materials for drug development. Recent studies have demonstrated that extracts of Lycium's fruits and roots have a range of physiologically active substances. The extract of Lycium's leaves has been reported to have excellent anti-oxidant and anti-microbial activity, but its anti-inflammatory efficacy is not known. The chlorophyll present in the leaves can act as an anti-oxidant or pro-oxidant depending on the presence of light. Therefore, this study analyzed the anti-inflammatory effects of Lycium's fruit extract (LFE), leaf extract (LLE), and leaf extract with chlorophyll removal (LLE with CR). Methods: This study examined the inhibitory effects of LFE, LLE, and LLE with CR on pro-inflammatory mediator production as well as on the expression of iNOS and COX-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and BALB/c mice. Results: LFE, LLE, and LLE with CR inhibited the production of pro-inflammatory mediators (NO, $TNF-{\alpha}$, IL-6, and $IL-1{\beta}$) and the expression of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells in a dose-dependent manner. Furthermore, the administration of LLE and LLE with CR inhibited the serum pro-inflammatory cytokine levels and suppressed DNA damage in BALB/c mice. In particular, LLE with CR exhibited the highest anti-inflammatory activity. Conclusion: These results suggest that the fruit and leaves of Lycium are potential therapeutic agents against inflammation.

• Korean Journal of Environment and Ecology
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• v.33 no.1
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• pp.9-15
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• 2019

Artiodactyla, which is an even-toed mammal, widely inhabits worldwide. In recent years, wild Artiodactyla species have attracted public attention due to the rapid increase of crop damage and road-kill caused by wild Artiodactyla such as water deer and wild boar and the decrease of some species such as long-tailed goral and musk deer. In spite of such public attention, however, there have been few studies on Artiodactyla in Korea, and no studies have focused on the trend analysis of Artiodactyla, making it difficult to understand actual problems. Many recent studies on trend used text-mining and co-occurrence analysis to increase objectivity in the classification of research subjects by extracting keywords appearing in literature and quantifying relevance between words. In this study, we analyzed texts from research articles of three countries (Korea, China, and Japan) through text-mining and co-occurrence analysis and compared the research subjects in each country. We extracted 199 words from 665 articles related to Artiodactyla of three countries through text-mining. Three word-clusters were formed as a result of co-occurrence analysis on extracted words. We determined that cluster1 was related to "habitat condition and ecology", cluster2 was related to "disease" and cluster3 was related to "conservation genetics and molecular ecology". The results of comparing the rates of occurrence of each word clusters in each country showed that they were relatively even in China and Japan whereas Korea had a prevailing rate (69%) of cluster2 related to "disease". In the regression analysis on the number of words per year in each cluster, the number of words in both China and Japan increased evenly by year in each cluster while the rate of increase of cluster2 was five times more than the other clusters in Korea. The results indicate that Korean researches on Artiodactyla tended to focus on diseases more than those in China and Japan, and few researchers considered other subjects including habitat characteristics, behavior and molecular ecology. In order to control the damage caused by Artiodactyla and to establish a reasonable policy for the protection of endangered species, it is necessary to accumulate basic ecological data by conducting researches on wild Artiodactyla more.

• Korean Journal of Food Science and Technology
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• v.45 no.5
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• pp.661-665
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• 2013

The aim of this study was to investigate the anti-amnesic effect of daebo (Castanea crenata) extract on trimethyltin chloride (TMT)-induced learning and memory impairment, in vivo. The inner skin of daebo was extracted using distilled water under reflux conditions. At the end of the adaptation period, ICR mice were divided into a control group, a TMT injection group (negative control), and a sample group (C5: 5 mg/kg body weight; C10: 10 mg/kg body weight; and C20: 20 mg/kg body weight), and were tested with learning and memory tests. The ethylacetate fraction of the daebo inner skin extract was found to increase TMT-induced memory deficit in the Y-maze and passive avoidance test. Brain tissue analysis showed that the ethylacetate fraction of daebo extract lowered the acetylcholine esterase (AChE) activity and malondialdehyde (MDA) content of neuronal cells, both of which are indicative of lipid peroxidation.

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2006.09a
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• pp.39-44
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• 2006

국제적으로 생물다양성 협약('92. 6) 및 생물다양성 협약총회('02. 4)에서 생물자원의 국가소유 권리 인정 후 생물주권 확보를 위한 국가 간 경쟁이 날로 치열해 지고 있다. 하지만 우리나라의 경우 10만종으로 추정되는 국내 생물종(種) 중 약 3만여종만 기록되어 있으며, 한반도 고유종도 2,322종만 문헌으로 확인되는 등 조사연구가 미흡한 상황에 있다. 또한 확보된 생물자원도 관리가 매우 미흡한 상태에 있다. 따라서 국가 생물자원 주권 확보 및 체계적인 생물자원 보전 관리를 위해 국가차원의 생물자원보전 종합대책을 수립하였다. 환경부는 동 종합대책을 통해 대한민국 영토에 분포 서식하고 있는 생물자원 정밀 탐색 조사를 통해 모든 생물의 표본을 수집 연구하여 자생생물의 총체를 확인하며, 자생생물의 분류분포생태 정보를 종합 정리한 한반도 생물지를 발간할 예정이다. 자생생물의 DB 구축 등 과학적인 생물자원 관리체계를 확립하고, 생물자원의 국외반출 관리를 강화할 예정이며, 생물분류 전문인력 육성, 권역별 생물자원과 설립, 생물자원 보전 연구시설 지원 등 생물자원 관리 인프라 구축을 추진할 예정이다. 또한 최근 급증하는 야생동물 질병(SARS, 조류독감 등)에 대한 조사 연구를 실시하며, 야생동물 구조 치료센터를 시 도별로 설립할 예정이며, 외래종의 관리를 더욱 강화하고, 멸종위기종의 보호복원을 체계적이고 지속적으로 추진할 예정이다. 동 종합대책은 생물자원 조사발굴 분야의 11개 과제, 생물자원보전 관리체계 확립 분야의 11개 과제, 생물자원보전 추진체계 구축 분야의 6개 과제 등 총 3개 분야 28개 세부추진과제로 구성되어 있다. 동 대책은 2013년까지 국비 2,960억원, 지방비 1,800억원 등 총 4,760억을 투자할 계획이다. 곳도 많아 온난화조건에서도 지역별 정밀기후 추정과 이에 근거한 최적품종의 선택, 이앙기 및 수확기 등 생육기간의 조절이 온난화 대응기술로서 유효할 것으로 기대된다.결과를 분석한 데이터를 차기 메일 발송에 꾸준히 적용함으로써 성공적인 이메일 마케팅 결과를 얻을 수 있을 것으로 기대된다.여 수평적인 의견도출과 각자 역할의 확대 및 변화를 시도할 수 있는 제작흐름이 되도록 고안된 제작구조이다.성을 환기시켜 객관적이고 비판적인 의식을 환기시키는 브레히트의 '소격화'의 효과가 소비자의 관심을 환기시켜 특정한 목적을 달성하려는 광고에 효율적으로 적용된 예 인 것이다. 재미, 기타 독특한 체험을 통해 소비자에게 유희라는 쾌락적 경험을 제공하고자 한다.고도로 통계적 유의차(p<0.001)가 있었다. 즐기는 음료로는 ${\ulcorner}$콜라${\lrcorner}$가 가장 많았으며(46.8%), 그 다음은 사이다, 주스 등의 순으로 나타났으나, 남 여 대학생간에는 유의성있는 차이는 없었다. 음식의 먹는 시기는 점심과 저녁사이의 ${\ulcorner}$간식${\lrcorner}$이 가장 많았으며(42.2%), 남 여 대학생간에는 유의한 차이는 없었다. 패스트푸드는 많은 사람들이 ${\ulcorner}$맛${\lrcorner}$이 좋기 때문에 이용하며(62.8%), 남 여 대학생간에는 통계적 유의성(p<0.05)이 인정되었다. 5. ${\ulcorner}$입맛의 서구화(36.4%)와 외식을 선호(29.1%)${\lrcorner}$ 하기 때문에 패스트푸드를 이용하게 된 것으로 응답 하였으며, 남 여 대학생간에

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.4
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• pp.392-397
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• 1993

The present work was undertaken to investigate the protective mechanism of Oenanthe iavanicu n-butanol extract on the carbon tetrachloride-induced hepatotoxicity in mice. It was observed that a striking enhancement of serum alanine aminotransferase and hepatic lipid peroxide content after carbon tetrachloride administration were markedly decreased by the presentment of Oenanthe javanica extract for 5 days. It was also observed that the hepatic aniline hydroxylase, catalase, glutathione S-transferase activity and glutathione content were not changed by the injection of Oenanthe javanica extract for 5 days. Whereas, hepatic xanthine oxidase activity was inhibited by the treatment of Oenanthe javanica extract for 5 days. After treatment with Oenanthe javanica extract, xanthine oxidase activity was decreased with dose and time-dependent manner as compared to control group. However, hepatic xanthine oxidase activity was not affected by the addition of Oenanthe javanica extract in vitro. These results suggest that the inhibition of hepatic xanthine oxidase activity by the injection of Oenanthe javanica extract is believed to be a possible protective mechanism for the carbon tetrachloride-indured hepatotoxicity in mice.

• Journal of Environmental Impact Assessment
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• v.26 no.1
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• pp.1-10
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• 2017

The study was carried out to understand the inhabiting status and biological features of nutria (Myocastor coypus) in the Jeju Island from May, 2013 to August, 2016. Five individuals were captured by traps and two individuals were collected in dead. Of the 7 individuals, those whose bio-information could not be known were excluded to perform autopsy of the rest of them. The results from morphological, cranial and anatomical analyses, it was found that the females achieved sexual maturation but had no breeding experience. An adult male showed similar sizes to those found in the Korean Peninsula. After collecting the 7 individuals in 2013, 1 nutria individual was filmed by the scouting camera in May, 2014 but not captured. The long-term investigation of the research area found no inhibiting individual. It is deemed the nutria was either died of natural death or migrated. In order to establish a proper nutria control, the environmental characteristics of Jeju Island should be considered where indigenous and introduced species coexist in a limited space. Our findings will provide helpful information for understanding biological features of nutria and planning protection program of natural ecosystems of Jeju Island.

• Microbiology and Biotechnology Letters
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• v.36 no.2
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• pp.87-95
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• 2008

Probiotics are live organisms that when administered in adequate amounts confer a health benefit on hosts. The administration of direct-fed microbials (DFM) such as lactobacilli and bacillus, may be a more direct approach to beneficially alter gastrointestinal microflora than altering dietary ingredients or supplementing with growth-promoting levels of antibiotics. It is apparent that microbes have an important influence on immune development and resistance to infection; that microbes are not static colonizers of our bodies, but are dynamic, symbiotic coresidents. And it can improve the surrounding environments; decrease the malodor caused by degrade the excrement. Recently, new paradigm such as environment protection and safe food have been settled. In domestic farm house, there is a great demand for probiotics as a substitute of antibiotics for the improvement of environmental quality and the production of a competitive goods. Probiotics circulated in a country have three categories: an animal medicine permitted by national veterinary research quarantine service (NVRQS), a support feed registered in city or country house, and not-registered goods. However, lots of unqualified goods were produced and circulated. And thus, it is in urgent need of evaluating the present situation and effect of probiotics. This study was conducted to evaluate the system of a probiotics as a livestock-environment improving agents for the alternation of antibiotics and quality control of it.

• Korean Journal of Environment and Ecology
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• v.8 no.1
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• pp.68-73
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• 1994

For a few people's leisure, the natural environment have being deteriorated ceaseless. The plan of the Chungchongpuk Province and the Yungdong District in Chungchongpuk-do which drive foreword the sport and leasure complex designed to construct ski slopes, golf course, and resort hotel in 6,000,000 $m^2$ of natural ecosystem around the Mulhan Valley at Mulhan-ri Sangchon-myon Yungdong-kun Chung-chcngbuk-do by Dongsin Leisure have concerned decrease on biological diversity serious. This study carried out by census Amphibia and Reptilia fauna in the Mulhan Valley to expect the impact of animal diversity by construction of leasure complex and to call attention to understand that impact. 8 species in 5 Families of 2 Orders in Amphibia and 5 species in 2 Families of 1 Order in Reptilia were observed in the Mulhan Valley during June 24, 1994 to June 25, 1994 which showed to be similar to the Natural Park in Korea. 4 of 8 species in Amphibia(Hynobius leechii, Onychodactylus fischeri, Bufo bufo gargarizans, and Rana dybowskii) and 3 of 5 species in Reptilia(Eluphe rufodorsata, Dinodon rufodonatum rufodonatum, and Agkistrodon saxatilus) were revealed the Special Wild Animal recorded by the Ministry of Environment in 1993. Therefore, the Minjujisan seems to have highly reason to conservation by these animal diversity. Around the Minjujisan province was significant connecting the Taebaek Mountains and the Sobaek Mountains on biogeographically with Dokyusan National Park. The plan of Leasure complex in the Mulhan Valley should be cancel in consideration of destruction around the Dokyusan National Park severely by the Muju Resort, Ski slopes, etc. The Minjujisan must be conserve to the Zone of Natural Environment on Amphibia and Reptilia diversity and animal migration route.

• Journal of the Korean Institute of Landscape Architecture
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• v.37 no.1
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• pp.50-64
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• 2009

The freshwater lakes located at the fringe of urban cities are a habitat for diverse organisms. However, they are facing severe danger of environment deterioration and water pollution caused by reckless development of the area. In this study, an ecological management plan was suggested to promote the biodiversity through appointing management area based on the research and analysis data of flora and fauna as well as maintain biodiversity and harmonize utilization of freshwater lakes such as Duryang Reservoir at Sacheon, Gyeongsangnam-do. Base on the data of ecological research and analysis, this study conducted research on biotope assessment, wild life habitat assessment and presence of protected species. As a result, the ecosystem conservation area including multi-layer structured natural forests, waterside and wetland that are home to various species and the edge area with high habitat diversity were recognized as highly preservable regions. Management areas were ecologically disturbed region, highly polluted commercial district and damaged waterside caused by fishing. Proactive management must be implemented through vegetation management such as vegetation transition and shrub planting as well as establishing pollutant management system. The deterioration of waterside and forest vegetation of freshwater lake has a direct influence on biodiversity and water quality. Therefore, the conservation area and development area should be totally separated from each other, and the development area must be restored and managed strictly.

• Journal of Radiation Protection and Research
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• v.37 no.1
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• pp.50-55
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• 2012

To evaluate the ability of Dongchongxiacao ($Paecilomyces$ $japonica$) extract (PJE) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairless mice and PJE-treated mice exposed chronically to ultraviolet (UV) were examined. The skin of the UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles across the back. PJE-treated mice showed a significantly decreased wrinkling score. By the 22nd week, 88.9% (i.p. with saline) or 44.4% (topical administration with cream base) of the UV-irradiated mice developed at least one tumor. PJE delayed tumor onset significantly. PJE (i.p.) was also effective in reducing the occurrence of UV radiation-induced skin tumors and reduced the number of tumors per mouse. After 22 weeks of treatment, 80.0% (i.p.) and 75.0% (topical) of the mice treated with PJE were tumor-free. Tumor multiplicity was reduced by 96.2% (i.p.) in the PJE treated groups. It is noted that skin that is chronically exposed to UV is subject to photoaging and photocarcinogenesis and regular use of PJE would prevent these photodamaging effects of UV.