• Title/Summary/Keyword: 독성지수

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Ecological Risk Assessment of Pesticide Residues in Agricultural Lake : Risk Quotients and Probabilistic Approach (농업용수를 공급하는 호소 수역 내 잔류 농약의 생태위해성평가 : 위해지수방법과 확률론적 방법)

  • Lee, Ji-Ho;Park, Byung-Jun;Park, Sang-Won;Kim, Won-Il;Hong, Su-Myung;Im, Geon-Jae;Hong, Moo-Ki
    • Korean Journal of Environmental Agriculture
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    • v.30 no.3
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    • pp.316-322
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    • 2011
  • BACKGROUND: Pesticides concentration was monitored in 50 agricultural lakes, and ecological risk for aquatic organism was assessed using risk quotient (RQ) and probabilistic methods. METHODS AND RESULTS: Pesticides concentrations detected in 50 agricultural lakes during peak season (June and September) were in the range of $0.17{\sim}0.99{\mu}g/L$. The RQ for algae and the other species was estimated to be 0.25 and below 0.01, indicating medium risk and no risk. Oxadiazon predominantly contributed to RQ value of 99% for algae, fishes, and amphibians. In terms of hazardous concentration at 5% of species ($HC_5$), ecological risk quotients (ERQ) for oxadiazon ranged from 0.18~0.33, showing a medium risk level. Overall, the concentrations of pesticides were much lower than $HC_5$), value. Probability of combined ecological risk for pesticides ranged from 1.82% to 2.41%. CONCLUSION(s): Combined ecological risk probability did not exceed the acceptable level of 5%, indicating no ecological risk for selected aquatic species. This study suggests that regular ecological risk assessment (ERA) will be required to protect and manage an agricultural lake. Not only ERA at screening level by comparing exposure with toxic effects for aquatic species also advanced ERA technique considering species in indigenous to Korea, chronic toxicity, pulse dose, fate, and environmental factors should be required.

Acute Oral Toxicity and Skin Irritation Studies on Natural Dyes Extracted from Chrysanthemum (국화로부터 추출한 천연염료에 대한 급성경구독성 및 피부자극성 시험에 대한 연구)

  • Kwon, Jung-Ki;An, In-Jung;Lee, Jin-Seok;Kim, Hae-Ri;Park, Ha-Seung;Kim, Dong-Chan;Choi, Byung-Jun;Lee, Kyu-Min;Park, Yong-Jin;Jung, Ji-Youn
    • Journal of Food Hygiene and Safety
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    • v.27 no.2
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    • pp.188-193
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    • 2012
  • This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was "0" in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score "0" of primary irritation index.

Risk Assessment of Heavy Metals in the Vicinity of the Abandoned Metal Mine Areas (폐금속광산지역 중금속의 위해성 평가)

  • Lee, Jin-Soo;Kwon, Hyun-Ho;Shim, Yon-Sik;Kim, Tae-Heok
    • Journal of Soil and Groundwater Environment
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    • v.12 no.1
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    • pp.97-102
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    • 2007
  • An environmental survey from three abandoned metal mine areas was undertaken on to assess the risk of adverse health effects on human exposure to heavy metals influenced by past mining activities. Tailings contained high concentrations of heavy metals may have a impact on soils and waters around the tailing piles. In order to perform the human risk assessment, chemical analysis data of soils, rice grains and waters for As, Cd, Cu and Pb have been used. The HQ values for heavy metals via the rice consumption were significantly higher compared with other exposure pathways in all metal mine areas. The resulting HI values in three mine areas were higher than 9.0, and their toxic risk due to rice ingestion was strong in these mine areas. The cancer risk of being exposed to As by the rice consumption from the A, B and C mine areas was $5.1\;{\times}\;10^{-3}$, $6.8\;{\times}\;10^{-3}$ and $3.1\;{\times}\;10^{-3}$, respectively. The As cancer risk via the exposure pathway of rice ingestion from these mine areas exceeds the acceptable risk of 1 in 10,000 set for regulatory purposes. Thus, the daily intakes of rice by the local residents from these mine areas can pose a potential health threat if exposed by long-term As exposure.

Preparation of Natural Wall Paint by Using Sericite Clay (견운모를 이용한 벽마감용 천연페인트 제조)

  • Kim, Munui;Lalhmunsiama, Lalhmunsiama;Lee, Seung-Mok;Jin, Kang-Jung
    • Applied Chemistry for Engineering
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    • v.28 no.5
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    • pp.501-505
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    • 2017
  • Due to the rapid urbanization and increased population, there is an increase in airtight nature of buildings which causes serious indoor air pollution. Among several indoor air pollutants, volatile organic compounds (VOCs) emitted from paint are of major concern. Therefore, there is an urge for the development of environmental friendly paint products. In this wok, a natural wall paint (NWP) was prepared by utilizing a natural clay material "sericite" as a main component. A small chamber test was carried out to identify the toxic substances release from NWP and the results were compared with two eco-friendly commercial paints. The total VOCs were detected in trace level inside the test chamber and their concentrations were below the recommended indoor air quality standards. Toluene was not detected for NWP, whereas formaldehyde was observed in trace level. The toxicity index results were compared with two commercial paints and found that NWP exhibited less harmful gas emission. Based on certification rating of building materials, NWP can be classified as the first grade of building materials. Due to the above advantages, the use of sericite as a major component in NWP will be a useful technique to maintain the indoor air quality.

A Research of Risk Assessment for Urethane Fire Based on Fire Toxicity (연소 독성 기반 우레탄 화재의 위험성 평가 연구)

  • Kim, Sung-Soo;Cho, Nam-Wook;Rie, Dong-Ho
    • Fire Science and Engineering
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    • v.29 no.2
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    • pp.73-78
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    • 2015
  • Fire in the risk management subject belongs to high risk disaster which accompanies personnel and materiel loss. So, management of disaster and safety is required to include fire prevention activities, fire risk prediction and investment of safety management expense. Combustion toxicity is required by gas toxicity test (KS F 2271), to minimize human damage. In this study, gas toxicity test were experimented with regard to urethane sample (Depth 5~25 mm) to obtain basic data. Fire effluent exposing to experimental animal were analyzed by FT-IR (Fourier transform infrared spectroscopy). Combustion toxicity index Lethal Fractional Effective Dose ($L_{FED}$) of ISO 13344 was calculated. According to the result of calculating Lethal Concentration 50% ($LC_{50}$) based on $L_{FED}$, $LC_{50}$ of urethane sample containing certain level of fire load is confirmed as $118{\sim}129g/m^3$. Through this study, applicability of this method was confirmed for fire risk assessment. This method can provide information to predict human damage by toxicity combustion gas for securing safety.

Acute Toxicity of Kuwait Crude Oil (WSF) to Mysid, Neomysis awatschensis (Neomysis awatschensis에 미치는 원유의 급성독성)

  • AHN Kyung-Wook;CHIN Pyung
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.19 no.6
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    • pp.599-607
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    • 1986
  • Acute toxicity of crude oil (WSF) on the mortality and respiration rates of Neomysis awatschensis was examined. This experiment was conducted by static and short-term bioassay procedure. In lethal test, the test animals were exposured to 8 different concentrations to determine $LC_{50}$ value (median lethal concentration). The concentrations of total hydrocarbon of 96-hr $LC_{50}$ value at $14^{\circ}C\;and\;20^{\circ}C$ were 1.01 ppm and 0.78 ppm, respectively. $LT_{50}$ (the median lethal time) also was determined. The $LT_{50}$ of 0.56 ppm was found within 100 hours, while the $LT_{50}$ of 5.6 ppm was 21 hours at $14^{\circ}C$. At $20^{\circ}C$, the $LT_{50}$ values of 0.56 ppm and 5.60 ppm were 95 hours and 17 hours, respectively. There was little difference between two temperature experiments. The effect of WSF on respiration rate was more sensitive than that on mortality, but no considerable difference was shown between different concentrations in this experiment. The results of these experiments indicated that relatively low concentration of dissolved crude oil fraction can impact on small crustacean in the marine ecosystem.

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Protection and Detoxification Effects of Oriental Herb Extract Mixture on TCDD-Induced Oxidative Stress (TCDD로 유발된 Oxidative Stress에 대한 생약재 추출물의 방어 및 해독효과)

  • Hwang, Jin-Kook;Lee, Kyung-Jin;Yang, Hee-Jin;Park, Ki-Moon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.3
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    • pp.294-301
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    • 2008
  • This study was carried out to investigate the protective effects and detoxification of oriental herb extracts mixture (Saururus chinensis, Taraxacum platycarpum, Ulmus macrocarpa, Glycyrrhiza glabra, Rhynchosia nulubilis) on TCDD-induced oxidative stress. Thirty five male rats were divided into 5 groups: normal control group received saline; vehicle control group received DMSO and acetone; only TCDD-treated group received multiple intraperitoneal injection of TCDD ($100{\mu}g/kg$) and saline; post-treated group of OHEM (400 mg/kg/day) received oral administration for 5 weeks after TCDD treatment; and pre-treated group of OHEM (400 mg/kg/day) received oral administration for 6 weeks from 1 week before TCDD treatment. The elevated serum activities of alanine transaminase (AST), aspartate transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and atherorganic index due to TCDD were significantly decreased by the treatment of OHEM (p<0.05); the pre-treatment of OHEM was especially effective. Hydropic lesions and cytoplasmic vacuolizations in the liver of TCDD-treated rats were inhibited by the treatment of OHEM. Also, OHEM treatment reduced edemas in small intestine villus of TCDD-treated rats. These results suggest that OHEM from various oriental herb extracts might be a useful protective and detoxification agent against TCDD.

The Study of Propellant Characteristic for Low Carbon & High Nitrogen Oxidizer (저탄소 고질소 산화제 적용 추진제 특성 연구)

  • Won, Jong-ung;Choi, Sung-han;Park, Young-chul
    • Journal of the Korean Society of Propulsion Engineers
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    • v.21 no.2
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    • pp.26-31
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    • 2017
  • Environmental problem of the solid propellants is an issue of growing importance in solid rocket. For examples, ammonium perchlorate (AP) as an solid propellants oxidizer could create a poisonous gas and atmospheric pollutions, such as HCl. Among the several oxidizers, N-guanylurea dinitramide (GuDN) is an effective candidate substance for eco-friendly oxidizer, which has high performance, pressure exponent, and eco-friendly smog during combustion for solid propellant of gas generator. In this paper, the theoretical analysis of characteristics as a gas generator propellant, propellant manufacturing processability, propellant hardness properties and combustion characteristics were studied.

Effect of Korean Red Ginseng on Clinical chemical Parameters in Male Guinea Pigs Exposed Acutely to 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin 투여로 급성독성을 유도한 웅성 기니픽에 있어 임상화학지수에 미치는 홍삼의 효과)

  • 김시관;황석연;김신희;곽이성;정영진
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.6
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    • pp.1349-1354
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    • 1999
  • This study was carried out to investigate the protective effect of Korean red ginseng water extract (KRG WE) on clinical chemical parameters in male guinea pigs acutely exposed to 2,3,7,8 tetrachlorodibenzo p dioxin(TCDD). Forty male guinea pigs(200 $\pm$20g) were divided into 4 groups. Normal controls(group 1) received vehicle and saline; group 2(single TCDD treated) received TCDD(5 g/kg, single dose) intraperitoneally; group 3 received KRG WE(200mg/kg, i.p.) for 2 weeks from 1 week before TCDD exposure; group 4 received KRG WE for 1 week since the day of TCDD exposure. Increase in body weight was retarded greatly by TCDD exposure. Body weight of animals in group 2 was significantly decreased starting 2 days after TCDD exposure. However, body weight of animals in group 3 increased throughout the experimental period, although the increasing rate was slower than that of group 1. Decrease in body weight was not observed during the experimental period in group 4. Increases in blood glucose, amylase, lipase, total cholesterol, triglyceride, GOT, GPT, and LDH levels by TCDD intoxication were significantly attenuated by the KRG WE treatment(p<0.05). These results provide a strong evidence that Korean red ginseng might be a useful protective agent against TCDD, an endocrine disruptor.

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Environmental Impact Assessment of Different Concrete Mixture Proportions according to Domestic Region and Season (국내의 지역 및 계절에 따른 콘크리트 배합별 환경영향평가)

  • Seo, Eun-A;Yang, Keun-Hyeok;Jung, Yeon-Back
    • Journal of the Korea Concrete Institute
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    • v.26 no.3
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    • pp.239-245
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    • 2014
  • This study analyzed a comprehensive database including 6331 ready-mixed concrete plant mixtures to quantitatively assess the environmental impact of concrete under mixture proportions variable according to the domestic region and season. The environmental impact indicator includes global warming, photochemical oxidant creation, abiotic resource depletion, acidification, eutrophication and human toxicity, which are determined from categorization, characterization, normalization and weighting process based on Korea lifecycle inventories. The determined environmental impact indicator was also normalized by concrete compressive strength ($f_{ck}$), which is defined as impact index, to calculate the environmental impact per unit strength of 1 MPa. The most common compressive strength of concrete used in the country is estimated to be 24 MPa and 27 MPa. For $f_{ct}$ of 24 MPa, the lowest environmental impact indicator is observed in Ulsan, whereas the highest region is Gwangju and Daegu. This difference according to domestic region is primarily resulted from by the replacement of different supplementary cementitious materials. Furthermore, the impact index of concrete with $f_{ck}$ of 24 MPa is higher by approximately 5% at wintertime than at summertime and standard season. The impact index gradually decreases with the increase of $f_{ck}$ up to 35 MPa, beyond which it remains constant.