• Title/Summary/Keyword: 독성지수

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자동차용 냉매가 환경에 미치는 영향

  • 김영일
    • The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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    • v.29 no.9
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    • pp.75-78
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    • 2000
  • 환경친화적 자동차에 대한 관심이 커질수록 여러 분야에서 시스템 설계의 영향을 더욱 더 잘 이해하려는 노력이 진행되고 있다. 자동차용 냉방기의 경우 냉방시스템의 세밀한 분석과 환경에 미치는 영향을 최소화하기 위한 설계가 이루어지고 있다. 그 중에서도 냉매의 선택과 그 냉매의 환경적 영향에 대한 자세한 연구가 필요하다. 몬트리올 조약 이후 자동차 산업계는 대부분 R-134a를 채택하고 있는데 이는 R-134a가 오존층을 파괴하지 않을 뿐 아니라 적절한 사이클 효율을 가지면서 안전하고 비독성이며 불연성이기 때문이었다. 최근 지구온난화와 이산화탄소($CO_2$)의 발생원에 대한 관심은 산업계가 사용냉매를 재검토하게 하는 계기가 되었으며, R-134a도 교토 조약의 규제냉매에 속해 있어 자동차용 냉방기의 대체냉매에 대한 연구가 시급하다고 여겨지고 있다. R-134a와 관련된 주된 논점은 냉매 누설시의 영향이다. R-134a의 지구온난화지수(GWP)는 1,300인데, 이는 누출되었을 때 1,300배의 이산화탄소가 누출된 것과 동일하다는 것을 의미하다. 최근 자연냉매의 선호와 맞물려 냉매로서 이산화탄소의 평가에 많은 관심이 모아지고 있다. 본 글에서 자동차용 냉방기의 대체냉매로서 이산화탄소의 상대적인 장점과 R-134a와의 비교에 대해 수행된 연구결과를 나타내었다.

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광양만의 유기주석화합물 오염과 생물농축

  • 심원준;김남숙;임운혁;홍상희;오재룡
    • Proceedings of the Korea Society of Environmental Biology Conference
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    • 2002.11a
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    • pp.25-32
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    • 2002
  • 유기주석화합물은 선박방오도료에 살생물제로 쓰이는 독성이 강한 물질로서 내분비계장애물질의 일종으로 알려지고 있다. 광양만에서 유기주석화합물의 오염현황을 파악하고자 표층퇴적물 및 생물체 중의 농도를 정성 및 정량분석하였으며, 생물에 미치는 영향을 파악하고자 복족류의 임포섹스(암컷에서 수컷의 성기가 발현되는 현상)를 측정하였다. 표층퇴적물 및 생물체 체내에서 phenyltin은 일부 정점을 제외하고는 모두 검출한계 이하의 값을 보였으나, butyltin은 대부분의 정점에서 검출되었다. 표층퇴적물, 참굴, 대수리 체내의 tributyltin (TBT)의 농도는 각각 미검출-29 ng/g, 178-2458 ng/g, 47-236 ng/g 범위를 보였다. TBT 화합물의 공간적인 분포는 선박활동과 밀접한 관련이 있었으며, 항구가 위치한 여수 인근을 제외하고는 광양내만에서 상대적으로 높은 값을 보였다. 한편 대수리 중의 임포섹스는 11개 정점에서 모두 관찰되었으며, 상대성기길이 지수는 47.9-107.8%의 범위를 보였다.

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Thermoelectric and electrical properties of amrophous IZO and crystalline ITO thin films (DC 마그네트론 스퍼터링법으로 증착한 비정질 IZO와 결정질 ITO박막의 열전 특성)

  • Byeon, Ja-Yeong;Kim, Seo-Han;Song, Pung-Geun
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2016.11a
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    • pp.159-159
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    • 2016
  • 세계적으로 대체 에너지는 중요한 이슈가 되고 있으며, 이들 중 열전 재료는 열 에너지를 전기 에너지로 바꿀 수 있는 열전 재료가 각광 받고 있다. 그 중, 박막 형태의 열전 재료는 벌크 형태에 비해 나노 구조화가 용이하여 열전 특성을 향상 시킬 수 있는 잠재력을 지니고 있다. 특히, 박막형 열전 소자는 정밀 온도 제어가 가능하며, 소형화 기기의 응용이 가능하여, 고 직접화 전자 소자의 발열 문제를 해결 할 수 있어 더욱 주목 받고 있다. 박막형 열전소자 중 산화물 반도체계에 대한 연구가 활발히 진행되고 있으며, 이러한 산화물 반도체는 기존의 화합물 반도체인 Pb-Te, Bi-Te 등의 기존의 재료에 비해 낮은 독성을 가진다. 또한, 고온에서 열적 안정성이 우수하여 고온에서 적용 가능하다는 장점을 가진다. 열전재료의 효율은 열전 성능 지수(ZT)와 Power factor(PF)로 평가된다.

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Cytotoxic Effects of Hydrolysable Tannins from Some Euphorbia Plants on the Human Tumor Cell Lines (유포르비아속 식물로부터 단리한 가수분해형 탄닌의 인체고형암 세포에 대한 세포독성효과)

  • Lee, Seung-Ho;Park, Ji-Soo;Kim, So-Young;Chung, See-Ryun;Choi, Sang-Un
    • YAKHAK HOEJI
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    • v.41 no.4
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    • pp.524-529
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    • 1997
  • Seventy three hydrolysable tannins and related compounds were isolated from seven Euphorbia plants. Among them, 28 compounds including nine gallotannins, eleven ellagitannins and eight related compounds were selected according to the structural similarity. Cytotoxicity of them on the human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 were evaluated by the SRB method in vitro. 3,4,6-Tri-O-galloyl-D-glucose was shown to exhibit most potent cytotoxic effect($4.4{\mu}g/ml).

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Optimal Cultur Conditions for the Production of Insecticidal Toxin by Xenorhabdus nematophilus Isolated from Steinernema carpocapsae (Steinernema carpocapsae로부터 분리된 Xenorhabdus nematophilus에 의한 살충물질 생산을 위한 최적 배양조건)

  • 유연수;박선호
    • KSBB Journal
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    • v.15 no.1
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    • pp.100-105
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    • 2000
  • Optimal medium composition, culture conditions, characteristics of phase variation and activity of insecticidal toxin by Xenorhabdus nematophilus isolated and identified from Korean entomopathogenic nematode Steinernema carpocapsae were examined. Optimal medium composition of this strain was 50-70 g/L yeast extract, 3 g/L $K_{2}HPO_{4}$, 1g/L $NH_{4}H_{2}PO_{4}$, 2g/L ${MgSO}_4$$\cdot$${7H}_{2}O$, 10g/L NaCl and, these, yeast extract was found as a limiting nutrient for cell growth. When Monod equation was applied, maxmum specific growth rate and Monod constant were estimated as 0.13 $hr^{-1}$ and 20g/L, respectively. The pH of culture medium increased up to 8.5-9.5 regardless of initial pH 6-7 as the cells continued to grow. The specific growth rate in a 7 L fermentor was 0.18 $hr^{-1}$, which was enhancement 1.4 fold compared to a flask culture. In case of phase variation, phase I fraction was maintained above 90% at the stationary phase for both flask and fermentor cultures. According to oral toxicity test of Gallena mellonella by Xenorhabdus nematophilus, the addition of cell pellets into feed inhibited normal growth of insect larvae and killed completely then after 20 days cultivation. When culture supernatant of this strain was injected into hemolymph of insect larva, the toxicity was strongest at 24hr cultivation in the early exponential phase and gradually decreased as the culture time proceeded.

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Changes in hematological parameters and plasma components of olive flounder, Paralichthys olivaceus exposed to acute microplastics (넙치, Paralichthys olivaceus의 미세플라스틱 급성 노출에 따른 혈액성상 및 혈장성분의 변화)

  • Kim, So-Hee;Kim, Ga-Hyun;Kim, Ji-Su;Kim, Jun-Hwan;Jeon, Yu-Hyeon;Cho, Jae-Hwang;Kim, Seok-Ryel;Kim, Dae-Hee
    • Korean Journal of Environmental Biology
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    • v.39 no.3
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    • pp.344-353
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    • 2021
  • Juvenile olive flounder, Paralichthys olivaceus (mean weight 66.7±7.1 g; mean length 19.2±0.9 cm) in a bio-floc environment were exposed to microplastic (PE: polyethylene, size 40-48 ㎛) at 0, 4, 20, 100, 500 and 2,500 mg L-1 for 96 hours. No P. olivaceus deaths were observed following microplastic exposure. In the plasma components, calcium was significantly decreased whereas there was no significant change with magnesium following microplastic exposure. Glucose was significantly decreased with over 100mg L-1 at 48 hours and 20mg L-1 at 96 hours. Cholesterol was significantly decreased with over 20mg L-1 after 48 hours, whereas there was no significant change in the total protein content. In enzymatic plasma components, the AST(Aspartate aminotransferase) was significant decreased by microplastic exposure. The results of this study indicate that acute exposure to microplastic induces blood physiological changes in P. olivaceus.

A Study on Combustion Characteristics of Finishing Materials in Interior Decoration (실내장식물 인테리어마감재의 연소특성에 관한 연구)

  • Cho, Kwang-Hyun;Lee, Bong-Woo;Yun, Mung-Oh
    • Journal of the Korean Institute of Gas
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    • v.23 no.4
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    • pp.10-18
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    • 2019
  • The Interior finishing materials tried to evaluate the combustion characteristics and the dangerous characteristic of Floor finish and Wall finish. We often use, conducting the experiment ISO 5660-1, Cone Calorimeter method, and ISO-TR-9122 FT-IR. According to the result of Cone calorimeter experiment, the tile carpet FF3 of Floor material had the highest THR $74.6mj/m^2$ because of the highest risk, and the PHRR of FF1 was $726kW/m^2$, which was easy to bum. As a result FT-IR test, The CO, $CO_2$ ratio was 8,146 PPM for roll carpet FF1 than tile carpet FF2, FF3 5,996, 5,171 PPM, which was a carpet with a high toxicity risk. In the case of wall finishes, The MDF plate(WF3) was THR $86.7mj/m^2$ with a high risk, PHRR $384kW/m^2$ was easy to ignite and toxicity index was 5.5. The CO, $CO_2$ ratio was 1,340~8,596 PPM, But the WF4 was the most toxic with 8,596 PPM.

Measurement of Minimum Inhibitory Concentration of Toxic Chemicals against Pseudomonas aeruginosa and Staphylococcus aureus (유해 화학물질 처리에 의한 녹농균과 포도상구균의 성장저해최소농도 측정)

  • Jiseon An;Jingyeong Kim;Jae Seong Kim;Chang-Soo Lee
    • Clean Technology
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    • v.29 no.2
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    • pp.135-144
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    • 2023
  • Pseudomonas aeruginosa and Staphylococcus aureus are the two most frequently encountered pathogens responsible for chronic wound infections, often coexisting in such cases. These infections exhibit heightened virulence compared to single infections, leading to unfavorable patient outcomes. The interaction among microorganisms within polymicrobial infections has been shown to exacerbate disease progression. Polymicrobial infections, prevalent in various contexts such as the respiratory tract, wounds, and diabetic foot, typically involve diverse microorganisms, with Pseudomonas aeruginosa and Staphylococcus aureus being the most commonly identified pathogens. This study aimed to compare the growth patterns of bacteria under a concentration gradient of toxic chemicals, focusing on a Gram-negative strain of Pseudomonas aeruginosa and a Gram-positive strain of Staphylococcus aureus. The minimum inhibitory concentration (MIC), which signifies the concentration at which bacterial growth is inhibited, was determined by performing broth microdilution and assessing the bacteria's growth curves. The growth curves of both Pseudomonas aeruginosa and Staphylococcus aureus were confirmed, and the exponential growth phases were applied to calculate the doubling times of bacteria. The MIC value for each toxic chemical was determined through broth microdilution. These results allowed for the identification of disparities in growth rates between Gram-positive and Gram-negative bacteria, as well as differences in resistance to individual toxic substances. We expect that this approach has a strong potential for further development towards the innovative treatment of bacteria-associated infections.

Relationship Between Standardized Precipitation Index and Groundwater Levels: A Proposal for Establishment of Drought Index Wells (표준강수지수와 지하수위의 상관성 평가 및 가뭄관측정 설치 방안 고찰)

  • Kim Gyoo-Bum;Yun Han-Heum;Kim Dae-Ho
    • Journal of Soil and Groundwater Environment
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    • v.11 no.3
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    • pp.31-42
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    • 2006
  • Drought indices, such as PDSI (palmer Drought Severity Index), SWSI (Surface Water Supply Index) and SPI (Standardized Precipitation Index), have been developed to assess and forecast an intensity of drought. To find the applicability of groundwater level data to a drought assessment, a correlation analysis between SPI and groundwater levels was conducted for each time series at a drought season in 2001. The comparative results between SPI and groundwater levels of shallow wells of three national groundwater monitoring stations, Chungju Gageum, Yangpyung Gaegun, and Yeongju Munjeong, show that these two factors are highly correlated. In case of SPI with a duration of 1 month, cross-correlation coefficients between two factors are 0.843 at Chungju Gageum, 0.825 at Yangpyung Gaegun, and 0.737 at Yeongju Munjeong. The time lag between peak values of two factors is nearly zero in case of SPI with a duration of 1 month, which means that groundwater level fluctuation is similar to SPI values. Moreover, in case of SPI with a duration of 3 month, it is found that groundwater level can be a leading indicator to predict the SPI values I week later. Some of the national groundwater monitoring stations can be designated as DIW (Drought Index Well) based on the detailed survey of site characteristics and also new DIWs need to be drilled to assess and forecast the drought in this country.

Effects of Anticancer Agents on Cell Cycle Kinetics and Sister Chromatid Exchanges in Cultured Human Lymphocytes (항암제(抗癌劑)가 배양임파구(培養淋巴球)의 세포분열주기(細胞分裂週期) 및 자매염색분체교환(姉妹染色分體交換)에 미치는 영향(影響))

  • Hwang, In-Dam;Ki, No-Suk;Park, Won-Kihl;Kim, Young-Oh;Lee, Jeong-Sang
    • Journal of Preventive Medicine and Public Health
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    • v.20 no.1 s.21
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    • pp.1-9
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    • 1987
  • Sister chromatid exchanges (SCEs) observed by means of bromodeoxyuridine substitution and fluorescence plus Giemsa (FPG) technique were proposed as a sensitive and quantitative assay for mutagenicity and cytotoxicity in short-term cultures of phytohaemagglutinin (PHA)-stimulated human lymphocytes. Therefore, this study was carried out to investigate the relation between anticancer agents and cytotoxic effects. Chromosomal analysis was performed on metaphase cells that had divided one, two, or three or more times after treatment for SCEs, mitotic indices (MI) and cell cycle kinetics by FPG technique. The results indicate that anticancer agents led to a dose dependent increase in SCE frequency except methotrexate. But, highly inhibited mitotic indices and delayed cell cycle kinetics were observed except for cyclophosphamide. The author suggest that the difference of SCE frequency is due to the differences in the cytotoxic action of anticancer agents, but although the induction of SCEs has a correlation with cell cycle delay, in some cases the induction of SCEs is not always related to cell cycle delay because of different cytotoxic action of anticancer agents.

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