• Pediatric Infection and Vaccine
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• v.18 no.2
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• pp.207-211
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• 2011

Dengue is an acute febrile viral disease which is found in tropical and sub-tropical regions around the world. Dengue fever has steadily increased in both incidence and distribution over the past 50 years. Even though Korea is not an endemic country for dengue fever, with the increasing numbers of overseas travelers in Korea, the numbers of imported dengue cases are steadily increasing. Here, we report a case of imported dengue hemorrhagic fever in a Korean child presenting with fever and epistaxis. Dengue fever should be considered if a patient who has a recent travel history to endemic areas showed classical symptoms.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.225-226
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• 2015

뎅기 바이러스는 전 세계적으로 빠르게 확산되고 있는 모기 매개 바이러스이다. 현재까지 4가지의 혈청형이 알려져 있는 뎅기 바이러스는 뎅기열, 뎅기 출혈열과 뎅기 쇼크증후군 등을 유발한다. 현재 뎅기 바이러스가 전 세계적으로 확산되고 있음에도 불구하고 확실한 치료제나 백신이 없기 때문에 초기 진단이 매우 중요하다. 아열대기후로 진입하는 우리나라에서도 흰줄숲모기가 자주 발견되기 때문에 이 질병으로부터 결코 자유롭지가 않다. 바이러스 감염을 진단하기 위한 진단키트를 개발하기 위해서는 타깃 유전자 부위 선정이 매우 중요하기 때문에 본 연구에서는 먼저 생명정보학을 기반으로 뎅기 바이러스만을 특이적으로 검출할 수 있는 항월결정부위를 예측하고 진단키트에 적용하고자 하였다. 4가지 유형의 뎅기 바이러스 유전자들을 찾고, ProtScale Tool 프로그램으로 친수성(hydrophilicity), 접근성(acc -essibility), 유연성(flexibility), 회전(${\beta}-turns$) 등의 특성을 분석하여 항원결정부위를 선정하였다. 이 항원결정부위를 이용하여 단일클론항체를 제작하였으며 향후 진단키트로의 적용 가능성을 확인하였다.

• Pediatric Infection and Vaccine
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• v.20 no.2
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• pp.98-104
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• 2013

Dengue fever is an important health problem for international travelers to all endemic areas. The steadily increasing numbers of tourists visiting endemic areas raise the risk of exposure, and imported dengue cases are increasingly observed in nonendemic area. Dengue has a wide spectrum of clinical presentations, often with unpredictable clinical evolution and outcome. While most patients recover following a self-limiting, non-severe clinical course, a small proportion progress to severe disease such as dengue hemorrhagic fever or dengue shock syndrome. Therefore, it is important to suspect dengue fever in every febrile patient returning from the tropics. Whenever it is suspected, a quick diagnosis and adequate managements are essential to avoid complications. We report two cases of imported dengue fever in Korean children presenting with fever, headache, nausea, and rash.

• The Journal of the Korea Contents Association
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• v.19 no.2
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• pp.259-268
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• 2019

Dengue virus is a typical mosquito-borne virus, and the half of the world's population is exposed to infection. Dengue virus causes relatively mild symptoms such as dengue fever. However, when not treated properly, it is known to cause severe symptoms such as dengue hemorrhagic fever and dengue shock syndrome with a mortality rate of over 20%. Development of dengue virus detection technology is very important because it is reported that early diagnosis of dengue fever can lower the mortality rate to less than 1%. In this study, patent search related to dengue virus detection technology was conducted in Korea, USA, Europe, Japan, and China. The quantitative analysis of 69 validated patents from the searched patents was conducted by country, year, and patent holder. In addition, in-depth analysis was carried out by classifying into three categories: molecular diagnostics, immuno-diagnostics, and cell culture-based diagnostics from all validated patents. From these results, we analyzed the patent trend related to dengue virus detection and dengue fever diagnosis technology and discussed the features and limitations of molecular diagnostics and immuno-diagnostics at present level. Furthermore, we discussed the direction of technology development and future prospects to overcome limitations.

• Pediatric Infection and Vaccine
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• v.27 no.2
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• pp.140-146
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• 2020

Dengue fever (DF) is endemic throughout tropical and subtropical regions; however, it is not endemic in Korea. Imported infectious diseases should be suspected when encountering returned travelers with non-specific symptoms such as fever, rash, and headache. Persistent vomiting, abdominal pain, hemorrhagic tendency, hepatic enzyme abnormalities, and proteinuria are risk factors for the development of severe DF in a patient with DF. Severe hyperglycemia is also known to be related to poor prognosis in acute illness, and with certain underlying diseases that present with hyperglycemia, such as diabetes, it is related to the progression of severe DF. We report a DF case with severe hyperglycemia in an adolescent returning from India. Pediatric DF cases reported in Korea were also reviewed.