• The Journal of Korean Medicine
• /
• v.16 no.2 s.30
• /
• pp.36-43
• /
• 1995

• The Journal of Korean Medicine
• /
• v.16 no.2 s.30
• /
• pp.248-269
• /
• 1995

• The Journal of Internal Korean Medicine
• /
• v.42 no.5
• /
• pp.982-990
• /
• 2021

Objectives: The aim of this study was to report the effectiveness of Korean medicine treatment for a patient with lateral medullary infarction who presented with central dizziness and hypoesthesia. Methods: The patient was treated with Korean medicine treatment, including acupuncture, moxibustion, and herbal medicine. We measured the progress of the case using the Numerical Rating Scale (NRS). Results: After the treatment, the NRS scores for dizziness and hypoesthesia decreased. Conclusions: This study suggests that Korean medicine treatment might be effective for lateral medullary infarction in patients who present with central dizziness and hypoesthesia.

• Herbal Formula Science
• /
• v.30 no.3
• /
• pp.183-189
• /
• 2022

Objective : This study aims to analyze the current use of body part terminology in Korean medicine formula data by comparing with ICD-11 body part terminology as a criteria. Methods : Body part terminology was extracted from the main treatment data within the Korean Medicine formula ontology and was analyzed in comparison with the ICD-11 body part terminology. Results : Out of 113 body part terminologies in Korean medicine, 92 were corresponded with ICD in a one-to-one, one-to-multi, or multi-to-one relation. Also, most body part terminologies were corresponded to superordinate concepts of ICD while 21 terminologies were not able to be corresponded to ICD. Conclusion : A majority of body part terminology in formula data could be corresponded to ICD but mostly refered to superordinate concepts. Results showed various types of corresponding relation which requires further study for precise and detailed correspondence. Also, study showed some terminologies were not applicable for correspondence which were mostly a unique body part concept of Korean medicine which requires further study to present Korean Medicine knowledge accurately in the language of ICD.

• Journal of Society of Preventive Korean Medicine
• /
• v.25 no.2
• /
• pp.33-43
• /
• 2021

Objectives : This study seeks to grasp the current status of Koryo medical research in North Korea, by focusing on researchers and research topics. Methods : A network analysis of co-authors and keyword which were extracted from Koryo Medicine - a North Korean traditional medicine journal, was conducted. Results : The results of author network analysis was a sparse network due to the low correlation between authors. The domain-wide network density of co-authors was 0.001, with a diameter of 14, average distance between nodes 4.029, and average binding coefficient 0.029. The results of the keyword network analysis showed the keyword "traditional medicine" had the strongest correlation weight of 228. Other keywords with high correlation weight was common acupuncture (84) and intradermal acupuncture(80). Conclusions : Although the co-authors of the Koryo Medicine did not have a high correlation with each other, they were able to identify key researchers considered important for each major sub-network. In addition, the keywords of the Koryo Medicine journals had a very high linkage to herbal medicines.

• Herbal Formula Science
• /
• v.27 no.1
• /
• pp.7-16
• /
• 2019

Objectives : Hemistepta lyrata Bunge (Bunge) has been used for treating wound, hemorrhage, fever in Korean traditional medicine. Present study investigated anti-inflammatory effect of H. lyrata chloroform extract (HLE) and its molecular mechanism involved. Methods : To assess anti-inflammatory effect of HLE, production of nitric oxide (NO) and expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines were measured on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Moreover, nuclear factor-${\kappa}B$ (NF-${\kappa}B$) signaling pathway was examined to elucidate its molecular mechanism. Results : Pretreatment of HLE inhibited NO production in a concentration dependent manner. HLE also decreased expression of iNOS and COX-2, and alleviated expressions of pro-inflammatory cytokines in LPS-stimulated RAW 264.7 cells. Moreover, HLE pretreatment inhibited phosphorylation of inhibitory-${\kappa}B{\alpha}$ and p65. Conclusions : These results suggest that HLE exhibits anti-inflammatory effect via inhibition of NF-${\kappa}B$.

• The Journal of Internal Korean Medicine
• /
• v.39 no.6
• /
• pp.1136-1149
• /
• 2018

Objectives: The aim of this study was to perform a meta analysis of randomized controlled trials (RCTs) that applied Opae-san to peptic ulcer. Methods: The databases NDSL, RISS, KISS, KISTI, Oasis, DBpia, Cochrane, EMBASE, Pubmed, and CNKI were searched to identify RCTs that evaluated the therapeutic response to Opae-san on peptic ulcer. The selected studies were assessed using Cochrane Group's risk of bias tool. Results: 12 RCTs were selected from a total of 312 identified. Combined therapies of Opae-san plus triple therapy were superior to only triple therapy in achieving the effective rate (risk ratio=1.26, 95% CI: 1.17 to 1.35, p<0.001, I2=0%), the helicobacter pylori eradication rate (risk ratio=1.23, 95% CI: 1.12 to 1.34, p<0.001, I2=7%) and the recurrence rate (risk ratio=0.31, 95% CI: 0.12 to 0.82, p=0.02, I2=0%). But only Opae-san was not superior in achieving the effective rate compared to anti gastric secretion drugs. Conclusions: The current evidence suggests that combined therapies of Opae-san plus triple therapy yield a higher effective rate, and helicobacter pylori eradication rate and a lower recurrence rate. However, in most of these studies, it is difficult to evaluate the bias and therefore better designed studies are needed.

• The Journal of Internal Korean Medicine
• /
• v.43 no.3
• /
• pp.485-492
• /
• 2022

Objective: The aim of this case report is to report the effect of Korean medicine treatment, including Shihogayonggolmoryo-tang, on anxiety and abdominal pulsation in a patient diagnosed with functional dyspepsia. Method: The patient was treated with Shihogayonggolmoryo-tang, including acupuncture, moxibustion, and cupping therapy. Changes in symptoms were evaluated using a self-reported numerical rating scale (NRS) score every morning. The gastrointestinal symptom score (GIS) was checked on admission and discharge day. Results: After 6 days, the NRS scores for anxiety, abdominal pulsation, abdomen discomfort, and GIS all decreased. Conclusion: The results suggest that Shihogayonggolmoryo-tang with Korean medicine could be effective for treating anxiety, abdominal pulsation, and accompanying abdomen symptoms. However, further evaluation is needed to clarify the relationship between the treatment's effect and Shihogayonggolmoryo-tang.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.35 no.1
• /
• pp.105-106
• /
• 2022

• The Korea Journal of Herbology
• /
• v.28 no.2
• /
• pp.61-65
• /
• 2013

Objectives : Samchulgeonbi-tang (shenzhujianpi-tang) has been prescribed as one of traditional herbal medicine for treatment of stomach diseases since ancient time in Korea. Samchulgeonbi-tang extract was fermented by Lactobacillus spp. for improving the effect. However, the toxicity and safety of fermented Samchulgeonbi-tang (FS) extract were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of FS extract. Methods : To evaluate the acute toxicity and safety of FS extract, several doses of FS extract, 0, 500, 1000 and 2000 mg/kg, were orally administered to 20 male and 20 female ICR mice, respectively. After treatment with FS extract, we observed mortality, general toxicity, behavior and change of body weight for the 14 days. After 14 days of oral administration, all mice were sacrificed and hematological parameters were analyzed from blood serum. Results : In present study, the toxic signs such as mortality or abnormal behaviors by FS extract were not observed. There are no significant differences between FS-treated group and control group in body weight, organ weights, and hematological parameters. Conclusions : The remarkable adverse effects by FS extract were not observed in ICR mice. Also, any death was not occurred at all treated FS doses, 500, 1000 and 2000 mg/kg. Therefore, the approximate lethal dose (ALD) of FS extract may be more than 2000 mg/kg.