• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.2
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• pp.111-118
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• 2024

A key component of wound healing is epithelialization, which involves the proliferation and migration of epidermal keratinocytes surrounding the wound. Increasing cortisol, a stress hormone, is known to slow the healing process by inhibiting cell proliferation and migration. This study aims to develop an ingredient that can promote delayed wound healing by cortisol through a combination of Centella asiatica (C. asiatica), known for its excellent wound healing effect, and Rosamarinus officinalis (R. officinalis) leaf known for their antipsychotic effect. R. officinalis leaf extract was found to inhibit the activity of 11β-HSD1, an enzyme involved in the production of cortisol. A combination of C. asiatica and R. officinalis leaf extracts (AlfaCalm) was found to enhance cortisol induced delayed keratinocyte migration to a greater extent than C. asiatica extract. AlfaCalm enhanced the expression of CDC42 and the formation of filopodia, which are crucial for the relaxation of the actin skeleton. These results suggest that AlfaCalm can be used as an effective wound healing material in stress condition.

• Journal of the Korean Data and Information Science Society
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• v.20 no.4
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• pp.673-684
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• 2009

Lower Prices are offered through sales by telemarketing. This is to serve our customers by the fastest and most appropriate referral product that is most important to attract insurance. Therefore, Considering the time the customer's preferred products and preferred customer for screening and targeting, depending on what is the difference between the premiums. This study of the logistic regression model using datamining techniques, the life insurance companies in outbound telemarketing to support sales of the effect you want to validate. To join existing life insurance companies for the customer response and sales strategy based on the L segment and by age group, family-love insurance, accident insurance, and cancer insurance were in progress for the modeling. Set model based on the progress of the campaign to existing customers marketing methods and how to extract and run the model results has proven the superiority of the model. In addition, over time, depending on the aging model is set to a decline in operating profit to maximize the profits th update the model which was derived.

• Journal of the Korean Vacuum Society
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• v.16 no.1
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• pp.52-57
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• 2007

The interaction force between biomolecules(DNA-DNA, antigen-antibody, ligand-receptor, protein-protein) defines not only biomolecular function, but also their mechanical properties and hence bio-sensor. Atomic force microscopy(AFM) is nowadays frequently applied to determine interaction forces between biological molecules and biomolecular force measurements, obtained for example using AFM can provide valuable molecular-level information on the interactions between biomolecules. A proper modification of an AFM tip and/or a substrate with biomolecules permits the direct measurement of intermolecular interactions, such as DNA-DNA, protein-protein, and ligand-receptor, etc. and a microcantilever-based sensor appeared as a promising approach for ultra sensitive detection of biomolecular interactions.

• The Journal of the Korea Contents Association
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• v.11 no.11
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• pp.503-513
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• 2011

Appreciation of nature and an understanding of the biological sciences by the general public are key to the popularization of modern science. In particular, informal and accessible venues such as museum exhibits occupy a crucial role in science education, and they depend heavily on fields related to macrobiology, including Ecology, Animal Behavior, and Environmental Science. Unfortunately, lack of engaged experts and superficial descriptions of natural phenomena all too often prevent scientific knowledge from being shared effectively with the general public. Raw information itself and knowledge are not in a form or structure accessible to nonspecialists. In order to move successfully deliver substantive comprehension of the biological knowledge to the general public, it is necessary to categorize information from a content-conscious perspective and transform it into useful biological content. Therefore, the role of scientists is critically important in a series of processes that include theme selection, editing, and even graphical layout of contents. These processes require not only a scientific and logical way of thinking, but also an aptitude for artistic presentation and effective communication. The concept of Translation is presented as a theoretical and operational framework for the popularization of science.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.29 no.1
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• pp.393-416
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• 2018

In this study, major steps of the research data management plan were derived through the research data management guidelines of major countries (NISO DMP in the US, UK DMP in UK archives, etc.). The results obtained are support for research data policy & planning, research data technical support, research data sharing support, research data legal mechanism support, and research data education support. In this study, we analyzed seven cases of data sharing among 7 domestic and foreign biotechnology. Shared use case countries are limited to the United Kingdom and the United States, which play a leading role in the management of research data. In Korea, shared cases were analyzed for the Korean Bio Information Center and related systems, which is a research and performance management and distribution agency designated by the Ministry of Science and Technology.

• Journal of Convergence for Information Technology
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• v.10 no.8
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• pp.60-67
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• 2020

This study was conducted through a focus group interview of 4 teams of 40 nursing students to provide basic data for the development of customized cadaver practice programs and life and nursing ethics education by identifying the anatomical observation experiences of nursing students through cadaver. We tried to grasp the meaning and essence of the anatomical observation experience using the Colaizzi analysis method. As a result of the analysis, 3 categories, 6 theme clusters, and 12 themes were derived. The theme clusters for each category are as follows: Unrest (worry, confrontation), reflection (the boundary between life and death, teaching of the body teacher), growth (step forward, a valuable experience that will never be again). It was an opportunity for nursing students to realize the mystery of the human body and the preciousness of life through the experience of cadaver, and to consider the altruistic life through donation while recognizing that death is also a process of life in a broad sense.

• The Korean Society of Law and Medicine
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• v.10 no.1
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• pp.39-75
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• 2009

The development of the biomedical science and technology has extended an argument about a status in constitutional law of unborn human life and a protection of the potential human life to that of an embryo and a gamete beyond a fetus. This argument has been focused on whether we should provide unborn or potential human life with human dignity and the right to life that are guaranteed by the constitutional law altogether or separately. If the right to life is given to unborn or potential human life, on what grounds can we restrict this right. Those who argue for the unity of the right to life with human dignity and the inseparability of those two claims that the right to life in itself should be guaranteed absolutely. According to the constitutional law, however, any constitutional right of the human person within the protection of essential part of the right can be compared with each other and restricted with some valid reasons from the legal perspective. This measure is unavoidable in reality because one right can come into conflict with another right frequently. Since fetus and embryo are in a process of developing into the human person, it is difficult to think that they are the same with the human person. For that reason, it is hard to consider that the right to life of fetus or embryo is the same with that of the human person. However, since a fetus has a special status as a potential human person, and an embryo also has a special value as a potential fetus upon an implantation, the right to life of fetus or embryo should be judged differently according to the stage of their development. A study on a constitutional status and protection of a fetus and an embryo is essential because unborn or potential human life is the origin of human person. Therefore, we have to make much account of their right to life and seek the legal respect for their inherent value.

• The Korean Society of Law and Medicine
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• v.10 no.1
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• pp.11-38
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• 2009

"Bioethics" may have various meanings depending on its roles. It may mean professional ethics for scientists and physicians, etc. It may also mean an academic discipline using interdisciplinary approach as well as a philosophical or a legal approach. "Bioethics" as an interdisciplinary study should often deal with public policy on bioethical issues. I call this role bioethics as a study of bioethics policy, which has to be developed as a new discipline. From this perspective, I deal with bioethical issues relevant to a human life before birth. There are various and often conflicting arguments about the moral status of a human life before birth such as the fertilization argument, the argument of genetic identity, so-called the "14 days" argument focusing on the formation of primitive streak, the argument of sentient being, and Michael Sandle's argument of an embryo as a being between a thing and a person. I argue that each of them is reasonable. Thus we are faced with reasonable disagreement on the views over whether a human life before birth has the same right to life as that of a person or whether right to life may be considered to be a matter of degree. If we acknowledge reasonable disagreement, as John Rawls pointed out, we should tolerate the views from ours in a plural society. Therefore, we cannot help making a policy that allows abortion and embryonic research with some limitations. When we say a certain act is morally permissible, "moral permissibility" does not mean that the act is morally right for all. Rather it means that the act cannot help being morally allowed for some persons although the others do not believe its moral rightness because they cannot right now rationally persuade others to accept their view.

• Journal of Biomedical Engineering Research
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• v.40 no.5
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• pp.206-214
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• 2019

Surgical methods and associated precision systems have been developed, but surgical procedures that require precise location and fine manipulation of the lesion remain a limitation. The combination of precision robot manipulation technology and 3D medical image navigation technology overcomes the limitations of minimally invasive surgery (MIS) and enables a more stable and successful operation. Surgical robots are surgical robots such as da Vince, and surgical robots using industrial robotic arms. There are various developments and researches of medical robots. In recent medical robot development, a new type of surgical robot based on an industrial robot arm capable of easily replacing the end effector according to the user's needs is being actively developed at home and abroad. Therefore, in this study, we developed safety and performance evaluation guideline for micro - surgical robots based on open robot platform using general purpose robot arm to help quality control of the medical device.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.438-438
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• 2015

기후변화 시나리오는 다양한 자연조건에 대한 불완전한 이해, 연산능력 등의 제한으로 매우 높은 불확실성이 내포되어 있으며, 국내의 다양한 연구에서도 제시되어 있듯이 매우 과소 추정되어 있는 문제점이 있다. 이러한 문제로 인하여 다양한 편의보정 기법을 통해 기후변화 시나리오의 불확실성을 줄이고자 하는 노력이 수행되었다. 그러나 편의보정 기법은 적용 방법이 서로 상이하기 때문에 보정에 따른 강우 특성이 다르게 나타나는 문제점이 있다. 이에 본 연구에서는 편의보정 기법에 따른 강우-유출 특성을 갑천유역을 대상으로 분석하였다. Change Factor(CF)와 Quantile Mapping(QM) 그리고 CF와 QM을 연계한 편의보정기법(CQ)에 따른 강우-유출 특성을 갑천유역을 대상으로 Change Factor(CF)에서 연평균(CF_Y)/월평균(CF_M) 교정계수를 이용하는 방법과 Quantile Mapping(QM)을 총 편의보정기간(QM_E)과 우기와 비우기(QM_P)를 구분하여 누적확률분포를 고려하는 방법, 그리고 CF와 QM을 연계한 편의보정기법(CQ) 총 5가지에 대해서 편의보정을 수행하고 유출특성을 SWAT모형을 이용하여 분석하였다. 과거 기간에 대해 CF_M과 QM_P는 첨두유량이 실측 첨두유량에 비해 2배 이상 크게 나타났으며, 특히 QM_P는 최대 강우 발생 월이 다른 편의보정 기법과는 다르게 나타나 월별 유출 분석시 큰 오류가 발생될 것으로 판단된다. 5가지의 편의보정 기법 중에 CQ가 과거 강수 크기, 발생 분포 및 빈도 재현을 가장 잘 반영하며, 미래기간에 대한 기간별(2030s, 2050s, 2070s, 2090s) 평균유량을 비교한 결과 본 연구에서 사용한 SRES A1B 시나리오의 이산화탄소 배출 시나리오의 특성을 유지한 미래 강우-유출해석이 이루어지는 것으로 나타났다. 기후변화 시나리오에 편의보정 기법 적용으로 자연적인 현상을 정확하게 모의하기에는 어려움이 많고 불확실성 역시 매우 크지만, 과거 강수발생 경향이나 편의보정의 특성을 알고 활용목적에 맞는 편의보정을 수행한다면 수자원 관리 계획 수립 등에 큰 도움이 될것으로 판단된다.