• Journal of Nutrition and Health
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• 제35권4호
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• pp.431-438
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• 2002

This study was performed to investigate the effects of green tea or antioxidant vitamins on lipid peroxidation and antioxidant enzyme system in various regions of rat brain aged 9 and 12 months. Male Sprague-Dawley rats were raised on the experimental diets; 3% green tea powder diet, antioxidant vitamins diet containing the $\beta$-carotene, vitamin C, vitamin E in the level same as in the 3% green tea powder diet, and control diet far 3 weeks. We measured concentrations of malondialdehyde (MDA) and the activities of superoxide dismutase (SOD), catalase, and glutathione peroxide (GSH-Px) in various brain regions such as cortex, cerebellum, striatum, and hippocampus. Green tea powder or antioxidant vitamin supplementation decreased MDA concentrations in the striatum and the hippocampus, and increased SOB activities in the striatum, and GSH-Px activities in the cortex. There was no significant difference in the observed antioxidative effects between the green tea powder and antioxidant vitamin supplementation. A significant difference between 9 month- and 12 month-old rats was found in MDA concentrations and GSH-Px activities in all brain regions. These results suggest that green tea powder can have protective effects on various regions of rat brain and that these effects on lipid peroxidation and antioxidant enzymes are different by age. In inhibiting lipid peroxidation, there was no difference between green tea powder and antioxidant vitamins.

• PNF and Movement
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• 제14권3호
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• pp.231-236
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• 2016

Purpose: The purpose of this study was to compare cerebral motor area activation between the diagonal and straight movements of the lower extremity. Methods: The subjects of this study consisted of two right-handed adults. Functional magnetic resonance imaging was conducted to measure brain activation following the diagonal and straight movements of the lower extremity. The primary motor area, premotor area, and supplementary motor area, which are closely related to exercise, were set as the regions of interest. Results: The brain activation by diagonal movement was an average of $1036{\pm}75$ voxel, and brain activation by straight exercise was an average of $773{\pm}55$ voxel. Conclusion: Based on these results, we conclude that the activation of the cerebral motor area is more effective for diagonal movements than for straight movements.

• Proceedings of the Korean Society of Applied Pharmacology
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.161-161
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• 1993

중추 Cholinergic성 신경계 작용약의 유발한 치매동물 모델의 타당성 여부를 확인하기 위해 흰쥐에 Scopolamine, Physostigmine 및 생약을 반복 투여하였을 때의 active avoidance에 미치는 영향을 단회 투여하여 가역적인 작용을 가질때의 영향과 비교하고 이때 대뇌피질에서의 Cholinergic성 신경계의 활성 변화를 측정하여 중추 Cholinergic성 신경계의 학습, 기억 과정에서의 역할 및 나아가 치매의 발생 원인 및 발병 져로 규명에 접근하고자 하였다. 6 주된 Wistar계 웅성 래트에 Cholinergic성 신경계 작용약인 Scopolamine(1 mg/kg), Posostigmine (0.1mg/kg)과 생약인 Ginseng Total Saponine(100 mg/kg), 오미자 추출물 (150 mg/kg)등을 단독 혹은 병용으로 피하와 복강내로 7 일간 반복 투여하면서 Shuttle Box를 이용하여 Active Avoidance 의 습득율을 측정하고 이후 실험동물을 단두치사하여 대뇌피질 영역에서의 Acetylcholine 농도와 Acetylcholinesterase 활성 변화를 Chemi luminosence 법을 이용하여 측정하였다.

• Journal of The Korean Society of Inherited Metabolic disease
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• 제2권1호
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• pp.1-6
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• 2002

출생 이후 머리둘레가 커지는 1개월 남아에게서 뇌초음파상 지주막하 공간이 확장되어 있고 백질의 음영이 증가되어 있었고 뇌 MRI 소견은 sylvian fissure의 확장과 양측 대뇌, 소뇌 피질과 백질이 T1 강조 영상에서 저신호강도와 T2 강조영상에서 고신호강도를 보였고 검사상 GA1 의심되었고 경피생검으로 얻은 섬유아세포 배양에서 glutaryl CoA dehydrogenase의 활성도가 전혀 없어 GA1을 확진하게 되었다. 이후 특수분유인 Glutatex(Abbott사) 수유와 riboflavin, carnitine 보충요법을 시행하여 대사성 위기나 급성 뇌증 위기는 없었고 양호히 발달하는 것을 경험하였기에 보고하는 바이다.

• Applied Microscopy
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• 제41권4호
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• pp.249-255
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• 2011

Neurons utilize a large quantity of energy for their survival and function, and thereby require active mitochondrial function. Mitochondrial morphology shows dynamic changes, depending on the cellular condition, and mitochondrial dynamics are required for neuronal development and function. In this study, we found that the length of mitochondria in the distal axon is significantly shorter than that of mitochondria in dendrites or proximal axons of cerebral cortical neurons, and the reason for this difference is the local fission within the axon. We also found that suppression of Drp1, a key regulator of mitochondrial fission, resulted in significant elongation of mitochondria in axons. Collectively, these results suggest that local mitochondrial fission within the axon contributes to region-dependent mitochondrial length differences in the axons of cortical neurons.

• Journal of the Korea Convergence Society
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• 제12권12호
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• pp.323-330
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• 2021

In this study, we intended to examine the difference in brain activation due to dominant and non-dominant hands using functional near-infrared spectroscopy(fNIRS) in 10 healthy adults. Box & Block Test(BBT) was conducted under two conditions: dominant hand and non-dominant hand. During the experiment, brain activity was measured using fNIRS and signals were analyzed using nirsLAB v2019.04 software after the experiment was completed. As a result, 6 out of 10 people showed activation of the cerebral hemisphere related to the dominant hand, and only 3 out of 10 people showed activation of the cerebral hemisphere related to the non-dominant hand. In other words, both dominant and non-dominant hand cconfirmed that the cerebral hemispheres related to dominant hands were more active. Therefore, it is believed that fNIRS can be used as a fundamental data applicable to children with sensory processing disorders that are difficult to identify dominant hand.

• Journal of Ginseng Research
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• 제32권4호
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• pp.341-346
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• 2008

In the present study, we assessed the effects of white ginseng and red ginseng extract on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of ginseng extracts was investigated using the Morris water maze and Y-maze test. Drug-induced amnesia was induced by treating animals with scopolamine (2 mg/kg, i.p.), an antagonist of muscarinic acetylcholine (ACh) receptor. Tacrine was used a positive control. Ginseng extract (200 mg/kg, p.o.), tacrine (10 mg/kg, p.o.) administration significantly reduced the escape latency during training in the Morris water maze (p<0.05). At the probe trial session, scopolamine significantly increased the escape latency on day 5 in comparison with control (p<0.01). The effect of ginseng extracts on spontaneous alternation in Y-maze was similar to that of scopolamine treated group. In addition, numbers of arm entries were similar in all experimental groups. Moreover, red ginseng extract significantly inhibited acetylcholinesterase activity in the cortex and serum (p<0.05). Brain ACh contents of ginseng extract treated groups increased more than that of scopolamine group, which did not show statistically significant. These results suggest that ginseng extract may be useful for the treatment of cognitive impairment.

• The Journal of Korean Physical Therapy
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• 제21권4호
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• pp.73-79
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• 2009

Purpose: Recently, neurostimulation studies involving manipulation of cortical excitability of the human brain have been increasingly attempted. We investigated whether transcranial direct current stimulation (tDCS) applied to the underlying cerebral cortex, directly induces cortical activation during fMRI scanning. Methods: We recently recruited five healthy subjects without a neurological or psychiatric history and who were right-handed, as verified by the modified Edinburg Handedness Inventory. fMRI was done while constant anodal tDCS was delivered to the underlying SM1 area?? immediately after the pre-stimulation for eighteen minutes. Results: Group analysis yielded an averaged map that showed that the SM1 area and the superior parietal cortex in the ipsilateral hemisphere were activated. The voxel size and peak intensity were, respectively, 82 and 5.22 in the SM1, and 85 and 5.77 in the superior parietal cortex. Conclusion: Cortical activation can be induced by constant anodal tDCS of the underlying motor cortex. This suggests that tDCS may be an effective therapeutic device for enhancing? physical motor function by modulating neural excitability of the motor cortex.

• Science of Emotion and Sensibility
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• 제8권4호
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• pp.321-332
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• 2005

This study is about the effect on the user's cognitive stress by font size when they read on PDA (Personal Digital Assistant). The evaluation was done through both subjective evaluation and physiological one, which is brain wave test, while the research and analysis were focused on the relationship between the user's cognitive stress and font, size. The two final results were found out as follows. 1) Font sizes, which were tested, were 8, 10, 12, 14, and 16points. Among theses, font size 14 was the least stressful for the users. while the most stressful size was found out 8 points. 2) The cerebral cortex reaction according to the font size activated occipital lobe, parietal lobe of occipital visual area. Here we could come to a very important conclusion that the smaller font size on mobile information appliances mate users the more stressed.

• Archives of design research
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• 제15권3호
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• pp.249-258
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• 2002

This study is about the effect on the user's cognitive stress by font size when they read on PDA(Personal Digital Assistant). The evaluation was done through both subjective evaluation and physiological one, which is brain wave test, while the research and analysis were focused on the relationship between the user's cognitive stress and font size. The two final results were found out as follows. 1) Font sizes, which were tested, were 8, 10, 12, 14, and 16 points. Among theses, font size 14 was the least stressful for the users, while the most stressful size was found out 8 points. 2) The cerebral cortex reaction according to the font size activated occipital lobe, parietal lobe of occipital visual area. Here we could come to a very Important conclusion that the smaller font size on mobile information appliances made users the more stressed.