• Tuberculosis and Respiratory Diseases
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• v.47 no.3
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• pp.331-338
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• 1999

Background: Nearly 10% of cancer patients will develop a second primary cancer within ten years after surgical removal of the primary tumor. The detection of risk factors for developing multiple primary tumors would be important This study was conducted to evaluate the clinical characteristics and abnormal p53 expression of lung cancer associated with multiple primary cancer(MPC). Method: Clinical characteristics and abnormal p53 expression were compared between 20 cases of lung cancer(NSCLC ; 16 cases, SCLC ; 4 cases) associated with MPC and 26 cases of primary non-small cell lung cancer. Result: MPC associated with lung cancer was gastric cancer(8), lung cancer(2), esophageal cancer(2), colon cancer(2), laryngeal cancer(1), bladder cancer(1), small bowel cancer(l), adrenal cancer(1), hepatocellular carcinoma(1), and breast cancer (1) in order. The clinical stage of primary NSCLC was relatively advanced, but NSCLC associated with MPC was even distribution at each stage. The detected incidences of abnormal p53 expressions were 62.5% in NSCLC associated with MPC and 76.9% in primary NSCLC(p>0.05). Conclusion: There was no difference in abnormal p53 expression between non-small cell carcinoma associated with multiple primary cancer and primary non-small cell carcinoma.

• Journal of the Korean Society of Radiology
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• v.84 no.1
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• pp.150-169
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• 2023

Multiple myeloma (MM) is a malignant hematologic disease caused by the proliferation of clonal plasma cells in the bone marrow, and its incidence is increasing in Korea. With the development of treatments for MM, the need for early diagnosis and treatment has emerged. In recent years, the International Myeloma Working Group (IMWG) has been constantly revising the laboratory and radiological diagnostic criteria for MM. In addition, as whole-body MRI (WBMR) has been increasing used in the diagnosis and treatment response evaluation of patients with MM, the Myeloma Response Assessment and Diagnosis System (MY-RADS) was created to standardize WBMR image acquisition techniques, image interpretation, and response evaluation methods. Radiologists need to have a detailed knowledge of the features of MM for accurate diagnosis. Thus, in this review article, we describe the imaging method for MM according to the latest IMWG guidelines as well as the image acquisition and response evaluation technique for WBMR according to MY-RADS.

• Journal of Hospice and Palliative Care
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• v.17 no.4
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• pp.207-215
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• 2014

Multiple bone metastases are common manifestation of many malignant tumors such as lung cancer, breast cancer, prostate cancer and renal cell carcinoma. Bone metastasis is secondary cancer in the bone, and it can lead to bone pain, fracture, and instability of the weight bearing bones, all of which may profoundly reduce physical activity and life quality. Treatment for bone metastasis is determined by multiple factors including pathology, performance status, involved site, and neurologic status. Treatment strategies for bone metastasis are analgesics, surgery, chemotherapy and radiotherapy. External beam radiotherapy has traditionally been an effective palliative treatment for localized painful bone metastasis. However, in some cases such as multiple bone metastases, especially osteoblastic bone metastasis originated from breast or prostate cancer, the radiopharmaceutical therapy using $^{89}Sr$, $^{186}Re$, $^{188}Re$, $^{153}Sm$ and $^{117m}Sn$ are also useful treatment option because of administrative simplicity (injection), few side effects, low risk of radiation exposure and high response rate. This article offers a concise explanation of the radiopharmaceutical therapy for multiple bone metastases.

• Journal of Dental Rehabilitation and Applied Science
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• v.30 no.2
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• pp.159-169
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• 2014

Panfacial fractures require complex multidisciplinary approaches for treatment. Functional stability of bilateral condylar-disc complex should be the goal of the treatment. A patient with complex clinical panfacial fractures, including a bilateral condylar fractures visited our clinic. Facial asymmetry, insufficient vertical space and multiple missing teeth of the patient were major problems. Closed reduction and splint treatment were tried for stable condylar position. A functional and esthetic rehabilitation was accomplished by using implants and full mouth rehabilitaion. Potential possibilities of unstable occlusion should be prevented with night guard and periodic occlusal adjustment.

• Nuclear Engineering and Technology
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• v.27 no.3
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• pp.358-373
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• 1995

The Heat Transport system loop stability of CANDU-6 reactor using the CANFLEX fuel bundle was studied. The Thermal-hydraulic behavior of CANFLEX fuel bundle is similar to the conventional 37-element fuel bundle since the reactor power and the frictional pressure drop through the fuel channel is almost the same each other, Mounter the CANFLEX fuel bundle gives higher critical channel power and more homogeneous enthalpy distributions in the subchannels than 37-element fuel bundle. The SOPHT modelling or the CANFLEX fuel bundle and the Reactor outlet Header(ROH) interconnection line was made and the stability analysis response of Wolsong-1 reactor with CANFLEX fuel bundle was obtained. Without the ROH interconnection line the Heat Transport system loop using 43-element fuel bundle is unstable like the current 37-element fuel bundle. With the ROH interconnection line, however, the Heat Transport system is stable within $\pm$1％ of nominal flow. In the Heat Transport system loop stability point of view for Wolsong-1 plant therefore, the CANFLEX fuel loading is considered to be acceptable.

• Journal of the Korean Orthopaedic Association
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• v.55 no.4
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• pp.338-342
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• 2020

Periosteal chondroma is a rare, slow-growing, benign cartilaginous tumor that develops between the periosteum and cortex, but there are no reports of multiple periosteal chondroma of the toes. A 19-year-old male presented with a palpable mass of the right fourth toe with tenderness for one year. A radiology examination revealed multiple, radio-lucent lesions with mild cortical irregularity. The magnetic resonance imaging findings were chondrogenic tumors with multiple, well-defined T1-low and T2-high signal enhanced lesions involved in the fourth proximal, middle, and distal phalanges. The tumors were removed by a surgical resection and curettage. Histologically, the tumors were proven to be periosteal chondroma.

• The Journal of the Korean bone and joint tumor society
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• v.17 no.1
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• pp.11-16
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• 2011

Purpose: This study was aimed to analyze the incidence and the anatomical distributions of HME (Hereditary Multiple Exostoses) on upper limbs and its related change in alignment of the upper limbs in HME patients. Materials and Methods: Thirty eight patients who had been diagnosed HME between 2001 and 2009, were categorized into two groups; (1) group A (1-2 involvements); (2) group B (${\geq}$3 involvements). We checked the carrying angle, VAS (Visual Analogue Scale), limitations in daily activities, cosmetic satisfaction according to the number of exostoses invasion. Results: Among the 38 patients, 23 patients (43 cases) had exostoses in the upper limbs. The locations of exostoses in the upper limbs were proximal humerus in 33 cases (30%), distal ulna in 31 cases (28.2%), and distal radius in 24 cases (21.8%). The carrying angle of group A and B was $10.7^{\circ}$, $13.8^{\circ}$, VAS was 1.3, 3.5, and the limitations in daily activities was 7.3, 6.6 of 8 points. The cosmetic satisfactory cases were 13 and 10 cases, respectively. Conclusion: The deformity in upper limbs was observed in 65% of the HME patients. As the number of invasion increases, carrying angle and VAS were increased but limitations in daily activities and cosmetic satisfaction were decreased.

• Journal of the Korean Arthroscopy Society
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• v.12 no.2
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• pp.91-92
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• 2008

후방십자인대 및 후외측인대 재건술 후 결과는 많은 발전이 있었지만, evidence medicine의 측면에서 재활 방법에 관한 전향적 연구는 없다. 현재까지의 재활 방법은 다양하게 소개되었지만 전방십자인대 재건술처럼 가속 재활을 하는 것은 바람직스럽지 않다. 후방십자인대, 후외측인대 그리고 다발성 인대 재건술 후 재활은 수술 방법과 환자의 재건된 인대의 상태, 하지 정렬 등에 따라서 개별화하여 점진적으로 진행하여야 할 것이고, 재활기간 동안 의사의 세심한 관찰이 필요하다.

• 대한족부족관절학회:학술대회논문집
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• 2008.11a
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• pp.13-13
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• 2008

• Korean Journal of Clinical Laboratory Science
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• v.52 no.3
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• pp.237-244
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• 2020

Currently, sexually transmitted diseases (STD) are referred to as "sexually transmitted infections" (STIs) in the sense of including asymptomatic infections. STIs have a range of interrelationships. This study used the STI defined by the Minister of Health and Welfare of the Republic of Korea, and targeted syphilis, gonorrhea, chlamydia infection, chancroid, genital herpes simplex, condyloma, human papillomavirus, and non-gonococcal urethritis. The factors were characterized by identifying multiple and simultaneous STIs. This study used the data from the laboratory information system of a consigned inspection institution located in Seoul from 2014 to 2019. In this study, multiple STIs were identified as overlapping STIs of a double infectious source (10 types) and multiple STIs of a third infectious source (6 types). Among the 16 types of multiple STIs, U. urealyticum (9 types), HSV-2 (8 types), C. trachomatis (7 types), HPV 6, 11 (7 types), N. gonorrhoeae (6 types), and T. pallidum (1 type) were included. Therefore, additional research on interrelationship studies, such as STIs, which has the highest proportion of multiple STIs, will be necessary.