• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.3
• /
• pp.284-288
• /
• 2018

The scuttle fly central nervous system (CNS) is unobservable during egg and larvae instar stage 1. During days 2~3 of larvae instar stage 2, the left and right hemisphere of the brain can be observed. Below the brain, the subesophageal ganglion (SOG) connects to the ventral nerve cord (VNC). During days 3~5 of larvae instar stage 3, the CNS enlarged slightly with no other changes. During days 1~3 of the pupal stage the CNS moved to the head with no distinguishable changes from the previous stage. During days 4~6 of the pupal stage, the left and right hemisphere of the brain had fused into one mass and the optic lobe (OL) located on the side of the brain completed its development. During days 7~9 of the pupal stage, the OL began to show eyeball pigment. The SOG was connected to the brain and the VNC began to separate, which was accompanied by an increase in nerve fibers. During days 10~12 of the pupal stage, the brain of the CNS and VNC was clearly distinguished and the brown pigmentation of OL became darker. During days 13~15 days of the pupal stage, the separated brain and VNC became connected by thin nerve fiber. The VNC began to separate into two with a greater increase in nerve fibers. The adult fly showed similar features to the previous stage, but the brain was located in the head and the VNC in the chest.

• Progress in Medical Physics
• /
• v.21 no.4
• /
• pp.348-353
• /
• 2010

The purpose of this study was to explore the potentials of a clinical 3T MRI in mouse brains and technical adaptation and optimization. T1-weighted images (T1WI), T2-weighted images (T2WI), FLAIR (Fluid Attenuated Inversion Recovery) images, Gadolinium enhanced T1-weighted images (Gd-T1WI), Diffusion weighted images (DWI) were acquired in brain of 2 mice (weight 20~25 g) with cerebral infarction by occlusion of right middle cerebral artery, 1 hour, 24 hours, 72 hours after infarction and 1 normal mouse brain using clinical 3T MRI scanner. We analyzed differentiation of striatum, ventricle, cerebral cortex, and possibility of detection of acute cerebral infarction. We could differentiate the striatum, ventricle, cerebral cortex on T2WI and on DWI, FLAIR, T1WI, the differentiation of each anatomy of brain was not definite, but acute cerebral infarction was detected on DWI of 1 hour, 24 hours, 72 hours after infarction and on T2WI, FLAIR of 24 hours, 72 hours after infarction. Clinical 3T MRI can be used in differentiation of anatomy of mouse brains and DWI can be helpul in detection of acute cerebral infarction in acute phase. With technical adaptation and optimization clinical 3T MRI can be useful tool for provide preclinical and clinical small animal studies.

• Journal of Chest Surgery
• /
• v.32 no.9
• /
• pp.790-798
• /
• 1999

Background: As the early outcome after coronary artery bypass grafting(CABG) has been stabilized, neurologic complication has now become one of the most important morbidity. The aim of this study was to find out the risk factors associated with the neurologic complications after CABG. Material and Method: In 351 patients who underwent CABG, the incidence and features of neurologic complications, with associated perioperative risk factors, were retrospectively reviewed. Neurologic complication was defined as a new cerebral infarction confirmed by postoperative neurologic examination and radiologic studies, or delayed recovery of consciousness and orientation for more than 24 hours after the operation. Result: Neurologic complications occurred in 18 patients(5.1%), of these nine(2.6%) were diagnosed as having new cerebral infarctions(stroke). Stroke was manifested as motor paralysis in four patients, mental retardation or orientation abnormality in four, and brain death in one. Statistical analysis revealed the following variables as significant risk factors for neurologic complications by both univariate and multivariate analyses: cardiopulmonary bypass longer than 180 minutes, atheroma of the ascending aorta, carotid artery stenosis detected by Duplex sonography, and past history of cerebrovascular accident or transient ischemic attack. Age over 65 years, aortic calcification detected by simple X-ray, and intraoperative myocardial infarction were significant risk factors by univariate analysis only. Neither the severity of carotid artery stenosis nor technical modifications such as cannulation of the aortic arch or single clamp technique, which were expected to affect the inciden e of neurologic complications, had significant relationship with the incidence. Conclusion: This study confirmed the strong association between neurologic complications after CABG and atherosclerosis of the arterial system. Therefore, to minimize the incidence of neurologic complications, systematic evaluation focused on atherosclerotic lesions of the arterial system followed by adequate alteration of operative strategy is needed.

• The Korean Journal of Nuclear Medicine
• /
• v.38 no.6
• /
• pp.528-531
• /
• 2004

Purpose: PET has some disadvantage in the imaging of small animal due to poor resolution. With the advent of microPET scanner, it is possible to image small animals. However, the image quality was not good enough as human image. Due to larger brain, cat brain imaging was superior to mouse or rat. In this study, we established the cat brain infarction model and evaluate it and its temporal charge using microPET scanner. Materials and Methods: Two adult male cats were used. Anesthesia was done with xylazine and ketamine HCl. A burr hole was made at 1cm right lateral to the bregma. Collagenase type IV 10 ${\mu}l$ was injected using 30 G needle for 5 minutes to establish the infarction model. $^{18}F$-FDG microPET (Concorde Microsystems Inc., Knoxville, TN) scans were performed 1, 11 and 32 days after the infarction. In addition, $^{18}F$-FDG PET scans were performed using human PET scanner (Gemini, Philips medical systems, CA, USA) 13 and 47 days after the infarction. Results: Two cat brain infarction models were established. The glucose metabolism of an infarction lesion improved with time. An infarction lesion was also distinguishable in the human PET scan. Conclusion: We successfully established the cat brain infarction model and evaluated the infarcted lesion and its temporal change using $^{18}F$-FDG microPET scanner.

• The Korean Journal of Nuclear Medicine
• /
• v.26 no.2
• /
• pp.230-234
• /
• 1992

뇌와 뇌간의 모든 기능이 정지되어 인공적으로 심폐 기능은 유지되고 있더라도 뇌의 혈액순환은 중지되고 전체 뇌에 경색이 있어 회복이 불가능한 상태를 뇌사라 한다. 이렇게 뇌와 뇌간의 모든 기능이 정지된 이후에는 곧 심장 정지가 뒤따른다. 심장과 폐의 기능 정지에 의해 죽음을 정의하는 것은 심폐소생 장치 및 생명유지 장치의 효과적인 발달로 이제는 뇌자체의 기능을 평가하는 것으로 대치되게 되었다. 최근 장기 이식술의 발달로 혈액순환을 비롯한 식물적인 기능은 인공적으로 유지되는 상태에서 가능한한 빠른시간내에 적용할 수 있는 뇌사판정 방법의 필요성이 대두되었다. 그래서 이러한 판정을 하는데 소요되는 시간을 줄이기 위한 뇌사를 확신할 수 있는 여러가지 진단 방법에 대한 관심이 고조되었다. 동위원소 뇌혈관촬영술도 이런 진단방법중 하나로 뇌혈액순환의 정지를 보여줌으로써 임상적으로 뇌사를 진단하는 데 보조적인 방법으로 사용될 수 있다.

• The Journal of Dong Guk Oriental Medicine
• /
• v.9
• /
• pp.25-33
• /
• 2000

Dizziness is one of the common symptoms in many patients. The disorders of the labyrinth, vestibular nerve, vestibular neclei, or their central connections are responsible for practically all vertigo. Most disorders of the central connections are the vascular diseases and tumors. This study is based on the clinical consideration of one patient who sufferd from the cerebellar infarction and the upper respiratory infection. The patient, 61 - year - old man was diagnosed as the cerebellar infarction has been troubled with dizziness, a headache, a sore throat, a cough etc. The symptoms are classed as the Sanchopungyeul.(上焦風熱) Pungdam(風痰), and we prescribed Qingyanligetang(淸咽利膈湯) for him and his symptoms took a tum for the better.

• Investigative Magnetic Resonance Imaging
• /
• v.6 no.1
• /
• pp.55-63
• /
• 2002

Purpose : We investigated the predictive values of relative CBV measured with perfusion MR imaging, and relative CBF measured with SPECT for tissue outcome in acute ischemic stroke. Material and Methods : Thirteen patients, who had acute unilateral middle cerebral artery occlusion, underwent perfusion MR imaging, and $^{99m}Tc-HMPAO$ SPECT within 6 hours after the onset of symptoms. Lesion-to-contralateral ratios of perfusion parameters were measured, and best cut-off values of both parameter ratios with their accuracy to discriminate between regions with and without evolving infarction were calculated. Results : Mean relative CBV ratios in regions with evolving infarction and without evolving infarction were $0.58{\pm}0.27$ and $0.9{\pm}0.17$ (p < 0.001), and mean relative CBF ratios in those regions were $0.41{\pm}0.22$ and $0.71{\pm}0.14$ (p < 0.001). The best cutoff values to discriminate between regions with and without evolving infarction were estimated to be 0.80 for relative CBV ratio and 0.56 for relative CBF ratio. The sensitivity, specificity and efficiency of each cutoff value were 80.6, 87.5, 82.7% for relative CBV ratio, and 72.2, 75.0, 73.0% for relative CBF ratio (p > 0.05 between two parameters). Conclusion Measurement of relative CBV and relative CBE may be useful in predicting tissue outcome in acute ischemic stroke.

• The Korean Journal of Nuclear Medicine
• /
• v.22 no.2
• /
• pp.157-161
• /
• 1988

Cerebral rete mirabile는 잘 알려진 뇌혈관 질환으로 뇌혈관촬영상 내경동맥이 심한 협착 혹은 폐색, 뇌저부의 이상혈관망 형성 및 다수의 연수막동맥간문합과 경경수막 외내경동맥간문합의 특징적 소견을 나타낸다. 최근 방사성의약품의 발전과 함께, Tc-99m-HMPAO를 이용한 뇌SPECT는 뇌혈류역학의 평가, 병소의 조기발견 및 병소의 정확한 위치를 알기위한 상용진단 방법이 되었다. 저자들은 뇌 혈관촬영으로 확진된 10명 의 Cerebral rete mirabile 환자에서 뇌 전산화단층촬영과 Tc-99m-HMPAO를 이용한 국소뇌혈류 SPECT를 검토하였다. 대상환자중 남자는 3명, 여자는 7명이었으며, 연령분포는 6세에서 38세이었다. 1) Tc-99m-HMPAO를 이응한 국소 뇌혈류 SPECT는 뇌의 경색부위 뿐만 아니라 허혈부위까지 나타냈으며, cerebral rete mirabile에서의 뇌의 침습된 부위를 나타내는데 있어서 뇌전산화단층촬영보다 우월하였다. 또한 모든 예에서 뇌전산화반층촬영보다 더 넓은 허혈부위를 보여주었다. 2) 다른 허혈성 뇌혈관질환과 비교하여 cerebral rete mirabile는 비균질성 방사능을 나타냈고, 이는 측부순환로에 의한 것으로 추측된다. 3) Tc-99m-HMPAO를 이용한 국소뇌혈류 SPECT는 뇌의 허혈부위의 범위를 평가, 문합수술의 계획 및 cerebral rete mirabile의 경과를 추적하는데 유용한 검사이다.

• Journal of the Korean Society of Radiology
• /
• v.83 no.3
• /
• pp.486-507
• /
• 2022

Cerebral small vessel disease (CSVD) includes vascular lesions detected on brain MRI, such as white matter hyperintensities, lacunar infarctions, microbleeds, or enlarged perivascular spaces. There is accumulating evidence that vascular changes may play an important role in development of Alzheimer's disease (AD), and CSVD lesions detected on brain MRI were reported to be associated with β-amyloid and tau proteins accumulation. As the vascular contribution has therapeutic potential, it is important to understand the association of CSVD with AD and AD biomarkers. This review begins with a brief introduction of AD and AD biomarkers, explains the association between AD and vascular changes, and then details the pathogenesis and MR imaging findings of CSVD. Afterwards, we discuss the association of CSVD with AD and AD biomarkers.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.28 no.4
• /
• pp.130-141
• /
• 2015

Objectives : The aim of this study is to report the effect of Korean medicine treatment on ocular motility disorders (ptosis, bilateral upward gaze palsy, adduction impairment, and strabismus) caused by thalamus, midbrain and pontine infarctions.Methods : The patient was treated by using acupuncture, hominis placenta pharmacoacupuncture, and electroacupuncture treatment. The change of ptosis was evaluated by measurement of palpebral fissure width. The change of gaze palsy and strabismus were evaluated by comparison the photographs of the extraocular movements of patient. Strabismus also was evaluated by corneal reflex test.Results : Gaze palsy and strabismus were improved. Ptosis disappeared after Korean medicine treatment.Conclusions : Korean medicine treatment should be effective for the ocular motility disorders caused by thalamus, midbrain and pontine infarctions.