• Electrical & Electronic Materials
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• v.18 no.7
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• pp.18-31
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• 2005

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.20-25
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• 2020

As nanoscience and nanotechnology advance, techniques for selective pattern growth have attracted significant attention. Silica nanoparticles (NPs) are used as a promising nanomaterials for bio-labeling, bio-imaging, and bio-sensing. In this study, silica NPs were synthesized by a sol-gel process using a modified Stöber method. In addition, the selective pattern growth of silica NPs was achieved by the surface functionalization of the substrate using a micro-contact printing technique of a hydrophobic treatment. The particle size of the as-synthesized silica NPs and morphology of selective pattern growth of silica NPs were characterized by FE-SEM. The contact angle by surface functionalization of the substrate was investigated using a contact angle analyzer. As a result, silica NPs were not observed on the hydrophobic surface of the OTS solution treatment, which was coated by spin coating. In contrast, the silica NPs were well coated on the hydrophilic surface after the KOH solution treatment. FE-SEM confirmed the selective pattern growth of silica NPs on a hydrophilic surface, which was functionalized using the micro-contact printing technique. If the characteristics of the selective pattern growth of silica NPs can be applied to dye-doped silica NPs, they will find applications in the bio imaging, and bio sensing fields.

• The Optical Journal
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• s.125
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• pp.22-23
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• 2010

1970년대 중반 일본에서 만들어진 메카트로닉스(Mechatronics)라는 용어는 기계공학(Mechanics)과 전자공학(Electronics)의 합성어로 1980년대 이후 전세계적으로 널리 사용되었다. 이후 컴퓨터 기술의 급속한 발전에 힘입어 메카트로닉스는 로봇, 공장자동화, CNC공작기계 등 현대산업의 근간을 이루는 핵심 기술로 자리매김 하였다. 최근에는 학문의 경계를 허무는 작업들이 더욱 속도를 내고 있는 가운데, 생활에서 늘 접하는 휴대폰, TV, 빔프로젝트 등의 제품에 시각적 신호를 창출하기 위한 광학적 요소가 결합되고 있다. 이를 우리는 옵토메카트로닉스(Optomechatronics)라는 영역으로 분류한다. 여기에 생체공학(Bionics)과 나노기술(Nano technology)의 결합을 필요로 하는 제품들이 또한 바이오옵토메카트로닉스(Bio-Optomechatronics)또는 나노바이오 옵토메카트로닉스(Nano-Bioopmechatronics)등의 새로운 영역 창출을 준비하고 있다.

• Analytical Science and Technology
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• v.28 no.6
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• pp.425-429
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• 2015

A cholesterol biosensor was developed using a modified carbon electrode with carbon nanotubes. The disposable cholesterol biosensor was modified with carbon nanotubes to enhance electron transfer during the enzymatic reaction of cholesterol. Cholesterol oxidase and peroxidase, with potassium ferrocyanide as a mediator, were immobilized on a screen-printed carbon nanotube electrode. The electrochemical cholesterol biosensor developed using carbon nanotubes showed a rapid and reliable signal for measuring total cholesterol. The cholesterol sensor showed a linear response in 5 seconds with a small volume (0.5 μL) in the range of 100~400 mg/dL, with a coefficient of variation of 4.0%.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.171-178
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• 2021

In this study, exosomal-like nano-vesicles derived from probiotics were isolated and various physiological activities were evaluated on the skin. This study show that Lactococcus lactis subsp. lactis (LL) are incubated, and then isolated LL derived exosomal nanovesicles (LVs) at the range of 70 ~ 200 nm by high-pressure homogenizer and ultrafiltration. The vesicle numbers were an average of 1.81 × 10¹¹ particles/mL. This study finds out the bacterial nanovesicles' beneficial effect on the skin. Fibrillin (FBN1) gene expression increased by 23% in fibroblast cells. Fibronectin (FN1) and filaggrin (FLG) gene expression increased by 65% and 400% in keratinocytes. We could see that cornified envelope (CE) formation ability was increased by 30% compared to the control group. Furthermore, collagen type I alpha 1 (COL1A1) protein expression increased by 83% compared to the UV-irradiated control group. These results suggest that LVs could help skin barrier improvement and used as an ingredient for cosmetics or pharmaceuticals.

• Korean Chemical Engineering Research
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• v.44 no.1
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• pp.1-9
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• 2006

Biodevices composed of biomolecular layer by mimicking the natural functions of cells and the interaction mechanisms of the constituted biomolecules have been developed in various industrial fields such as medical diagnosis, drug screening, electronic device, bioprocess, and environmental pollution detection. To construct biodevices such as bioelectronic devices (biomolecular diode, bio-information storage device and bioelectroluminescence device), protein chip, DNA chip, and cell chip, biomolecules including DNA, protein, and cells have been used. Fusion technology consisting of immobilization technology of biomolecules, micro/nano-scale patterning, detection technology, and MEMs technology has been used to construct the biodevices. Recently, nanotechnology has been applied to construct nano-biodevices. In this paper, the current technology status of biodevice including its fabrication technology and applications is described and the future development direction is proposed.

• Analytical Science and Technology
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• v.23 no.2
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• pp.165-171
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• 2010

Glucose oxidase ($GOD_{ox}$) immobilized biosensor was fabricated by two methods. In one of the methods, gold nanoparticles (Au-NPs) prepared by ${\gamma}$-irradiation were loaded into the poly(maleic anhydride)-grafted multi-walled carbon nanotube, PMAn-g-MWCNT electrode via physical entrapment. In the other method, the Au-NPs were prepared by electrochemical reduction of Au ions on the surface of PMAn-g-MWCNT electrode and then GODox was immobilized into the Au-NPs. The $GOD_{ox}$ immobilized biosensors were tested for electrocatalytic activities to sense glucose. The sensing range of the biosensor based on the Au-NPs physically modified PMAn-g-MWCNT electrode was from $30\;{\mu}M$ to $100\;{\mu}M$ for the glucose concentration, and the detection limit was $15\;{\mu}M$. Interferences of ascorbic acid and uric acid were below 7.6%. The physically Au deposited PMAn-g-MWCNT paste electrodes appear to be good sensor in detecting glucose.

• ICROS
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• v.22 no.3
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• pp.43-57
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• 2016

미래 농업은 생산, 유통, 소비 등의 모든 시스템이 연결되고 여기에 ICT 로봇 나노(NT) 바이오(BT)의 첨단기술을 결합해 자율적으로 운영되는 신성장동력 산업으로 진화될 것으로 예상된다. 이에 따라 농업은 정밀농업기술, 자동화 및 농업용 스마트 로봇 등의 다양한 공학기술의 접목과 함께 발달되고 있다. 최근에는 농업에 적용이 어려울 것이라고 예상되던 마이크로 나노 바이오공학의 접목도 시도되고 있으며 이에 따른 미래 농업의 전망은 아주 밝다고 볼 수 있다. 본 논문에서는 미래 농업을 위한 바이오시스템공학에 대해 자동화, 로봇화, 마이크로 나노농업공학 및 농업생명가공공학을 중점으로 주요기술들을 설명하고 국내 외 연구개발 동향을 살펴보고자 한다.

• Applied Chemistry for Engineering
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• v.27 no.2
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• pp.145-152
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• 2016

In this study, CuO was introduced on MWCNTs dispersed with Au nanoparticles to improve the glucose sensing capability of electrochemical biosensors. Nano-cluster shaped CuO was synthesized due to the presence of Au nanoparticle, which affects glucose sensing performance. The biosensor featuring CuO/Au@MWCNTs nanocomposite as an electrode material when 0.1 mole of CuO was synthesized showed the highest sensitivity of $504.1{\mu}A\;mM^{-1}cm^{-2}$, which is 4 times better than that of MWCNTs based biosensors. In addition, it shows a wider linear range from 0 to 10 mM and lower limit of detection (LOD) of 0.008 mM. These results demonstrate that CuO/Au@MWCNTs nanocomposite sensors are superior to other CuO based biosensors which are attributed that the nano-cluster shaped CuO is favorable for the electrochemical reaction with glucose molecules.

• Journal of the KSME
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• v.45 no.1 s.290
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• pp.45-52
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• 2005