Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Improvement in Sensitivity of Electrochemical Glucose Biosensor Based on CuO/Au@MWCNTs Nanocomposites

CuO/Au@MWCNTs 나노복합재 기반 전기화학적 포도당 바이오센서의 민감도 개선

  • Park, Mi-Seon (Department of Applied Chemistry and Biological Engineering, Chungnam National University) ;
  • Bae, Tae-Sung (Korea Basic Science Institute (KBSI) Jeonju Center) ;
  • Lee, Young-Seak (Department of Applied Chemistry and Biological Engineering, Chungnam National University)
  • 박미선 (충남대학교 대학원 바이오응용화학과) ;
  • 배태성 (한국기초과학지원연구원) ;
  • 이영석 (충남대학교 대학원 바이오응용화학과)
  • Received : 2015.10.28
  • Accepted : 2015.12.10
  • Published : 2016.04.10
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Abstract

In this study, CuO was introduced on MWCNTs dispersed with Au nanoparticles to improve the glucose sensing capability of electrochemical biosensors. Nano-cluster shaped CuO was synthesized due to the presence of Au nanoparticle, which affects glucose sensing performance. The biosensor featuring CuO/Au@MWCNTs nanocomposite as an electrode material when 0.1 mole of CuO was synthesized showed the highest sensitivity of $504.1{\mu}A\;mM^{-1}cm^{-2}$, which is 4 times better than that of MWCNTs based biosensors. In addition, it shows a wider linear range from 0 to 10 mM and lower limit of detection (LOD) of 0.008 mM. These results demonstrate that CuO/Au@MWCNTs nanocomposite sensors are superior to other CuO based biosensors which are attributed that the nano-cluster shaped CuO is favorable for the electrochemical reaction with glucose molecules.

본 연구에서는 전기화학적 바이오센서의 포도당 감지능을 높이고자 금 나노 입자가 분산된 다중벽탄소나노튜브(multi-walled carbon nanotube, MWCNTs)에 CuO를 도입하였다. 금 나노 입자로 인하여 나노 클러스터(cluster) 형상을 갖는 CuO가 합성되었으며, 이는 포도당 감지능력에 매우 큰 영향을 나타내었다. 0.1 mole의 CuO가 합성되었을 때 CuO/Au@MWCNTs 나노복합재를 전극재료로서 바이오센서는 $504.1{\mu}A\;mM^{-1}cm^{-2}$으로 가장 높은 민감도를 보여주었으며, 이 값은 MWCNTs만을 전극으로 이용할 때보다 약 4배 정도 컸다. 또한, 0-10 mM의 긴 선형 구간(linear range)과 0.008 mM의 낮은 LoD (limit of detection) 값을 보여주었다. 이러한 실험 결과들은 CuO/Au@MWCNTs 나노복합재가 CuO를 이용한 다른 전기화학적 바이오센서보다 우수하다는 것을 입증하였으며, 이는 나노 클러스터 형상의 CuO가 포도당 감지에서 전기화학적 반응에 유리하기 때문으로 사료된다.

Keywords

References

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