• Biomolecules & Therapeutics
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• v.3 no.1
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• pp.72-79
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• 1995

The antiulcer effects of newly synthesized prostaglandin derivatives were investigated in various experimental ulcer models and on gastric secretion in rats. HK-3 and HK-4, PG $E_2$derivatives, prevented the formation of acute gastric ulcer induced by ethanol or aspirin in pylorus-ligated rats. The ulcer formation was moderately inhibited by HK-1 and HK-2, PG $F_{2{\alpha}}$ derivatives, and aggravated by SK-1, SK-2 and SK-3, PG $F_{2{\alpha}}$ derivatives. HK-3 and HK-4 reduced the volume, acid output and pepsin output of gastric juice in pylorus-ligated rats. The gastric perfusion with physiologic saline(pH 6.0) showed relatively constant acid secretion and indomethacin increased the acid secretion. The acid secretion was markedly decreased by PG $E_2$but PG $F_{2{\alpha}}$ caused little change. Prostaglandin derivatives, especially HK-3 arid HK-4, significantly inhibited the acid secretion induced by indomethacin. The results show that, PG $E_2$ derivatives, HK-3 and HK-4, inhibit acid secretion and also have protective effects on gastric ulceration induced by ethanol or aspirin.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.400-407
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• 2009

The purpose of this study is to investigate hypotensive effect of BDR-29, new herbal preparation of Cassiae Semen, Prunellae Spica, Uncariae Ramulus et Uncus, and Tribuli Semen, in stroke-prone spontaneously hypertensive rats (SHR-SP). SHR-SP were treated with BDR-29 at a dose of 100, 200 mg/kg/day orally for 13 weeks. In the BDR-29 treat group, mean blood pressure and systolic blood pressure were significantly reduced (p<0.05). In phenylephrine-precontracted arota and carotid artery, BDR-29 induced endothelium-dependent vascular relaxation. Hematological findings and biochemical examination revealed no evidence of specific toxicity related to BDR-29. In addition, BDR-29 was markedly attenuated intima-media thickness of thoracic aorta with progression of atherosclerosis. SHR-SP were treated with BDR-29 were significantly increased eNOS expression in arota. These results indicated that BDR-29 improves blood pressure as well as initial atherosclerotic lesion.

• The Journal of Korean Society for School & Community Health Education
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• v.11 no.1
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• pp.27-39
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• 2010

Objectives: This study was conducted to find out caries preventive effect on permanent teeth among children who brush teeth with fluoride-containing toothpaste by supervised weekly fluoride mouthrinsing program in elementary schools. Methods: The epidemiologic dental survey was performed on the elementary schoolchildren of supervised weekly fluoride mouthrinsing program (FMR) with 0.2 percent neutral sodium fluoride solution and control group in 2007. Caries preventive effect on permanent teeth by fluoride mouthrinsing program were calculated by DMFT index and DMFS index between FMR group and control group. Results: By DMFT index between FMR group and control group, caries rates on permanent teeth of the fourth-, fifth- and sixth-grade children participating in FMR program were 34.1%, 40.8% and 31.5%, respectively. By the DMFS index between FMR group and control group, caries preventive rates on permanent teeth of the fourth-, fifth- and sixth-grade children participating in FMR program were calculated 25.4%, 37.7% and 33.5%, respectively. Conclusions: We suggest that fluoride mouthrinsing program should be developed to all elementary schools to prevent dental caries.

• Journal of Korean society of Dental Hygiene
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• v.10 no.3
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• pp.449-457
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• 2010

Objectives : This study was performed to investigate the recognition of the educators in preschool education institutions on children's oral health promotion. Methods : The subjects of this study included 918 preschool teachers who have been performing an oral health education program for children at preschool centers in Seoul. For this study, the survey was conducted from September 2008 to November 2008 through a questionnaire. Results : It has been found that 58.5% of the given preschool institutions have implemented an oral health promotion program and 99.1% of the respondents recognized the importance of the oral health. 53.9% of the respondents used sweets as a reward for good deeds. Regarding the behaviors of oral health promotion, the daily tooth-brushing and the implementation of a regular oral check-up accounted for 69.0% and 59.5% respectively. The subjects recognized that they have responsibility for the tooth-brushing instruction(91.6%) and provision of an oral inspection(78.3%). It has been also found that the case of performing the oral health program with older age and higher work experiences was significantly high(p<0.05). Conclusions : The recognition and performance of kindergarten teachers on children's oral health affects daily life and healthful living habits of children. Therefore oral health education program for the teachers has to be developed.

• Environmental Analysis Health and Toxicology
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• v.22 no.2 s.57
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• pp.137-145
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• 2007

The effect of cadmium chloride $(CdCl_2)$ on the expression of E-cadherin was examined in bEnd.3 mouse brain endothelial cells. $CdCl_2$ induced $PGE_2$ release, which were blocked by non-steroidal antinflamatory drugs (NSAIDs) such as indomethacin and NS398 indicating the expression of COX-2 might contribute to $PGE_2$ production. $CdCl_2$ decreased the expression of E-cadherin, but not VE-cadherin at levels of mRNA and protein. Reduced expression level of E-cadherin was restored by NSAIDs, which was reversed by the addition of $PGE_2$. $CdC_2$-induced decrease of E-cadherin level was also recovered by antioxidants including N-acetylcyteine (NAC) and trolox. Together with previous report which showed $CdCl_2$ induced COX-2 expression in a cellular oxidative stress dependent manner, these data suggest that $CdCl_2$ decreases E-cadherin expression through induction of cellular oxidative stress and in turn COX-2 expression in brain endothelial cells.

• Korean Journal of Oriental Medicine
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• v.18 no.3
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• pp.147-154
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• 2012

Objectives : This study was performed to find best extraction solvent for application of Ulmi cortex to food or herbal medicine as an antioxidant only using water, ethanol and their mixtures. Methods : The Ulmi cortex extracts were prepared using water and 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% (v/v) ethanol, and were evaluated yields, total polyphenol contents, DPPH and ABTS radical scavenging activities, lipid peroxidation activities, and catechin and epicatechin contents. Results : Among the Ulmi cortex extracts, the yield was highest in water extract (8.9%) and lowest in ethanol extract (3.8%). The yield of 30% ethanol extract (8.5%) also was very high to similar with water extract. The total polyphenol content was highest in the 30% ethanol extract ($253.6{\mu}g/mg$ extract) and lowest in water extract ($109.0{\mu}g/mg$ extract). The DPPH radical scavenging activity was highest in ethanol extract (IC50, $8.53{\mu}g/ml$), ABTS radical scavenging activity was highest in 60% ethanol extract (IC50, $3.08{\mu}g/ml$), and the inhibition of lipid peroxidation was highest in 70% ethanol extract (IC50, $7.96{\mu}g/ml$). As ethanol content of extraction solvent increased from 0% to 30%, the antioxidant activities were remarkably increased whereas from 30% to 100%, the antioxidant activities were increased or decreased a little. Conclusions : The findings of the present study suggest that 30% ethanol is best solvent for extraction of Ulmi cortex, considering yield, polyphenol content, and antioxidant activities with extraction cost.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1132-1138
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• 2009

Vascular inflammation is an important event in the development of vascular diseases such as tumor progression and atherosclerosis. This study was to investigate the inhibitory effects of WK-38, a new herbal prescription for the treatment of atherosclerosis, on vascular inflammation in human umbilical vein endothelial cells (HUVEC). WK-38 is composed of Rhei Rhizoma, Magonoliae Cortex, Moutan Cortez Radicis. Pretreatment with WK-38 was significantly blocked TNF-$\alpha$-induced expression level of cell adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), and endothelial cell selectin (E-selectin) in a dose-dependent manner. TNF-$\alpha$-induced cell adhesion in co-cultured U937 and HUVEC was also blocked by pretreatment with WK-38. Moreover, WK-38 significantly suppressed p65 NF-${\kappa}B$ translocation into the nucleus by TNF-$\alpha$ as well as the phosphorylation and degradation of $I{\kappa}B-{\alpha}$. In conclusion, the present data suggested that WK-38 could suppress TNF-$\alpha$-induced vascular inflammatory process, though inhibition of NF-${\kappa}B$ activation in HUVEC.

• Journal of Oriental Neuropsychiatry
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• v.12 no.1
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• pp.97-109
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• 2001

Objectives : This study aimed to evaluate the anti-stress effects of Ansymondam-tang and Gamiondam-tang on the contents of monoamines in the regional brain of mice forced cold swimming stress in $4^{\circ}C$ water. Methods : The experimental animals were forced cold swimming stress for 3 minutes, and administered of Ansymondam-tang(2.2mg/10g) and Gamiondam-tang(0.83mg/10g) extract for 7 days before stress. The monoamines contents were measured by HPLC method in various part(frontal cortex, hypothalamus, corpus striatum and hippocampus) of mice brain. Results: 1. In frontal cortex, the contents of norepinephrine were increased with statistical significantly in all of the administered group compared to control group. The contents of dopamine and serotonin were increased in Gamiondam-tang administered group has a statistical significance. 2. In hypothalamus, the contents of dopamine were increased with statistical significance in all of the administered group compared to control group. 3. In corpus striatum the contents of norepinephrine were decreased and the contents of dopamine were increased with statistical significance in all of the administered group compared to control group. The contents of serotonin were increased in Gamiondam-tang administered group has a statistical significance. 4. In hippocampus the contents of norepinephrine were decreased with statistical significance in Gamiondam-tang administered group compared to control group. The contents of dopamine were increased in Ansymondam-tang administered group has a statistical significance. Conclusion : This study reaches a conclusion that Ansymondam-tang and Gamiondam-tang has significant effects .on reducing and preventing stress in mice. Especially Gamiondam-tang is more effective in the statistical significance than Ansymondam-tang on the monoamines change in the mice brain.

• Korean Journal of Pharmacognosy
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• v.36 no.4 s.143
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• pp.311-317
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• 2005

GCSB-5 is a purified extract from a mixture of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen, and Eucommiae Cortex) that have been widely used for the treatment of inflammatory diseases in the East Asia. The aim of this study was to investigate the anti-inflammatory potential of GCSB-5. The animals used in this study were administered either vehicle or GCSB-5 (30, 100, 300, and 600 mg/kg) orally. The GCSB-5 significantly inhibited the increased of acetic acid-induced vascular permeability (30.9%-34.2% inhibition at 30-300 mg/kg). The swelling of the rat's hind paw induced by carrageenan was significantly inhibited by GCSB-5 in doses of 100, 300, and 600 mg/kg. Maximal inhibition (50.9%) was obtained with GCSB-5 at dose of 300 mg/kg. However, it did not have any anti-inflammatory action in the rheumatoid arthritis induced by Freund's complete adjuvant or in the granuloma induced by carrageenan. Our finding suggest that GCSB-5 has a anti-inflammatory activity.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.58-58
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• 2009

선박의 선체부분인 선수, 선미 등을 이루고 있는 곡형 외판의 제작은 강판을 원하는 형상으로 성형하기 위하여 벤딩롤러 및 유압프레스를 이용한 냉간가공과 산소-프로판가스 화염을 적용한 선상가열, 삼각가열을 이용한 열간가공으로 크게 구분할 수 있다. 선상가열을 이용한 곡면가공의 원리는 가열토치를 이용하여 강판을 가열하면 가열부는 팽창하게 되고 냉각시에는 수축하게 된다. 이 때 두께방향으로의 소성변형으로 인한 수축량의 차이로 인해 굽혀지게 된다. 최근에는 선박이 고기능 및 대형화로 인해 3차원 곡형 외판 형상이 복잡해지고, 강도를 향상시키기 위하여 합금원소(C, Nb, V, Ti)를 첨가하거나 열처리(노말라이징)를 이용한 고장력강재인 중후판의 적용이 증가하고 있다. 이러한 고강도강재를 선상가열공정으로 제작한 곡형 외판재는 가열, 냉각의 열사이클로 인해 취화되어 인성이 저하 될 수 있다. 본 연구에서는 Normalizing 열처리재인 490MPa급 강재를 이용하여, 현장에서 작업자의 미숙련으로 인해 발생 할 수 있는 최대의 가혹한 조건과 재질에 큰 영향을 미치지 않는 범위를 선정하여 선상가열시의 가열, 냉각조건에 따른 강재의 재질특성을 조사하고자 한다. 이를 위해 가열시 가열부위의 정확한 온도 측정에 역점을 두었으며, 각각 다른 선상가열 조건에 따른 시편을 제작하기 위하여 선상가열 실험장치를 제작하였다. 선상가열 실험 결과 최고가열온도 $1300^{\circ}C,\;950^{\circ}C$에서 수냉 조건인 경우 급격한 인성저하 현상이 발생하며 비록 공냉이라 하더라도 결정립 조대화로 인성 저하가 발생하였다. $800^{\circ}C$가열 후 수냉개시온도를 $700^{\circ}C$이하로 수냉한 경우에는 인성 저하 현상이 개선되고 있음을 알 수 있다.