Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Studies on the Synthesis and Biological Activity of Prostaglandin Derivatives II. Effects of Prostaglandin Derivatives on Acute Gastric Ulcer and Gastric Secretion in Rats

프로스타글란딘 유도체의 합성과 그의 생물학적 활성에 관한 연구 II. 위궤양과 위산분비에 대한 프로스타글란딘 유도체의 효과

  • Cho, Tai-Soon (College of Pharmacy, Sung kyun kwan University) ;
  • lee, Sun-Mee (College of Pharmacy, Sung kyun kwan University) ;
  • Ham, Won-Hun (College of Pharmacy, Sung kyun kwan University) ;
  • Lee, Byung-Mu (College of Pharmacy, Sung kyun kwan University) ;
  • Kim, Kyoung-Rae (College of Pharmacy, Sung kyun kwan University) ;
  • Chi, Sang-Cheol (College of Pharmacy, Sung kyun kwan University) ;
  • Ko, Jun-Ill (College of Pharmacy, Sung kyun kwan University) ;
  • Park, In (College of Pharmacy, Sung kyun kwan University) ;
  • Oh, Chang-Young (College of Pharmacy, Sung kyun kwan University) ;
  • Park, Ho-Koon (Korea Institute of Science and Technology) ;
  • Kim, Hyoung-Ja (Korea Institute of Science and Technology) ;
  • Lee, Hyang-Woo (College of Pharmacy, Sung kyun kwan University)
  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 함원훈 (성균관대학교 약학대학) ;
  • 이병무 (성균관대학교 약학대학) ;
  • 김경례 (성균관대학교 약학대학) ;
  • 지상철 (성균관대학교 약학대학) ;
  • 고준일 (성균관대학교 약학대학) ;
  • 박인 (성균관대학교 약학대학) ;
  • 오창영 (성균관대학교 약학대학) ;
  • 박호군 (한국과학 기술원) ;
  • 김형자 (한국과학 기술원) ;
  • 이향우 (성균관대학교 약학대학)
  • Published : 1995.03.01
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Abstract

The antiulcer effects of newly synthesized prostaglandin derivatives were investigated in various experimental ulcer models and on gastric secretion in rats. HK-3 and HK-4, PG $E_2$derivatives, prevented the formation of acute gastric ulcer induced by ethanol or aspirin in pylorus-ligated rats. The ulcer formation was moderately inhibited by HK-1 and HK-2, PG $F_{2{\alpha}}$ derivatives, and aggravated by SK-1, SK-2 and SK-3, PG $F_{2{\alpha}}$ derivatives. HK-3 and HK-4 reduced the volume, acid output and pepsin output of gastric juice in pylorus-ligated rats. The gastric perfusion with physiologic saline(pH 6.0) showed relatively constant acid secretion and indomethacin increased the acid secretion. The acid secretion was markedly decreased by PG $E_2$but PG $F_{2{\alpha}}$ caused little change. Prostaglandin derivatives, especially HK-3 arid HK-4, significantly inhibited the acid secretion induced by indomethacin. The results show that, PG $E_2$ derivatives, HK-3 and HK-4, inhibit acid secretion and also have protective effects on gastric ulceration induced by ethanol or aspirin.

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