• The Korean Journal of Food And Nutrition
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• v.29 no.3
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• pp.431-437
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• 2016

Macrophages play a pivotal role in the innate and adaptive immune systems. This study investigated the immuno-modulatory activities of polysaccharides separated from Chrysanthemum zawadskii var. latilobum (CZPS) in macrophages. Polysaccharides from Chrysanthemum zawadskii var. latilobum were extracted by the ethanol precipitation method. RAW 264.7 mouse macrophage cell line was treated with CZPS (4 to $128{\mu}g/mL$), and there was no cytotoxicity at a dose below $32{\mu}g/mL$. The levels of nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-${\alpha}$ and interleukin (IL)-6, IL-$1{\beta}$) production in the CZPS treated group ($32{\mu}g/mL$) were $6.5{\pm}0.12{\mu}m$ (NO), $1252.8{\pm}79.85$ (TNF-${\alpha}$), $305.4{\pm}29.41$ (IL-6), and $683.3{\pm}59.71$ (IL-$1{\beta}$), respectively, and they were significantly increased when compared to the control group; $2.2{\pm}0.03{\mu}m$ (NO), $452.3{\pm}38.34$ (TNF-${\alpha}$), $31.7{\pm}5.75$ (IL-6), and $184.1{\pm}11.52$ (IL-$1{\beta}$). Additionally, protein expression of inducible nitric oxide synthase (iNOS) and phosphorylation of MAPKs and NF-${\kappa}B$ expression were significantly increased upon CZPS treatment. Therefore, these results indicated that polysaccharides separated from Chrysanthemum zawadskii var. latilobum (CZPS) may have a potential immunomodulatory activity in macrophages through MAPKs and NF-${\kappa}B$ signaling, and this information is useful for the development of immune enhancing adjuvant materials using a natural ingredient.

• Korean Journal of Food Science and Technology
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• v.51 no.2
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• pp.152-159
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• 2019

To characterize new physiologically active components in Korean apple vinegar, a crude polysaccharide (KAV-0) was prepared by precipitation with 80% (v/v) ethanol. KAV-0 mainly comprises 38.2% mannose, 19.1% galactose and 14.3% glucose. In an in vitro cytotoxicity analysis, KAV-0 promoted the proliferation of peritoneal macrophages and RAW 264.7 cells in a dose-dependent manner, and showed no cytotoxicity in B16-BL6 melanoma cells. Murine peritoneal macrophages and RAW 264.7 cells stimulated by KAV-0 produced various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis factor $(TNF)-{\alpha}$, and nitric oxide (NO). Intravenous (i.v.) administration of KAV-0 significantly augmented NK cell cytotoxicity against Yac-1 tumor cells. In experimental lung metastasis caused by B16-BL6 melanomas, prophylactic i.v. administration of KAV-0 at a dosage of $1,000{\mu}g/mouse$ inhibited lung metastasis by 53.0%. These results suggest that the crude polysaccharide (KAV-0) isolated from Korean apple vinegar has a considerably high anti-metastatic activity and immunomodulatory activities beneficial to human health.

• Proceedings of the KIEE Conference
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• 2008.11a
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• pp.351-353
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• 2008

The establishment of electrical works technology roadmap and its categorization are proposed from survey. This technical mad map could contribute on the direction for R&D policies of the government and companies, the cooperation studies between academies, institutes, and enterprises, and new market formation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2001.04a
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• pp.350-353
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• 2001

Due to the widen demand of plastic part in automobiles, more accurate numerical simulation works are needed to find optimum molding process like filling fiber orientation pressure control. Therefore, C-mold software was applied for the simulation of injection molding process and cooling process in this research. The purpose of this study is developing a ball seat which made by injection process with PA66 resin and it is applied to the automobile suspension system. It must secure low friction, wear resistance and dimensional accuracy. Specially this study aims to get the quality stabilization of injection molded bass-seat parts.

• Proceedings of the KIEE Conference
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• 2003.07e
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• pp.132-134
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• 2003

Insulator that is used in electric power equipment superannuation and being damaged disorder can. Such as defected insulator has repair or change must because defective influence in electrical equipment. There are many method developed for detecting the defected insulators, analyzed various test of devide voltage, electric field, ultrasonic and discharge pulse. But methods of detecting ultrasonic of discharge, electric field or leakage current could not application in the field, In this paper, we compare the advantage and the limitation of the method to detect defected insulator, and wish proposed using corona camera.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.608-611
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• 2000

This study is for stabilizer, a parts of automotive suspension system, that would be changed to Plastic Material. The part is designed and analyze by PRO-E. The position of Weld Line is founded by the C-mold, computer software with FEM. Then a Mold is designed by consideration with locating Weld Line. Mechanical property tests, such as tensile test, compression test, ball pull-out test, fatigue test and durability test are done the part by SAE test spec. Most of all the result of the tests show over requirement result without the compression test.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.825-828
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• 1997

The market share of plastic fuel tube in automobile part is now growing rapidly. Especially fuel tube makers have had their efforts to develop tube module not only with dimensional accuracy, spring back and cost competitiveness. In this study, we used steam bending process for heat relaxation on PA12 plastic fuel tube's 128 types experimental bending conditions. we present the results of this process system in term of dimensional accuracy, and spring back.

• Proceedings of the Optical Society of Korea Conference
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• 2000.02a
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• pp.266-267
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• 2000

최근에 Stranski-Krastanov 방법을 이용한 나노미터 크기의 변형된 섬 구조 제작에 많은 관심을 보이고있다.$^{(1)}$ 이는 결함이 적고, 균일한 저차원의 반도체 구조가 광전자 장치에 지대한 발전을 가져올 것으로 기대되기 때문이다. 예를들어 양자 선이나 양자 점은 반도체 레이저의 이득 영역으로 좋은 특성을 가지는 것으로 알려졌다.$^{(2)}$ 이 논문에서 우리는 Chemical Beam Epitaxy (CBE)를 이용하여 InP 기판 위에 격자상수가 맞지 않는 InAs 층의 성장과 Photoluminescence (PL) 측정을 통해 이 구조의 특성에 대해서 알아보고자 한다. (중략)

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.2073-2074
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• 2008

In this study, methodologies for the establishment of electrical works technology roadmap and its categorization are proposed analyzing different technologies and organizations roadmaps, existing electrical works technology roadmaps, new technology roadmaps, and so on. These methodologies could contribute on the direction for R&D policies of the government and companies, the cooperation studies between academies, institutes, and enterprises, and new market formation.

• Magazine of the Korean Society of Agricultural Engineers
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• v.45 no.3
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• pp.116-126
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• 2003

In this study, we research about the relationships of human longevity and environments, inducted the significant factors of longevity from the statistical analysis, and represented spatial distribution of longevity using geographic information system. The factors confining human longevity can be categorized by geography/geology, climate/weather, economy, and social welfare. After analyzing statistical data, dependent variable which means the longevity index is defined by the ratio of population more than 85 years old among population more than 65 years old. The results of analysis show that longevity are related with waterworks ratio, temperature, local tax ratio, and latitude. In this study we discussed about the spatial characteristics which are represented by variance of the longevity index and described a spatial relationship between the longevity index and significant factors which are chosen by statistical analysis. In the further study, in order to sustain the longevity of a region, it is necessary for the effective rural planning to propagate a longevity of rural areas.