• 생약학회지
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• 제45권1호
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• pp.17-22
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• 2014

Grapes has long been used for food, and reported as containing polyphenol which has antioxidant and anti-cancer effects. Neuroinflammation is chronic inflammation at the brain, lead to neurodegenerative diseases. In this study, quercetin-3-O-glucuronide (QG) isolated from the leaf of Vitis labruscana has anti-neuroinflammatory effects. QG were investigated using MTT assay, western blot, nitric oxide (NO) assay, prostaglandin $E_2$ ($PGE_2$) assay, cytokine assay in lipopolysaccharide (LPS)-induced inflammation in BV2 cells. QG dose-dependently attenuated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), accordingly inhibited the production of NO and $PGE_2$. QG decreases the levels of proinflammatory cytokine such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interlukin-$1{\beta}$ (IL-$1{\beta}$). Thereby, QG may offer therapeutic potential for treatment of neurodegenerative disease related to neuroinflammation.

• 생약학회지
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• 제48권1호
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• pp.25-30
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• 2017

This study was performed to evaluate the lifespan extending effects of the dried ginger (Zingiber officnale Roscoe, Zingiberaceae). Ethanol extract of the dried ginger was successively partitioned as methylene chloride, ethyl acetate, n-butanol and $H_2O$ soluble fractions, and lifespan-extending effects of the fractions were investigated using Caenorhabditis elegans model system. Ethyl acetate-soluble fraction showed the most potent longevity property. Furthermore, ethyl acetate-soluble fraction elevated thermal stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction, food intake and growth, however, ethyl acetate-soluble fraction treatment led to an up-regulation of locomotory ability of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.

• 한국소음진동공학회논문집
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• 제21권3호
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• pp.212-219
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• 2011

In this paper, intrusion detection technique based on the sound field variation of audio frequency in the security space is proposed. The sound field formed by sound source can be detected with the microphone when the obstacle or intruder is positioned. The sound field variation due to the intruder is mainly caused by the interference of audio wave. With the help of numerical simulation of sound field formations, the increase or decrease of sound pressure level is analyzed not only by the obstacle, but also by the intruder. Even the microphone is positioned behind the source, sound pressure level can be increased or decreased due to the interference of sound wave. Frequency response test is performed with Gaussian white noise signal to get the whole frequency response from 0 to half of sampling frequency. There are three security cases. Case 1 is the situation of empty space with and without intruder, case 2 is the situation of blocking obstacle with and without intruder, and case 3 is the situation of side blocking obstacle with and without intruder. At each case, the frequency response is obtained first at the security space without intruder, and second with intruder. From the experiment, intruder size of diameter of 50 cm pillar can be successfully detected with the proposed technique. Moreover, the case 2 and case 3 bring about bigger sound field variation. It means that the proposed technique have the potential of more credible security guarantee in real situation.

• 동의생리병리학회지
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• 제27권2호
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• pp.183-188
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• 2013

Ultraviolet (UV) B irradiation induces the production of matrix metalloproteinases (MMPs), which are responsible for the degradation or synthesis inhibition of collagenous extracellular matrix in connective tissues, causing skin photoaging. In this study, we examined the inhibitory effect of MMP-1 expression of yam extract in tumor necrosis factor-alpha (TNF-${\alpha}$)-stimulated human dermal fibroblast neonatal (HDFn) cell and preventive effect of UVB-induced damage in hairless mice skin. The synthesis of procollagen and the release of MMP-1 in HDFn cells were measured by EIA kit and MMP-1 assay kit, respectively. UVB radiation was applied to the backs of the mice three times a week for 8 weeks. Mice were randomly divided into three groups, and were topical application with the Dioscorea batatas (DB, 6%) or vehicle. Reduction of TNF-${\alpha}$-induced procollagen synthesis was increased by DB (50 ug/ml), which was higher than positive control group (TGF-${\beta}$). Also, pre-treatment of HDFn cells with DB inhibited TNF-${\alpha}$-induced release of MMP-1. In vivo study, we found that preventive effect of DB against UV-induced epidermal thickness. DB suppressed the expression of MMP-3 and MMP-13 induced by UVB irradiation. Our results show that DB have preventive effect of UV-induced skin damage in hairless mice.

• Annals of Clinical Neurophysiology
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• 제10권1호
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• pp.43-47
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• 2008

Background: Acute brachial plexitis is an acute idiopathic inflammatory disease affecting brachial plexus, which is characterized by initial severe pain in shoulder followed by profound weakness of affected arm. This is a retrospective study to evaluate the clinical and electrophysiological profile of acute brachial plexitis. Methods: Sixteen patients with acute brachial plexitis were sampled. The electrodiagnostic studies included motor and sensory nerve conduction studies (NCSs) of the median and ulnar, sensory NCSs of medial and lateral antebrachial cutaneous nerves, and needle electromyography (EMG) of selected muscles of upper extremities and cervical paraspinal muscles. The studies were performed on both sides irrespective of the clinical involvement. Results: In most of our patient, upper trunk was predominantly affected (14 patients, 87.50%). Only two patients showed either predominant lower trunk affection or diffuse affection of brachial plexus. All had an acute pain followed by the development of muscle weakness of shoulder girdle after a variable interval ($7{\pm}8.95$ days). Ten patients (62.50%) had severe disability. In NCSs, the most frequent abnormality was abnormal lateral antebrachial cutaneous sensory nerve action potentials (SNAPs). On needle EMG, all the patients showed abnormal EMG findings in affected muscles. Conclusions: In this study, pain was the presenting feature in all patients, and the territory innervated by upper trunk of the brachial plexus was most frequently involved. The most common NCS abnormality was abnormal SNAP in lateral antebrachial cutaneous nerve. Our findings support that the electrodiagnostic test is useful in localizing the trunk involvement in acute brachial plexitis.

• 한국측량학회지
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• 제29권2호
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• pp.113-121
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• 2011

본 연구에서는 기하학적 정보를 바탕으로 생성된 유사도 기반의 면 객체 자동매칭 방법을 제안하였다. 이를 위하여 서로 다른 공간자료에서 교차되는 후보 매칭 쌍을 추출하고, CRITIC방법을 이용하여 연동 기준별 가중치를 자동으로 생성하여 선형조합으로 추출된 후보매칭 쌍 간의 형상유사도를 측정하였다. 이때, 훈련자료에서 조정된 상자도표의 특이점 탐색을 적용하여 도출된 임계값 이상인 경우가 매칭 쌍으로 탐색된다. 제안된 방법을 이종의 공간자료(수지치도 2.0과 도로명주소 기본도)의 일부지역에 적용한 결과, 시각적으로 형상이 유사하고 교차되는 면적이 넓은 건물객체가 매칭 되었으며, 통계적으로 F-Measure가 0.932로 높게 나타났다.

• 한국측량학회지
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• 제29권2호
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• pp.175-181
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• 2011

원격탐사 분야에서 고해상도의 멀티스펙트럴 영상은 위성센서의 기술적인 제약 때문에 직접적으로 취득하기 어렵다. 이러한 문제를 극복하기 위하여 다양한 위성영상 융합 기법이 제안되어졌다. 그러나, 대부분의 영상융합기법들은 원 멀티스펙트럴 영상의 분광정보를 왜곡시키거나 고해상도 흑백영상의 공간해상도에 비하여 융합영상의 공간해상도가 저하되는 문제점을 지닌다. 최근 들어 융합영상의 분광왜곡을 최소화시키면 서 공간해상도를 효율적으로 증가시킬 수 있는 공간상관도 기반의 하이브리드 융합 기법이 제안되었다. 본 연구에서는 하이브리드 융합기법에 다양한 공간상관도 추출 식을 적용하여 보고 이에 따른 분광/공간정보 왜곡의 양을 비교 평가하였다. 실험 결과 라플라시안 필터를 이용한 하이브리드 융합 기법이 다른 고주파 정보 추출 기법에 비하여 하이브리드 융합 기법에 효과적으로 적용할 수 있다는 것을 확인할 수 있었다.

• 한국측량학회지
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• 제29권5호
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• pp.487-496
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• 2011

본 연구는 단일 임계값으로 결정된 변화화소를 버퍼존 개념을 적용하여 재추출함으로써, 보다 신뢰도 높은 무감독변화탐지를 수행하는데 목적이 있다. 우선, 그래프 생성기법과 직선과의 최대거리를 통해 결정된 임계값을 기반으로 세 개의 버퍼존을 생성하였다. 이 중 변화화소와 무변화화소가 혼재하는 구간인 버퍼존II에 대해 무감독분류를 수행하여 변화화소를 재추출하였다. Hyperion 초분광영상을 사용하여 제안기법을 적용하였으며, 단일 임계값 방법을 적용한 변화탐지 결과와의 비교를 통해 제안기법의 성능을 평가하였다. 결과를 통해, 버퍼존 기법이 다소 많은 변화화소를 추출하였으나, 산림지역에 대해 보다 정확한 변화탐지를 수행함을 확인할 수 있었다.

• 한국음향학회지
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• 제19권7호
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• pp.34-41
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• 2000

본 논문에서는 장거리 통신시스템의 적응 반향제거 기에서 퍼지제어 시스템에 기초한 새로운 동시통화 검출방법을 제안하였다. 이 방법에서, 동시통화 검출을 위한 퍼지추론의 두 입력 변수는 근단 신호와 실제 반향 신호가 더해진 소요 신호와 에러 신호 사이의 상호상관계수와 소요 신호와 추정된 신호 사이의 상호상관계수를 사용하였다. 퍼지 제어기에서 사다리꼴 소속함수로 퍼지화하고 if-then 추론규칙을 이용하여 max-min 합성하였으며, 합성된 결과를 무게중심법에 의하여 디퍼지화한 값으로 동시통화와 반향경로 변화 그리고 동시통화시 반향경로 변화를 검출하도록 하였다. 퍼지 동시통화 검출기는 기존의 알고리듬보다 동시통화와 반향경로 변화를 추정할 수 있었으며 동시통화시에 반향경로 변화에도 좋은 성능을 보였다.

• 한국도로학회논문집
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• 제17권6호
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• pp.19-26
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• 2015

PURPOSES : This study intends to develop an inorganic soil pavement material using industrial by-products and to evaluate its applicability as a road pavement material. METHODS : In this study, a compressive strength experiment was conducted based on the NaOH solution molarity and water glass content to understand the strength properties of the soil pavement material according to the mixing ratio of alkali activator. In addition, the strength characteristic of the inorganic soil pavement material was analyzed based on the binder content. The performance of the soil pavement was evaluated by conducing an accelerated pavement test and a falling weight deflectometer (FWD) test. RESULTS : As a result of the soil pavement material test based on the mixture ratio of alkali activator, it was identified that the activator that mixed a 10 M NaOH solution to water glass in a 5:5 ratio is appropriate. As a result of the inorganic soil pavement materials test based on the binder content, the strength development increased sharply when the amount of added binder was over 300 kg; this level of binder content satisfied 28 days of 18 MPa of compression strength, which is the standard for existing soil pavement design. According to the measured results of the FWD test, the dynamic k-value did not show a significant difference before or after the accelerated pavement testing. Furthermore, the effective modulus decreased by approximately 50%, compared with the initial effective modulus for pedestrian pavement. CONCLUSIONS : Based on these results, inorganic soil pavement can be applied by changing the mixture proportions according to the use of the pavement, and can be utilized as road pavement from light load roads to access roads.