• Proceedings of the IEEK Conference
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• 2006.06a
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• pp.261-262
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• 2006

According to the previous work, various well known methods including maximum a posteriori probability classifier (MAP) and multi layer perceptron networks classifier (MLP) showed competitive results. Since even the small errors often leads to a fatal result, we investigated the method that reduces classification error perfectly by screening out some ambiguous patterns. Those ambiguous patterns can be examined by routine biopsy. We incorporated an ambiguous category in MAP and MLP. Classification results involving 216 spectra gave 100% sensitivity for the case of MLP.

• Proceedings of the IEEK Conference
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• 2006.06a
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• pp.239-240
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• 2006

In this study, we examined all peaks of confocal Raman spectra as peaks are the most important features for discrimination between basal cell carcinoma (BCC) and normal tissue (NOR). 14 peaks were extracted from these peaks using decision tree. For dimension reduction, frequently selected 4 peaks were chosen. They are located at 1014, 1095, 1439, $1523cm^{-1}$. These peaks were used as an input feature of the multilayer perceptron networks (MLP). According to the experimental results, MLP gave classification error rate of about 6.5%.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.1
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• pp.64-70
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• 2007

Raman spectroscopy is known to have strong potential for providing noninvasive dermatological diagnosis of skin cancer. According to the previous work, various well known methods including maximum a posteriori probability (MAP) and multilayer perceptron networks (MLP) showed competitive results. Since even the small errors often leads to a fatal result, we investigated the method that reduces classification error perfectly by screening out some ambiguous patterns. Those ambiguous patterns can be examined by routine biopsy. We incorporated an ambiguous pattern class in MAP, linear classifier using minimum squared error (MSE), MLP and reduced coulomb energy networks (RCE). The experiments involving 216 confocal Raman spectra showed that every methods could perfectly classify BCC by screening out some ambiguous patterns. The best results were obtained with MSE. According to the experimental results, MSE gives perfect classification by screening out 8.8% of test patterns.

• Archives of Plastic Surgery
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• v.38 no.6
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• pp.883-885
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• 2011

Purpose: Nevus sebaceus is a congenital hamartomatous lesion, typically involving head and neck. Various benign and malignant neoplasms can develop in association with nevus sebaceus. We report a case of simultaneous occurrence of squamous cell carcinoma and basal cell carcinoma in nevus sebaceus. Methods: A 73-year-old man presented with erythematous to black verrucous nodules on the right subauricular area. The upper part was accompanied with inflammation and ulceration, and no specific findings suspicious for malignant degeneration were found in the lower part preoperatively. The mass was totally excised and the defect was directly closed. Lymph nodes were not involved on concomitant neck dissection. Results: Histopathologic examination confirmed the presence of squamous cell carcinoma in the upper part and basal cell carcinoma in the lower part of a nevus sebaceus. Negative margins were achieved on resection. No clinical problems were found during the 3-month follow-up period. Conclusion: We experienced a rare case of simultaneous occurrence of squamous cell carcinoma and basal cell carcinoma within the same nevus sebaceus. Because patients with nevus sebaceus have risk of malignant changes, surgical excision and work-up for recurrence and metastasis should be considered in suspicious cases. And even in a totally asymptomatic case, the possibility of occult secondary cancer should be informed before surgery in aged patients.

• Archives of Craniofacial Surgery
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• v.14 no.2
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• pp.107-110
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• 2013

Background: Basal cell carcinoma (BCC) is the most common skin cancer. About 74% cases of basal cell cancer occur on the head and neck. Basal cell carcinoma on the face may have a higher degree of subclinical spread than tumors arising elsewhere. And incompletely excised BCCs become more aggressive when they recur. So the surgical removal and reconstruction of BCC located on the face are important to make perfect curing and cosmetic results. Methods: A retrospective study was done with 128 patients (137 cancers) who were treated with BCC on the face since 1987 to 2011. General data of these cases such as the primary site of cancer, age and sex of the patients, operative methods, and recurrence rate were reviewed. Results: The ratio of men to women was 1:1.4. And 86.9% of the patients with BCC were older than the age of 50 years with the mean age of 65.8 years. The distribution of facial basal cell carcinoma was on the nose, eyelids, cheek, and nasolabial fold. Surgical methods for treatment were local flap, full thickness skin graft, primary closure, and split thickness skin graft. Specifically, local flap consists of V-Y advancement flap, cheek advancement flap, limberg flap, forehead flap, nasolabial flap, rotation flap, transposition flap, bilobed flap, and island flap. Six cases recurred and all of them were treated with reoperation. Conclusion: The authors reviewed facial basal cell carcinoma cases in our hospital. This study might be helpful to choose appropriate operation method to manage BCC on face in Korea.

• Journal of Chest Surgery
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• v.34 no.2
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• pp.162-166
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• 2001

배경: 흉선암은 드문 질환으로 치료경과 및 예후가 침윤성 흉선종에 비해 나쁜 것으로 알려져 있으며 병기의 분류나 병기에 따른 치료방법이 아직 표준화 되어있지 않아 치료에 어려운 점이 있다. 이에 본교실에서 흉선암으로 진단되었던 환자들의 피료방법 및 성적을 분석하여 그 결과를 보고하고자 한다. 대상 및 방법: 계명대학교 동산의료원 흉부외과학교실에서는 1984년 8월에서 흉선암으로 진단되었던 8례의 환자를 대상으로 의무기록을 참고하여 병기에 따른 치방법료 및 예후 등을 후향적으로 분석하였다. 결과: 연령은 23세에서 67세까지로 평균 46세였으며 전흉부통증이 주증상이었다. 조직학적으로는 임파상피양암(lymphoepithelioma-like carcinoma)이 2례, 편평상피암(squamous cell carcinoma)이 2례, 기저세포암(basaloid carcinoma)이 1례, 혼합형(mixed type)이 3례 있었다. 임상적 병기분류는 Masoka의 분류법을 사용하였으며 제I기 2례, 제II기 4례, 제III기 1례, 제IVAr기가 1례 있었다. 4례의 환자에서는 종양의 완전적출이 가능했으며 3례에서는 고식적 수술을 시행하였다. 1례의 환자는 주위조직으로의 침윤과 심낭에 퍼져있어 조직생검만을 시행하였다. 전례에서 보조적 항암치료를 받았고 술후 병기가 제III기 이상이거나 종양의 절제가 불완전했던 5례의 환자에서는 보조적 방사선치료를 병행하였다. 이들 중 5례에서 술후 보조적 항암치료 및 방사선치료를 받고 현재까지 생존해있다. 평균추적기간은 55.3$\pm$64.6 개원이었고, 3례의 환자는 사망하였으며 4례의 환자는 종양의 재발증거 없이 생존해있다. 결론: 종양의 조기진단과 완전종양적출후 적극적인 보조적 항암치료 및 방사선치료가 흉선암을 치료하는데 도움이 될 것으로 사료된다.

• Korean Journal of Head & Neck Oncology
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• v.2 no.1
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• pp.49-59
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• 1986

The surgical reconstruction of major defects of the head and neck such as those following accidental injuries or resection of tumors has been facilitated and advanced by the development of myocutaneous flaps which provide both muscle bulk and skin coverage. Of the many available myocutaneous flaps, the pectoralis major myocutaneous flap has many advantages such as abundant tissue with an excellent vascularity, anatomic proximity, long arc of rotation, reliability and versatility, so it is used most frequently in head and neck reconstruction. It is the purpose of this paper to present our experiences with two cases of pectoralis major myocutaneous island flaps used in reconstruction of major defects of face; one is after resection of very large basal cell carcinoma of the left oral commissure and the other is after resection of a huge fibrous mass and destructed facial bones caused by chronic osteomyelitis.

• The Korean Journal of Gastroenterology
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• v.72 no.5
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• pp.258-261
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• 2018

Esophageal basaloid squamous carcinoma (BSC) is a rare, aggressive variant of squamous cell carcinoma. BSC is usually diagnosed in advanced stage and its prognosis is relatively poor. A 59-year-old male with subepithelial lesion of the esophagus that was incidentally discovered during health promotion examination was referred to our hospital. Esophagogastroduodenoscopy showed a 10-mm bulging mucosa with an intact surface at 34 cm from incisor teeth. Endoscopic ultrasonography revealed a smooth margined homogenous hypoechoic lesion, measuring $11.3{\times}3.9mm$ with a submucosal layer of origin. The patient underwent endoscopic mucosal resection of the subepithelial lesion. Pathologic examination of the resected specimen revealed BSC with involvement of vertical margin by tumor. The patient then underwent radiotherapy, and is doing well without recurrence for 35 months. We report a case of esophageal BSC confined to submucosal layer successfully treated with endoscopic resection followed by radiation.

• Archives of Plastic Surgery
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• v.35 no.6
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• pp.698-702
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• 2008

Purpose: Basal cell carcinoma is one of the most common cancers in the western population and the annual incidence rate is still on an increasing course. In Asian countries such as Korea, the incidence of basal cell carcinoma is reported to be remarkably low but is estimated to be in a steep increase nowadays. This study was to analyze the recent clinical trends of basal cell carcinoma in Korea by reviewing a single institution's experience. Methods: Throughout an 11-year period, the surgical excision of 143 cases of basal cell carcinoma was performed in our department. General data of these cases such as the primary site of cancer, age and sex of the patient, operative methods, recurrence rate were reviewed retrospectively. Results: Among the 143 patients included in this study, 82 patients were men and 61 patients were women. The ages ranged from 27 to 89 years with a mean age of 64.0 years. The head and neck region was the most frequently involved primary site for the cancer as 95.1% of the total cases occurred in this area. Especially the nose and perinasal area were the most frequent region, which was followed by the periorbital area, cheek, and perioral area. During this study period, 9 cases showed recurrence of the cancer as the overall recurrence rate was 6.3%. Conclusion: Gradual increase in the incidence of basal cell carcinoma was demonstrated in this study. Basal cell carcinoma showed high incidence in the old-age population as 68.5% of the total patients were more than 60 years of age. High recurrence rate was noted in the nasal region especially after local flap reconstruction. A more cautious approach is to be required when handing such high risk lesions. Multiple factors such as extended life span, increased outdoor leisure activity and exposure to sunlight, higher accessibility to medical services and increased understanding of the public about skin cancer are assumed to be the main reasons for this increase of basal cell carcinoma.

• Journal of Chest Surgery
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• v.39 no.12 s.269
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• pp.949-952
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• 2006

Spontaneous pneumothorax is rarely occurred as an initial sign of primary lung cancer. As a lot of these cases have already advanced, even then surgical resection is performed, the prognosis is often undesirable, We happened to find a ruptured cavity on a 65-year-old male patient who had suffered from pulmonary tuberculosis in the past, while performing VATS bullectomy for simple spontaneous pneumothorax, Then, as a result of frozen biopsy, it was diagnosed as squamous cell cancer Because the tumor was infiltrated from the upper lobe into the lower lobe passing by fissure, we should remove by pneumonectomy and the pathologic stage was found stage I(T2N0M0). When we made an follow-up observation for one year and a half, there was neither relapse nor complication. When there appears spontaneous pneumothorax to the high risk group for lung cancer who were smokers over forty-year old, with chronic bronchitis or pulmonary emphysema, it needs to have a closer observation on a base lung disease such as lung cancer through chest CT, and it is also necessary to make more active approach by performing the surgical operation through a thoracoscopy when there is a continued air release.